Anatomical Types Research Articles

A novel three-step process for the identification of inner ear malformation types.

We hypothesize that visualizing inner-ear systematically in both cochlear view (oblique coronal plane) and in mid-modiolar section (axial plane) and following three sequential steps simplifies, identification of inner-ear malformation types. Pre-operative computer-tomography (CT) scans of temporal bones of 112 ears with various inner ear malformation (IEM) types were taken for analysis. Images were analyzed using DICOM viewers, 3D slicer, and OTOPLAN®. The inner-ear was captured in the oblique-coronal plane for the measurement of length and width of cochlear basal turn which is also called as A-, and B-values respectively (Step 1). In the same plane, the angular-turns of lateral-wall (LW) of cochlear basal turn were measured (Step 2). As Step 3, the mid-modiolar section of inner ear was captured in the axial plane by following the A-value and perpendicular to cochlear view. From the mid-modiolar section, the outer-contour of inner ear was captured manually by following contrasting gray area between fluid filled and bony promontory and was compared to known resembling objects to identify IEM types (Step 3). Following reference values have emerged from our analysis: A-, and B-values (Step 1) on average are >8 mm and >5.5 mm respectively, in normal cochleae (NA), enlarged vestibular aqueduct syndrome (EVAS), incomplete partition (IP) type-I and -II, whereas it is <8 mm and <5.5 mm respectively, in IP type-III and cochlear hypoplasia (CH). Angular-turn of LW is consistently observed in cochlear basal turn (Step 2), is 540° in NA and EVAS, 450° in IP-II, and 360° in IP types I & III. In subjects with CH type, angular-turn of LW is either 360° or 450° or 540°. In true mid-modiolar section, outer-contour of inner-ear (Step-3), other than in CH and cystic inner-ear malformations, resembles recognizable shapes of known objects. Absence of EVA is an additional characteristic that confirms diagnosis of CH when the A-, B-values, and angular-turn of LW can be similar to other anatomical types. Drawing a straight line along posterior edge of internal auditory canal (IAC) in axial view can differentiate a true common cavity (CC) from cochlear aplasia-vestibular cavity (VC). Three-step process proposed in this study captures inner-ear in cochlear view as well in mid-modiolar sections visualizing key features of inner-ear in identification of IEM types. Level 1.

Offset nail fixation for intertrochanteric fractures improves reduction and lag screw position.

Surgery for intertrochanteric fractures using intramedullary hip nails (IHNs) is among the most common surgical procedures in the orthopedic field. Although IHNs provide good overall outcomes, they sometimes cause complications, such as loss of reduction and cut-out. Here, we investigated the usefulness of IHNs with an anterior offset (Best Fit Nail® [BFN]) in maintaining fragment reduction and ensuring proper lag screw position compared with conventional non-offset nails (Proximal Femoral Nail Antirotation® [PFNA]), using postoperative computed tomography (CT). Fifty consecutive patients with intertrochanteric fractures who underwent surgery with BFNs (BFN group) and 50 patients who underwent surgery with PFNAs (PFNA group) were retrospectively analyzed. Indices evaluated by postoperative CT were displacement distance of proximal fragment relative to distal fragment, reduction status (intramedullary, anatomical, and extramedullary types), lag screw direction, and angle between lag screw and femoral neck axis (deviation angle). Median [interquartile range] displacement distance was significantly smaller in the BFN group (0 [0, 0] mm) compared with the PFNA group (5.2 [3.6, 7.1] mm) (p<0.001). Reduction status was significantly better in the BFN group (anatomical type, 40 cases; intramedullary type, in 9 cases, and extramedullary type in 1 case) than in the PFNA group (anatomical type, 6 cases; intramedullary type, 43 cases; extramedullary type, 1 case) (p<0.001). Deviation of lag screw direction was observed in significantly fewer cases in the BFN group (20 cases; 40%) compared with the PFNA group (36 cases; 72%). Lag screw deviation angle was significantly smaller in the BFN group (-0.71°±4.0°) compared with the PFNA group (6.9°±7.1°). No adverse events related to surgery were observed in either group. Intertrochanteric fracture surgery using offset BFNs exhibited significantly smaller displacement distance, better reduction status, and higher frequency of no deviation with central lag screw position, compared with surgery using non-offset PFNAs.

