Angular Head Research Articles

Cell-type-specific cholinergic control of granular retrosplenial cortex with implications for angular velocity coding across brain states.

Cholinergic receptor activation enables the persistent firing of cortical pyramidal neurons, providing a key cellular basis for theories of spatial navigation involving working memory, path integration, and head direction encoding. The granular retrosplenial cortex (RSG) is important for spatially-guided behaviors, but how acetylcholine impacts RSG neurons is unknown. Here, we show that a transcriptomically, morphologically, and biophysically distinct RSG cell-type - the low-rheobase (LR) neuron - has a very distinct expression profile of cholinergic muscarinic receptors compared to all other neighboring excitatory neuronal subtypes. LR neurons do not fire persistently in response to cholinergic agonists, in stark contrast to all other principal neuronal subtypes examined within the RSG and across midline cortex. This lack of persistence allows LR neuron models to rapidly compute angular head velocity (AHV), independent of cholinergic changes seen during navigation. Thus, LR neurons can consistently compute AHV across brain states, highlighting the specialized RSG neural codes supporting navigation.

Primacy of vision shapes behavioral strategies and neural substrates of spatial navigation in marmoset hippocampus

The role of the hippocampus in spatial navigation has been primarily studied in nocturnal mammals, such as rats, that lack many adaptations for daylight vision. Here we demonstrate that during 3D navigation, the common marmoset, a new world primate adapted to daylight, predominantly uses rapid head-gaze shifts for visual exploration while remaining stationary. During active locomotion marmosets stabilize the head, in contrast to rats that use low-velocity head movements to scan the environment as they locomote. Pyramidal neurons in the marmoset hippocampus CA3/CA1 regions predominantly show mixed selectivity for 3D spatial view, head direction, and place. Exclusive place selectivity is scarce. Inhibitory interneurons are predominantly mixed selective for angular head velocity and translation speed. Finally, we found theta phase resetting of local field potential oscillations triggered by head-gaze shifts. Our findings indicate that marmosets adapted to their daylight ecological niche by modifying exploration/navigation strategies and their corresponding hippocampal specializations.

Linking Digital Traits from Facial Expression, Voice, and Head Motion to Montgomery–Åsberg Depression Rating Scale Subscales

IntroductionThe 10-item Montgomery–Åsberg Depression Rating Scale (MADRS) measures different dimensions of depression symptomatology. Digital traits may generate deeper understanding of the MADRS subscales and provide insights about depression symptomatology.ObjectivesTo identify digital traits that predict specific MADRS subscales and ascertain which digital traits are important for which MADRS subscales.Methods During a Phase II decentralised clinical trial in major depressive disorder (MDD), patients completed the MADRS and used AiCure (LLC, New York, NY, USA), a smartphone application, to complete image description tasks at baseline. Digital measurements identified from the literature as relevant to MDD symptomatology were conducted using audio and video data derived from the image description tasks. Digital measurements included speech (rate, sentiment and first-person singular pronouns), vocal acoustics (intensity, pause fraction and fundamental frequency), facial expressivity (regional facial movement) and head pose (Euclidean and angular head movement). Digital traits analysis involved data pre-processing followed by machine learning (ML) using Elastic Net, Decision Tree, and Random Forest models; model performance was evaluated using 5-fold cross-validation and mean absolute error (MAE). Important digital traits were calculated by percentage change in MAE after permuting a specific variable. Important digital traits for the MADRS Apparent Sadness subscale score were mapped to defined, interpretable domains.ResultsThe ML model predictions varied for different MADRS subscales (Table). Overall, Elastic Net and Random Forest models outperformed Decision Tree across all subscales scores other than suicidal thoughts. Half of the literature-based digital traits contributed to the prediction of ≥1 MADRS sadness sub-scale score. The important digital traits for the Apparent Sadness subscale score could be mapped to 4 domains (Figure); this aligned with findings from the literature.Image:Image 2:ConclusionsDigital traits collected from patients with MDD were able to predict certain MADRS subscales better than others.FundingBoehringer Ingelheim.Disclosure of InterestZ. Zhu Employee of: Boehringer Ingelheim Pharmaceuticals, Inc., Y. Wu Employee of: Boehringer Ingelheim Pharmaceuticals, Inc., J. Seidel Employee of: Boehringer Ingelheim International GmbH, D. Roy Employee of: Boehringer Ingelheim Pharmaceuticals, Inc., E. Salzmann Employee of: Boehringer Ingelheim International GmbH

Electrophysiological Properties of the Medial Mammillary Bodies across the Sleep-Wake Cycle.

