ANCOVA Test Research Articles

Integrating a blended discovery learning model with a bioenial website to empower science process skills and scientific attitude

This study aims to determine; 1) the effect of integrating blended discovery learning with a bioenial website to empower Science Process Skills (SPS) of grade X students on the material of environmental change and preservation and 2) the effect of integrating blended discovery learning with a bioenial website to empower the scientific attitude of grade X students on the material of environmental change. The research method used a quasi experiment with a quantitative approach. The research design used posttest only control group design to measure SPS and pretest-posttest nonequivalent control group design to measure scientific attitudes. The population in this study were X grade students of SMA Negeri A Sukoharjon the 2022/2023 academic year. The samples of this study were X2 class as experimental class 1 as many as 36 students, X4 as experimental class 2 as many as 36 students, and X5 as control class as many as 36 students. The sampling technique used was cluster random sampling. Data collection questionnaire (scientific attitude), observation (SPS, scientific attitude, syntax implementation), and documentation. Data analysis technique used ANOVA hypothesis test for SPS and ANCOVA for scientific attitude. The ANOVA test results showed the effect of integrating blended discovery learning with the bioenial website to empower SPS. The results of further testing with LSD show that Blended Discovery Learning is a treatment that is significantly different among the three class groups. The ANCOVA test results show that there is no effect of integrating blended discovery learning with the bioenial website to empower scientific attitudes

Empowering prospective teachers’ scientific and digital literacy through exploring-resuming integrated criticizing (ERIC) in biology classroom

Prospective Science teachers need well-developed science and digital literacy to help the process of thinking, learning, communicating, working together, and working with their creativity. Unfortunately, various studies show that students' abilities regarding these two types of literacy still need to improve, especially in first-year students. This study aims to (1) analyze the potential impact of the ERIC learning model with the lesson study-based TPACK framework on science and digital literacy and (2) analyze the contribution of lesson study implementation during ERIC learning to the professional development of educators. This study used a concurrent mixed method. In-depth analysis through lesson study was conducted during the implementation of the ERIC learning model in a quasi-experimental setting. The collected data was then analyzed using the ANCOVA test to reveal the difference in mean scores between the experimental and control classes. At the same time, the results of learning observations and reflection on the lesson study phase were analyzed qualitatively. The results showed that the ERIC learning model with the TPACK framework had a significant effect on scientific and digital literacy. In addition, implementing lesson study enables educators to become more aware of students' learning difficulties and needs and, therefore, develop deeper knowledge about learning requirements

LEVERAGING RURAL AREAS & EMPLOYMENT IN AGRICULTURAL & NON AGRICULTURAL SECTORS TO ERADICATE HOMELESSNESS IN USA: A STUDY OF RURAL, SUBURBAN, AND URBAN CoCs INCLUDING A MAJOR CITY CoC

The study aims to explore the potential of using rural areas to develop strategies to end homelessness, including job creation initiatives, by examining the relationships between homelessness, urban and rural areas, and unemployment rates. Using descriptive analysis; histograms, summary tables, and regression analysis, the research finds a lower incidence of homelessness in rural areas. Regression results indicate that homelessness increases by 1294 individuals in urban areas but decreases by 402 individuals in rural areas per unit increase in the count of rural areas. Additionally, homelessness increases by 202 individuals for every unit increase in the unemployment rate. ANCOVA testing confirms the significant impact of Area Category (<0.001) on homelessness, with unemployment rates being lowest and highest in Largely Rural areas among the sampled locations.

The effect of exercise on sleep habits of children with type 1 diabetic: a randomized clinical trial

BackgroundAdequate sleep and exercise are important components of the human lifestyle. Paying attention to these two factors is very important to improve the condition of children with type 1 diabetes. Therefore, this study aimed to investigate the effect of exercise on sleep habits in children with type 1 diabetes.Material & methods62 children with type 1 diabetes participated in this clinical trial. They will be divided into the intervention group (31) and the control group (31). Sleep habits were measured using the Children’s Sleep Habits Questionnaire (CSHQ). All children’s parents completed the CSHQ. The intervention for the experimental group consisted of 8 weeks of regular exercise program. The exercise program was prepared as an educational video and provided to parents. Paired sample t-test and ANCOVA test were used with SPSS 23.Results62 children with an average age of 9.32 ± 2.02 were studied. Fifty-four and eight% of the children were girls and the rest were boys. The analysis of the variance test showed a significant difference (F = 144.72, P ≤ 0.01) between the average score of the sleep habits of the control group (62.45 ± 5.12) and the experimental group (47.06 ± 4.39).ConclusionSleep habits in the experimental group improved after 8 weeks of exercise training using educational videos. Exercise as a non-pharmacological treatment is an effective way to manage diabetes and improve sleep quality in diabetic children.

