Animal Subjects Research Articles

They Cannot Be Left to the Brutality of a Cruel Group: An Ottoman Scholar’s Treatise on Dogs

Abstract Several studies have been written on the subject of animals in the Ottoman Empire, with a focus on dogs in particular. Most of these studies cover the subject through various sources, including history books, biographies, travelogues, and diaries. Although studying the issue via these sources is important, several works written in the Ottoman period, especially distinct treatises, provide more concrete information on the subject. These treatises have the unique quality of providing insight into many points, especially with relevance to the concepts on which the scholars and thinkers of the period examined the human-animal relationship, and also the arguments they advanced to establish this relationship. One such treatise was written by Mustaqīmzāde (d. 1202/1788) in the 12th/18th century. This treatise deals with many issues, especially the human-dog relationship, the characteristics dogs have, why people should be compassionate towards dogs, and the problems of having a negative attitude towards dogs. In this article, I give a brief biography of Mustaqīmzāde, summarize the changing attitude of Ottomans towards dogs, discuss the content of Mustaqīmzāde’s treatise, and finally translate it into English and present an edition of the text.

The Structure of Organization and Management of the Research at Universities in the USA

The study aimed to identify the features of the structure of organization and management of the research at universities in the USA so that those features are used as variables in further research. The study used the method of content analysis of qualitative type to identify patterns of the structure of organization and management of the research in universities in the USA. It was found that the structure of organization research management at universities in the USA relies on four domains such as scientific, organisational (institutional), financial and legislative. The university research activity in the USA is regulated by federal law. The research office is involved in proposal development, negotiation, and management of the award, ensuring regulatory compliance regarding intellectual property protection and technology transfer, communication of policies and processes, dissemination of funding opportunities, and the sufficient level of committed effort dedicated to a project and certification. The office draws the emphasis on compliance with the below-outlined areas such as fiscal – cost transfers and sharing, direct charging, effort, financial and income monitoring and reporting, and research – animal subject (IACUC) and human subject (IRB) protections, conflicts of interest, environmental health and safety, export controls, invention disclosure, and reporting, scientific overlap and misconduct. The structure of organization and management of the research is based on the above collaborative work which is called shared governance with the bottom-up management approach. Further research is needed in the bottom-up management application prerequisites to be used in Ukraine.

Деякі питання правового регулювання страхування тварин як обов'язкового виду страхування

Agricultural insurance is a prerequisite for the existence of agriculture, especially for agricultural countries. The present time poses serious climatic, economic, and biological challenges to agricultural production. Insurance should become a tool that will help to balance the risks between all participants in agricultural insurance relations. Insurance should reduce the negative impact on agricultural production and living standards in the country. In the article on the basis of analysis of normative-legal acts, regulating the procedure of agricultural animals insurance the problematic issues are investigated and the ways of elimination of collisions in legal regulation of this type of insurance are offered. The problems of determining the list of animals subject to compulsory insurance are investigated and solutions are proposed. The question of legal expansion of the range of insurance risks for insurance contracts of animals in the framework of the Law of Ukraine «On peculiarities of insurance of agricultural products with state support» is analyzed. The proposed additions to the regulatory and legal acts in the field of insurance of breeding animals will lead to the harmonization of relevant legislation, as well as improve awareness of breeding animals for regulatory authorities, consumers of relevant products and insurers. Keywords: insurance, compulsory animal insurance, breeding animal insurance, insurance risk, insurance of agricultural products with state support

Hepatoprotective Role of Virgin Coconut Oil and Neem Extract in Acetaminophen Induced Liver Toxicity

Aim: To study the comparative hepatoprotective effect of Virgin Coconut Oil (VCO) and Neem (Azadirachta indica) leaf extract in acetaminophen (Paracetamol) induced liver toxicity. Methods: About 60 mixed population of rats (male/female) of Wistar and Sprague-Dawley species were randomly selected for the proposed study and are segregated into four equal groups. Every group contains 15 animal subjects. Group A was the control group given normal diet. In Group B, the rats were treated with a single dose of 2gm / kg body weight paracetamol, orally. Simultaneously, Group C were given an oral Neem extract of 500mg/kg body weight for 2 weeks days in combination with single dose of Paracetamol, while Group D were provided with 6.7ml/Kg/body weight Virgin Coconut Oil (VCO) for 15 days. Data was analyzed using SPSS Version 20.0 with level of significance being kept at p-value ≤0.05. Results: The mean values of ALT were 23.1, 100.5, 29.85, and 31.09 U/L in Group A, B, C, and D respectively. While, the mean values of AST were 25.6 U/L (Group A), 41 U/L (Group B), 19.3 U/L (Group C), and 15.2 U/L (Group D). The ALP showed maximum response indicated by the mean values of 221 U/L, 444 U/L, 241 U/L, and 243 U/L in Group A, B, C, and D respectively. Group B suggested the paracetamol induced liver toxicity indicated by the increase in hepatic DMEs right after the acetaminophen induction. Conclusion: Azadirachta Indica and Virgin Coconut Oil displayed hepatoprotective effects on the Wistar and Sprague-Dawley rats that were subjected to Paracetamol. Keywords: hepatic, Drug Metabolizing enzymes, Acetaminophen, Virgin coconut oil, Neem extract, Paracetamol, Wistar