A novel anatomic classification to guide transcatheter aortic valve replacement for pure aortic regurgitation.

The success of transcatheter aortic valve replacement (TAVR) in native aortic regurgitation (AR) is limited by the absence of calcified anchoring structures. We sought to evaluate transfemoral TAVR in patients with native AR using a novel aortic root imaging classification. From March to November 2021, 81 patients with severe AR were prospectively enrolled in 2 cardiac centers in China. All were evaluated using multidetector computed tomography (MDCT) and classified into 4 anatomic types in reference to transcatheter heart valve (THV) anchoring: Type 1: anchoring at the left ventricular outflow tract (LVOT), annulus, and ascending aorta (AA); Type 2: anchoring at the annulus and AA; Type 3: anchoring at the annulus and LVOT; and Type 4: anchoring at only 1 level or none at all. Based on the dual-anchoring strategy, patients with Types 1-3 were considered TAVR candidates. Procedural and 30-day outcomes were assessed according to Valve Academic Research Consortium-3 definitions. TAVR was performed in 32 (39.5%) patients (71.9±8.0 years of age, 71.9% were male) using 2 self-expanding THVs. Types 1, 2, and 3 comprised 13 (40.6%), 11 (34.4%), and 8 (25.0%) cases, respectively. The procedural and device success rates were 100% and 93.8%, respectively, with 2 THV migration. Eight patients (25.0%) required a permanent pacemaker, and 2 (6.3%) developed moderate paravalvular leaks. No deaths or other major complications occurred during the study. The novel anatomic classification and dual-anchoring strategy were associated with a high procedural success rate with favorable short-term safety and clinical outcomes.

Reference notes for operating surgeons from classical positions and research methods of academician V.N. Shevkunenko (1872–1952) school based on new data regarding typical anatomy of the neck

Objective. To reflect new information on the typical anatomy of the neck in brief notes for endocrine surgeons from the classical positions and research methods of the school of Academician V.N. Shevkunenko.&#x0D; Materials and methods. The design of the study (from 1994 to the present day) consisted of three main directions. While developing an optimal technique of cervical somatometry, 775 healthy individuals (300/38.7 % men, 475/61.3 % women) were examined. The topographo-anatomical block 426 unfixed corpses of persons who died suddenly (290/68 % men, 136/32 % women). Section, dissection, plastination, morphometry, anthropometry, standard histological technique were used. The clinical part of the study included 214 patients (28/13.1 % men, 186/86.9 % women).&#x0D; Results. The article presents the data of analysis and systematization of accumulated data on the typical anatomy of the neck in the form of a brief abstract for operating surgeons from the classical positions of topographic anatomists of Voronezh and St. Petersburg schools of Academician V.N. Shevkunenko.&#x0D; Conclusions. The revealed new typical features of the shape, sizes, structure and position of the thyroid gland (presence or absence of the pyramidal lobe, retrothyroid processes, Zuckerkandl's tubercle), its blood supply, basic and additional guidelines for the search and visualization of the parathyroid glands and recurrent laryngeal nerve during surgery and preoperative diagnosis, the concept of high-risk areas of surgical actions, the features of the bilateral symmetrical and/or asymmetric arrangement and structure of the anatomical formations of the neck can be used during the surgery, widely introduced into the educational process of students, residents, postgraduate courses and for improving the skills of endocrine surgeons during master classes.

Relationship Between Diagnostic Anatomic Shoulder Parameters and Degenerative Rotator Cuff Tears: An MRI Study.

