Bamboo scrimber, as a renewable and sustainable material engineered from bamboo, is inevitably subjected to impact loadings in engineering applications. To study the dynamic behaviour and failure mechanism of bamboo scrimber panels under low-velocity impact, a series of drop hammer impact tests were conducted on 36 panels. The peak force, deformation and energy absorption of bamboo scrimber panels were obtained and analysed. The influence of impact energy, impactor shape and impact angle on the dynamic behaviour of panels was quantitatively characterised. Besides, based on test observations and microscopic views, the failure mechanism of bamboo scrimber panels under different impact types was revealed, including the energy absorption mechanism through fibre fracture, fibre debonding, fibre pull-out and matrix failure. Test results showed that with increasing impact energy, the peak force of panels impacted by the spherical and flat impactors increased, while that of panels impacted by the wedge impactor did not vary significantly. The deformation and energy absorption of panels also increased with increasing impact energy. Notably, the impactor shape obviously influenced the dynamic behaviour of panels, causing a higher peak force of panels impacted by the flat impactor and a larger deformation of panels impacted by the wedge impactor. The failure mechanism of panels depended highly on the impact energy and the impactor shape. Finally, a comparative study of single versus repeated impacts revealed that the deformation of bamboo scrimber panels under repeated impacts was less than that of panels under a single impact when the same amount of energy was imposed to the panel. This study provided a basis for the use of bamboo scrimber to resist impact loadings.