The medial mammillary bodies (MBs) play an important role in the formation of spatial memories; their dense inputs from hippocampal and brainstem regions makes them well placed to integrate movement-related and spatial information, which is then extended to the anterior thalamic nuclei and beyond to the cortex. While the anatomical connectivity of the medial MBs has been well studied, much less is known about their physiological properties, particularly in freely moving animals. We therefore carried out a comprehensive characterization of medial MB electrophysiology across arousal states by concurrently recording from the medial MB and the CA1 field of the hippocampus in male rats. In agreement with previous studies, we found medial MB neurons to have firing rates modulated by running speed and angular head velocity, as well as theta-entrained firing. We extended the characterization of MB neuron electrophysiology in three key ways: (1) we identified a subset of neurons (25%) that exhibit dominant bursting activity; (2) we showed that ∼30% of theta-entrained neurons exhibit robust theta cycle skipping, a firing characteristic that implicates them in a network for prospective coding of position; and (3) a considerable proportion of medial MB units showed sharp-wave ripple (SWR) responsive firing (∼37%). The functional heterogeneity of MB electrophysiology reinforces their role as an integrative node for mnemonic processing and identifies potential roles for the MBs in memory consolidation through propagation of SWR-responsive activity to the anterior thalamus and prospective coding in the form of theta cycle skipping.

The Effect of the Lateral First Metatarsal Head Shape on Hallux Valgus in Forced Turnout in Pre-Pointe Female Ballet Dancers: A Pilot Study.

A rounded lateral first metatarsal head shape is associated with higher rates of hallux abducto valgus recurrence following corrective surgery; however, the effect of the lateral first metatarsal head shape on the hallux abduction angle (HAA) has not yet been explored in a nonpathologic, pre-pointe ballet dancer population. The primary purpose of this study was to investigate the effect of the lateral first metatarsal head shape on the HAA when pre-pointe female dancers force their turnout. Seventeen female, pre-pointe ballet students (mean age, 10.8 ± 0.95 years) participated in this study. Fluoroscopic images of each dancer's dominant foot were taken, and the lateral first metatarsal head shape was classified visually. Each dancer performed three consecutive stances of natural double-leg upright posture: both functional and forced turnout. HAAs were obtained by marking medial bony landmarks on paper and were compared to photographic measurements. No significant difference was found between the round and angular lateral first metatarsal head shape for the change in HAA from natural double-leg upright posture to forced turnout. Hallux abduction angle significantly increased by 4.6° (P < .001) in forced turnout compared to the natural double-leg upright posture for the photographic method, whereas the paper method demonstrated an increase of 2.6° (P = .007). No statistical differences were found between the paper and photographic methods in measuring the HAA for all stances. Our findings suggest no association between the HAA and lateral first metatarsal head shape; however, HAA does increase when a dancer assumes forced turnout. The paper method demonstrated similar reliability to the photographic method and shows the potential for future use as a clinical tool in assessing hallux abducto valgus.

The effect of ball pressure and maximal isometric neck strength on head acceleration during purposeful heading in adult football players during heading drills

ObjectiveThis randomised repeated measures study explored the effect of ball pressure and maximal isometric neck strength on head acceleration during purposeful heading in adult football players during heading drills within a laboratory environment. MethodsRecreational football players (n ​= ​17) attended one familiarisation session to determine baseline maximal isometric neck strength, followed by two experimental sessions where they randomly trialled two conditions (>72-h apart). The first condition included 20 rotational headers with a match-ball at low-pressure (58.6 ​kPa; 8.5 psi) and the second included 20 rotational headers with a match-ball at high-pressure (103.4 ​kPa; 15.0 psi) whilst instrumented with an inertial measurement unit. ResultsA statistically significant difference between conditions for both peak linear head acceleration (F ​= ​15.2; p= ​ < ​ 0.001) and peak angular head velocity (F ​= ​5.71; p ​= ​0.018) during purposeful heading. The low-pressure ball condition demonstrated a 12 ​% reduction in peak linear acceleration and 6 ​% reduction in peak angular velocity when compared with high-pressure ball condition. Additionally, neck strength significantly predicted head acceleration during purposeful heading (p ​ = ​ <0.05). ConclusionThese findings suggest that lower ball pressure and higher neck strength can lower head acceleration during heading in adult football players during heading drills within a laboratory environment.

