Ann Arbor Conference Research Articles

Gaining Traction in the Treatment of Adrenocortical Carcinoma

Gaining Traction in the Treatment of Adrenocortical Carcinoma

Book Review: The Red Cell: Sixth Ann Arbor Conference

Book Review: The Red Cell: Sixth Ann Arbor Conference

Book Reviews

Book Reviews in Thie Article:Leukemia Markers. Edited by W. Knapp.Bone Ischaemia and Infarction in Sickle Cell Disease. By Stanley P. Bohrer.The Red Cell: Fifth Ann Arbor Conference. Edited by G. Brewer.Fibrinolysis. By Neville Marsh.

BOOKS

Book reviewed in this article:Peter Jones (ed) Haemophilia home therapy (1981).Leon Poller (ed) Recent advances in blood coagulation ‐ 3.George J Brewer (ed) (1981) The red cell: 5th Ann Arbor conference. Alan R Liss IncAnatoly Bezkorovainy (1980) Biochemistry of nonheme iron.

Histiocytic lymphoma (reticulum-cell sarcoma) of bone. Current strategy for orthopaedic surgeons.

We retrospectively reviewed the cases of eight patients with histiocytic lymphoma (reticulum-cell sarcoma) appearing as a primary bone lesion. Histological findings were classified according to the criteria of Rappaport. Lesions were staged as suggested by the Ann Arbor Conference. After thorough staging, four of the eight patients were shown to have more extensive disease than was initially thought, which altered the therapeutic approach used. Thorough staging is necessary for improved survival of patients with histiocytic lymphoma of bone. We suggest a diagnostic strategy for patients with histiocytic lymphoma presenting in bone that leads to appropriate therapy.

Pruritus and Hodgkin's Disease

To the Editor.— In the article Prognostic Importance of Pruritus in Hodgkin's Disease (240:2738, 1978), Feiner and colleagues presented evidence to suggest that the presence of severe itching in early-stage disease at the time of diagnosis augurs for an atypical A course with remission durations comparable with those found in patients with traditional B symptoms. Furthermore, their review raises the suspicion that patients with pruritus alone do not merit the A classification and may warrant the B designation. These authors also emphasize that although the participants in the Ann Arbor Conference on the Staging of Hodgkin's Disease, as well as the American Joint Committee for Cancer Staging and End-Results Reporting, excluded pruritus as a prognostically important symptom in Hodgkin's disease, they believe that severe itching may presage a poor outcome. That evaluation of pruritus as a prognostic index should be accomplished is unquestioned. During the early days of radiology residency

Prognostic Importance of Pruritus in Hodgkin's Disease

In 1971 participants in the Ann Arbor Conference on Hodgkin's disease thought that pruritus had no independent prognostic importance. We reviewed our series of patients with Hodgkin's disease and found six patients in whom severe itching was a major clinical problem. When compared with similarly treated patients without pruritus, these patients appeared to have more-aggressive disease. Severe itching, alone or with B symptoms, needs further study, since it may presage a poor prognosis.

Limited extranodal Hodgkin's disease: Unfavorable prognosis and therapeutic implications

The Ann Arbor Conference on the staging of Hodgkin's disease suggested that the prognosis in patients with “E” stage Hodgkin's disease is similar to that in comparable patients with only nodal disease. A comparative analysis was undertaken of 84 patients with pathologically staged IIA to IIIA disease and 18 patients with stage II EA to III EA disease. The lung was the principal site of extranodal extension (15 patients). Both groups were treated concurrently with either extended field irradiation alone or limited field irradiation followed by MOPP chemotherapy (nitrogen mustard, vincristine, procarbazine and prednisone). Relapse rates after irradiation alone were 29 per cent for the patients with stage HA to IIIA disease and 82 per cent for the patients with “E” stage disease. Patients who received adjuvant chemotherapy had relapse rates of 6 per cent and 14 per cent, respectively. Most “E” stage relapses were regional recurrences within the lung parenchyma. Wilcoxon analysis revealed a significantly shorter remission duration and survival for the patients with “E” stage disease after irradiation alone, but there were no differences between the two patient populations treated with irradiation followed by chemotherapy. These data indicate that the prognosis in patients with “E” stage Hodgkin's disease of the lung is poor when they are treated with irradiation alone, and that adjuvant chemotherapy should be considered for such patients.

