Panchakarma, a cornerstone of Ayurveda, encompasses a set of therapeutic procedures aimed at detoxification and rejuvenation. Vamana therapy is crucial in cleansing the body of excess Kapha dosha. Central to the effec-tiveness of Vamana therapy is the concept of Agni, or digestive fire, which regulates metabolism and digestion in the body. This study explores the pivotal role of Agni in the Vamana procedure, elucidating its significance in preparing the body for purification and ensuring optimal outcomes. Materials and methods: Different Ayurveda textbooks and research articles were reviewed to understand the rela-tion between Agni and Vamana karma. Results: Agni-wise assessment of this data revealed a statistically significant difference in the duration of Deep-ana pachana. The influence of Agni has also been observed in the appearance of Fat and positive Hay’s test at different Vega. A difference is also observed in pH when analysed from the Agni point of view. A change is also noted in the quantity of Sneha consumed and the other parameters like Vega nireekshana kala, Akanthapana, etc., when compared between Mandagni, Madhyamagni and Vishamagni. Conclusion: Understanding the interplay between Agni and Vamana therapy sheds light on the intricate mecha-nisms underlying this ancient detoxification practice, paving the way for its integration into modern healthcare paradigms.