Anterior Superior Mediastinum Research Articles

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Case Presentation: A 61-year-old African American female with a past medical history of sarcoid, diabetes, hypertension, end-stage renal disease status post–left nephrectomy presented for surgical evaluation for a potential kidney transplant. Upon work-up for renal transplant, the patient was found to have an intact parathyroid hormone level of 1,888 pg/mL (reference range, 12 to 72 pg/mL), serum calcium of 9.9 mg/dL (reference range, 8.8 to 10.2 mg/dL), serum creatinine of 8.9 mg/dL (reference range, 0.60 to 1.20 mg/dL), and serum phosphorus of 3.5 mg/dL (reference range, 2.4 to 4.4 mg/dL). The physical examination was normal. Given the degree of elevation of parathyroid hormone, the patient underwent evaluation with 99mTc sestamibi radionucleotide scan with single-photon emission computed tomography (SPECT)/computed tomography (CT). The planar images showed increased uptake in the anterior superior mediastinum, with no abnormal uptake in the areas of parathyroids and normal uptake in salivary glands and thyroid (Fig. 1). Further evaluation with SPECT/CT showed a focal area of increased radiotracer uptake in the anterior superior mediastinum (Fig. 2). What is the diagnosis? Fig. 2 View Large Image Figure Viewer

Angiosarcoma originating in the anterior mediastinum

Rationale:Angiosarcomas are malignant vascular tumors, and angiosarcoma occurring in the anterior mediastinum is rare. Here we report a case of angiosarcoma that originated in the anterior mediastinum treated with surgery, followed by radiotherapy and synchronous chemotherapy.Patient concerns:A 56-year-old female was admitted to our hospital with chest pain for 3 days. Chest computerized tomogram (CT) examination showed a heterogeneous mass in the anterior superior mediastinum, and after injection of contrast agent, the mass showed obvious heterogeneous enhancement. Magnetic resonance imaging (MRI) with T1 weighted image (T1WI) showed isointensity and T2 weighted image (T2WI) showed heterogeneous signal intensity, the mass showed an obvious heterogeneously enhancement after intravenous administration of contrast material.Diagnosis and interventions:Surgical resection operation was carried out. According to its morphologic and immunohistochemic feature of tumor cells which expressing CD31, CD34, and ERG, the tumor was categorized as an angiosarcoma. After operation, the patient received radiotherapy and synchronous chemotherapy.Outcomes:At present, 8 months postoperatively, no signs of recurrence have been observed.Lessons:Although angiosarcoma in anterior mediastinum is rare, when a mass located in this area, a more careful immunohistological analysis should be performed to avoid overlooking the presence of angiosarcoma.

Comparison of video-assisted thoracoscopic surgery and thoracotomy in the treatment of mediastinal cysts.

This study aims to compare the results of videoassisted thoracoscopic surgery and thoracotomy in the treatment of mediastinal cystic lesions. Sixty patients (28 males, 32 females; mean age 36.1±19.4 years; range, 2 days to 82 years) who were performed thoracotomy or video-assisted thoracoscopic surgery for mediastinal cyst treatment in our clinic between January 1997 and December 2016 were retrospectively evaluated. Chest radiography and thorax computed tomography were used in all participants for diagnosis. Magnetic resonance imaging was used additionally in 23 participants. Of the patients, mediastinal cysts were localized in anteriorsuperior mediastinum in 19 (31.7%), middle mediastinum in 19 (31.7%) and posterior mediastinum in 22 (36.6%). Histopathologically, 17 bronchogenic cysts, 15 hydatid cysts, 10 pericardial cysts, seven cystic teratomas, four enteric cysts, four thymic cysts, two lymphangiomas and one thoracic duct cyst were identified. While thoracotomy was performed in 34 patients (56.7%), video-assisted thoracoscopic surgery was performed in 26 patients (43.3%). Mean duration of thoracotomies and video-assisted thoracoscopic surgeries was 123.6±24.7 minutes and 87.4±17.6 minutes, respectively (p<0.01). Mean duration of hospital stay was 8.2±4.3 days after thoracotomy and 4.3±1.2 days after video-assisted thoracoscopic surgery (p<0.01). While postoperative complications developed in four patients (two pneumothoraxes, one pleural effusion, one chylothorax), no mortality was observed in any of them. Main treatment method for mediastinal cysts is surgery. Thoracoscopic approach significantly reduces patient's duration of surgical procedure and postoperative duration of hospital stay. We believe that minimally invasive approaches will be administered more frequently compared to open surgeries for mediastinal cysts in the near future.

