Dental implants are prosthetic devices that are surgically placed in direct contact with the jawbone to support intra-oral functions and esthetics. Diabetes mellitus may contribute to peri-implant bone loss. During the last few years, there have been... Read More
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Effects of metformin on the bioactivity and osseointegration of dental implants: A systematic review
- Journal of Taibah University Medical Sciences
- VOL. 18
on Feb 1, 2023
- Animal Models
- Osseointegration Of Dental Implants
- ARRIVE
- Osseointegration Of Implants
- Potential Sources Of Bias
- Peri-implant Bone Loss
- More +
PET imaging in animal models of Parkinson’s disease
- Behavioural Brain Research
- VOL. 438
on Feb 1, 2023
- Animal Models
- Multiple System Atrophy
- Advances In Positron Emission Tomography
- Leucine Rich Repeat Kinase
- Parkinson's Disease
- Imaging In Animal Models
- More +
Alpha-synucleinopathies, such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy, are characterized by aberrant accumulation of alpha-synuclein and synaptic dysfunction leading to motor and cognitive deficits. Animal models... Read More
Drosophila as a diet discovery tool for treating amino acid disorders
- Trends in Endocrinology & Metabolism
- VOL. 34
on Feb 1, 2023
- Animal Models
- AADs
- Rapid Neurological Decline
- Genetic Tractability
- Synthetic Diet
- Neurological Death
- More +
Amino acid disorders (AADs) are a large group of rare inherited conditions that collectively impact one in 6500 live births, often resulting in rapid neurological decline and death during infancy. For several AADs, including phenylketonuria, dietary ... Read More
Cognitive deficits after general anaesthesia in animal models: a scoping review
- British Journal of Anaesthesia
- VOL. 130
on Feb 1, 2023
- Animal Models
- General Anaesthetic Drugs
- Disorders In Adult Patients
- Volatile Anaesthetic Drugs
- Cognitive Deficits
- Structured Review Process
- More +
It remains controversial whether general anaesthetic drugs contribute to perioperative neurocognitive disorders in adult patients. Preclinical studies have generated conflicting results, likely because of differing animal models, study protocols, and... Read More
Osteoinductive Bone Morphogenic Protein, Collagen Scaffold, Calcium Phosphate Cement, and Magnesium-Based Fixation Enhance Anterior Cruciate Ligament Tendon Graft to Bone Healing In Animal Models: A Systematic Review
- Arthroscopy: The Journal of Arthroscopic & Related Surgery
- VOL. 39
on Feb 1, 2023
- ACLR
- Calcium Phosphate Cement
- Bone Healing In Animal Models
- Healing In Animal Models
- Systematic Review
- Web Of Science Databases
- More +
To perform a systematic literature review to analyze the results of the invivo animal models and strategies that use osteoinductive materials to enhance the tendon graft-bone interface for anterior cruciate ligament reconstruction (ACLR). Following t... Read More
Combined metabolic activators improve metabolic functions in the animal models of neurodegenerative diseases
- Life Sciences
- VOL. 314
on Feb 1, 2023
- AD Animal Models
- Animal Models Of PD
- Precursors Of Nicotinamide Adenine Dinucleotide
- PD Rats
- PD
- High-fat Diet Groups
- More +
Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), are associated with metabolic abnormalities. Integrative analysis of human clinical data and animal studies have contributed to a better understanding... Read More
LncRNA SNHG15 mediates 1-methyl-4-phenylpyridinium (MPP+)-induced neuronal damage through targeting miR-29c-3p/SNCA axis
- Neurological Research
- VOL. 45
on Feb 1, 2023
- Neuronal Damage
- Production Of Inflammatory Factors
- CCK-8 Proliferation Assay
- Therapy Of PD
- Progression Of PD
