A unified hypoplastic model is formulated by incorporating the anisotropic critical state theory to describe the fabric effect in sand under both monotonic and cyclic loading conditions. An evolving deviatoric fabric tensor that characterizes the internal microstructure of sand is introduced into the hypoplastic model in conjunction with the intergranular strain concept. A scalar-valued fabric anisotropic variable indicating the interplay between the fabric and the loading direction is employed to account for the impact of fabric anisotropy on both the dilatancy and shear strength of sand. The model is demonstrated to be capable of simulating the anisotropic behavior of sand, using a single set of parameters under both monotonic and cyclic loading conditions, as evidenced by the satisfactory match with experimental results from various sources. In particular, by considering the influence of fabric evolution on the dilatancy of sand, the model adequately accounts for the fabric change effect and accurately captures the deviatoric strain accumulation, cyclic mobility, and the flow liquefaction phenomenon under cyclic loading condition.