Transcervical thymectomy

Background: The aim of this article is to describe the technique of minimally invasive extended thymectomy performed through the transcervical video-thoracoscopic (VATS) approach with elevation of the sternum for the thymic tumors with/without myasthenia gravis (MG). Methods: The operation is done through the collar incision in the neck of a length of 4–8 cm. To facilitate an access to the mediastinum a one-tooth hook connected to the Zakopane bar (Aesculap-Chifa, Nowy Tomysl, Poland) is inserted under the sternal notch for elevation of the sternum. Careful anatomical dissection of the structures of the lower neck region is done with preservation from injury of the thyroid gland, the parathyroid glands and both laryngeal recurrent nerves. The thymus gland is resected en-bloc with the surrounding fatty tissue of the lower neck and the anterior superior mediastinum. The blood vessels supplying the thymus are secured and divided—these are inferior thyroid veins and the thymic veins. For better control, a video-thoracoscope (VATS) is inserted to the mediastinum through the cervical incision. The lowers poles of the thymus are separated from the pericardium and the specimen is removed. Usually, the right lower pole is dissected first and the left lower pole is managed during further dissection of the aortopulmonary window is a difficult, but very important part of transcervical thymectomy. Results: There were 18 patients (2 for MG with associated thymic tumors and 16 for the tumors/cysts of the anterior mediastinum without MG) in the period 1/1/2009 to 31/12/2017. The morbidity was 5.6%, with no mortality. The mean time of the procedure was 105.4 min (45–150 min). Conclusions: The transcervical approach combined with VATS and lifting of the sternum facilitates thymectomy in case of small thymic tumors with/without MG. This technique is more difficult and less extensive that subxiphoid thymectomy.

Pitfalls and mimics: The many facets of normal paediatric thymus

The thymus is a lymphatic organ that was often thought of as an organ of mystery by the ancientGreeks. A soft, pliable lymphatic organ positioned in the anterior superior mediastinum, itdoes not compress or displace the adjacent structures. It is disproportionately larger in thepaediatric population and then gradually regresses to ‘hide’ in the mediastinum as the childadvances into puberty. It regresses in size under conditions of stress and may be absent invarious congenital abnormalities such as DiGeorge syndrome and conditions of stress. Thethymus appears in a variety of shapes and sizes on a paediatric chest radiograph and at timesmay be misinterpreted as pathology. This article describes the normal thymus as it appears onpaediatric radiography, and addresses mimickers.

Robotic thoracic surgery of the anterior superior mediastinal bronchogenic cyst.

The patient, a 48-year-old man, was admitted due to “chest pain for 20 days” and “presence of anterior superior mediastinal mass”. He suffered from chest pain 20 days ago, which became severer when coughing. However, no tenderness or heart palpitations were noted. Chest CT at the local hospital showed a roundish hypodense lesion at the anterior superior mediastinum. Further abdominal ultrasound in a medical university-affiliated hospital showed no other abnormality. He then visited our hospital for further management. His general conditions were acceptable. The chest pain persisted, which became severer when coughing. He also had chest tightness and mildly irritating dry cough. However, he had no fever, night sweats, heart palpitations, or precordial discomfort. His mental status, physical performance, appetite, and sleep were normal, and the body weight did not obviously change. Urination and defecation were normal.

Coupe des trois vaisseaux et de la trachée en période prénatale : aspects anormaux

Good knowledge of normal characteristics of prenatal three vessels and trachea view allows not only to detect, but also to identify abnormalities such as normal variants and malformations of interest to main vessels (trunk of the pulmonary artery and its branches, the aorta and the superior vena cava) and various vascular structures in the anterior-superior mediastinum. These abnormalities may be isolated or associated with other anomalies of cardiac architecture.

