AbstractAnnual January/July midlatitude daytime asymmetry in monthly median NmF2 and model thermospheric parameters has been considered during deep solar minimum, (2008–2009), when solar and geomagnetic activities were at the lowest level, to analyze the background effect due to the Sun‐Earth minimum distance, perihelion, in the vicinity of the December solstice. Averaged over 10 midlatitude station pairs, the NmF2 asymmetry was found to be ≈1.23, while the average asymmetry for the annual component in NmF2 variations is ≈1.17. Annual asymmetry in monthly median neutral composition and temperature predicted by Mass Spectrometer Incoherent Scatter 86 (MSIS86) and MSISE00 thermospheric models along with the 7% increase in solar EUV flux in the vicinity of the December solstice is sufficient to explain the observed annual asymmetry in NmF2. A hierarchy of aeronomic parameters responsible for the observed asymmetry in NmF2 has been established: the main contributor is atomic oxygen—about 50% of the total effect, [N2] contributes around 35% strongly compensating the [O] contribution, and solar EUV and Tn provide <10% each. The zonal mean annual asymmetry in MSIS86 atomic oxygen column density was shown to be 1.18 at low and middle latitudes, and this is close to the estimated asymmetry for the annual component in NmF2 variations. The earlier proposed mechanism of the December anomaly is considered as a plausible one to explain the 1.18 January/July asymmetry in the atomic oxygen variations and consequently the NmF2 annual daytime asymmetry at middle latitudes under the deep solar minimum.