Penerapan Model Pembelajaran Problem Based Learning Pada Pelajaran Teknologi Jaringan Berbasis Luas

This study aimed to determine the increase in student activity and learning outcomes through the implementation of the Problem Based Learning (PBL) model. This research is based on the fact that the average score of students is deficient; as many as 18 students have not completed, while 16 students have completed learning. This research is classroom action research conducted in 3 cycles. The method of data collection was carried out through observation. Data analysis was carried out by comparing the test results in cycle 1, cycle 2, and cycle 3 with descriptive techniques. The results of this study indicate that the application of the Problem Based Learning model assisted by Edmodo in the subject of Animation can improve student learning outcomes. In the first cycle, it was 47%, in the second cycle, it increased to 74%, then in the third cycle it increased to 88%, so with these data, it can be concluded that the achievement of the research success criteria for student learning outcomes has been achieved. Thus, it can be concluded that class IX students' learning outcomes and learning activities in the Lua-Based Network Technology lesson at SMKN 1 SEMENDAWAI SUKU III have increased.

997. RLS-0071 Improves Survival in a Rat Model of Intestinal Necrosis

BackgroundIntestinal necrosis and perforation are potentially life-threatening medical conditions that can lead to bacterial sepsis and systemic inflammatory response syndrome. Various etiologies can compromise the intestinal wall causing leakage of luminal contents including enteric bacteria and precipitate aggressive immunological responses including the complement system and neutrophils. RLS-0071 is a peptide inhibitor of the classical and lectin pathways and known modulator of various neutrophil mediated effectors including myeloperoxidase activity and NETosis.MethodsIn this study we evaluated the extent to which immunomodulation via inhibition of the complement system and neutrophil effectors would alter survival in the setting of intestinal necrosis. Adolescent male Long-Evans rats were subject to cecal ligation and puncture (CLP) with one cohort receiving 40 mg/kg of RLS-0071 thirty minutes after surgery while the control group received no treatment. Survival of the rats was then assessed up to 5 days after surgery. ResultsAnimals treated with RLS-0071 demonstrated nearly 1.5-fold increase in survival compared to the untreated group. In order to further elucidate the increase in survival we explored inflammatory responses as assessed by markers of NETosis i.e., free DNA in plasma, and the pro-inflammatory cytokine, IL-6. A reduction in blood levels of free DNA and the inflammatory cytokine IL-6 were observed for animals treated with RLS-0071.RLS-0071 increases survival of rats after cecal ligation Kaplan-Meier survival curve assessment. The red line indicates the outcome after 75% CLP in animals not receiving treatment (n=13), whereas red curves represent the outcome after animals received a single dose of 40 mg/kg RLS-0071 (n=11).RLS-0071 reduces free DNA levels in the blood Plasma was isolated before surgery (pre-bleed) (n=7) and from animals subject to CLP with (n=4) and without (n=3) RLS-0071 administration 24 hours post-surgery. Plasma samples were incubated with PicoGreen. Fluorescence was read at an excitation wavelength of 485 nm and an emission wavelength of 520nm in a microplate reader. Data are means and standard error of the meansRLS-0071 reduces IL-6 levels in the blood Plasma was isolated before surgery (pre-bleed) (n=8) and from animals subject to CLP with (n=3) and without (n=5) RLS-0071 administration 24 hours post-surgery. Plasma samples were analyzed in an IL-6 ELISA according to the manufacturer’s instructions. Data are means and standard error of the means.ConclusionThe results of these experiments demonstrate that RLS-0071 can increase survival after intestinal perforation by multi-pronged modulation of complement activation, neutrophil immune mechanisms and cytokine mediated inflammatory responses.Disclosures Kenji Cunnion, MD, MPH, ReAlta Life Sciences Inc (Board Member, Employee, Shareholder) Parvathi Kumar, MBBS, ReAlta Life Sciences Inc (Employee) Brittany Lassiter, BS, ReAlta Life Sciences Inc (Employee) Katherine LaValle, DVM, ReAlta Life Sciences Inc (Employee) Neel Krishna, PhD, ReAlta Life Sciences Inc (Employee, Shareholder)