The use of the trapdoor incision for access to thoracic inlet pathology in children

Lesions at the thoracic inlet are difficult to access via a thoracic or cervical approach. The use of the anterior cervico-thoracic trapdoor incision has been reported to give good exposure to the anterior superior mediastinum in adults. We report our experience of four cases where a trapdoor incision was used to gain excellent access and exposure to thoracic inlet pathology in children.

Single-Port Thymectomy Through an Infrasternal Approach

We report a surgical procedure in which a port and devices designed for single-incision endoscopic surgery are employed for thymectomy through an infrasternal approach. As this single-port thymectomy procedure can be performed through a single 3.5-cm incision in the abdominal region usually concealed under clothes, it is esthetically excellent and is among the least invasive thymectomy procedures because no sternal incision is applied and no intercostal nerve is injured. Investigation of the safety of this procedure and long-term therapeutic outcomes for myasthenia gravis and anterior mediastinal tumors is necessary.

Symptomatic pericardial cyst: a case series

Pericardial cysts are most commonly located at the cardiophrenic angle or, rarely, in the posterior or anterior superior mediastinum. The majority of pericardial cysts are asymptomatic and are found incidentally. Symptomatic pericardial cysts present with dyspnoea, chest pain, or persistent cough. We describe four patients with symptomatic pericardial cysts who were treated with either echocardiographically guided percutaneous aspiration or video-assisted thoracoscopic surgery, or both; thoracotomy; or conservative therapy.

MEDIASTINAL EXTENSION OF A GOITER

A 72-year-old woman presented with a 2-month history of right thoracic pain and cough. Physical examination revealed diminished sounds of breathing from the right lung and an enlargement of the right thyroid, but the lower poles of the thyroid were not palpable. The serum thyroid function tests (thyrotropin and free thyroxine levels) were normal. A neck ultrasound was performed which showed a large goiter with the right lobe extending into the anterior superior mediastinum; the lower part of the mass was not detectable because of the sternum. Chest radiography (Figure 1) revealed a mass of convex form to the lung and tracheal deviation (arrows). Thoracic magnetic resonance imaging (Figure 2) showed a large goiter (12 × 13 × 6 cm) extending from the laryngeal cartilage into the right hilum, displacing vascular structures (black arrows) and causing both compression and deviation of the trachea (white arrows). A total thyroidectomy was performed. Histologic examination revealed a multinodular goiter. The patient made a good recovery and has no symptoms after surgery. The diff erential diagnosis of anterior mediastinum includes thymomas, lymphomas, germ cell tumours, congenital cysts, intrathoracic thyroid tissue, and parathyroid lesions. This case establishes that substernal goiter should be considered in the diff erential diagnosis of mediastinal masses. The preoperative diagnosis is essential and is based on magnetic resonance images. Surgery is the treatment of choice for substernal goiter. Most substernal goiter cases can be safely treated through the neck approach, while thoracotomy or sternotomy is required for selected cases. Prognosis is excellent following a successful excision.

Primary Mediastinal (Thymic) Large B-Cell Lymphoma: A Short Review With Brief Discussion of Mediastinal Gray Zone Lymphoma

Primary mediastinal (thymic) large B-cell lymphoma (PMBCL) is a subtype of diffuse large B-cell lymphoma (DLBCL). It commonly presents as a bulky lesion in the anterior-superior mediastinum with symptoms related to local invasion or compression. Microscopic examination typically shows infiltration of medium-large cells surrounded by collagen fibrosis. The neoplastic cells express B-cell markers, and CD30 often shows heterogeneous staining. Comparative genomic hybridization has identified gains in loci of 9p24 and 2p15 as well as Xp11.4-21 and Xq24-26. Amplification of REL and BCL11A at 2p as well as elevated expression of JAK2, PDL1, and PDL2 at 9p has been demonstrated. Nodular sclerosis classic Hodgkin lymphoma needs to be differentiated from PMBCL and cases with overlapped features have been described as mediastinal gray zone lymphoma. Primary mediastinal (thymic) large B-cell lymphoma carries a favorable prognosis in comparison to conventional DLBCL.

