Background: The all-aperture fixation technique for anatomical medial patellofemoral ligament (MPFL) reconstruction using a double-loop semitendinosus autograft has been proposed as a strong and biomechanically sound surgical procedure. The aim of the study was to describe the surgical procedure and report the early and mid-term results of MPFL reconstruction using patellar knotless anchors and femoral interference screws. These procedures were performed in the same institution. Methods: This is a retrospective case series studying 10 patients with chronic patellofemoral instability who underwent anatomical MPFL reconstruction by means of patellar knotless anchors and femoral interference screws. The Tegner–Lysholm score with clinical data such as apprehension test and knee range of motion (ROM) were assessed preoperatively and postoperatively. Results: After a mean follow-up of 19.4 mo, all the cases had good clinical outcomes, and none of the cases had any recurrence. The mean Lysholm score and knee ROM significantly improved from 59 and 101 preoperatively to 80.2 and 125, respectively (P<0.001). Conclusions: The technique of anatomical double-bundle MPFL reconstruction by patellar knotless anchors and femoral interference screws is an effective, reproducible, and easy technique for restoring stability and function of the patellofemoral joint. Level of Evidence: Level IV.