Animal husbandry and crop farming are specialized for development in separate areas on the Tibetan Plateau. Such a pattern of isolation has led to current concerns of rangeland and farming system degradation due to intensive land use. The crop-livestock integration, however, has been proven to increase food and feed productivity thorough niche complementarity, and is thereby especially effective for promoting ecosystem resilience. Regional synergy has emerged as an integrated approach to reconcile rangeland livestock with forage crop production. It moves beyond the specialized sectors of animal husbandry and intensive agriculture to coordinate them through regional coupling. Therefore, crop-livestock integration (CLI) has been suggested as one of the effective solutions to forage deficit and livestock production in grazing systems. But it is imperative that CLI moves forward from the farm level to the regional scale, in order to secure regional synergism during agro-pastoral development. The national key R & D program, Technology and Demonstration of Recovery and Restoration of Degraded Alpine Ecosystems on the Tibetan Plateau, aims to solve the problems of alpine grassland degradation by building up a grass-based animal husbandry technology system that includes synergizing forage production and ecological functioning, reconciling the relationship between ecology, forage production and animal husbandry, and achieving the win-win goals of curbing grassland degradation and changing the development mode of animal husbandry. It is imperative to call for regional synergy through integrating ecological functioning with ecosystem services, given the alarming threat of rangeland degradation on the Tibetan Plateau. The series of papers in this issue, together with those published previously, provide a collection of rangeland ecology and management studies in an effort to ensure the sustainable use and management of the alpine ecosystems.