Non-Hodgkin's lymphomas.V. Results of radiotherapy

Four hundred and five patients with non-Hodgkin's lymphomas, referred between 1960 and 1971, were carefully evaluated for extent of disease prior to therapy. Tumors were histologically classified according to the criteria of Rappaport et al and patients staged by the criteria of the Ann Arbor Conference. Of 234 patients, Stages I-IIIE, 215 received initial radiotherapy, 91% with a curative intent. Follow-up time ranged from 1–12 years. Calculations were made of actuarial survival and disease-free-survival for each group of patients according to initial stage, histologic type of lymphoma, and type of radiotherapy. Patients with diffuse histiocytic (DH) lymphoma exhibited a 65% probability of tumor relapse during the first year of follow-up in contrast to the 19% probability for comparably staged patients with nodular mixed histiocytic-lymphocytic (NM) and nodular lymphocytic poorly differentiated (NLPD) lymphomas. Patients with diffuse mixed (DM), diffuse lymphocytic (DLPD), and nodular histiocytic (NH) lymphomas exhibited an intermediate risk of relapse during the first year (39-45%). Patients with NM and NLPD manifested a pattern of continued late relapse whereas those with DH lymphoma seldom experienced new evidence of tumor after the first year of disease-free observation. Patients with localized extralymphatic lymphoma (IE, IIE, IIIE) demonstrated patterns of clinical behavior following radiotherapy similar to those observed in patients whose lymphomas were confined to lymphatic tissue (I, II, III). The data offer strong support for the continued use of the Rappaport et al. histologic classification and the Ann Arbor clinical staging system in the radiotherapeutic managemement of patients with the non-Hodgkin's lymphomas.

TESOL Today: A View from the Center

At the close of the 1957 Ann Arbor Conference on Linguistics and the Teaching of English as a Foreign Language, one of the participants is reported to have remarked that the most important thing about the Conference was that it had taken place. Explaining this, Archibald Hill comments: specific conclusions and agreements reached at a first meeting of this sort may well be less important than the fact that communication between quite various groups of people concerned with a common problem which is growing steadily more pressing was successfull established. 1 The Ann Arbor Conference, which was held under the auspices of the Linguistic Society of America and the Committee on International Exchange of Persons of the Conference Board of Associated Research Councils, with funds from the Ford Foundation, was not the first conference on the teaching of English as a foreign language which, by that time, was an established field of interest in several American universities and an area of growing involvement and concern to several United States Government agencies and foundations. It was, however, the first serious attempt to give attention to the increasingly important need to establish lines of communication in a field that was growing rapidly then, and was destined to grow at a much greater pace in the next decade. One of the direct results of the Ann Arbor Conference was the establishment of the Center for Applied Linguistics in 1959, through a grant by the Ford Foundation made to the Moder Language Association of America, of which the Center was a part until it became incorporated in 1964. The principal function of the Center was to be that of an informal, internationally oriented clearinghouse and coordinating body in the application of linguistics to practical language problems, with the teaching of English as a foreign or second language as one of its major areas of interest. The task, as the Center saw it, involved not only collecting and disseminating information on as many aspects of the field as possible, and acting as liaison among institutions, individuals, and government agencies, but, going a step further, anticipating new needs and rising demands and trying to mobilize existing resources or helping to create new machinery to meet them. To do this it was sometimes necessary for the Center to take responsibility in the initial stages of a new project or program, as for instance, its role in

Civil Engineering Education That Is

A civil engineering educator presents a 20% sample, consisting of 35 colleges of engineering and 32 employers of engineers involving 212 separate interviews with responsible engineering educators and employers. Also described are findings and interpretations on topics concerning engineering curricula such as admission requirements, admission to advanced standing, honors programs, remedial courses, number of years for first degree, common-core courses, engineering sciences, humansitic-social courses, ROTC politics, engineering orientation, field trips, professional ethics, construction, electronic computers, Ann Arbor Conference on Civil Engineering Education, and graduate education; on topics concerning instructors such as qualifications, promotion, practical experience, salaries, teaching loads, teaching methods, and extra-curricular activities; on topics relating to departmental administration; and on topics relative to what engineering employers think about the various aspects of engineering education and continuing post-graduate education.

Undergraduate Curricula in Physics: A Report on the Princeton Conference on Curriculum S

Starting with the recommendations of the Second Ann Arbor Conference for two distinct undergraduate physics major programs, R and S, the Princeton Conference on Curriculum S continued the consideration of the conceptual and practical problems of providing appropriate instruction in physics to undergraduate majors having a variety of educational goals. Major discussion was concerned with the nature of the S curriculum and its relation to R, with the desirability of providing more open curricular structures, and with the problems of obtaining an optimum mixture of the elements of analysis and synthesis in intellectually vigorous courses. Several sample skeleton outlines of possible major curricula were produced by Conference working groups, and it is expected that progress in developing the working materials for the S Curriculum will be continued.

Comments on the Recommendations of the Second Ann Arbor Conference

First Page

Recommendations of the Second Ann Arbor Conference on Undergraduate Curricula for Physics Majors

Guided by the deliberations of two earlier conferences on curricula for physics majors, the Second Ann Arbor Conference has recommended that two different major programs, characterized by courses at essentially the same intellectual level, be offered. One has as its primary objective the most direct preparation of students for graduate work and research; the other emphasizes the synthesis of physics with the adjoining sciences and with other components of our culture. Because the first of the two curricula was discussed more fully by the conference than was the second, and because it is closer to what most strong departments now attempt, it is defined more precisely than is the second. The considerations that led the conferees to these recommendations are given. Neither curriculum is defined in terms of specific courses—the conference preferred to attempt a description of the characteristics that a student should acquire or develop during this undergraduate career. Most important to this description are statements of what he should be able to do. Statements of what he should know are included only to sharpen the primary description. Estimates of the number of semester hours required by each curriculum are given.

The Ann Arbor Conference on the Higher Commercial Education

The Ann Arbor Conference on the Higher Commercial Education