Peer review declaration

Peer review declaration

Melasma Clinical Features, Diagnosis, Epidemiology and Etiology: An Update Review

Melasma is one of the commonest dermatological challenges that facing dermatologists in the whole world. Most of the previously published articles regarding melasma usually focused on its management and the newly discovered drugs; however, the understanding of the suspected etiology and the pathogenesis is very critical to treat this skin disorder in a correct manner. Therefore, this review is an attempt to do a comprehensive updating on the present understanding of the melasma epidemiology, etiology, its role in pregnant, post-menopausal women, and in males, besides its clinical features and diagnosis through searching in many scientific databases including EMBASE, Cochrane Library, PubMed, Pubmed Central (PMC), Medline, Web of Science, and Scopus. This review approaches recognizing the pathogenesis that can provide ideas to solve the therapeutic problems which connect to melasma. Therefore, this article is entirely established on previously performed studies so that no new studies on animal or human subjects were conducted by the author.

РОЛЬ β, α1 И α2-АДРЕНО РЕЦЕПТОРОВ В РЕГУЛЯЦИИ ЧАСТОТЫ СЕРДЦЕБИЕНИЙ ЛАБОРАТОРНЫХ ЖИВОТНЫХ, ПОДВЕРЖЕННЫХ РАЗЛИЧНЫМ РЕЖИМАМ ДВИГАТЕЛЬНОЙ АКТИВНОСТИ

For the first time, studies were conducted to study the features of the heart rate response of laboratory animals exposed to various modes of motor activity when administered with β, α1 and α2-blockers. It was found that in all the experimental groups of animals studied, a decrease in the heart rate response was observed in the first week after the introduction of β, α1 and α2-adreno blockers. It was revealed that the initial reaction of the heart rate on the introduction of β, α1 and α2-blockers depends on the level of motor activity of laboratory animals. It was found that the most pronounced decrease in the heart rate response to the introduction of different subtypes of adreno-blockers is observed in the group of animals with limited motor activity. At the same time, the smallest decrease in the heart rate response occurs in the group of animals subject to enhanced motor mode. It was revealed that in the group of experimental animals, during further muscle training, by the end of the fourth week, there was a less pronounced decrease in the heart rate response to the administration of β, α1 and α2-adreno blockers. It was found that in a group of animals subject to a regime of limited motor activity, by the end of the fourth week of hypokinesia, the most pronounced decrease in the heart rate response to the introduction of β, α1-targeted blockers occurs.

Beastly Modernisms: The Question of Animal Speech and Psychology in James Joyce and Virginia Woolf

This essay analyses the ways in which James Joyce and Virginia Woolf addressed from a very early stage key issues related to contemporary posthumanist theories such as the question of animal speech and psychology. Both Joyce’s description of human-animal encounters in Ulysses and Woolf’s depiction of a sentient animal subject in Flush: A Biography at first present, and then subvert, the idea of the use of language as evidence of a human surpassing of the animal. By challenging preconceived notions of species distinctions, these authors ultimately decenter the human to focus instead on the centrality of animal subjectivity and sensory experience. While the question of a sharp divide between human and nonhuman animals along the axis of speech can be traceable to the anthropocentric tradition of western humanism and not least to such a possible source as Cervantes (whose novella “The Dialogue of the Dogs” is listed as part of both Joyce’s Trieste library and the library of Leonard and Virginia Woolf), the idea of expanding the typically modernist focus on inner life by also including other forms of subjectivity may have derived from the coeval, burgeoning fields of zoology, ethology and comparative psychology. Drawing from these sources and popular areas of knowledge which formed part of the cultural climate of the time, both Joyce and Woolf explore cross-species intersubjectivity in ways that shift the terms of representation away from anthropocentric views in order to affirm, blur and deny the boundaries between the human and the non-human.

