Annual Cancer Incidence Research Articles

Impact of Medicaid Expansion on Incidence and Mortality from Gastric and Esophageal Cancer.

Individuals in Medicaid expanded states have increased access to treatment for medical conditions and other health care resources. Esophageal and gastric cancer are associated with several modifiable risk factors (e.g. smoking, drinking, Helicobacter pylori infection). The impact of Medicaid expansion on these cancers incidence and mortality remains uninvestigated. We evaluated the association between Medicaid expansion and gastric and esophageal cancer incidence and mortality in adults aged 25-64. We employed an observational design using a difference-in-differences method with state level data, from 2010 to 2017. Annual, age-adjusted gastric and esophageal cancer incidence and mortality rates, from the CDC Wonder Database, were analyzed. Rates were adjusted for by several socio-demographic factors. Expansion and non-expansion states were similar in percent Hispanic ethnicity and female gender. The non-expansion states had significantly higher proportion of Black race, diabetics, obese persons, smokers, and those living below the federal poverty line. Adjusted analyses demonstrate that expansion states had significantly fewer new cases of gastric cancer: -1.6 (95% CI 0.2-3.5; P = 0.08) per 1,000,000 persons per year. No significant association was seen between Medicaid expansion and gastric cancer mortality (0.46 [95% CI -0.08 to 0.17;P = 0.46]) and esophageal cancer incidence (0.8 [95% CI -0.08 to 0.24; P = 0.33]) and mortality (1.0 [95% CI -0.06 to 0.26; P = 0.21]) in multivariable analyses. States that adopted Medicaid expansion saw a decrease in gastric cancer incidence when compared to states that did not expand Medicaid. Though several factors may influence gastric cancer incidence, this association is important to consider during health policy negotiations.

Expert consensus on surgical treatment of tongue squamous cell carcinoma

The annual incidence of oral cancer in the world is more than 300 000, and the five-year survival rate is 50%~60%. Every year, 145 400 people died due to tongue cancer, of which tongue cancer accounts for nearly 40%. Although tongue cancer has tumor heterogeneity and individual differences in prognosis, surgery is still the first choice for the treatment of tongue cancer. The effect of tongue cancer surgery can directly determine the survival time of patients. The defect caused by tongue cancer surgery seriously affects the patients' physical functions such as appearance, language, chewing and swallowing. The surgical treatment of tongue cancer with functional reconstruction can improve the quality of life of patients. In the past few decades, genomics has enhanced understanding of tongue cancer. The preclinical tumor model preserves the tumor heterogeneity, which has a great application prospect in the discovery of tumor biomarkers and the clinical translation of drugs. Many advances have been made in the diagnosis and treatment of tongue cancer, but there are still many controversies in clinical practice. Therefore, this expert consensus summarizes the progress and controversial hot spots of surgical diagnosis and treatment of tongue cancer, mainly including preoperative diagnosis and evaluation, surgical treatment points and postoperative functional rehabilitation.

Access to Radiation Therapy: From Local to Global and Equality to Equity.

The discipline of radiation oncology is the most resource-intensive component of comprehensive cancer care because of significant initial investments required for machines, the requirement of dedicated construction, a multifaceted workforce, and recurring maintenance costs. This review focuses on the challenges associated with accessible and affordable radiation therapy (RT) across the globe and the possible solutions to improve the current scenario. Most common cancers globally, including breast, prostate, head and neck, and cervical cancers, have a RT utilization rate of > 50%. The estimated annual incidence of cancer is 19,292,789 for 2020, with > 70% occurring in low-income countries and low-middle–income countries. There are approximately 14,000 teletherapy machines globally. However, the distribution of these machines is distinctly nonuniform, with low-income countries and low-middle–income countries having access to < 10% of the global teletherapy machines. The Directory of Radiotherapy Centres enlists 3,318 brachytherapy facilities. Most countries with a high incidence of cervical cancer have a deficit in brachytherapy facilities, although formal estimates for the same are not available. The deficit in simulators, radiation oncologists, and medical physicists is even more challenging to quantify; however, the inequitable distribution is indisputable. Measures to ensure equitable access to RT include identifying problems specific to region/country, adopting indigenous technology, encouraging public-private partnership, relaxing custom duties on RT equipment, global/cross-country collaboration, and quality human resources training. Innovative research focusing on the most prevalent cancers aiming to make RT utilization more cost-effective while maintaining efficacy will further bridge the gap.