The effect of animated movies on speaking skills among motivated English foreign language learners: Elementary level

AbstractTechnology has become an integral part of our daily lives, permeating every aspect. One area where technology has shown potential to enhance English as a Foreign Language (EFL) learning is through the use of animated movies. Despite the growing significance of technology in education, research is scarce in this specific area. Therefore, the aim of this study, conducted in 2023, was to investigate the impact of animated movies on the development of speaking abilities among motivated EFL learners. A total of 370 elementary students studying EFL in various institutions participated by responding to questionnaires. A multiple‐stage cluster sampling approach was employed to select the participants. The students were divided into two groups: the experimental group (EG) and the control group (CG). The selection of 15 animated films from a pool of 50 was performed using the Lawsh CVR (content validity ratio) and CVI (content validity index) algorithms, following validation by professionals. The study was designed as an experiment, and descriptive statistics and the ANCOVA test were employed to analyse the quantitative data. The findings revealed a significant difference between the pre‐test and post‐test results of the EG in English‐speaking skills, vocabulary learning, English pronunciation skills, understanding and recognition. According to the study, animated movies have the potential to aid teachers and EFL students in enhancing their speaking skills. This research sheds light on the benefits of incorporating animated movies into language learning environments, offering valuable insights for both educators and learners alike.

Effect of kinesio taping and exercise on functional impairment in patients with different degrees of knee osteoarthritis

BACKGROUND: Kinesio Taping (KT) is used for musculoskeletal problems. KT optimizes and reduces mechanical stresses on soft tissues. However, the benefits of KT and traditional exercises for different severities of knee osteoarthritis (OA) remains controversial. OBJECTIVES: This study aimed to investigate the effects of tension KT and traditional physical therapy on different severities of knee OA. METHODS: Fifty-six male patients with knee OA, aged 60–75-y years, were allocated to groups A and B based on grades 1 and 2 and grades 3 and 4 on the Kellgren-Lawrence scale, respectively. Tension KT and traditional physical therapy were administrated to both groups for 6-wks. The extensor peak moment of quadriceps and knee flexion range of motion (ROM) were recorded using an isokinetic dynamometer and universal goniometer, respectively. Visual analog scale (VAS) was used to score pain level. Statistical analysis was performed using the ANCOVA test. RESULTS: ANCOVA revealed an increase in peak extensor moment of quadriceps (Pre: 51.6 ± 2.8 Nm; Post: 63.3 ± 4.3 Nm), knee flexion ROM (Pre: 112.8∘7.2; Post: 122.9∘4.8), and pain improvement (Pre: 5.1 ± 1.07; Post: 2.8 ± 1.6) in group A (p< 0.001). Group B showed insignificant improvements in all outcome measures (p> 0.05). CONCLUSION: KT with traditional physical therapy improved knee pain, quadriceps strength, and knee ROM in older males with knee OA grades 1 and 2. KT and traditional physical therapy were insufficient to produce considerable effects on grades 3 and 4 of knee OA.

Effect of the role, playing position and the body characteristics on physical performance in female soccer players

The aims of this study were to know the physical demands according to the playing position and team role, and to assess the effect of the body characteristics on the physical performance of semi-professional female soccer players. Forty-five female semi-professional soccer players during 9 home-matches of the 2021–2022 season were analyzed and GPS devices (GPEXE ®) were used. ANCOVA tests were performed with playing time as covariate. The results showed greater physical demands in forwards and wide-midfielders and offensive role players. Total distance, metabolic power, accelerations, deaccelerations, and distance covered to medium and high speed obtained a strong effect size in these analyses according to the playing position. Furthermore, relationships between body weight and physical performance were found (p < 0.05). In conclusion, the main finding of this study showed that semi-professional female soccer players compete differently, caused by differentiated functions, evidenced in the playing positions and role in the team. Offensive role, forwards and wide-midfielder female players performed the highest physical demands in the competition. This study has shown relevant information for coaches, S&C coaches, and training staff of the semi-professional female soccer teams in order to propose new keys and ways of planning training sessions.