Damnatio ad bestias: Performing Animality and Womanhood in Contemporary Irish and Galician Poetry

The concomitant subjection of women and animals was denounced as early as 1990 by Carol J. Adams in The Sexual Politics of Meat, where she identified the intersections of discourses that aim at the subjugation of women and animals and censured those practices that animalize women and feminize animals for the better exploitation of both. More recent ecofeminist debates, however, have highlighted women’s vindication of animality with the aim to recuperate one’s repressed animal nature and rebel against oppressive anthropocentric and androcentric constrictions (Velasco Sesma 2017). This article focuses on contemporary Irish and Galician poetry concerned with the performativity of animality and womanhood in contemporary society and engaged in the emancipation of women and animals from patriarchal oppression. Ireland and Galicia have shared longstanding cultural bonds and, since the 1990s, have experienced a conspicuous accession of women writers who have participated in the feminist and environmental debates of their respective communities. This article exposes the intersecting discourses and practices that subdue animals and women, as evinced in contemporary Irish and Galician writing, and shows how poetry can become a locus of resistance and woman-animal complicity in the struggle for mutual emancipation.

Metabolomics prospect of obesity and metabolic syndrome; a systematic review.

Due to growing concerns about the obesity pandemic as a worldwide phenomenon, a global effort has been made for managing it and associated disorders. Accordingly, metabolomics as a promising field of "OMICS" is presented for investigating different molecular pathways in obesity and related disorders through the evaluation of specific metabolites in both animal and human subjects. Herein, the aim of the present study as the first systematic review is to evaluate all available studies about different mechanisms and their biomarkers discovery using metabolomics approaches. The study was designed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Using a comprehensive search strategy we searched in databases including; Web of Science, PubMed, and Scopus using specific keywords. Based on predefined inclusion/exclusion criteria study selection has been conducted considering the type of studies, participant, and outcome measures. Quality assessment was done using CASP (Critical Appraisal Skills Programme) checklist followed by data extraction according to a predefined data extraction sheet. Among the articles that resulted from electronic search, a total of 74 articles met our inclusion criteria. The most prevalent studied metabolites were amino acids and lipid derivatives and both targeted and non-targeted approaches were applied for metabolomics studies. This systematic review summarized a wide range of studies regardless of the age, history, language, and type of the study. Further studies are needed to compare the application of emerging methods in the treatment of obesity and related disorders. The online version contains supplementary material available at 10.1007/s40200-021-00917-w.

Eucalyptus globulus essential oil increased neovascularization and vascular endothelial growth factor expression in male wistar rats exposed to UVB

Background: Eucalyptus globulus essential oil contained 1,8-cineol, which may accelerate wound healing. This study aimed to prove Eucalyptus globulus essential oil's effect on increasing neovascularization and Vascular Endothelial Growth Factor (VEGF) expression in Wistar rats skin exposed to ultraviolet B (UVB).
 Methods: A Post-test only controls group study design was applied on 36 male Wistar rats, aged 3-4 months old, weighing 150-200 grams. The animal subject was exposed to UVB (65 mJ/cm2, 65 seconds for seven days), injured on their back using a punch biopsy with a diameter of 10 mm, and divided into two groups. For seven days, on the wound, the control group was given 2 cc of 0.9% NaCl twice a day, while the treatment group was given Eucalyptus globulus essential oil (2 cc). Both groups were given oral Amoxicillin three times a day. The skin tissue was taken on day eight to assess neovascularization and VEGF expression.
 Results: The results show that neovascularization in the treatment group was higher than in the control group (p < 0.05). Meanwhile, the median VEGF expression in the treatment group was also higher than in the control group (p < 0.05).
 Conclusions: Topical administration of Eucalyptus globulus essential oil increased neovascularization and VEGF expression in the skin of male Wistar rats injured and exposed to UVB. Further research is needed to assess the effectiveness of the essential oil in enhancing neovascularization and VEGF expression in humans with multiple exposures at different doses to optimize the wound-healing effect.

Some issues of legal regulation of animal insurance as a compulsory type of insurance