Preoperative neoadjuvant chemotherapy in patients with breast cancer evaluated using strain ultrasonic elastography.

BACKGROUNDThe incidence of breast cancer in China is increasing while its mortality rate is decreasing. The annual breast cancer incidence in China is 39.2 million, accounting for two-thirds of the urban population. In China, breast cancer is the fifth most common malignant tumor overall and the most common in women, accounting for 17% of female malignant tumors. AIMTo investigate the accuracy of strain ultrasound elastography (SUE) on the evaluation of preoperative neoadjuvant chemotherapy (NAC) in breast cancer.METHODSOverall, 90 patients with breast cancer treated at our hospital between January 2018 and February 2019 were selected for this study. The patients received six cycles of NAC with docetaxel, epirubicin, and cyclophosphamide. Surgical treatment was also performed, and pathological reactivity was assessed. The patients were evaluated using conventional ultrasonography and SUE before biopsy. The differences between groups were analyzed to calculate the mean and standard deviation with significance measured using a t-test, while multivariate analysis was performed using logistic regression analysis.RESULTSOf the patients analyzed, 20 had a pathological complete remission (pCR) while 70 did not achieve pCR after NAC. The ratio of the elastic strain ratio (SR) and elastic score of 4–5 in patients with pCR were 5.5 ± 1.16 and 15.00%, respectively; these were significantly lower than those in patients without pCR (85%) and significantly higher than in patients without pCR (14%). SR and elastic score 4–5 were independent factors influencing NAC efficacy (OR=0.644, 1.426 and 1.366, respectively, P < 0.05). SR was positively correlated with elasticity score (rs = 0.411, P < 0.05). The area under the receiver operator characteristic curve of SR and SR combined with elastic score in predicting patients without pCR was 0.822 and 0.891, respectively (P < 0.05).CONCLUSIONStrain ultrasonic elastography may be used to evaluate the effects of preoperative NAC in patients with breast cancer.

Radiotherapy and cancer status in Latin America: economic analysis of investment opportunities up to 2030

Timely access to radiotherapy treatments for cancer in Latin America is hindered by substantial delays in investment. We herein report on the current incidence of the ten most frequent malignancies and on radiotherapy-related logistics across Latin America with the objective of identifying resource gaps and facilitate the planning of health-care investments up to 2030. Data were collected from the International Atomic Energy Agency's (IAEA) Directory of Radiotherapy Centers and matched to open-source databases and individual surveys sent to national scientific societies in participant countries (Argentina, Bolivia, Brazil, Chile, Colombia, Ecuador, Mexico, Paraguay, Peru, Uruguay, and Venezuela). Demographic, economic, and epidemiological data were gathered from the World Bank and the Global Cancer Observatory registries. The incidence rates of the ten most common cancers treated with radiotherapy in each country were multiplied by the respective radiotherapy use rate according to the IAEA's Time-Driven Activity-Based-Costing model. Country-specific adjustments were made and the following assumptions were factored for the analysis: 240 working days, 60 patients treated per teletherapy unit per day, and 25 external beam radiotherapy fractions required per diagnosis at a cost of US$ 1703·75 or equivalent per full treatment, and four brachytherapy fractions for cervical (75% of total) and endometrial (27%) cancer and one boost fraction for prostate cancer (5%) diagnosis, at a cost of US$ 1426·40 per treatment. These values were adopted from India (for cervix cancer data) and Spain (endometrial cancer data), which are countries with a cancer incidence profile similar to that of Latin America. The prostate brachytherapy use rate was adopted from recently published US data. Human resource requirements were estimated according with the observed annual cancer incidence, keeping with IAEA's recommendations. 10-year incidence and costs projections were calculated according to the estimated demography dynamics and time value of money equation for each country for the period 2020-30. Current and projected cancer incidences and radiotherapy, personnel, and logistic requirements are reported through absolute numeric differences and mean values. Potentially saved lives (equivalent to 50% of newly included patients after increasing radiotherapy capacities to recommended levels) and monetary return, assumed as a mean regional monthly wage multiplied by the rescued life-years, are also reported. Information concerning the 11 most populous countries in Latin America was obtained. As of 2020, a population of 557 213 447 individuals was recorded, accounting for 85% of the Latin American inhabitants and projected to increase to 772 038 620 (an increase of 214 825 173) by 2030. The 2020 overall cancer incidence was 1 055 892 cases and the mean 2020 incidence per country was 95 990 (SD 135 013). The 10-year projection was of 1 460 154 new cases with a mean of 132 741 (SD 188 832) per country, highlighting the high variability in needs across the region. Overall external beam radiotherapy use rate was estimated for 663 236 annual new cases in 2020, versus 916 592 annual new cases by 2030, and overall brachytherapy use was estimated for 90 428 annual new cases in 2020 and 125 152 annual new cases by 2030. The 2020 regional availability of treatment fractions was 11 822 400 for external beam radiotherapy and 216 960 for brachytherapy. Conversely, the 2020 required number of fractions was 13 241 088 (+12·2%) for external beam radiotherapy and 361 672 (+66·7%) for brachytherapy; and the projected required number of fractions in 2030 is 18 324 720 (+55·0%) for external beam radiotherapy and 500 744 (+130·8%) for brachytherapy. If the projected demand was to be covered, an additional 181 622 lives could potentially be saved by 2030, accounting for a 2-year total financial return of US$ 1 963 776 038·20, assuming 50% of additionally treated patients will be reincorporated to the economically active population. Bridging the gap in radiotherapy up to 2030 will save lives and reduce the financial toxicity of cancer management in Latin America. Governmental and private investment in radiotherapy is urgently required to shorten access disparities and reach these goals. None.