Experience and analysis of level VII cervical lymph node metastases in patients with papillary thyroid carcinoma

PurposePapillary thyroid cancer with level VII (anterior superior mediastinal lymph nodes) lymph node metastasis belongs to Stage IV a according to the Americal Joint Committee on Cancer cancer staging. The aim of our study was to identify clinicopathologic factors that are related to level VII cervical lymph node metastasis and to suggest recommendations for level VII dissection.MethodsWe reviewed 195 patients with papillary thyroid carcinoma who had their initial operation containing level VII dissection from April 2006 to June 2007. Level VII dissection involved lymph nodes in the anterior superior mediastinum and tracheoesophageal grooves, extending from the suprasternal notch to the innominate artery. Clinicophathologic factors, such as gender, age and lateral neck metastasis, related to Level VII metastasis were analyzed by tumor size, multifocality of tumor, extrathyroidal extension and lymphovascular invasion.ResultsNine (4.6%) of 195 patients with papillary thyroid carcinoma had level VII metastasis. Clinicopathologic factors that were related to level VII metastasis included lateral neck metastasis (P < 0.01), tumor size (P < 0.01) and lymphovascular invasion (P < 0.05).ConclusionIf preoperatively, the tumor size is over 1.5 cm, or there is lateral neck metastasis, level VII dissection must be considered. If there is lymphovascular invasion pathologic findings postoperatively, special attention should be paid for detection of level VII recurrence.

Synchronous primary intrapulmonary and mediastinal thymoma-A case report

We report an extremely rare case of Synchronous primary intrapulmonary and mediastinal thymoma in a Chinese patient. We describe the histological and radiological findings, which support the possibility of multicentric thymoma. Resection of the mass in the left anterior superior mediastinum and upper lobectomy of right lung were performed, with lymph Nodes clearance, superior vena cava, left and right brachiocephalic veins resection, reconstruction of left brachiocephalic vein to right auricle and reconstruction of right brachiocephalic vein to superior vena cava.

Invasive thymoma with intraorbital metastases

Thymomas are epithelial neoplasm of thymus and most common primary neoplasm of anterior and superior mediastinum affecting males and females equally. It occurs usually in the fifth to seventh decade. Approximately one-third of thymomas are invasive. Metastases to distant extrathoracic sites such as the liver, lung, lymph node, kidneys, ovary and brain occur infrequently. This is more common with invasive thymomas. Although brain has been shown to be a site of infrequent metastases, intraorbital metastases has not yet been reported. Here we report one such case of invasive thymoma of anterior superior mediastinum, which later metastasized to orbit as well as the brain.

Treatment of advanced thymoma and thymic carcinoma.

Although thymic epithelial tumors are rare, they are relatively common among neoplasms of the anterior superior mediastinum. They usually exhibit indolent behavior, but do have the capacity to invade surrounding structures and metastasize to distant sites. Thymic carcinomas are rare, but are highly aggressive tumors that are associated with a poor prognosis. The mainstay of therapy is complete surgical resection. Locally advanced thymoma and thymic carcinoma require a multimodality treatment approach with a combination of surgery, chemotherapy, and radiation therapy to decrease the chances of recurrence and improve survival. The risk of disease recurrence lasts for a number of years after completion of primary therapy. A majority of cases of recurrent disease present as pleural recurrences. Once again, surgical resection of recurrent disease represents the cornerstone of successful therapy and is critical to long-term survival. In recent years, a better understanding of the biologic basis of thymic epithelial tumors has led to the emergence of targeted therapy directed against this malignancy.

