Introduction There has been limited data regarding failure after arthroscopic repair of superior glenoid labrum tears. This study investigates factors associated with failure and re-operation in this patient population. Methods This is a non-concurrent cohort of consecutive patients undergoing arthroscopic labrum repair at a single institution by two fellowship-trained surgeons over a ten year period. Results There were 348 patients included in this study with a mean age of 33.4 (95% CI 32.1-35.9) and an average clinical follow-up of 12.3 months (95% CI 10.9-13.8). The overall re-operation rate was 6.3% with a revision labrum repair rate of 4.3%. The interval between the index procedure to the second procedure was approximately 50 weeks. Subsequent surgery and failure after arthroscopic labrum repair were significantly correlated with workers' compensation (OR 4.6, p < 0.001, CI 1.8-11.7), the use of tobacco (OR 12.0, p=0.03, CI 1.2-114.9) and the use of absorbable anchors (100% correlation, p<0.001). The Odds Ratio (OR) of having a repeat surgery was 12.7 (95% CI 4.9-32.9, p<0.001) with poly-96L/4D-lactic acid (PLDLA, Mini-Revo, Linvatec) and also increased with the use of poly-70L/30D-lactic acid (PLDLA, Bio-Fastak, Bio-Suturetak) anchor material manufactured by Arthrex (p=0.04) after removing the patients exposed to PLDLA anchors from Linvatec. The rates of repeat surgery with PLDLA anchors from Linvatec and PLDLA anchors from Arthrex were 24% and 4%, respectively. None of the patients treated with non-absorbable suture anchors (PEEK or metallic) returned to operating room (p < 0.001). After controlling for associated factors in a multivariate analysis, the use of absorbable anchors, in particular PLDA anchors from Linvatec (OR 14.7, p<0.001) and having a work-related (OR 8.1, p<0.001) injury remained independent factors associated with both repeat surgery and after labrum repair. Conclusion The results of this study strongly support a recommendation against the use of poly-lactic acid suture anchors for glenoid labrum repair surgery. There has been limited data regarding failure after arthroscopic repair of superior glenoid labrum tears. This study investigates factors associated with failure and re-operation in this patient population. This is a non-concurrent cohort of consecutive patients undergoing arthroscopic labrum repair at a single institution by two fellowship-trained surgeons over a ten year period. There were 348 patients included in this study with a mean age of 33.4 (95% CI 32.1-35.9) and an average clinical follow-up of 12.3 months (95% CI 10.9-13.8). The overall re-operation rate was 6.3% with a revision labrum repair rate of 4.3%. The interval between the index procedure to the second procedure was approximately 50 weeks. Subsequent surgery and failure after arthroscopic labrum repair were significantly correlated with workers' compensation (OR 4.6, p < 0.001, CI 1.8-11.7), the use of tobacco (OR 12.0, p=0.03, CI 1.2-114.9) and the use of absorbable anchors (100% correlation, p<0.001). The Odds Ratio (OR) of having a repeat surgery was 12.7 (95% CI 4.9-32.9, p<0.001) with poly-96L/4D-lactic acid (PLDLA, Mini-Revo, Linvatec) and also increased with the use of poly-70L/30D-lactic acid (PLDLA, Bio-Fastak, Bio-Suturetak) anchor material manufactured by Arthrex (p=0.04) after removing the patients exposed to PLDLA anchors from Linvatec. The rates of repeat surgery with PLDLA anchors from Linvatec and PLDLA anchors from Arthrex were 24% and 4%, respectively. None of the patients treated with non-absorbable suture anchors (PEEK or metallic) returned to operating room (p < 0.001). After controlling for associated factors in a multivariate analysis, the use of absorbable anchors, in particular PLDA anchors from Linvatec (OR 14.7, p<0.001) and having a work-related (OR 8.1, p<0.001) injury remained independent factors associated with both repeat surgery and after labrum repair. The results of this study strongly support a recommendation against the use of poly-lactic acid suture anchors for glenoid labrum repair surgery.