Abstract This work presents a new methodology for flow regimes identification and volume fraction predictions in water–gas–oil multiphase systems. The approach is based on gamma-ray pulse height distributions (PHDs) pattern recognition by means the artificial neural networks (ANNs). The detection system uses appropriate fan beam geometry, comprised of a dual-energy gamma-ray source and two NaI(Tl) detectors adequately positioned in order measure transmitted and scattered beams, which makes it less dependent on the regime flow. The PHDs are directly used by the ANNs without any parameterization of the measured signal. The system comprises four ANNs. The first identifies the flow regime and the other three ANNs are specialized in volume fraction predictions for each specific regime. The ideal and static theoretical models for annular, stratified and homogeneous regimes have been developed using MCNP-X mathematical code, which was used to provide training, test and validation data for the ANNs. The energy resolution of NaI(Tl) detectors is also considered on the mathematical model. The proposed ANNs could correctly identify all three different regimes with satisfactory prediction of the volume fraction in water–gas–oil multiphase system, demonstrating to be a promising approach for this purpose.