Genome-Wide Association Study of Chronic Dizziness in the Elderly Identifies Loci Implicating MLLT10, BPTF, LINC01224, and ROS1.

Chronic age-related imbalance is a common cause of falls and subsequent death in the elderly and can arise from dysfunction of the vestibular system, an elegant neuroanatomical group of pathways that mediates human perception of acceleration, gravity, and angular head motion. Studies indicate that 27-46% of the risk of age-related chronic imbalance is genetic; nevertheless, the underlying genes remain unknown. The cohort consisted of 50,339 cases and 366,900 controls in the Million Veteran Program. The phenotype comprised cases with two ICD diagnoses of vertigo or dizziness at least 6months apart, excluding acute or recurrent vertiginous syndromes and other non-vestibular disorders. Genome-wide association studies were performed as individual logistic regressions on European, African American, and Hispanic ancestries followed by trans-ancestry meta-analysis. Downstream analysis included case-case-GWAS, fine mapping, probabilistic colocalization of significant variants and genes with eQTLs, and functional analysis of significant hits. Two significant loci were identified in Europeans, another in the Hispanic population, and two additional in trans-ancestry meta-analysis, including three novel loci. Fine mapping revealed credible sets of intronic single nucleotide polymorphisms (SNPs) in MLLT10- a histone methyl transferase cofactor, BPTF- a subunit of a nucleosome remodeling complex implicated in neurodevelopment, and LINC01224- a proto-oncogene receptor tyrosine kinase. Despite the difficulties of phenotyping the nature of chronic imbalance, we replicated two loci from previous vertigo GWAS studies and identified three novel loci. Findings suggest candidates for further study and ultimate treatment of this common elderly disorder.

Angular Head Velocity Cells within Brainstem Nuclei Projecting to the Head Direction Circuit.

The sense of orientation of an animal is derived from the head direction (HD) system found in several limbic structures and depends on an intact vestibular labyrinth. However, how the vestibular system influences the generation and updating of the HD signal remains poorly understood. Anatomical and lesion studies point toward three key brainstem nuclei as key components for generating the HD signal-nucleus prepositus hypoglossi, supragenual nucleus, and dorsal paragigantocellularis reticular nuclei. Collectively, these nuclei are situated between the vestibular nuclei and the dorsal tegmental and lateral mammillary nuclei, which are thought to serve as the origin of the HD signal. To determine the types of information these brain areas convey to the HD network, we recorded neurons from these regions while female rats actively foraged in a cylindrical enclosure or were restrained and rotated passively. During foraging, a large subset of cells in all three nuclei exhibited activity that correlated with the angular head velocity (AHV) of the rat. Two fundamental types of AHV cells were observed; (1) symmetrical AHV cells increased or decreased their firing with increases in AHV regardless of the direction of rotation, and (2) asymmetrical AHV cells responded differentially to clockwise and counterclockwise head rotations. When rats were passively rotated, some AHV cells remained sensitive to AHV, whereas firing was attenuated in other cells. In addition, a large number of AHV cells were modulated by linear head velocity. These results indicate the types of information conveyed from the vestibular nuclei that are responsible for generating the HD signal.SIGNIFICANCE STATEMENT Extracellular recording of brainstem nuclei (nucleus prepositus hypoglossi, supragenual nucleus, and dorsal paragigantocellularis reticular nucleus) that project to the head direction circuit identified different types of AHV cells while rats freely foraged in a cylindrical environment. The firing of many cells was also modulated by linear velocity. When rats were restrained and passively rotated, some cells remained sensitive to AHV, whereas others had attenuated firing. These brainstem nuclei provide critical information about the rotational movement of the head of the rat in the azimuthal plane.