Canadian medical oncology workforce and cancer incidence trends: Supply and proxy demand analyses from 1994 to 2020.

e13526 Background: It is unclear whether the Canadian medical oncology workforce has kept pace with the country’s rising cancer incidence over the last three decades. This study sought to characterize the national and provincial trends in the medical oncologist (MO) and MO trainee workforce during the last 27 years and explore the relationship between workforce and cancer incidence. Methods: Publicly available databases from the Canadian Medical Association (CMA; 1994-2019) and Canadian Institute of Health Information (CIHI) database (1994-2020) were utilized to estimate the number, demographics, and regional distribution of practicing MOs in Canada from 1994 to 2020. Cancer incidence by province was obtained from Statistics Canada for the period 1990 to 2018, except for Quebec where only 1990-2010 data was available, and then projected to 2020 across five regions (The West Coast, The Prairies, Ontario, Quebec and Atlantic Canada) using Canadian population statistics from Statistics Canada and age-period-cohort modeling. To estimate changes in demand for, and supply of, medical oncology services over time, annual cancer incidence to MO provider ratios were calculated. Finally, the Canadian Post MD Education Registry (CAPER) database (1994-2020) was used to characterize the number of MO trainees. Results: Between 1994 and 2020, annual cancer incidence nationally rose from 120,255 cases to 225,800 cases (88%), while the number of MOs increased from 161 to 642 (298%). Incident cancer cases to medical oncologist (MO) ratio dropped from 749:1 in 1994 to 352:1 in 2020. This ratio fell in all five analyzed regions from 1994 to 2020 (Atlantic Canada 1836:1 to 447:1, The Prairies 1257:1 to 377:1, The West Coast 909 to 261:1, Ontario 682:1 to 411:1 and Quebec 543:1 to 300:1). In 1994, 24% of MO providers were ≥ 50 years old compared with 40% in 2020. Nationally, the MO workforce has nearly reached gender parity with 46% female in 2020 versus 25% in 1994. Trends in Canadian MO trainees have largely mirrored MO trends with a 203% increase in the annual trainee cohort from 34 in 1994 to 103 in 2020. In 1994, 34% of trainees were female compared with 63% in 2020. The largest proportion of the country's MOs (34% in 2020) and MO trainees (49%) are located in Canada’s most populous province, Ontario. Conclusions: Although the Canadian MO workforce has shown considerable growth between 1994-2020, a higher proportion of MO providers are nearing retirement age and may influence future workforce trends. Moreover, our study was not able to take into consideration referral patterns or the increasing number and complexity of systemic therapies that also influence MO workload. Ongoing monitoring of human resource levels in medical oncology and cancer incidence data are key metrics to meaningfully inform MO training programs of an appropriately sized trainee cohort and ensure future demands for MO services in cancer care are met.

Impact of the COVID-19 pandemic on cancer incidence and mortality

Impact of the COVID-19 pandemic on cancer incidence and mortality

Changing Epidemiology of Oral Cavity Cancer in the United States.

