Objective: We aimed to evaluate work productivity on the quality of life and disease activity in ankylosing spondylitis. Material and methods: One hundred ankylosing spondylitis patients were included in the study. Disease activity was assessed by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), quality of life was assessed by Ankylosing Spondylitis Quality of Life questionnaire, work productivity was assessed by work productivity and activity impairment questionnaire. Results: Absenteeism, presenteeism, work productivity loss and activity impairment scores were positively correlated with BASDAI. We found correlation between absenteeism, presenteeism, work productivty loss, activity impairment scores and poor quality of life. Conclusion: As a result of our study, work productivity should be considered in clinical practice. Assessment of work productivity in routine clinical practice can contribute to a better understanding of problems in patients' behavior to treatment.