BackgroundIn child and adolescent psychiatry departments, the number of hospitalizations for anorexia nervosa (AN) has been increasing in recent years. In the phase of severe undernutrition, these patients may exhibit disturbances in their immune functions. Based on this observation, many French practitioners had chosen to avoid long hospitalizations during the first wave of COVID-19. They had in mind a risk of contagion between adolescents, in which infections can be frequently asymptomatic. Fear of an increased risk of a severe form of COVID-19 in AN patients has led to early returns home, where they would probably be safer than in our departments. Is this strategy still relevant for the second wave? Has an increased risk of a severe form been identified in the adolescent AN patients? MethodWe have recalled the French recommendations on the subject. Then we carried out a review of the international literature via Medline, Google Scholar as well as data from the American organization Center for Disease Control and Prevention. ResultsThe evolution of knowledge about the pandemic has clearly established a lower risk of infection in adolescents than in adults. It seems that the virus spares this population, most of them remaining asymptomatic or paucisymptomatic. Reassuringly, AN or low body weight has not been shown to pose a risk for the severe form of COVID-19. Conversely, the literature reports that lockdown worsens the symptoms of AN (food restriction, hyperactivity) in at least a third of these patients. Most of the patients expressed a high level of anxiety during the first lockdown. It may even have been difficult for these patients to continue to access care when they were confined. ConclusionIn the end, it seems wise not to reproduce the strategy of early return home in adolescents with AN. Current data support the need for continuity of care, as well as the continuation of hospital care when necessary, while a too rapid discharge runs the risk of destabilizing the patient in an already long and difficult course of care in the usual time.