Lentiviral vector-based dendritic cell vaccines induce protective T cell responses against viral infection and cancer in animal models. In this study, we tested whether preventative and therapeutic vaccination could be achieved by direct injection of... Read More
Animal Models Research Articles
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Directly injected lentiviral vector–based T cell vaccine protects mice against acute and chronic viral infection
- JCI Insight
- VOL. 7
on Sep 22, 2022
A review of formulations and preclinical studies of inhaled rifampicin for its clinical translation
- Drug Delivery and Translational Research
on Sep 21, 2022
AbstractInhaled drug delivery is a promising approach to achieving high lung drug concentrations to facilitate efficient treatment of tuberculosis (TB) and to reduce the overall duration of treatment. Rifampicin is a good candidate for delivery via t... Read More
Animal models in intrauterine adhesion research.
- Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
on Sep 21, 2022
Intrauterine adhesion (IUA) is a gynaecological disease caused by uterine cavity surgeries and infections that leads to partial or total occlusion of the uterine cavity. However, the underlying mechanism(s) and progression of the disease have not yet... Read More
Hypertension, Neurovascular Dysfunction, and Cognitive Impairment.
- Hypertension (Dallas, Tex. : 1979)
on Sep 21, 2022
Hypertension affects a significant proportion of the adult and aging population and represents an important risk factor for vascular cognitive impairment and late-life dementia. Chronic high blood pressure continuously challenges the structural and f... Read More
Biologia Futura: four questions about ageing and the future of relevant animal models
- Biologia Futura
on Sep 21, 2022
AbstractUnderstanding how active and healthy ageing can be achieved is one of the most relevant global problems. In this review, I use the “Four questions” framework of Tinbergen to investigate how ageing works, how it might contribute to the surviva... Read More
The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation
- Cancer Discovery
on Sep 21, 2022
Abstract Clonal hematopoiesis (CH) is an aging-associated condition characterized by the clonal outgrowth of mutated preleukemic cells. Individuals with CH are at an increased risk of developing he... Read More
Cadmium-induced preeclampsia-like phenotype in the rat is related to decreased progesterone synthesis in the placenta
- Xenobiotica
on Sep 21, 2022
Cadmium (Cd) is a toxic element, which is associated with preeclampsia (PE).We treated pregnant rats with cadmium chloride from gestational days (GDs) 9-12 to introduce the PE-like animal model. Maternal systolic blood pressures (SBPs) and body weigh... Read More
Proteasomal deubiquitylase activity enhances cell surface recycling of the epidermal growth factor receptor in non-small cell lung cancer
- Cellular Oncology
on Sep 21, 2022
The epidermal growth factor receptor (EGFR) represents a top therapeutic target in the treatment of non-small cell lung cancer. EGFR expression is intricately modulated by receptor endocytosis, during which EGFR ubiquitylation and deubiquitylation pl... Read More
Translating Animal Models of Ischemic Stroke to the Human Condition
- Translational Stroke Research
on Sep 20, 2022
Ischemic stroke is a leading cause of death and disability. However, very few neuroprotective agents have shown promise for treatment of ischemic stroke in clinical trials, despite showing efficacy in many successful preclinical studies. This may be ... Read More
Immunomodulatory Effects of Combined Ethanol Extracts of Curcuma mangga and Picria fel-terrae on Cellular- and Humoral-Mediated Immunity in Wistar Rats and Mice
- Evidence-Based Complementary and Alternative Medicine
- VOL. 2022
on Sep 20, 2022
Previous studies have shown that the extracts of Curcuma mangga Valeton & Zijp rhizomes and Picria fel-terrae Lour. leaves could modulate cellular- and humoral-mediated immunity in macrophages and animal models. In the present study, the immunomo... Read More
Characterization of CRH-Binding Protein (CRHBP) in Chickens: Molecular Cloning, Tissue Distribution and Investigation of Its Role as a Negative Feedback Regulator within the Hypothalamus–Pituitary–Adrenal Axis