- LncRNA SNHG15
- More +
ABSTRACT Background Parkinson’s disease (PD) is the most prevalent neurodegenerative disease in the elderly people. Long non-coding ribose nucleic acids (LncRNAs) can serve as molecular sponges for micro RNA (miRNA) and regulate gene expression, whi... Read More
Innate immune dysfunction and neuroinflammation in autism spectrum disorder (ASD)
- Brain, Behavior, and Immunity
- VOL. 108
on Feb 1, 2023
- Animal Models
- Dysfunction In ASD
- ASD
- Immune Dysfunction In ASD
- Neuroinflammation In Autism Spectrum Disorder
- Prevalence Of ASD
- More +
Autism spectrum disorder (ASD) is a highly heterogeneous neurodevelopmental disorder characterized by communication and social behavior deficits. The presence of restricted and repetitive behaviors often accompanies these deficits, and these characte... Read More
Diminazene aceturate uses different pathways to induce relaxation in healthy and atherogenic blood vessels
- Biochemical Pharmacology
- VOL. 208
on Feb 1, 2023
- DIZE
- ACE2 Expression
- Direct Relaxing Effect
- Internal Iliac Arteries
- Healthy Vessels
- Arachidonic Acid
- More +
Diminazene aceturate (DIZE), a putative angiotensin-converting enzyme 2 (ACE2) activator, elicits relaxation in various animal models. This study aimed to determine the relaxing mechanisms in internal iliac arteries utilised by DIZE in healthy and at... Read More
The NLRP3 Inflammasome in Stress Response: Another Target for the Promiscuous Cannabidiol
- Current Neuropharmacology
- VOL. 21
on Feb 1, 2023
- Effects In Psychiatric Disorders
- NLRP3 Inflammasome
- CBD
- Pathway In Microglia
- NLRP3 Inflammasome Pathway
- Stress-related Psychiatric Disorders
- More +
Abstract: Many psychiatric patients do not respond to conventional therapy. There is a vast effort to investigate possible mechanisms involved in treatment resistance, trying to provide better treatment options, and several data points toward a poss... Read More
New synthetic nano-immunotherapy (OncoTherad®) for non-muscle invasive bladder cancer: Its synthesis, characterization and anticancer property
- Tissue and Cell
- VOL. 80
on Feb 1, 2023
- NMIBC
- High-risk Non-muscle Invasive Bladder Cancer
- NMIBC Treatment
- BCG
- BCG Treatment
- Preventing Tumor Recurrence
- More +
Bacillus Calmette-Guérin (BCG)-based intravesical immunotherapy has been applied as gold standard treatment for high-risk non-muscle invasive bladder cancer (NMIBC) for almost half a century. However, several patients with high-risk disease experienc... Read More
Design, synthesis, and evaluation of JTE-013 derivatives as novel potent S1PR2 antagonists for recovering the sensitivity of colorectal cancer to 5-fluorouracil
- Bioorganic Chemistry
- VOL. 131
on Feb 1, 2023
- Animal Model
- S1PR2
- S1PR2 Antagonist
- DPD
- L02 Cells
- DPD Expression
- More +
Targeting sphingosine-1-phosphate receptor 2 (S1PR2) has been proved as a promising strategy to reverse 5-fluorouracil (5-FU) resistance. Here, we report the discovery of the novel JTE-013 derivative compound 37h as a more effective S1PR2 antagonist ... Read More
Chemopreventive and anti-tumor potential of vitamin E in preclinical breast cancer studies: A systematic review
- Clinical Nutrition ESPEN
- VOL. 53
on Feb 1, 2023
- Invitro Studies
- Animal Models Of Breast Cancer
- Antioxidant Activity
- Synthetic Vitamin
- Breast Cancer
- Delayed Tumor Development
- More +
Vitamin E has been investigated for its antitumor potential, including the ability to change cancer gene pathways as well as promote antioxidant and pro-oxidant activity. Therefore, this systematic review aimed to evaluate antitumor and chemopreventi... Read More
Type-1 interferon-dependent and -independent mechanisms in cyclic GMP–AMP synthase–stimulator of interferon genes-driven auto-inflammation