Predicting head injury metrics during low- to moderate-speed frontal collisions using computational simulations

ObjectivesSubjective reports of mild traumatic brain injury (mTBI) are common following low-energy motor-vehicle collisions. Biomechanical analyses are useful in providing a quantitative means for determining the likelihood of sustaining mTBI. While occupant dynamics in low-speed rear impacts have been extensively investigated, peer-reviewed studies on occupant dynamics during low-speed frontal collisions are sparse. The objective of this study is to present a validated computational method to quantify the biomechanical response of the head in low- and moderate-speed frontal collisions. Data and methodsThis study used data from a previously-published series of four instrumented in-line front-to-rear staged collisions using 2014 Honda Accord sedans at closing velocities of approximately 7.4 kph (test L1), 12.7 kph (test L2), 21.7 kph (test L3), and 33.6 kph (test L4) kph. A model of the test vehicle occupant compartment was created using the MAthematical DYnamic MOdeling (MADYMO) software using methods previously described. Crash pulse data from L4 were applied to the MADYMO model. Seat belt parameters were optimized to achieve reasonable agreement between simulation results and test data for relevant head injury metrics (linear head acceleration [LHA], angular head acceleration [AHA], and HIC15). Crash pulses from the other tests in the series (L1, L2, and L3) were then applied to the model and peak values for LHA, AHA, and HIC15 were compared to the physical test data to demonstrate validation. ResultsThe optimization of seat belt and seat parameters within the MADYMO model resulted in accurate prediction of ATD dynamics demonstrated in Test L4. The simulation-predicted peak LHA was within 0.2 g of the test value, peak AHA was within 64 rad/s2, and HIC15 was within 0.46. When applied to the remainder of the tests (L1, L2, and L3), the optimized model showed excellent accuracy in predicting peak LHA and HIC15. When compared to the physical test data, the simulation-predicted values for LHA were within 0.4 g or less and the HIC15 values were within 0.4 or less across all tests. The model generally over-predicted AHA, particularly for the lower-severity collisions (L1 and L2). ConclusionsWe have demonstrated a reliable methodology for developing a biomechanical computational model to predict head injury metrics in low- to moderate-speed frontal collisions. This approach can be particularly valuable in forensic investigations of real-world crashes. Pre-existing crash test data can be used in conjunction with exemplar vehicle information to validate a MADYMO model. Appropriate crash pulse data from classical accident reconstruction techniques, event data recorders, or simulations can then be applied to the model to accurately predict head dynamics for real-world vehicle occupants without the need for full-scale staged crash tests.

Finite element evaluation of an American football helmet featuring liquid shock absorbers for protecting against concussive and subconcussive head impacts.

Introduction: Concern has grown over the potential long-term effects of repeated head impacts and concussions in American football. Recent advances in impact engineering have yielded the development of soft, collapsible, liquid shock absorbers, which have demonstrated the ability to dramatically attenuate impact forces relative to existing helmet shock absorbers. Methods: To further explore how liquid shock absorbers can improve the efficacy of an American football helmet, we developed and optimized a finite element (FE) helmet model including 21 liquid shock absorbers spread out throughout the helmet. Using FE models of an anthropomorphic test headform and linear impactor, a previously published impact test protocol representative of concussive National Football League impacts (six impact locations, three velocities) was performed on the liquid FE helmet model and four existing FE helmet models. We also evaluated the helmets at three lower impact velocities representative of subconcussive football impacts. Head kinematics were recorded for each impact and used to compute the Head Acceleration Response Metric (HARM), a metric factoring in both linear and angular head kinematics and used to evaluate helmet performance. The head kinematics were also input to a FE model of the head and brain to calculate the resulting brain strain from each impact. Results: The liquid helmet model yielded the lowest value of HARM at 33 of the 36 impact conditions, offering an average 33.0% (range: -37.5% to 56.0%) and 32.0% (range: -2.2% to 50.5%) reduction over the existing helmet models at each impact condition in the subconcussive and concussive tests, respectively. The liquid helmet had a Helmet Performance Score (calculated using a summation of HARM values weighted based on injury incidence data) of 0.71, compared to scores ranging from 1.07 - 1.21 from the other four FE helmet models. Resulting brain strains were also lower in the liquid helmet. Discussion: The results of this study demonstrate the promising ability of liquid shock absorbers to improve helmet safety performance and encourage the development of physical prototypes of helmets featuring this technology. The implications of the observed reductions on brain injury risk are discussed.

