You have accessJournal of UrologyProstate Cancer: Staging I1 Apr 2018MP53-06 PREVALENCE AND PATHOLOGICAL CHARACTERISTICS OF ANTERIOR PROSTATE CANCER IN A COHORT OF RADICAL PROSTATECTOMY PATIENTS DIAGNOSED BY BIOPSIES AND MRI. Gautier Marcq, Claire Pinçon, Jérôme Rizk, Jean-Christophe Fantoni, Sébastien Aubert, Xavier Leroy, and Arnauld Villers Gautier MarcqGautier Marcq More articles by this author , Claire PinçonClaire Pinçon More articles by this author , Jérôme RizkJérôme Rizk More articles by this author , Jean-Christophe FantoniJean-Christophe Fantoni More articles by this author , Sébastien AubertSébastien Aubert More articles by this author , Xavier LeroyXavier Leroy More articles by this author , and Arnauld VillersArnauld Villers More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.1677AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES MRI improves prostatic cancers diagnosis, but few published reports have looked at pathological characteristics at radical prostatectomy (RP) of anterior cancers diagnosed through systematic MRI and biopsies. The goal of our study was to analyze pathological data of anterior prostate cancers - location and extent of tumors and surgical margins - in a large cohort of patients diagnosed with pre-operative MRI and treated with RP. METHODS Single center cohort study from January 2009 to June 2016. We included patients with prostatic cancer diagnosed on MRI and targeted transrectal US-guided biopsy who underwent RP. Pathological data collected on RP specimen included tumor localization, Gleason grades of primary (PT) and secondary tumor (ST), presence, location and extent (focal: < 3mm and extended: ≥3mm) of positive surgical margins (PSM). Student test and chi-square analysis were performed. RESULTS A total of 1,002 patients were included in the analysis. The median age was 63 years-old (Interquartile range (IQR): 59-68). The median PSA was 6.8 ng/mL (IQR: 5.2-9.5). PT was anterior in 129 cases (13%). In 745 (75%) cases there was a ST. ST was anterior in 92 (13%) posterior in 638 (85%) with missing data in 2%. Median tumor size was 20 mm (IQR: 15-24) for anterior PT (p<0.001) and 16 mm (IQR: 12-22) for posterior PT. Extended PSM were more common for anterior PT than for posterior PT (19% vs 12%, p=0.04). Gleason grade (p=0.46) and stage (p=0.71) were similar between anterior and posterior PT. CONCLUSIONS MRI based detection of prostatic cancers treated by RP is associated with a 13% anterior location of primary tumor. Anterior cancers share similar grade and stage with posterior cancer but had a larger size and more extensive PSM. Separate oncological outcomes of patient with anterior vs posterior tumors need to be evaluated. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e706 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Gautier Marcq More articles by this author Claire Pinçon More articles by this author Jérôme Rizk More articles by this author Jean-Christophe Fantoni More articles by this author Sébastien Aubert More articles by this author Xavier Leroy More articles by this author Arnauld Villers More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...