The Siddha system of medicine uses an opulent source of plants, metals, minerals, and marine and animal products for the preparation of medicine. The pearl oyster shell is a bivalve mollusc that lives in fresh and saltwater and generates pearls. The three major structural components of pearls are oblong, conchiolin, and calcium carbonate (CaCO3). Recently, interest in developing medications from marine materials has surged. In the fields of cancer, pain, and inflammation, many marine natural compounds are presently undergoing clinical trials. Pearl oyster shell, also known as Muthuchippi, is a key sea-derived medicine in the Siddha system of medicine. These shells include iron oxide, alumina, silica, calcium carbonate, phosphate, and sulfate of calcium and magnesium. Since it has been specially recommended to improve the strength, nutrition, and vitality of weak patients as well as for palpitations, digestion, heart tonic, and appetizer, pearl oysters are important in Siddha medicine. Traditionally, the calcined pearl oyster shell has been used to treat musculoskeletal diseases, anorectal diseases, respiratory diseases, and gastrointestinal diseases due to their high calcium carbonate content. This study aims to review several papers on the therapeutic potential of pearl oyster shells in treating various ailments. A comprehensive search of multiple databases, including PubMed and Google Scholar, yielded several papers for evaluation. According to this study, pearl oyster shells are utilized to cure a wide range of illnesses in all traditional Indian medical systems. Yet, there is scanty scientific data to support the efficacy of numerous indications. To substantiate this significant drug in the research forum, additional in-vitro and in-vivo studies must be carried out.
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