We aim to more accurately characterize the current distribution and rates of squamous cell carcinoma (SCC) cases across various oral cavity subsites in the United States. Retrospective cohort. Database study evaluating cancer incidence in the United States from 2001 to 2017. We utilized the US Cancer Statistics Public Use Database, which includes deidentified cancer data reported to the Centers for Disease Control and Prevention's National Program of Cancer Registries and the National Cancer Institute's SEER (Surveillance, Epidemiology, and End Results), capturing 97% of newly diagnosed cancers. We restricted our analysis to SCC arising from oral cavity subsites from 2001 to 2017. We calculated trends in annual cancer incidence rates using SEER*Stat, as well as annual and average annual percentage change and joinpoints with the National Cancer Institute's Joinpoint program. Most oral cavity SCC cases arise from the oral tongue (41.7%), followed equally by lip and floor of mouth (each 16.5%), gingival (10.6%), buccal (6.7%), retromolar trigone (5.6%), and hard palate (2.3%) involvement. The overall incidence of oral tongue SCC continues to rise with an average annual percentage change of 1.8% (95% CI, 1.6%-2.1%; P < .001), with a 2.3% increase among women. This increase is seen among males and females of all age groups. Cancers involving the gum, buccal mucosa, and hard palate were also found to be increasing in rate, albeit to a lesser degree and with substantially lower incidence. The tongue is the most frequently involved subsite of oral cavity SCC and is increasing in incidence among males and females of all ages.

Language matters: representations of ‘heart failure’ in English discourse—a large-scale linguistic study

AimsHeart failure (HF) has a lower public profile compared with other serious health conditions, notably cancer. This discourse analysis study investigates the extent to which HF is discussed in general...

Cervical mediastinoscopy in diagnosis and treatment of lung cancer

Lung cancer remains the leading cause of cancer mortality. It ranks first in the incidence of cancer in the world. According to the European Association of Oncologists, the annual incidence of lung cancer is increasing with every passing year and amounts to about 1.8 million new cases worldwide. Men have a higher prevalence of lung cancer (33.8 per 100,000) than their female counterparts (13.5 per 100,000). In most cases, it is diagnosed at an advanced stage (III — IV), which is characterised by mediastinal lymphadenopathy. Early detection of lung cancer allows seeking early treatment. Lung cancer screening is used to find a tumour and/or lung cancer metastasis, determine its location and size as well as its morphological verification.&#x0D; Objective — to define the most accurate invasive and non‑invasive methods of verification and diagnosis of mediastinal lymphadenopathy and improve diagnosis and treatment of lung cancer through the extensive use of cervical mediastinoscopy and creation of an algorithm for its optimal use.&#x0D; Materials and methods. The study included 146 patients. A wide range of clinical, laboratory, endoscopic (Endobronchial ultrasound transbronchial needle aspiration (EBUS‑TBNA), Cervical Mediastinoscopy (CM)), radiographical (Computed tomography (CT), Positron emission tomography (PET)), morphological, immunohistochemical and statistical methods were used. Statistical analysis was performed using Statistics for Windows Version 10.0 (Stat Soft Inc., USA).&#x0D; Results. The study involved 146 patients who underwent screening for mediastinal lymphadenopathy using mediastinoscopy. According to the laboratory findings, 98 patients had lung cancer. The rest of the cases were presented by other pathologies. Colorectal and stomach cancers were most commonly seen. In one case, the patient had a comorbidity, a combination of lung cancer and colorectal cancer.&#x0D; Conclusions. Mediastinoscopy is the most effective diagnostic method for mediastinal lymphadenopathy, especially in lung cancer.

Ambient air emissions of endocrine-disrupting metals and the incidence of hormone receptor- and HER2-dependent female breast cancer in USA.