Numerous radiographic measurement methods related to rotator cuff tears (RCTs) have been described. The most widely used of these parameters is the critical shoulder angle (CSA) as measured via radiography. However, magnetic resonance imaging (MRI) measurements provide more accurate results than direct radiography. To determine the relationship between anatomic shoulder parameters and RCT type via MRI scans. Cross-sectional study; Level of evidence, 3. The data and physical examination notes of 389 patients were retrospectively analyzed, and 242 patients were included in the study. Patients were divided into 2 groups: those with RCT (n = 127) and those without RCT (control group; n = 115). Using suitable MRI sections, the CSA, lateral acromial angle, acromial index, superior glenoid inclination, acromion-greater tuberosity impingement index, and acromiohumeral distance were compared between the RCT and control groups. The correlation of these shoulder parameters with the presence of RCT was investigated, and the predictive value of each parameter was examined using receiver operating characteristic (ROC) analysis. There were significant positive relationships between the presence of RCT and CSA, acromial index, acromion-greater tuberosity impingement index, and superior glenoid inclination, with the strongest correlation belonging to CSA (r = 0.716). There were also significant negative relationships between presence of RCT and lateral acromial angle (r = -0.510) and acromiohumeral distance (r = -0.222). The ROC analysis revealed CSA to be the best predictor for the presence of RCT (area under the ROC curve = 0.899). The study outcomes showed that CSA as measured on MRI is the best predictor for determining the presence of RCTs. In patients with shoulder pain attributed to RCT, it may be helpful to examine the CSA on MRI.

Impact of pulmonary veins anatomy on the outcomes of radiofrequency ablation for paroxysmal atrial fibrillation in the era of contact force-sensing ablation catheters.

Pulmonary vein (PV) isolation (PVI) has become the cornerstone of atrial fibrillation (AF) ablation in patients with paroxysmal AF (PAF). PVI durability is influenced by many factors including PVs anatomy. Data regarding the influence of PVs anatomical variations on the outcomes of PAF ablation in the era of contact force-sensing ablation catheters are scarce and contradictory. Consecutive patients referred to our center for a first ablation of PAF using radiofrequency (RF) were included. PVs anatomy was classified into 3 groups: typical anatomy (4 distinct veins), left common ostium (LCO), and right accessory PV (RAPV). The primary outcome was recurrence of atrial arrhythmia episode during a 12-month follow-up after ablation. Two hundred twenty-three patients were included (mean age 58.4 ± 10.8years and 70.9% male). Among this cohort, 141 patients (63.2%) had typical PV anatomy, 53 (23.8%) had a LCO, and 29 (13.0%) had a RAPV. The existence of a RAPV was not associated with a higher rate of AF recurrences (22 (14.3%) vs. 7 (10.1%), p = 0.519). After multivariate analysis, the presence of an LCO did not appear to be associated with the AF recurrence rate at 12months (OR = 1.69, 95%CI 0.95-2.49, p = 0.098). Maintenance of antiarrhythmic drugs after ablation was the only factor independently associated with a decreased risk of AF recurrence at 12months (OR = 0.76, 95%CI 0.60-0.97, p = 0.046). This study suggests that the presence of an LCO or a RAPV is not associated with a higher rate of AF recurrence at 12months after radiofrequency PVI using contact force-sensing catheters in PAF patients.

Anatomical classification and clinical outcomes of biliary strictures in living donor liver transplantation using right liver grafts.

This study aimed to classify the anatomical types of biliary strictures, including intrahepatic biliary stricture (IHBS), after living donor liver transplantations (LDLTs) using right liver grafts and evaluate their prognosis. Among 692 adult patients who underwent right liver LDLT, 198 recipients with biliary strictures (28.6%) were retrospectively reviewed. Based on data obtained during the first cholangiography, the patients' biliary strictures were classified into the following three types according to the levels and number of branches involved: Types 1 (anastomosis), 2 (second-order branch [a, one; b, two or more; c, extended to the third-order branch]), and 3 (whole graft [a, multifocal strictures; b, diffuse necrosis]). IHBS was defined as a nonanastomotic stricture. Among the 198 recipients with biliary strictures, the IHBS incidence rates were 38.4% ( n = 76). The most common type of IHBS was 2c ( n = 43, 56.6%), whereas Type 3 ( n = 10, 13.2%) was uncommon. The intervention frequency per year significantly differed among the types (Type 1, 2.3; Type 2a, 2.3; Type 2b, 2.8; Type 2c, 4.3; and Type 3, 7.2; p < 0.001). The intervention-free period for more than 1 year, which was as follows, also differed among the types: Type 1, 84.4%; Type 2a, 87.5%; Type 2b, 86.7%; Type 2c, 72.1%; and Type 3, 50.0% ( p = 0.048). The graft survival rates of Type 3 (80.0%) were significantly lower than those of the other types ( p = 0.001). IHBSs are relatively common in right liver LDLTs. Although Type 3 IHBSs are rare, they require more intensive care and are associated with poorer graft survival rates than anastomosis strictures and Type 2 IHBS.