- Genes
- VOL. 13
on Sep 20, 2022
Corticotropin (ACTH) is a pituitary hormone playing important roles in stress response within the hypothalamus–pituitary–adrenal (HPA) axis. The biosynthesis and secretion of ACTH are controlled by multiple factors, including corticotropin-releasing ... Read More
Lithium Benzoate Exerts Neuroprotective Effect by Improving Mitochondrial Function, Attenuating Reactive Oxygen Species, and Protecting Cognition and Memory in an Animal Model of Alzheimer’s Disease
- Journal of Alzheimer's Disease Reports
- VOL. 6
on Sep 20, 2022
Background: Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease affecting many cellular pathways, including protein aggregation, mitochondrial dysfunction, oxidative stress (OS), and neuroinflammation. Currently, no effective treat... Read More
Edible bird’s nest, an Asian health food supplement, possesses anti-inflammatory responses in restoring the symptoms of atopic dermatitis: An analysis of signaling cascades
- Frontiers in Pharmacology
- VOL. 13
on Sep 20, 2022
Edible bird’s nest (EBN) is a Chinese delicacy possessing skin rejuvenating functions. To verify skin anti-inflammatory function of EBN, water extract and enzymatic digest of EBN, as well as the major sialic acid, N-acetyl neuraminic acid (NANA), wer... Read More
Comparison of RNA localization during oogenesis within Acipenser ruthenus and Xenopus laevis
- Frontiers in Cell and Developmental Biology
- VOL. 10
on Sep 20, 2022
The oocyte is a unique cell, from which develops a complex organism comprising of germ layers, tissues and organs. In some vertebrate species it is known that the asymmetrical localization of biomolecules within the oocyte is what drives the spatial ... Read More
Examining enteric nervous system function in rat and mouse - an inter-species comparison of gastrointestinal motility
- American Journal of Physiology-Gastrointestinal and Liver Physiology
on Sep 20, 2022
Gastrointestinal motility is crucial to gut health and has been associated with different disorders such as inflammatory bowel diseases and post-operative ileus. Despite rat and mouse being the two animal models most widely used in gastrointestinal ... Read More
The role of microRNAs in neurodegenerative diseases: a review
- Cell Biology and Toxicology
on Sep 20, 2022
MicroRNAs (miRNAs) are non-coding RNAs which are essential post-transcriptional gene regulators in various neuronal degenerative diseases and playact a key role in these physiological progresses. Neurodegenerative diseases, such as Alzheimer's diseas... Read More
Characterization of the immune system of Ellegaard Göttingen Minipigs - An important large animal model in experimental medicine
- Frontiers in Immunology
- VOL. 13
on Sep 20, 2022
Interest in Ellegaard Göttingen Minipigs (EGMs) as a model in experimental medicine is continuously growing. The aim of this project is to increase the knowledge of the immune system of EGMs as information is still scarce. Therefore, we studied the p... Read More
Former Training Relieves the Later Development of Behavioral Inflexibility in an Animal Model Overexpressing the Dopamine Transporter
- Molecular Neurobiology
on Sep 20, 2022
AbstractA range of dopamine-dominating neuropsychiatric disorders present with cognitive deficits. In accordance, the dopamine transporter overexpressing rat model (DAT-tg rat) displays cognitive deficits by means of behavioral inflexibility and lear... Read More
Thyroidectomy- And Ptu-Induced Hypothyroidism: Effect Of L-Thyroxine On Suppression Of Spatial And Non-Spatial Memory Related Signaling Molecules
- Current Molecular Pharmacology
- VOL. 15
on Sep 20, 2022
Background: The calcium/calmodulin protein kinase II (CaMKII) signaling cascade is crucial for hippocampus-dependent learning and memory. In adult rats, Hypothyroidism impairs hippocampus-dependent learning and memory, which can be prevented by simp... Read More
Characterizing the Pathogenesis and Immune Response of Equine Herpesvirus 8 Infection in Lung of Mice
- Animals
- VOL. 12
on Sep 20, 2022
Equine herpesvirus type 8 (EHV-8), associated with abortion and severe respiratory disease in donkeys and horses, causes significant economic losses in the global equine industry. However, the pathogenicity of EHV-8 is still unknown. Mice are widely ... Read More