Limited evidence exists on the relationship between exposure to endocrine-disrupting metals in ambient air and hormone receptor- and HER2-dependent breast cancer. This study investigates the association between ambient air emissions of endocrine-disrupting metals and the incidence of female breast cancer of different receptor status. County-level data from the US national datasets were analyzed for the association between emissions of various metals including arsenic, cadmium, chromium VI, lead, and mercury, and the annual age-adjusted incidence of hormone receptor-dependent breast cancer for 1990-2016 and HER2-dependent breast cancer for 2010-2016 using adjusted linear regression models. Lead emissions showed the strongest association among the metals examined with the incidence of different receptor status breast cancers, including ER-positive, ER-negative, PR-negative, HER2-negative, and Triple-negative breast cancers, with the adjusted β ranging from 917.26 for ER-negative to 3182.37 for HER2-negative breast cancer. Arsenic and mercury showed significant associations with the incidence of ER-positive, ER-negative, PR-positive, and PR-negative breast cancers. However, cadmium emissions were only significantly associated with ER-negative breast cancer. Moreover, chromium was not associated with any subtypes of breast cancer. Among all of the metals, only lead and mercury emissions showed significant associations with HER2-negative and Triple-negative breast cancer incidence. The results from this study suggest that increased exposure to endocrine-disrupting metals, especially lead, in ambient air could be associated with an increased incidence of female breast cancers with various receptor status in the US. Prospective studies are warranted to further explore this relationship.

Burden of Coronary Heart Disease and Cancer from Dietary Exposure to Inorganic Arsenic in Adults in China, 2016.

Background and Objectives:Inorganic arsenic (iAs) can cause a wide range of health problems, including coronary heart disease (CHD) and lung, bladder, and skin cancer. Although dietary iAs intake is the primary source of iAs, the burden of CHD and cancers from dietary iAs exposure in Chinese adults has not been well known.Methods:To estimate the iAs exposure level in Chinese adults’ diet, we systematically collected food-specific iAs concentrations in China from Chinese and English literature databases during 2000-2020. Food consumption was extracted from two nationwide food and nutrition surveys in China. The population attributable fraction was calculated based on the dose-response relationship between iAs and CHD risk. Combining the 2016 Chinese tumor registry data, we calculated the annual incidence of cancer from dietary iAs exposure to measure the disability-adjusted life year (DALY) in 2016.Findings:The total amount of daily foodborne iAs intake was 0.55 μg/kg bw/day among Chinese adults. The DALY of foodborne iAs-associated CHD was 3,017,510, which accounted for 10.18% of total CHD DALY in Chinese adults in 2016. Moreover, the carcinogenic DALY for lung cancer, bladder cancer, and skin cancer of Chinese residents in 2016 related to dietary iAs was 314.24, 9.89, and 167.32 thousand, accounting for 2.05%, 1.70%, and 35.5% of the total cancer burden, respectively.Conclusions:Our findings suggested that dietary iAs exposure causes a substantial disease burden in Chinese adults. More efforts for foodborne iAs control are critical to reducing the disease burden of CHD and cancer in China and other countries with similar dietary patterns.

How a faecal immunochemical test screening programme changes annual colorectal cancer incidence rates: an Italian intention-to-screen study

BackgroundThis study aimed to evaluate the effectiveness of a biennial faecal immunochemical test (FIT) screening programme in reducing annual colorectal cancer (CRC) incidence in its dynamic target population.MethodsThe target population included over 1,000,000 persons aged 50–69 living in a region of northern Italy. The average annual response rate to invitation was 51.4%. Each observed annual age-standardised (Europe) rate per 100,000 persons between 2005, the year of introduction of the programme, and 2016 was compared with each expected annual rate as estimated with age-period-cohort (men) and age-period (women) models.ResultsFor both sexes, the rates observed in 1997–2004 and those expected in 2005–2016 were stable. Observed rates increased in 2005, peaked in 2006 (the first full year of screening), dropped significantly below the expected level in 2009, and continued to decrease until 2013 (the eighth full year), after which no further significant changes occurred. In the pooled years 2013–2016, the observed incidence rate per 100,000 persons was 102.2 [95% CI: 97.4, 107.1] for men, 75.6 [95% CI: 71.6, 79.7] for women and 88.4 [95% CI: 85.3, 91.5] for both sexes combined, with an observed:expected incidence rate ratio of 0.68 [95% CI: 0.65, 0.71], 0.79 [95% CI: 0.76, 0.82] and 0.72 [95% CI: 0.66, 0.81], respectively.DiscussionThe study provided multiple consistent proofs of a causal relationship between the introduction of screening and a stable 28% decrease in annual CRC incidence after eight years.

A Tale of Two Centers: Visual Exploration of Health Disparities in Cancer Care.