Imaging features and biopsy yield of soft tissue metastatic lesions: 10-year single tertiary center experience.

To evaluate imaging features of soft tissue metastases, technical factors associated with diagnostic yield of image-guided biopsy, and clinical impact of biopsy results on patient outcomes. A total of 1605 image-guided soft tissue biopsies were retrospectively identified from December 2010 to December 2020. Included lesions were histologically proven musculoskeletal soft tissue metastases. Lesions were excluded if intraabdominal, intrathoracic, retroperitoneal, associated with osseous lesions or surgical scar implants or arising from skin or lymph nodes. Image guidance modality, needle size, number of cores, and lesion location, size, and depth from skin were recorded. Patient demographics, malignancy history, biopsy-driven changes in management, and survival rate after biopsy were collected. Forty-six patients met the inclusion criteria with a biopsy diagnostic yield of 44/46 (95.7%). Metastases were most commonly located truncal (82.6%, p < 0.001) and intramuscular (78.3%, p < 0.001). A total of 37/46 (80.4%) biopsies were US-guided. And 9/46 (19.6%) were CT-guided. There was no significant difference in the number of cores or mean needle gauge between diagnostic and nondiagnostic biopsies. At time of review, 23 (50%) patients were deceased, with a mean survival of 13.5months after biopsy. The majority (71.7%) of patients had a known primary malignancy at time of biopsy, most commonly lung (24.2%) and breast (24.2%). Overall survival showed no association with anatomic location (p > 0.83) or tissue type (p > 0.34). The most common biopsy-driven outcome was initiation of chemotherapy, immunotherapy, and/or radiotherapy (52.2%). Image-guided biopsy for soft tissue metastases has high diagnostic yield and commonly influences clinical management. Metastases were most commonly intramuscular in the trunk and are associated with poor prognosis.

BIOPSY ON THE LEFT, PNEUMOTHORAX ON THE RIGHT: IS IT A HUMAN BUFFALO LUNG?

BIOPSY ON THE LEFT, PNEUMOTHORAX ON THE RIGHT: IS IT A HUMAN BUFFALO LUNG?

A SERIES OF GENETIC EVENTS: FIP1L1/PDGFR REARRANGEMENT LEADING TO EOSINOPHILIC MYOCARDITIS

A SERIES OF GENETIC EVENTS: FIP1L1/PDGFR REARRANGEMENT LEADING TO EOSINOPHILIC MYOCARDITIS

A UNIQUE CASE OF CONCURRENT EHLERS DANLOS SYNDROME (EDS) AND POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME (POTS) ASSOCIATED WITH ORTHOSTATIC HYPERTENSION RESPONDING TO IV FLUIDS

A UNIQUE CASE OF CONCURRENT EHLERS DANLOS SYNDROME (EDS) AND POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME (POTS) ASSOCIATED WITH ORTHOSTATIC HYPERTENSION RESPONDING TO IV FLUIDS