Musculoskeletal Injuries, Exercise Behaviors, and Reproductive Health Are Related to Physical Fitness of Female First-Responders and Health Care Providers.

Musculoskeletal injuries (MSKi) are the most common injury type experienced by first-responders and health care providers (HCPs), making them a significant threat to physical and mental well-being. Female reproductive health and injury history has been related to physical fitness in female members of the Canadian Armed Forces. This relationship has not been explored in Canadian protective services personnel (first-responders) or HCPs. Fifty-seven females employed as firefighters, paramedics, law enforcements, or HCPs completed a physical fitness protocol to assess the following: (1) muscular power (standing long jump and medicine ball throw), (2) muscular strength (4 repetition maximum (4RM) back squats and bench press), (3) muscular endurance (Biering-Sorenson test, single-leg wall sit, and push-ups), (4) flexibility (sit-and-reach), and (5) aerobic capacity (graded treadmill VO2max test). Spearman rho correlation analyses were applied to descriptive analysis, independent-samples t-test, one-way ANCOVA (adjusted by age), and chi-square test. Spearman rho correlation analyses were used to compare physical fitness results for female reproductive health history (e.g., parity status), previous MSKi, and physical activity behaviors (e.g., sports participation). A p value of <0.05 is considered significant. History of childbirth, body composition, and exercise behaviors were related to physical fitness (i.e., standing long jump, Biering-Sorenson test, bench press, and back squat) in law enforcement, firefighting, paramedicine, and health care personnel. Physical training programs aimed at supporting parous first-responders or HCPs should emphasize lower body power, lower body strength, and upper body strength.

Interleukin-15 Contributes to the Benefits of Βeta-Alanine Supplementation on the Performance of Elite Volleyball Players

Background: Volleyball involves intermittent activities closely linked to explosive power and muscular strength. Utilizing the ergogenic supplement beta-alanine can positively influence the balance between anabolic and catabolic factors, potentially enhancing the benefits of sports activities. Objectives: This study aimed to examine the effect of 4 weeks of beta-alanine supplementation on serum myokine levels, as well as aerobic and anaerobic power in elite volleyball players aged 22 - 28 years. Methods: In this quasi-experimental study, 22 male volleyball players from the Division 1 Volleyball League, aged between 22 and 28, were selected and randomly divided into two groups of 11: A supplement group and a control group. The supplement group received 6.4 g/day of beta-alanine (in 8 doses of 800 mg) for 4 weeks. The ANCOVA test was used for data analysis, with a significance level set at P ≤ 0.05. Results: Beta-alanine supplementation significantly increased serum myokine levels (interleukin-15, myonectin, and irisin) compared to the control group (P &lt; 0.05). Additionally, 4 weeks of beta-alanine supplementation was associated with a significant increase in measures of aerobic and anaerobic power (Bruce and Wingate tests) compared to the control group (P &lt; 0.05). Conclusions: Supplementation with Beta-Alanine led to improved performance (aerobic and anaerobic power) by increasing anabolic responses (irisin) and indicators of muscle hypertrophy (IL-15 and myonectin) in elite volleyball players.

Selection of the Processing Method for Green Banana Chips from Barraganete and Dominico Varieties Using Multivariate Techniques

Due to their contribution to human health, healthy snacks have garnered the attention of the scientific community and the food industry. This study was conducted to determine the suitability of frying and baking processing methods for producing green banana chips using two varieties: Barraganete and Dominico. The aim was to identify a treatment geared toward producing healthy snacks. Initially, the physicochemical properties of the raw materials were analyzed, revealing significant differences in starch, fat, fiber, and protein content. Subsequently, the bananas were processed into baked and fried chips. Multivariate statistical techniques such as ANCOVA, MANOVA, and post-hoc tests were applied to examine the influence of initial characteristics and detect variations attributable to the cooking method. The main findings show that the initial protein level had a significant covariate effect on the final content in the chips. The Dominico variety generally proved more suitable for making baked chips, retaining higher percentages of protein, starch, and fiber and lower fat content than Barraganete. Baked chips showed significantly lower sodium and fat values than fried ones when differentiated by processing method. The “Dominico + Baked” treatment emerged as the superior alternative, with favorable levels of protein and starch and low levels of sodium and fat, positioning it as the most suitable for producing a healthy snack.