A current assessment of the THOR 50M in rear impacts

Objective This study presents a comparison of the Test Device for Human Occupant Restraint (THOR) 50M and Hybrid III (HIII) 50M anthropomorphic test device (ATD) geometries and rear impact head and neck biofidelity to each other and to postmortem human surrogate (PMHS) data to evaluate the usefulness of the THOR in rear impact testing. Methods Both ATDs were scanned in a seated position on a rigid bench seat. A series of rear impact sled tests with the rigid bench seat with no head restraint support were conducted with a HIII-50M at 16 and 24 kph. Tests at each speed were performed twice with the THOR-50M to allow an assessment of the repeatability of the THOR-50M. A comparison of the test results from THOR-50M testing were made to the results of a previous study that included PMHS. Rear impact sled tests with both ATDs in a modern seat were then conducted at 40 kph. Results The THOR-50M head was 48.4 mm rearward and 60.1 mm higher than the HIII-50M head when seated in the rigid bench seat. In the repeated rigid bench testing at 16 and 24 kph, the THOR-50M head longitudinal and vertical accelerations, upper neck moment, and overall kinematics showed good test-to-test repeatability. In the rigid bench tests, the THOR-50M neck experienced flexion prior to extension in the 16 kph tests, where the neck of the HIII only experienced extension. At 24 kph both ATDs only experienced extension. The THOR-50M head displaced more rearward at both test velocities. The rigid bench tests show that the THOR-50M neck allows for more extension motion or articulation than the HIII-50M neck. The rigid bench test also shows that the head longitudinal and vertical accelerations, angular head kinematics, and upper neck moments were reasonably comparable between the ATDs. The THOR-50M results were closer to the average of the PMHS results than the HIII-50-M results, with the exception of the upper neck. In the 40 kph tests, with a modern seat design, the THOR-50M resulted in more deformation of the seatback with greater head restraint loading than the HIII-50M. The THOR-50M head backset distance was less. Conclusion This study provides insight into the differences and similarities between the THOR and the HIII-50M ATD geometries, instrumentation responses, and kinematics, as well as the repeatability of the THOR-50M in rear impacts testing. The overall geometries of the THOR-50M and the HIII-50M are similar. The seated head position of the THOR-50M is slightly further rearward and higher than the HIII-50M. The results indicate that the THOR-50M matches the PMHS results more closely than the HIII-50M and may have improved neck biofidelity in rear impact testing. The results indicate that the studied THOR-50M responses are repeatable within expected test-to-test variations in rear impacts. Early data suggest that the THOR-50M can be used in rear impact testing, though a more complete understanding of the THOR-50M differences to the HIII ATDs will allow for better correlation to the existing body of HIII rear impact testing.

Padded Helmet Shell Covers in American Football: A Comprehensive Laboratory Evaluation with Preliminary On-Field Findings.

Protective headgear effects measured in the laboratory may not always translate to the field. In this study, we evaluated the impact attenuation capabilities of a commercially available padded helmet shell cover in the laboratory andon the field. In the laboratory, we evaluated the padded helmet shell cover's efficacy in attenuating impact magnitude across six impact locations and three impact velocities when equipped to three different helmet models. In a preliminary on-field investigation, we used instrumented mouthguards to monitor head impact magnitude in collegiate linebackers during practice sessions while not wearing the padded helmet shell covers (i.e., bare helmets) for one season and whilst wearing the padded helmet shell covers for another season. The addition of the padded helmet shell cover was effective in attenuating the magnitude of angular head accelerations and two brain injury risk metrics (DAMAGE, HARM) across most laboratory impact conditions, but did not significantly attenuate linear head accelerations for all helmets. Overall, HARM values were reduced in laboratory impact tests by an average of 25% at 3.5m/s (range: 9.7 to 39.6%), 18% at 5.5m/s (range: -5.5 to 40.5%), and 10% at 7.4m/s (range: -6.0 to 31.0%). However, on the field, no significant differences in any measure of head impact magnitude were observed between the bare helmet impacts and padded helmet impacts. Further laboratory tests were conducted to evaluate the ability of the padded helmet shell cover to maintain its performance after exposure to repeated, successive impacts and across a range of temperatures. This research provides a detailed assessment of padded helmet shell covers and supports the continuation of in vivo helmet research to validate laboratory testing results.