Agrarian insurance is a prerequisite for the existence of agriculture, especially for agrarian countries. The present puts before agricultural production serious climatic, economic, and biological challenges. Insurance should become a tool that will help balance risks between all participants in agrarian insurance relations and reduce the adverse impact on agricultural production and the standard of living in the state. Proceeding from this, the purpose of this study was to investigate the issue of legal regulation of animal insurance as a compulsory type of insurance and outline the prospects for the development of such types of insurance. The method for investigating this issue was the analysis of the current national legislation, which suggested that the legal regulation of animal insurance meets its conditions in national regulations. Based on the analysis of regulations governing the procedure for insurance of farm animals, the study examined the problematic issues and suggested ways to eliminate conflicts in the legal regulation of this type of insurance. The problems of determining the list of animals subject to compulsory insurance were investigated and ways to solve them were proposed. The paper analysed the issue of legal expansion of the range of insurance risks for animal insurance contracts within the framework of the Law of Ukraine “On the Specifics of Insurance of Agricultural Products with State Support”. The proposed amendments to the regulations in the field of breeding animal insurance will harmonize the corresponding legislation, as well as improve awareness of breeding animals for regulatory authorities, consumers of relevant products and insurers. The materials of this paper are of practical value for further research of the legal regulation of animal insurance, their improvement, and identification of new issues in national regulations.

Abstract 9423: Virtual Reality (VR) Guided Telerobotic Cardiac Catheter Ablation is Feasible Over Low Bandwidth Network Connection

Introduction: Telerobotic operation in which a remote surgeon performs an operation over distance has long held the promise of providing a more equitable distribution of healthcare in rural and underserved regions of the world. One of the technological limitations that has hampered the adoption of telerobotic surgery is the need for a broadband connection to transmit high-resolution video of the operative field. Hypothesis: We hypothesized that we could develop a low-bandwidth system for telerobotic cardiac catheter ablation that deploys a virtual reality (VR)-based surgical guidance system to allow remote operation without the need for high-resolution video transmission. Methods: We assembled a portable pre-clinical telerobotic catheter ablation system from commercial-grade components by 3 rd party vendors. Raw sensor data from the catheter ablation system requiring a bitrate of less than 100kb/sec was streamed in real-time over distance using a standard internet connection. We used a proprietary service (DOPL Technologies, Seattle, WA) and an Oculus Quest (Oculus, Inc. Menlo Park, CA) to generate a shared, virtual operative field and operating room environment. No video data was transmitted. The Institutional Animal Care and Use Committee of the University of Washington (Seattle, WA) approved the study performed on a 14-week (27 kg) Yorkshire pig. The operator was located 6 miles from the OR at the time of the operation. Results: A successful proof of concept telerobotic cardiac catheter ablation in an animal model was performed without video transmission. The remote surgeon applied radiofrequency energy lesions in the animal’s cavotricuspid isthmus region. The visual depiction of the operative environment was successfully constructed in virtual reality from sensor data generated from the animal subject and surgical instruments. The remote operator conducted the ablation while interacting in a shared virtual OR environment with members of the surgical team present in the physical operating room and three remote observers. Conclusions: Telerobotic cardiac catheter ablation is feasible without video transmission. This approach could reduce network bandwidth requirements for telerobotic operations in rural areas.

Tsukumogami

We are at the beginning of an artificial intelligence revolution that has the potential to shift our perspectives on several fronts, including on the moral worth of artificially intelligent objects. Such shifts might be especially poignant when considering research aiming to create AI systems empathetic to human needs for, among other contexts, application in healthcare. This comic uses the ancient Japanese folklore of Tsukumogami, tools that have acquired souls, to invite readers to meditate on their relationship between the inanimate object and the animate subject.

The Effect of Type-2 Diabetes on Cognitive Status and the Role of Anti-diabetes Medications

Type-2 diabetes mellitus prevalence is constantly increasing; this is explained by the increase of its risk factors and the amelioration of its management. Therefore, people are living longer with diabetes mellitus, which, in turn, has revealed new complications of the disease. Dementia is represented mainly by Alzheimer's disease and is an interesting topic of study. Accordingly, statistics have shown that dementia incidence is doubled in diabetic patients.The establishment of a relation between type-2 diabetes mellitus was studied on several levels in both humans and animal subjects. First, insulin receptors were found in the brain, especially the hippocampus, and insulin transport to the brain is mainly accomplished through the blood-brain barrier. Secondly, several studies showed that insulin affects multiple neurotransmitters in favor of promoting memory and cognition status. Thirdly, multiple pathological studies showed that insulin and Alzheimer's disease share many common lesions in the brain, such as beta-amyloid plaques, amylin-Aβ plaques, hyper-phosphorylated tau protein, and brain atrophy, especially in the hippocampus. After recognizing the positive effect of insulin on cognitive status, and the harmful effect of insulin resistance on cognitive status, multiple studies were focused on the role of anti-diabetes medications in fighting dementia. Consequently, these studies showed a positive impact of oral anti-diabetes medication, as well as insulin in limiting the progression of dementia and promoting cognitive status. Moreover, their effects were also noticed on limiting the pathological lesions of Alzheimer's disease.Accordingly, we can consider type-2 diabetes mellitus as a risk factor for dementia and Alzheimer's disease. Therefore, this can be used on the pharmaceutical level by the promising implication of antidiabetics as a treatment of dementia and Alzheimer's disease or at least to limit its progression. However, multiple clinical studies should be dedicated to proving the true benefits of anti-diabetes medications in treating dementia before they can be used in reality.