UNTREATED PULMONARY ARTERIOVENOUS MALFORMATIONS IN A CARDIORESPIRATORY STORM

UNTREATED PULMONARY ARTERIOVENOUS MALFORMATIONS IN A CARDIORESPIRATORY STORM

Soft Tissue Calcifications in the Head and Neck Region

Background: Soft tissue calcifications are most commonly seen in two-dimensional radiographs. Some may be physiological, and some may be pathological and need treatment. CBCT images provide valuable information about anatomic structures and pathologies. These soft tissue calcifications can be seen clearly in CBCT without superimposition and can be diagnosed appropriately. Aim and Objectives: This study aimed to assess the type and prevalence of calcifications found in CBCT volumes obtained for various diagnostic purposes. The objective of the present study was to determine the prevalence of soft tissue and to find their anatomic location, size, and type as well as their relation to age and gender. Materials and Method: Three hundred full-skull CBCT volumes were retrieved retrospectively from the age-group of 9–75 yrs and were evaluated for calcifications. The study sample included CBCT volumes taken for all diagnostic purposes, and those which contained artifacts were excluded. Results: Of 300 CBCT volumes, 133 were females, and 167 were males. Among them, 446 calcifications were encountered in 177 individuals. Their distribution was pineal gland calcification (24.8%), tonsillolith (18%), choroid plexus calcification (24%), pulp stone (12.4%), calcified stylohyoid chain (8%), sialolith (4%), triticeous cartilage calcification (2%), phlebolith (3%), and extracranial carotid artery calcification (1%). Conclusion: Although most of the calcifications are asymptomatic and require no treatment, correct identification of these findings will reduce further diagnostic assessment and provide more appropriate treatment plans. It will also provide the ability to evaluate underlying diseases comprehensively, and practitioners will have life-saving information by early diagnosis.

BIOPROSTHETIC AORTIC VALVE FAILURE IN END-STAGE RENAL DISEASE AND REINTERVENTION

BIOPROSTHETIC AORTIC VALVE FAILURE IN END-STAGE RENAL DISEASE AND REINTERVENTION

A CHANGE OF HEART: A CASE OF CARDIAC AMYLOIDOSIS

A CHANGE OF HEART: A CASE OF CARDIAC AMYLOIDOSIS

The discoid lateral meniscus in children: a narrative review of pathology, diagnosis and treatment.

The discoid lateral meniscus (DLM) is a congenital abnormality of the meniscal shape, characterized by a typical central hypertrophy and a diameter larger than a regular meniscus, potentially leading to knee pain and symptoms, especially in children. The present study provides an update and a general review of this uncommon meniscal pathology. The incidence of discoid meniscus is about 0.4-17% for the lateral and 0.1-0.3% for the medial, although, being often asymptomatic, the true prevalence is unknown. We aim to enhance awareness on this subject to medical care provider. A literature search was performed on PubMed, including articles written in English until October 2021. The articles regarding etiology, diagnosis and management of DLM in children or in patients younger than 18 years were reviewed using the narrative approach. Recent literature has shown that DLM is one of the most frequent congenital anomalies of the knee encountered during childhood. While asymptomatic children with incidental finding can be managed nonoperatively, symptomatic painful DLM should be addressed surgically, restoring typical anatomy using saucerization, tear repair, and stable fixation of the meniscus. The risk of osteoarthritis progression seems to be higher in children with operated DLM, imposing prolonged follow-up and cartilage preserving strategies for these patients.

Epidemiological Characteristics of Primary Tumors 0f the Central Nervous System According to Anatomical Location and Type of Lesion in a Level IV Hospital in Colombia in the Period Between 2008-2019

Introduction: According to figures from GLOBOCAN 2020, tumors of the central nervous system have an incidence of 1.6% with a mortality of 2.5%. For Colombia, 1,901 new cases were registered, with an incidence of 1.7% and 1,650 deaths, with a mortality of 3%. Aim: To describe the epidemiological characteristics of patients diagnosed with primary tumors of the central nervous system at a central military hospital in the period between 2008-2019. Materials and methods: A cross-sectional descriptive study was proposed, collecting data from the period between 2008 and 2019. 177 cases met these criteria, of which the sociodemographic variables were estimated, and the survival for these was determined through the Kaplan-Meyer analysis of the tumors. Results: The average 5-year survival for men is 22% and for women 27%. 18.6% of the 177 patients diagnosed with primary brain tumors in the study died after histopathological diagnosis, of which 60.6% were men and 39.4% women. Conclusions: The highlighted sociodemographic aspects represent a contribution to the generation of new evidence for primary tumors of the central nervous system in our country.

