A CPW-fed antenna sensor with high quality factor is designed to identify the skin cancer. The proposed antenna operates in the ISM band at 2.47 GHz frequency. The proposed antenna aims to exploit the variations in dielectric constants of skin, fat, and muscle tissues to enable non-invasive and early detection of skin cancer. The antenna design process involves considerations for achieving a high frequency shift and quality factor to discern subtle variations in dielectric properties. Electromagnetic simulations, utilizing advanced numerical techniques are employed to analyze the antenna's performance in different tissue environments. The proposed antenna design is optimized for enhancing its sensitivity to changes in the dielectric constants associated with healthy and cancerous skin tissues. To validate the antenna's effectiveness, experimental setups using tissue-mimicking phantoms are utilized. This research not only emphasizes the technical aspects of antenna design but also underscores the potential clinical applications for non-invasive skin cancer detection.