The annual incidence of head and neck cancers (HNC) worldwide is more than 550,000 cases, with around 300,000 deaths each year. However, the incidence rates and disease-characteristics of HNC differ between treatment centers and different populations, due to undetermined reasons, which may or not include socioeconomic factors. The multi-faceted and multi-variate nature of the data in the context of the emerging field of health disparities research makes automated analysis impractical. Hence, we present a visual analysis approach to explore the health disparities in the data of HNC patients from two different cohorts at two cancer care centers. Our approach integrates data from multiple sources, including census data and city data, with custom visual encodings and with a nearest neighbor approach. Our design, created in collaboration with oncology experts, makes it possible to analyze the patients' demographic, disease characteristics, treatments and outcomes, and to make significant comparisons of these two cohorts and of individual patients. We evaluate this approach through two case studies performed with domain experts. The results demonstrate that this visual analysis approach successfully accomplishes the goal of comparing two cohorts in terms of different significant factors, and can provide insights into the main source of health disparities between the two centers.

Histomorphometric features of oral tumors in Hyderabad, Pakistan.

Introduction: Oral cancers (oral cavity cancers) are the eleventh most commonly occurring cancers globally. The annual incidence of oral cancer is around 0.27 million cases while 0.13 million cases of pharyngeal cancers excluding nasopharynx occurring in developing countries. The incidence and mortality caused by these cancers show variability according to the geographic location in which it is diagnosed.&#x0D; Objectives: To evaluate the histomorphometric features, tumours arising at oral region, among patients in Isra University, Hyderabad.&#x0D; Methodology: This cross-sectional study was conducted at Isra University Hyderabad between January 2018 to December 2020. Patients; aged 18 or above of either gender; presented with chronic oral ulcer for ≥ 3 months duration, growth or swelling in the oral cavity were included in the study after taking consent. The morphological and histopathological findings of all the tissues after taking biopsy from the lesion were evaluated and finding recorded in a pre-design proforma.&#x0D; Results: During study period total 143 biopsies performed; 89(62.2%) were male patients while 54(37.8%) were female patients. Most (39.20%) of the patients belongs to age group of 43-52 years. Most commonly involved tumors location was the buccal mucosa/cavity (34.2%) followed by gums and alveolus (25.2%). Biopsy data after histopathological evaluation revealed that majority of patients were suffering from the squamous cell carcinoma (92.3%). Majority (35.0%) of patients were in stage II of TNM staging while half (50.3%) of the patients were in advance stages (stage III and IV).&#x0D; Conclusion: Buccal mucosa/cavity is the most common anatomical site for oral carcinoma with predominance of middle age group and male. Oral squamous cell carcinoma is the most prevalent oral cancer with majority of patients presented in advance stages (III and IV) and grade (II) of tumor. &#x0D; &#x0D; Keywords: Buccal mucosa, Oral tumors, Squamous cell carcinoma.&#x0D;

A Bibliometric Analysis of Atrophic Gastritis From 2011 to 2021.

BackgroundAtrophic gastritis (AG), which is characterized by a decreased number or disappearance of the glandular structures and secretory dysfunction, is linked to chronically inflamed stomach. It has been estimated that the annual incidence of gastric cancer (GC) is 0.1% for patients with AG. Early eradication of Helicobacter pylori (H. pylori) can reduce the risk of GC development. Additionally, the follow-up and management of AG are necessary to prevent GC. Exploring novel methods of the automatized analysis of data for apprehending knowledge in any medical field is encouraged, especially when a body of literature suggests the necessity of doing so. Accordingly, herein, we aim to systematically review the current foci and status of AG research using bibliometric analysis.MethodsArticles and reviews related to AG published from 2011 to 2021 in the Web of Science Core Collection were retrieved. Microsoft Office Excel 2019 and GraphPad Prism were used to show the annual number of publications and scientific productivity of authors through time. CiteSpace and VOSviewer were used to generate network maps about the collaborations among countries, institutions, and authors as well as reveal hotspots of AG research. The relationships among the author's keywords, cited references, and the top authors were summarized by a Sankey plot (three-fields plot).ResultsA total of 1,432 publications were included in the present study. China remained the most productive country, with the highest number of publications (377, 26.32%). Vanderbilt University contributed the most publications of any single institution (56, 3.91%). James R Goldenring was the most active and influential scholar, with the highest number of publications and greatest centrality. The most prolific journal in this field was World Journal of Gastroenterology (62, 4.32%). Gastroenterology (997, 69.62%) was the most co-cited journal. Exploring the origin of gastric metaplasia, especially spasmolytic polypeptide-expressing metaplasia (SPEM) was a major topic in AG research.ConclusionsThis bibliometric study provides a comprehensive analysis of the scientific progress of AG over the past decade. Metaplasia is a hot topic and could be a promising area of research in the coming years.