- Current Opinion in Immunology
- VOL. 80
on Feb 1, 2023
- cGAS-STING Pathway
- Monogenic Interferonopathies
- Prime Repair Exonuclease
- T1IFNs
- cGAS-STING Activation
- Stimulator Of Interferon
- More +
The cyclic cyclic gaunosine monophosphate adenosine monophosphate (GMP-AMP) synthase-stimulator of interferon genes (cGAS-STING) pathway senses cytosolic dsDNA and initiates immune responses against pathogens. It is also implicated in several auto-in... Read More
Universal automated classification of the acoustic startle reflex using machine learning
- Hearing Research
- VOL. 428
on Feb 1, 2023
- SR
- Startle Reflex Paradigm
- Improve Data Reliability
- Machine Learning-based Method
- Pharmaceutical Efficacy
- Somatosensory Stimulus
- More +
The startle reflex (SR), a robust, motor response elicited by an intense auditory, visual, or somatosensory stimulus has been widely used as a tool to assess psychophysiology in humans and animals for almost a century in diverse fields such as schizo... Read More
Intestinal fungi and systemic autoimmune diseases
- Autoimmunity Reviews
- VOL. 22
on Feb 1, 2023
- Animal Models
- Human Intestine
- Intestinal Fungi
- Systemic Lupus Erythematosus
- Inflammatory Bowel Disease
- Systemic Autoimmune Diseases
- More +
Nearly 20years of studies have shown that fungi and the human immune system (non-specific immunity and specific immunity) and bacterial--fungal interactions maintain a balance that can't lead to diseases. Fungi--microorganism that lives in human inte... Read More
Effect of temperature on gastro-esophageal cancer outcomes: A SEER study.
- Journal of Clinical Oncology
- VOL. 41
on Feb 1, 2023
- Improvement In OS
- EC Patients
- DSS
- GC Patients
- AAT
- National Centers For Environmental Information
- More +
467 Background: Cold stress suppresses antitumor response in animal models, leading to tumor growth . Recent studies have also shown a negative correlation between the average annual temperature (AAT) and cancer incidence. We hypothesized that esop... Read More
Diffusion radiomics for subtyping and clustering in autism spectrum disorder: A preclinical study
- Magnetic Resonance Imaging
- VOL. 96
on Feb 1, 2023
- Animal Models
- ASD
- ASD Population
- Diffusion MR Imaging
- Radiomic Analyses
- Neurite Density Index
- More +
Autism spectrum disorder (ASD) is a highly prevalent, heterogenous neurodevelopmental disorder. Neuroimaging methods such as functional, structural, and diffusion MRI have been used to identify candidate imaging biomarkers for ASD, but current findin... Read More
SETD2 gene expression and the molecular landscape of colorectal cancer (CRC).
- Journal of Clinical Oncology
- VOL. 41
on Feb 1, 2023
- Gene Expression In CRC
- CRC
- Increased Tumor Mutational Burden
- Tumorigenesis In Animal Models
- TPM
- Caris Life Sciences
- More +
184 Background: SETD2, a key methyltransferase modulating histone 3 gene transcription, has been shown to act as a tumor suppressor gene by reducing oxidative stress, colonic inflammation and tumorigenesis in animal models. SETD2 gene expression ha... Read More
Biomechanical properties of the stomach: A comprehensive comparative analysis of human and porcine gastric tissue
- Journal of the Mechanical Behavior of Biomedical Materials
- VOL. 138
on Feb 1, 2023
- Human Gastric Tissue
- Radial Compressive
- Radial Compression
- Radial Compression Tests
- Porcine Tissue
- Viscoelastic Constitutive Models
- More +
Stomach-related disorders impose medical challenges and are associated with significant social and economic costs. The field of biomechanics is promising for understanding tissue behavior and for development of medical treatments and surgical interve... Read More