Penerapan PMR Berbantuan Alat Peraga Obibul Terhadap Hasil Belajar Siswa Pada Materi Operasi Hitung

The aim of this research is to determine the differences in student learning outcomes taught using the realistic mathematics approach (PMR) assisted by Obibul teaching aids and the learning outcomes of students taught using the direct learning model. The research method used is the experimental method, with a design namely pretest-posttest control group design. Sampling used a random sampling technique from 3 classes, namely classes VII.A, VII.B and VII.C, two classes were selected as samples with a total of 25 students as respondents for each class. Based on the results of the lottery drawing, class VII.B was selected as the experimental class which used a realistic mathematics approach (PMR) assisted by Obibul teaching aids while class VII.A was selected as the control class which used a direct learning model. The instrument used for research is in the form of a description/essay. Hypothesis testing uses the ANCOVA test which produces Fcount = 5.73, which is compared with the value of 𝐹table = 3.94 so that 𝐻0 is rejected. The results of this research concluded that there were differences in the learning outcomes of students who were taught using the realistic mathematics approach (PMR) assisted by Obibul teaching aids and the learning outcomes of students who were taught using the direct learning model.

Virtual Reality Laboratory Laws of Inheritance Enhancing Students' Technological Literacy

The lack of introduction and habituation to using interactive media in learning can cause students to have low technological literacy. Virtual reality technology can help us learn the law of inheritance of traits. This research aims to develop learning media using virtual reality technology that is valid, practical, and effective in improving students’ technological literacy. The stages we carried out refer to the development model of William W. Lee and Diana L. Owens. Media feasibility is based on the results of material validation, media, small group trials, and media implementation to high school students. Technological literacy was measured using a questionnaire and observation sheet. The subjects consisted of 127 students taking the material on the law of Inheritance of Traits. The results of the study obtained a material validation percentage of 100% (very valid), media validation of 89% (valid), and small group trials of 90% (very practical). The results of the virtual reality laboratory effectiveness test show the significance value of the ANCOVA test of 0.000 is smaller than α (α = 0.05). These results indicate that the developed media are valid, practical, and effective for improving students’ technological literacy in learning the law of Inheritance of Traits.

Tech-Enhanced Learning

The current study uses the lens of Robert Gagne’s nine events of instruction and the flipped classroom approach to construct a proposed educational module to teach the instructional technology course for preservice teachers at Al Ain University in UAE. The content was broken down into small parts and presented to students through videos and interactive learning exercises. A quasi-experiment was conducted to study the designed module’s effectiveness. The sample involved two groups of 50 female postgraduates from different fields of specialization. The experimental group students were taught through the implementation of the flipped microlearning module, while the control group was taught the same way, except that the educational content was conveyed without chunking. The researcher collected data by administering an achievement test and using the UTAUT questionnaire to determine student acceptance of the module. The result of the ANCOVA test revealed the existence of a substantial difference between the two groups, as f reached 4.427 in favor of the experimental group, with a significance level of 0.038. The questionnaire findings indicated high student acceptance of the module. The findings are of great importance for educational policy and curriculum designers and highlight the advantages of this module in enhancing student performance in different specialist fields.

Efficacy of Nano-curcumin Supplementation on Depression, Anxiety, Stress and Clinical Symptoms in Migraine Patients: A Randomized Double-blind Clinical Trial