A Genetic Basis for Improving the Reproductive Qualities and Productivity of South-Kazakh Merinoes.

Food shortages may be among the most significant negative consequences of overpopulation. In order to meet the nutritional needs of livestock origin, the number of available animals cannot be increased; however, ways must be sought to increase production per livestock unit. Livestock breeding is the science and art of establishing genes that are effective in the economical production of livestock, which creates superior livestock and poultry. The quality of the main stock of animals, the characteristics of the initial population according to the main characteristics of breeding, biological and internal characteristics, biochemical parameters of sheep blood with different genotypes, and its economic efficiency have been studied to achieve the aim of the present study. The animal subjects in this study were the South Caucasian merino sheep (Group I) and the mixed breed sheep (male of Australian merino x female of South Kazakhstan merino) (Group II). The age-related changes in the body weight of the resulting offspring were studied by weighing them at birth and 4, 7, and 18 months of age. Moreover, external body mass measurements were taken from these animals at the same time. In addition, absolute, daily average, and relative increases in their live weight were determined based on the weighting data and the considered blood parameters. According to the results of the present investigation, relatively high values of variability coefficients of blood acid capacity, globulin content, aldolase activity, alkalinity, and acid phosphatase were reported. The levels of total protein, albumin, globulin, and haptoglobin of the second group were 7.42%, 27.64%, 12.9%, and 9.7%, respectively, which had a significant increase, compared to those in the first group (P<0.05). The scientific research data are reflected and proved in this paper, which can serve as a specific contribution to zootechnical science to use the breeding-tribal work in practice and conditions of different forms of ownership. Moreover, the results of this study can be useful in the improvement of breeding-tribal work and technology of high quality, compass well as competitive and ecologically clean sheep production in the conditions of maximum year-round seasonal use of foothill and foothill-steppe pastures in the south of Kazakhstan.

Towards a Tri-Color Wireless Photometry System for the Monitoring of Neuronal Activity in the Basal Forebrain and Hippocampus.

Healthy cholinergic function is important for brain function, and disruption of the system is thought to be the cause of dementia, including Alzheimer's disease. The 'Cholinergic Hypothesis' theorizes that cognitive decline is due disruption of the cholinergic system, defined by the low concentration of neurotransmitters such as acetylcholine (ACh) and neurotransmitter-releasing elements such as calcium ions (Ca2+). The ability to measure ACh and Ca2+ concentrations enables researchers to make inferences on the relationship between these indicators that play a role in the onset of neurological conditions. Current commercial devices have one or more of the following limitations: i) they are tethered making it difficult to verify in naturally behaving animal subjects, ii) they are capable of only measuring a single indicator at any given time, or iii) they have multiple shanks that penetrate the cortex. We propose a tri-color miniaturized photometry system capable of optically stimulating indicators in neurons located in the hippocampus and basal forebrain and optically reading the neurons' response. The resulting device has an average gain of 123 dB and a power consumption of 29 mW, comparable to other state-of-the-art devices.

ETHICAL PRINCIPLES OF RESEARCH

There are number of ethical principles that should be taken by undergraduate and master’s level. It has often been seen in psychological research that some time the nature of study is such that it is possible to study from a practical point of view but it is not possible to do it from a moral point of view. Moral are those ethical principle that should follow to every researcher during their research work. Research ethics provided guideline for the responsible and monitor research scholar conducting research to insure a high ethical standard. The following points are identified as ethical research are protection and welfare of participant, informed consent, use of deception, debriefing of subject, subjects right to withdrawal from the investigation, invasion from privacy in observational research and confidentialityand the anonymity of data. Not only this subject also have right that if it is mandatory to publish their data then their name should not be given in it. If the researcher does not do this then it poses an ethical problem. It is clear when psychological research done on human subject then some problem related to morality arise.In order to solution these problem, two important country (America and Britain) in the world that have made some code of ethics but still such problem arise. Such moral problems arise not only with human subject but also using animal subject and these problems are also resolved by following the same moral code.