Abstract Purpose: To determine the oral lesions of smoking amongst adolescents and adults in Lagos State, Nigeria. Methods: A multistage sampling method was used to select 3 Local Government areas from the three districts in Lagos state. Using an interviewer-administered questionnaire and oral examination data was collected from 2,486 participants. Questions included; duration and amount of cigarettes smoked. While the examination was done with the use of ORALID to identify lesions, and ‘Bedfont Pico smokerlyzer’ to validate smoking status. The chi-square test was used to test differences in proportions. Results: Adolescents constituted 16.5% of the study population, and 58.4% of the total were males. The prevalence of current smokers was 9.2%, and of this 73.6% were daily smokers. There was a 2.6 times higher risk of halitosis (26.6% vs 10.4%), 7.7 times higher risk of smoker’s palate (15.3% vs 2.0%), and 8.6 times higher risk of melanosis (21.6% vs 2.5%) in current smokers compared to nonsmokers. A statistically significant association was noted between smoking status and the presence of oral lesions (P <0.0001). Abnormal oral finding was noted in 3.9% of the subjects, and this was significantly higher in current smokers (21.1%) than in nonsmokers (4.1%). Conclusion: The occurrence of oral lesions was significantly higher in current smokers compared to nonsmokers. Appropriate tobacco cessation programs and prompt management of potentially malignant lesions are recommended measures to reduce the occurrence of oral cancers in cigarette smokers. Citation Format: Oladunni Ogundana, Omolara Uti, Oyinkansola Sofola, Wasiu Adeyemo. Oral Lesions Associated With Tobacco Smoking in Adolescents/Adults Dwellers in Lagos, Nigeria [abstract]. In: Proceedings of the 11th Annual Symposium on Global Cancer Research; Closing the Research-to-Implementation Gap; 2023 Apr 4-6. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(6_Suppl):Abstract nr 66.