Background:: Migraine is a debilitating neuroinflammatory disorder. Patients with migraine often experience elevated levels of depression, anxiety, and stress, which are associated with the frequency and severity of migraine attacks. Curcumin has been shown to have regulatory effects on depression, anxiety, and stress, as well as analgesic properties through various mechanisms. The objective of this study was to assess the impact of nanocurcumin supplementation on depression, anxiety, stress, and clinical manifestations in patients with migraine. Methodology:: This study was conducted as a randomized, double-blind clinical trial. A total of forty-four patients with episodic migraines were recruited for the trial. Stratified randomization was employed to ensure a balanced distribution of participants based on BMI and sex. The patients were equally assigned to two groups using permuted block randomization: 1) the intervention group, which received 80 mg of nano-curcumin, and 2) the placebo (control) group, which received a paraffin-based placebo. The intervention and control periods lasted for 2 months. Anthropometric and demographic data, clinical signs and symptoms (including headache frequency, duration, and severity as reported by the patients), as well as stress, anxiety, and depression scores (using the Dass-21 questionnaire), were recorded before and after the study. The collected data were analyzed using SPSS 22. For normally distributed data, paired t-tests and independent t-tests were utilized. Non-normal data were analyzed using the Wilcoxon test and Mann-Whitney U test. The chi-squared test was employed for categorical variables. To account for confounding factors, the ANCOVA test was conducted. A p-value of ≤ 0.05 was considered statistically significant. The intention-to-treat method was applied to address outliers and missing data. Results:: Based on the findings, the current study demonstrates that supplementation with nano-curcumin can effectively mitigate symptoms of depression and anxiety (p &lt; 0.05). Regarding stress, a noticeable reduction within the nano-curcumin group was observed, although it did not reach statistical significance when compared between groups (p &gt; 0.05). Moreover, nano-curcumin exhibited a significant decrease in the frequency, duration, and severity of headaches (p &lt; 0.05). Conclusion:: Our research findings have shown that supplementation with nano-curcumin can effectively decrease the frequency, severity, and duration of headaches while also alleviating symptoms of depression and anxiety in comparison to the placebo group. Hence, curcumin exhibits significant potential as an adjuvant therapy to enhance the treatment of migraines.

Effects of a neuromuscular training program on the performance and inter-limb asymmetries in highly trained junior male tennis players

BackgroundThe objective of this study was to assess the effectiveness of neuromuscular training on the performance of highly trainer junior tennis players. MethodsTwelve male tennis players (age: 13.4 ± 0.36 years; weight: 50.2 ± 6.29 kg; height: 163 ± 4.41 cm) participated and were randomly divided into two groups. The experimental group (EG) performed neuromuscular training that included exercises for speed, strength, throws, agility, jumps and coordination twice a week for a duration of 10 weeks. Performance was evaluated using various variables, including bilateral and unilateral countermovement jump, 30 cm drop jump and horizontal jump, 505 change of direction test conducted with both the right and left legs, 20-m sprint, and overhead 3 kg medicine ball throw. Asymmetries were also evaluated during the unilateral tests. The impact of the training was assessed through the utilization of ANCOVA tests and effect size measurements. ResultsThe results indicated a significant enhancement in the EG, specifically in bilateral vertical jump and horizontal jump, as well as explosive strength and speed. Conversely, the control group (CG) did not display similar advancements. Furthermore, there was no increase in asymmetries. ConclusionThis suggests that the implementation of a neuromuscular training program could prove to be an effective approach in enhancing explosive power in the lower limbs among young competitive tennis players. Finally, this training program could contribute to the enhancement of their physical attributes in lower body of young tennis players.

The effect of hip abductor strengthening exercises on lower limb strength asymmetry and balance in women with multiple sclerosis: A randomized controlled clinical trial

IntroductionPatients with multiple sclerosis tend to use and move their body segments in an unbalanced way, which causes asymmetry of muscle strength, especially in the lower limbs. Among these muscles, the hip abductor muscles play a more important role in stabilizing the pelvis and maintaining balance. The purpose of this research was to investigate the effect of hip abductors exercises on lower limb strength asymmetry and balance in people with multiple sclerosis. Materials & methodsIn this clinical trial with a pre-test-post-test design, 40 women with multiple sclerosis were purposefully selected and randomly divided into experimental and control groups. The experimental group performed hip abductor muscle strengthening exercises for 8 weeks and each session lasted 30 min. The control group did not receive any intervention and continued their daily activities. The strength of knee flexors and extensors, plantar-flexors and ankle dorsi-flexors was measured using a dynamometer. Static and dynamic balance was also evaluated using the stork test and timed get up and go test, respectively. ANCOVA test was used at a significance level of 0.05 to investigate the intergroup effects. ResultsThe results showed a significant decrease in the strength asymmetry of the knee extensor (P = 0.001) and knee flexor (P = 0.001) muscles in the experimental group. However, no significant difference was observed in the asymmetry of the strength of the ankle dorsi-flexor (P = 0.160) and plantar-flexor muscles (P = 0.698). The results also showed a significant improvement in static (P = 0.001) and dynamic balance (P = 0.001) in the experimental group. Discussions & conclusionsStrengthening the hip abductors improves the symmetry of the strength of the knee extensor and flexor muscles. It also improves the balance of people with multiple sclerosis.