The Impact of the Angular Head Movement’s Velocity during Diagnostic Maneuvers on Proper Benign Positional Paroxysmal Vertigo Diagnosis and Therapy

Based on the current state of the BPPV field, there are no guidelines that specify an angular head movement's velocity (AHMV) during diagnostic maneuvers of BPPV. The aim of this study was to evaluate the impact of AHMV during diagnostic maneuvers on proper BPPV diagnosis and therapy. The analysis covered the results obtained in 91 patients with a positive result of the Dix-Hallpike (D-H) maneuver or the roll test. The patients were divided into four groups based on values of AHMV (high 100-200°/s and low 40-70°/s) and the BPPV type (posterior: PC-BPPV or horizontal: HC-BPPV). The parameters of the obtained nystagmuses were analyzed and compared to AHMV. There was a significant negative correlation between AHMV and latency of nystagmus in all study groups. Furthermore, there was a significant positive correlation between AHMV and both maximum slow phase velocity and average frequency of nystagmus in the PC-BPPV groups, whereas it was not observed in the HC-BPPV patients. Complete relief of symptoms was reported after 2 weeks and was better in patients diagnosed with maneuvers performed with high AHMV. High AHMV during the D-H maneuver allows the nystagmus to be more visible, increasing the sensitivity of diagnostic tests and is crucial for a proper diagnosis and therapy.

2DHeadPose: A simple and effective annotation method for the head pose in RGB images and its dataset

Head pose estimation is one of the essential tasks in computer vision, which predicts the Euler angles of the head in an image. In recent years, CNN-based methods for head pose estimation have achieved excellent performance. Their training relies on RGB images providing facial landmarks or depth images from RGBD cameras. However, labeling facial landmarks is complex for large angular head poses in RGB images, and RGBD cameras are unsuitable for outdoor scenes. We propose a simple and effective annotation method for the head pose in RGB images. The novelty method uses a 3D virtual human head to simulate the head pose in the RGB image. The Euler angle can be calculated from the change in coordinates of the 3D virtual head. We then create a dataset using our annotation method: 2DHeadPose dataset, which contains a rich set of attributes, dimensions, and angles. Finally, we propose Gaussian label smoothing to suppress annotation noises and reflect inter-class relationships. A baseline approach is established using Gaussian label smoothing. Experiments demonstrate that our annotation method, datasets, and Gaussian label smoothing are very effective. Our baseline approach surpasses most current state-of-the-art methods. The annotation tool, dataset, and source code are publicly available at https://github.com/youngnuaa/2DHeadPose.

Plain Radiographs are Insufficient for Evaluation of First Metatarsal Pronation in Patients Undergoing Surgery for Hallux Valgus