Breast Cancer Stage Migration in Saudi Arabia: Examining the Influence of Screening.

Breast Cancer Stage Migration in Saudi Arabia: Examining the Influence of Screening.

The influence of covid 19 on screening and management of colorectal cancers, case study of the agadir oncology centre

Colorectal cancer (CRC) is the 3rd cancer in the world after lung cancer and breast cancer, its incidence has increased over the past decade. It occupies the first place among digestive cancers in Morocco (40.3%), However, given the absence of a national cancer registry, there is no epidemiological data on all of Morocco. Based on data from the Greater Casablanca Cancer Registry (RCRC), the annual national cancer incidence is estimated at 101.7 new cases per 100,000 populations, which would equate to 30,500 new cancer cases each year.&#x0D; In terms of frequency by sex, colorectal cancer is the second most common cancer in women and the third most common in men. It has significant human and financial consequences. Despite therapeutic and preventive advances, which have reduced mortality due to colorectal cancer, colorectal cancer still kills people around the world.&#x0D; However, the advent of the Covid 19 pandemic has caused a delay in screening and a disruption in management, this article summarizes the main results of this delay and the risks on the evolution of colorectal cancers. The study is carried out at the Regional Oncology Centre of Agadir (CRO).&#x0D; Keywords: screening, management, Covid 19, colorectal cancer.

Locoregional flaps versus skin grafts in the nose: aesthetic considerations after cancer ablation

Background The annual incidence of skin cancer has been increasing, and surgical ablation is presently the treatment of choice for skin cancer. However, it leaves soft tissue defects that require reconstruction. The methods for reconstruction include locoregional flaps (LRFs) and full-thickness skin grafts (FTSGs). We compared these two surgical methods for reconstruction of defects in the nose, which is prominently visible and the most common site of facial skin cancer, and assessed the cosmetic results by evaluating the scars.Methods This retrospective study was conducted between July 2012 and January 2021. Patients were evaluated for scars after at least 6 months of follow-up. Patients were divided into LRF and FTSG groups. The scars were evaluated using the Vancouver Scar Scale.Results In total, 27 patients were included in this study. Their mean age was 66.8 years. Eighteen patients underwent LRF, and nine patients underwent FTSG. The average defect size was 1.55 cm² in the LRF group, and 1.38 cm² in the FTSG group. The average scar score was 1.44 points in the LRF group and 3.67 points in the FTSG group. The LRF group showed significantly lower total scores than the FTSG group.Conclusions Although LRFs and FTSGs are useful reconstructive methods for nasal soft tissue defects, this study showed that LRFs are superior to FTSGs in terms of aesthetic results.

Trends in the incidence of thyroid cancer in Incheon Province, South Korea, from 2004 to 2013: A representative sample study from Incheon cancer registry.

This study aimed to assess the trends in the incidence of thyroid cancer in Incheon Province, South Korea, from 2004 to 2013 and to identify its association with thyroid cancer screening. We evaluated randomly sampled data of 10% of thyroid cancer patients collected between 2004 and 2013 from the Incheon Cancer Registry, Incheon, South Korea. The expected annual incidence rates of thyroid cancer from 2004 to 2013 were calculated, and the trends in annual incidence change were assessed using a Poisson regression model. In addition, the annual proportion change in the thyroid cancer population according to the detection method and tumor size was also calculated by evaluating the linear-by-linear association. The average expected prevalence of thyroid cancer was 30 per 100,000 individuals from 2004 to 2013. The expected annual incidence of thyroid cancer per 100,000 individuals increased from 7 in 2004 to 49 in 2013, with an annual 1.25-fold difference (p<0.001). Screening helped improve the detection of thyroid cancer annually, with the proportion increasing by screening detection (p<0.001). Majority (54%) of the tumors were small (<10mm) and their detection rate increased from 2004 to 2013 (p<0.001). The incidence of thyroid cancer has increased from 2004 to 2013 in Incheon Province, South Korea, with the increase being most significant for small tumors. These findings indicate that the increased incidence is primarily due to the widespread use of screening and not an actual increase in clinically significant thyroid cancer.