Effect of Game-Specific Training on Dribbling among Hockey Players

This study sought to determine the effects of game-specific training on hockey players’ dribbling. For this study, thirty male hockey players from Namakkal, Tamilnadu, were selected at random to serve as subjects. They were between the ages of 18 and 25. The participants were split into two equal classes after being selected at random. The control group (CG) and experimental group (game-specific training) were created. For six weeks, the study group practiced game-specific training in addition to their regular activities three days a week. The experimental treatment was only available at night. The experimental group did not receive any training. Both groups took a pre-test before the training to gauge their dribbling prowess through a subjective evaluation. A post-test was conducted once the experimental phase was completed. The significance level was set at 0.05 and the ANCOVA test was employed.

RELATIONSHIP BETWEEN DEGREE OF OPTICAL NERVE DAMAGE ON LEVEL OF DEPRESSION AND ANXIETY PATIENT WITH PRIMARY GLAUCOMA

Introduction &amp; ObjectivesGlaucoma is one of the leading causes of irreversible global blindness and the second most commoncause of blindness in the world after cataracts. Depression and anxiety often occur in glaucomapatients when glaucoma is first diagnosed, the effect of decreased vision function in glaucoma, sideeffects of glaucoma therapy both medically and surgically and financial effects due to length oftreatment and loss of job due to limited vision. This study aims to determine the relationship of thedegree of optic nerve damage to the level of depression and anxiety in patients with primaryglaucoma.&#x0D; MethodsThis research is an analytic, prospective observational research with a cross-sectional studyapproach. The relationship between independent variables and dependent variables was analyzed.&#x0D; ResultsThe Man Whitney test found a significant difference in anxiety scores between the severe and mildto moderate groups with a p value of 0.020 . The ANCOVA test found that there was a relationshipbetween the degree of optic nerve damage in primary glaucoma and the level of anxiety aftercontrolling for control variables.&#x0D; ConclusionThis study can be concluded that there is a difference in the level of anxiety between the degree ofsevere and mild to moderate optic nerve damage. The level of anxiety itself corresponds to thedegree of damage to the optic nerve. The more severe the damage to the optic nerve, increased ofthe patient's anxiety score.

Association of Microalbuminuria with Glucose Levels, Microvascular and Macrovascular Complications in Relation with Blood Pressure in Diabetes Mellitus Type 2

Objectives: Determine the association of Microalbuminuria (MAU) with glucose markers, micro vascular and macrovascular complications in relation with blood pressure in patients with type 2 diabetes mellitus. Material and Method: This study was cross sectional study and data collected in Chemical laboratory of pathology department of Dr Akbar Niazi Teaching Hospital. It carried out during the time period of December 2021 to January 2022. Patients were divided into 2 groups which fulfill the inclusion and exclusion criteria patients having diabetes mellitus type 2 with good glucose control, HbA1c &lt; 7% (n=33) patients having diabetes mellitus type 2 with bad control HbA1c ≥7% (n=33) each group were further divided into 2 sub-groups Patients with Pre-hypertension (n) and patients with HTN (n). The sampling technique of this study was non-probability convenience sampling was done. Data/Documentation was collected by Performa and laboratory investigation. Spss version 21 used to analyze the data. Normality of data was assessed by KS test. Quantitative test was measured as mean and standard deviation. Qualitative variables were calculated as number percentage. ANCOVA test and chi square test were used for comparison of quantitative and qualitative variables respectively. Pearson correlation was applied to determine the association of MAU with glucose levels and diabetes related complications. Result: Among total 66 patients, the sample of patients were included 47 males (71.2%) and 19 females (28.8%). Patients of type 2 diabetes mellitus in HbAlc ≥7% group showed higher levels of Blood Glucose level, MAU, Systolic BP and Diastolic BP as compared to HbA1c &lt; 7% group. The comparison of the variables between 2 groups showed statistical differences in nephropathy and cardiovascular complications. In HbA1c ≥ 7% group, correlation of MAU with Systolic BP, Diastolic BP, Fasting Blood Glucose (FBG), HbA1c, Nephropathy, and Cardiovascular events were statistically significant. In Pre-HTN group, MAU was significantly correlated with Fasting blood glucose level, HbA1c, Nephropathy and cardiovascular complications. Patients of HTN showed more significant association with blood pressure (BP), Blood Glucose, HbA1c, Cardiovascular events with MAU as evident by higher r-values as compared to pre-HTN group. Regarding nephropathy, r-value was slightly higher in Prehypertensive group. Conclusion: Patients with uncontrolled diabetes mellitus have increased risk of developing HTN, MAU as well as diabetes related complication including nephropathy and cardiovascular events. More over MAU showed significant positive association with BP, blood glucose levels, nephropathy and cardiovascular events. Both pre- hypertensive and hypertensive patients showed significant positive association of MAU with blood glucose levels and diabetes related complication including nephropathy and cardiovascular events. This study suggested that Prehypertensive and hypertensive patients with altered blood glucose levels have increased risk of MAU, that why proper evaluation and treatment of MAU may lead to early diagnosis and decrease progression of HTN, diabetes mellitus type 2 and its related complications.