Category: Midfoot/Forefoot; Bunion Introduction/Purpose: Previous studies using weight-bearing CT (WBCT) have suggested that up to 30% of patients with hallux valgus may have excessive pronation of the first metatarsal when defined as a metatarsal pronation angle (MPA) of greater than 16 degrees (Najefi et al.). The MPA is calculated on coronal slices of a CT or MRI, but axial imaging is not the norm in the assessment of these patients. It is however unclear how accurate radiographs are at determining pronation. This study aimed to assess the degree of pre-operative first metatarsal pronation in patients undergoing surgery for hallux valgus using radiographs and WBCT. Methods: This was a retrospective review of patients undergoing scarf osteotomy for hallux valgus correction. Patients were included if they had both plain radiographs and WBCT. Patients were excluded if they had any prior surgery to the foot in question. Pre-operative weightbearing plain radiographs of the foot were analyzed and the classification by Okuda et al. was used to determine if pronation was present using the shape of the lateral edge of first metatarsal head. Pre-operative WBCTs were reviewed and MPA calculated. Twenty-two feet were included. Results: In total 10 feet (45.5%) had an ‘angular’ first metatarsal head, 9 (40.9%) had an ‘intermediate’ head shape, and 3 (13.6%) had a ‘round’ head on plain radiographic assessment. The overall mean MPA was 16.25 degrees (range 2.1-30), and 12 (54.5%) feet had an MPA of greater than 16 degrees (excessively pronated). There was a strong correlation between increasing MPA and increasing roundness of the metatarsal head (Eta = 0.952). The mean MPA was 14.4 degrees in the angular head group, 17.0 degrees in the intermediate group, and 20.1 degrees in the round head group. In the intermediate and round groups 9 feet (75%) had greater pronation than the normal range. By contrast, only 3 (30%) of feet in the round head group had pronation greater than 16 degrees. Conclusion: In this surgical population of hallux valgus patients, the overall prevalence of excessive first metatarsal pronation was greater than in general cohorts of hallux valgus patients. Patients with intermediate and round shaped heads on plain radiographs tended to have greater first metatarsal pronation than those with angular shaped heads, although the correlation was not perfect. This suggests that plain radiographic assessment of metatarsal rotation may not be accurate as there may be discrepancies due to changes in foot position or angle of beam while acquiring the radiographs. Although further work is still required to determine whether there is clinical benefit from addressing the pronation, axial imaging (such as with WBCT) may be useful in the intermediate and round groups for accurate assessment of pronation and to determine if it is significant. This may be especially relevant in surgical candidates in whom osteotomies such as a scarf are being considered, where pronation cannot be addressed.

Remote AFIS: development and validation of low-cost remote tower concepts for uncontrolled aerodromes

Remote tower systems are widely established as a means to provide efficient air traffic control (ATC) from a remote location. However, even these cost-effective systems cause procurement, implementation, and maintenance costs, which make them unaffordable for non-ATC aerodromes with low revenues, often only offering an aerodrome flight information service (AFIS) or UNICOM information service. In this paper, two more inexpensive concepts enabling remote control at these aerodromes are presented. They are based on a simplified camera set-up comprising a pan-tilt-zoom-camera (PTZ-camera) and a simple panoramic camera. A virtual reality-headset (VR-headset) is used to display the video streams and to control the PTZ-camera. The results of a validation study with nine ATC and AFIS officers using live traffic at the Braunschweig-Wolfsburg aerodrome (BWE) are presented. They are discussed with respect to perceived usability, virtual reality induced cybersickness, and operator acceptance. The system’s cost is compared to that of a conventional remote tower set-up. Furthermore, measured objective data in the form of angular head rotation velocities are presented and requirements for the camera set-up are deduced. In conclusion, the developed concept utilizing both the panorama camera and PTZ-camera was found to be sufficiently usable and accepted by the validation participants. In contrast, the concept based only on the PTZ-camera suffered from jerky and delayed camera movements leading to considerable cybersickness and making it barely usable.

Influence of the frame of reference on head acceleration events recorded by instrumented mouthguards in community rugby players

ObjectivesTo highlight the need for standardisation in the communication of head impact telemetry from instrumented mouthguards (iMG). The purpose of this study is to examine how the frame of reference...

Pilot characterization of head kinematics in grassroots dirt track racing

Objective The objective of this study was to utilize an instrumented mouthpiece sensor to characterize head kinematics experienced by grassroots dirt track race car drivers. Methods Four dirt track race car drivers (ages 16–19) were instrumented with custom mouthpiece sensors capable of accurately measuring head motion during racing. Sensors were deployed before races and recorded tri-axial linear acceleration and rotational velocity for approximately 10 min at 200 Hz. Film review was performed to identify data associated with racing laps. For each lap, moving average kinematics were computed and subtracted from the head motion signals to obtain ‘adjusted’ head motion accounting for lower frequency variance due to periodic motion around the track. From adjusted data, linear and angular head perturbations (i.e., deviations from moving average) were extracted using a custom algorithm. Results Data was collected during 400 driver-races. A total of 2438 laps were segmented from mouthpiece recordings. The median (95th percentile) peak linear acceleration, rotational velocity, and rotational acceleration of all laps were 5.33 (8.28) g, 2.89 (4.60) rad/s, and 179 (310) rad/s2, respectively. Angular perturbations occurred most frequently about the anterior-posterior axis (median lap frequency = 6.39 Hz); whereas linear perturbations occurred most frequently in the inferior-superior direction (7.96 Hz). Nine crash events were recorded by the mouthpiece sensors. The median (95th percentile) peak head kinematics of these events were 13.4 (36.6) g, 9.67 (21.9) rad/s, and 630 (1330) rad/s2. Conclusions Mouthpiece sensors can be used to measure head kinematics during active racing. Laps, head perturbations, and crashes may be useful units of observation to describe typical head kinematic exposure experienced by drivers while racing. Subsequent research is needed to understand the associations between repetitive racing exposure and neurological function. Higher magnitude events (i.e., crashes) are not uncommon and may result in concussion or more severe injury. Results represent novel characterizations of head kinematic exposure experienced in a dirt track racing environment. This information may inform evidence-based strategies (e.g., vehicle/seat design) to improve driver safety.