Etiology of Pediatric Uveitis in a Tertiary Pediatric Eye Hospital in Egypt

ABSTRACT Purpose To report the causes of childhood-onset uveitis in a tertiary pediatric ophthalmology hospital in Egypt. Methods Retrospective study of the medical records of all uveitis patients following up at a tertiary pediatric ophthalmology hospital in Egypt from January 2017 to December 2020. Results The present study included 388 patients. The most common anatomical category was intermediate uveitis (30.4%), and around half of these children had pars planitis. This was followed by panuveitis (25.5%), posterior uveitis (23.5%), and anterior uveitis (20.6%), in decreasing frequency. Juvenile idiopathic arthritis, toxoplasmosis, and Vogt–Koyanagi–Harada syndrome were the most common causes of anterior uveitis, posterior uveitis, and panuveitis respectively. Cataract (40.5%), glaucoma (33.8%), and cystoid macular edema (31.6%) were the most frequent ocular complications. Conclusion The present report provides the relative prevalence of the different anatomical types of uveitis, as well as their main causes in a cohort of Egyptian patients with childhood-onset uveitis.

Effect of anatomical differences and intraocular lens design on negative dysphotopsia.

To assess the effect of ocular anatomy and intraocular lens (IOL) design on negative dysphotopsia (ND). Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands. Ray-tracing study based on clinical data. Ray-tracing simulations were performed to assess the effect of anatomical differences and differences in IOL design on the peripheral retinal illumination. To that end, eye models that incorporate clinically measured anatomical differences between eyes of patients with ND and eyes of pseudophakic controls were created. The anatomical differences included pupil size, pupil centration, and iris tilt. The simulations were performed with different IOL designs, including a simple biconvex IOL design and a more complex clinical IOL design with a convex-concave anterior surface. Both IOL designs were analyzed using a clear edge and a frosted edge. As ND is generally considered to be caused by a discontinuity in peripheral retinal illumination, this illumination profile was determined for each eye model and the severity of the discontinuity was compared between eye models. The peripheral retinal illumination consistently showed a more severe discontinuity in illumination with ND-specific anatomy. This difference was the least pronounced, 8%, with the frosted edge clinical IOL and the most pronounced, 18%, with the clear edge biconvex IOL. These results show that small differences in the ocular anatomy or IOL design affect the peripheral retinal illumination. Therewith, they can increase the severity of ND by up to 18%.

Long-term results of biventricular correction for patients with double outlet right ventricle.

The purpose of this study was to report outcomes of double outlet right ventricle biventricular repair at a single institution in developing countries and to investigate post-operatively determined risk factors for mortality and late intervention. Patients with double outlet right ventricle who underwent biventricular repair in our centre from January 2009 to December 2021 were included. A total of 96 patients (male/female = 61/35) with biventricular repair were included. According to its specific anatomical type, the appropriate individual surgical plan was selected. Multivariate analysis indicated that prolonged cardiopulmonary bypass time(OR = 1.044; p = 0.012) and pre-operative moderate or above pulmonary hypertension(OR = 24.558; p = 0.023) were independent risk factors for early mortality. Univariate analysis showed that different anatomical types and different surgical methods had similar late intervention and late mortality. Concomitant coarctation of the aorta(OR = 40; p = 0.020) and concomitant ventricular septal defect enlargement(OR = 26.667; p = 0.005) were independent risk factors for late intervention by multivariate analysis. Selection of appropriate surgical techniques based on different anatomical types often results in similar late outcomes. For patients with concomitant ventricular septal defect enlargement during the operation, it is necessary to fully expand and avoid damage to the conduction bundle. We should timely intervention in patients with coarctation of the aorta and pay attention to the occurrence of left ventricular outflow tract obstruction during follow-up.