Quantitative fetal MRI with diffusion tensor imaging in cases with 'short' corpus callosum.

It has been suggested previously that the presence of Probst bundles (PB) in cases with a short corpus callosum (SCC) on diffusion tensor imaging (DTI) may help to differentiate between corpus callosal (CC) dysplasia and a variant of normal CC development. The objectives of this study were to compare DTI parameters between cases of SCC vs normal CC and between cases of SCC with PB (SCC-PB+) vs SCC without PB (SCC-PB-). This was a retrospective study of patients referred to the Necker Hospital in Paris, France, for magnetic resonance imaging (MRI) evaluation of an apparently isolated SCC detected by sonography between November 2016 and December 2022 (IRB: 00011928). MRI was performed using a 1.5-Tesla Signa system. T2-weighted axial and sagittal sequences of the fetal brain were used to measure the length and thickness of the CC. 16-direction DTI axial brain sequences were performed to identify the presence of PB and to generate quantitative imaging parameters (fractional anisotropy (FA) and apparent diffusion coefficient (ADC)) of the entire CC, genu, body and splenium. Cases in which other associated brain abnormalities were detected on MRI were excluded. Cases were matched for fetal gender and gestational age with controls in a 1:3 ratio. Control cases were normal fetuses included in the LUMIERE on the FETUS trial (NCT04142606) that underwent the same DTI evaluation of the brain. Comparisons between SCC and normal CC cases, and between SCC-PB+ and SCC-PB- cases were performed using ANOVA and adjusted for potential confounders using ANCOVA. Twenty-two SCC cases were included and compared with 66 fetuses with a normal CC. In 10/22 (45.5%) cases of SCC, PB were identified. As expected, dimensions of the CC were significantly smaller in SCC compared with normal CC cases (all P < 0.01). In SCC-PB+ vs SCC-PB- cases, FA values were significantly lower in the entire CC (median, 0.21 (range, 0.19-0.24) vs 0.24 (range, 0.22-0.28); P < 0.01), genu (median, 0.21 (range, 0.15-0.29) vs 0.24 (range, 0.17-0.29); P = 0.04), body (median, 0.21 (range, 0.18-0.23) vs 0.23 (range, 0.21-0.27); P = 0.04) and splenium (median, 0.22 (range, 0.16-0.30) vs 0.25 (range, 0.20-0.29); P = 0.03). ADC values were significantly higher in the entire CC, genu and body in SCC-PB+ vs SCC-PB- cases (all P < 0.05). In SCC-PB+ cases, all FA values were significantly lower, and ADC values in the CC body were significantly higher compared with normal CC cases (all P < 0.05). In SCC-PB- cases, there was no significant difference in FA and ADC compared with normal CC cases (all P > 0.05). Fetal DTI evaluation of the CC showed that FA values were significantly lower and ADC values tended to be significantly higher in SCC-PB+ compared with normal CC cases. This may highlight alterations of the white matter microstructure in SCC-PB+. In contrast, isolated SCC-PB- did not demonstrate significant changes in DTI parameters, strengthening the possibility that this is a normal CC variant. © 2023 International Society of Ultrasound in Obstetrics and Gynecology.