Studies show that prestressed anchor cable antislide piles have good antiseismic characteristics. As an important parameter in the design of anchor-cable piles, the effect of anchor-cable inclination on the seismic response of the anchor-cable pile system has been rarely studied so far. In the present study, the seismic response characteristics of the anchor-pulled pile under different cable inclinations are studied using a large-scale seismic model test platform and numerical methods. The obtained results show that the inclined angle of the anchor cable has a great influence on the seismic response of the pile-anchor system. It is found that under the same seismic conditions, the axial force of the anchor cable becomes smaller as the anchor dip angle increases, while the pile top displacement becomes larger. The dynamic earth pressure behind the pile changes from the sliding surface to the pile top, indicating that the earth pressure near the sliding surface and the pile top is of active and passive earth pressure types, respectively. This pressure decreases with the increase of the anchor dip angle, thereby affecting the performance of the antisliding pile.