Mediastinal thymolipoma: An analysis of 10 cases

Thymolipoma is a benign tumour composed of thymic elements and adipose tissue. It may be associated with myasthenia gravis or immune disorders. We aimed to evaluate the clinical and radiological features of thymolipoma. The clinical data from 10 cases of thymolipoma, diagnosed at our centre between 2002 and 2004, were analysed retrospectively. There were six female and four male patients, whose ages ranged from 16 to 67 years, with a mean age of 34.1 years. All but two patients had pulmonary or extrapulmonary symptoms. Five patients also had myasthenia gravis. All thymolipomas were localized in the anterior superior mediastinum. The surgical approach was sternotomy in nine cases and thoracotomy in one case. Thymectomy was performed on all patients. Thymolipomas are unusual tumours and may be associated with myasthenia gravis. Surgical resection is the most appropriate treatment modality.

Unexpected abnormal extra-cardiac mediastinal accumulation of technetium-99m-tetrofosmin in patient with acute pericarditis

A 58-year old woman had felt some chest pains on effort for several days. She was admitted to the emergency room with severe and refractory chest pain after exercise. Electrocardiogram showed marked ST-segment elevations in II, III, aVF and V1-6 electrodes. Echocardiogram revealed neither wall motion asynergy in the left ventricle nor abnormal pericardial effusion. Chest X-ray showed normal findings, and mild elevation of C-reactive protein was observed in the blood chemistry data. Her chest pain was relieved by nitroglycerin administration. Emergent technetium-99m-tetrofosmin myocardial imaging did not show any abnormal perfusion in the left ventricle. However, an abnormal extra-cardiac mediastinal accumulation was detected in the planar image. Contrast-enhanced chest CT scanning also demonstrated an inhomogeneously enhanced tumor in the anterior superior mediastinum. The tumor was surgically removed and was finally diagnosed as an invasive thymoma. Technetium-99m-tetrofosmin scintigraphy happened to provide useful information for diagnosing acute pericarditis with mediastinal tumor.

Non-neoplastic mediastinal cysts.

The non-neoplastic mediastinal cysts (NNMCs) form a group of uncommon benign lesions of a congenital origin. The significant controversy regarding these cysts is whether to manage with observation or surgical resection. The aim of this study is to analyse the utility of thoracic computed axial tomography (CT) in imaging diagnosis of the NNMCs and the results of surgery in these lesions. Twenty NNMCs underwent surgery between 1980 and 2000. The preoperative study of mediastinal cystic masses includes a complete blood test, chest radiography (CR) and, for the last 15 years, a thoracic CT and/or nuclear magnetic resonance. All the patients underwent surgery in our thoracic surgery department and were reviewed in outpatients at 1 month, 6 months, 1 year and biannually thereafter. The form of manifestation, clinical features, imaging techniques, surgical operation, morbidity, mortality and follow-up are analysed. Ten corresponded to bronchogenic cysts, the most common symptom of which was chest pain. CR showed a mass in the anterior-superior mediastinum in nine cases, and CT (five cases) revealed a cystic tumour in the anterior mediastinum. All were removed surgically, with three patients presenting with mild complications. Seven corresponded to pleuro-pericardial cysts, four being asymptomatic. CR showed a right paracardial mediastinal tumour, which was confirmed by CT (four cases). All were removed surgically, with two patients presenting with mild complications. Three corresponded to enteric cysts. CR showed a tumour in the posterior mediastinum, with CT confirming its cystic nature (two cases). Excision of the cyst was done in all cases, which corresponded to duplication cysts: two oesophageal and one gastric. All the patients are asymptomatic and recurrence-free after a follow-up of 11 +/- 10 years. NNMCs are benign lesions in which the lesions in which the surgery can be done with a low morbidity and mortality rate, enables us to rule out malignancy and offers a definitive cure. Actually the thoracic CT permit a correct diagnosis pre-surgery in function of the radiologic characterisation and topography.

Mediastinal epithelioid hemangioendothelioma resected by hemi-plastron window technique

We report a case of epithelioid hemangioendothelioma arising from the left brachiocephalic vein in the anterior superior mediastinum of a 41-year-old man. The tumor was resected by local excision using a novel approach, the “hemi-plastron window” technique. The patient had an uneventful postoperative course and no recurrence of tumor 28 months after surgical treatment. We describe this surgical approach and discuss its advantage for cervicothoracic tumors.