How Peripheral Vestibular Damage Affects Velocity Storage: a Causative Explanation.

Velocity storage is a centrally-mediated mechanism that processes peripheral vestibular inputs. One prominent aspect of velocity storage is its effect on dynamic responses to yaw rotation. Specifically, when normal human subjects are accelerated to constant angular yaw velocity, horizontal eye movements and perceived angular velocity decay exponentially with a time constant circa 15-30s, even though the input from the vestibular periphery decays much faster (~ 6s). Peripheral vestibular damage causes a time constant reduction, which is useful for clinical diagnoses, but a mechanistic explanation for the relationship between vestibular damage and changes in these behavioral dynamics is lacking. It has been hypothesized that Bayesian optimization determines ideal velocity storage dynamics based on statistics of vestibular noise and experienced motion. Specifically, while a longer time constant would make the central estimate of angular head velocity closer to actual head motion, it may also result in the accumulation of neural noise which simultaneously degrades precision. Thus, the brain may balance these two effects by determining the time constant that optimizes behavior. We applied a Bayesian optimal Kalman filter to determine the ideal velocity storage time constant for unilateral damage. Predicted time constants were substantially lower than normal and similar to patients. Building on our past work showing that Bayesian optimization explains age-related changes in velocity storage, we also modeled interactions between age-related hair cell loss and peripheral damage. These results provide a plausible mechanistic explanation for changes in velocity storage after peripheral damage. Results also suggested that even after peripheral damage, noise originating in the periphery or early central processing may remain relevant in neurocomputations. Overall, our findings support the hypothesis that the brain optimizes velocity storage based on the vestibular signal-to-noise ratio.

Tacklers' Head Inertial Accelerations Can Be Decreased by Altering the Way They Engage in Contact with Ball Carriers' Torsos.

ABSTRACTPurposeThis study aimed to investigate how four types of successfully executed, legal front-on, one-on-one torso tackles influence the tacklers’ and ball carriers’ inertial head kinematics.MethodsA total of 455 successful front-on, one-on-one torso tackle trials completed by 15 rugby code players using three-dimensional motion capture were recorded. Tackles differed with respects to the height of the contact point on the ball carrier’s torso. A series of mixed general linear models were conducted.ResultsThe tackler sustained the highest peak resultant linear (P < 0.001) and angular (P < 0.01) head accelerations when contacting the lower torso to execute a “dominant” tackle compared with mid or upper torso, although these latter tackle types had the lowest ball carrier inertial head kinematics. When executing a “smother” tackle technique, a significant decrease in peak resultant linear head acceleration was observed with a vertical “pop” then lock action used, compared with the traditional upper torso tackling technique (P < 0.001).ConclusionsModifying the tackler’s engagement with a ball carrier’s torso, with respect to height and technical execution, alters the inertial head kinematics of the tackler and the ball carrier. The traditional thinking about optimal tackle technique, as instructed, may need to be reevaluated, with the midtorso being a potential alternative target contact height, whereas changes in tackle execution may be relatively protective for tacklers when executing either a dominant or smother tackle. This study provides critical scientific evidence to underpin revised coaching tackling technique interventions that might enhance player safety. Tackles in which the tackler contacts the ball carrier around the midtorso region, rather than lower torso, produce the lowest acceleration and thus may contribute to reducing head injury risk for the tackler.