Purpose: In support of a robust outcome registry initiative, we present a workflow and architecture design for an efficient dose‐volume registry module. Methods: The UCLA Radiation Oncology registry management system is composed of two separate database modules; a SQL‐based patient attribute module and a dose‐volume module that is defined based upon two data structures; data_tech and data_dose. The data_tech object defines site‐specific, technical treatment details referenced to a patient identifier. The data_dose object connects with the data_tech object using the patient identifier as a primary key. Each contour in the data_dose object is defined based upon standard dose‐volume endpoints and assigned a structure index referenced to an anatomy dictionary. The patient index key connecting the data_tech and data_dose objects provides for aggregate dose‐volume analysis as a function of treatment details and anatomical index. Results: Upon physician approval of a particular treatment plan, the planning dosimetrist or physicist exports the dose‐volume data for long term storage and updates the data_tech object with the relevant planning and treatment delivery parameters. A MATLAB interface was developed and tested with the Eclipse planning system to read all applicable dvh export files and create the two‐dimensional data_dose object. A second MATLAB module processes the data_tech and data_dose objects to perform aggregate processing and statistical analysis of the data. We have tested the module design using a subset of prostate, H&N and breast treatment plans. The integer indexing scheme allows for efficient queries across a mixed group of dose‐volume structures and site‐specific treatment parameters Conclusions: The indexing architecture associated with the data_tech and data_dose registry modules provides an efficient method for extracting subset parameters from the complete data set. Future work will connect the dose‐volume registry with the SQL‐based patient outcome module to allow for outcome analysis as a function of treatment and dose‐volume details.