Patient Anamnesis Research Articles

Atypical arachnoid cyst with progression: a case report

A 26-year-old female patient applied to the outpatient clinic in 2018 due to pain that had been present for a long time (16 years) and had recently spread from the top of the head to the nape of the neck. It was learned from the patient's anamnesis that her pain was relieved with analgesics. Although no pathological findings were found in the neurological examination, brain MRI was requested to reveal possible intracranial pathological conditions. In the MRI images taken, a cystic mass with a lobulated contour and thin septa of 24x31x40 mm and similar intensity to CSF was detected in the right parasagittal area posteriorly at the vertex level. The patient's control brain MRI images 3 months later showed no increase in cyst size. However, the patient's anamnesis, which came for a control in 2022, showed that his current complaints and headaches had increased. The MR images showed that the existing cyst had reached a size of approximately 60x35 mm. Medical treatment was initially planned for the patient (Acetazolamide, 750 mg/day). The MR taken one month later showed that there was no reduction in the cyst size and the optic discs were slightly swollen in the fundus examination. Considering the cyst growth, the patient's failure to benefit from medical treatment and the swelling noted in the optic discs, the patient was fitted with a cystoperitoneal shunt. The patient's early postoperative tomography image showed a significant reduction in the cyst (50.15x25.66) and a slightly swollen optic disc image with blurred borders was detected in the fundus examination. The patient's complaints regressed, and in the radiological images it was determined that the cyst continued to shrink [(45.8x23.19 mm) and (41.1x20.3 mm)], the shunt was in place, and she had no clinical complaints. As a result, it was argued that patients with atypically located arachnoid cysts, as in this case, should be taken under close clinical and radiological follow-up, and surgical treatment methods should definitely be considered in patients who are found to have an increase in cyst size and clinical findings during this follow-up and who do not respond despite medical treatment.

БЕЗОПАСНОСТЬ ПРИМЕНЕНИЯ ОМАЛИЗУМАБА У РАЗЛИЧНЫХ ГРУПП ПАЦИЕНТОВ

The article is devoted to an analytical review of studies to assess the clinical safety of omalizumab. The analysis showed that targeted therapy using genetically engineered biological drugs, which include, in particular, omalizumab, is increasingly used in the treatment of allergic diseases. In general, most studies show the clinical efficacy of omalisamab in bronchial asthma, allergic rhinitis, anaphylactic conditions, allergic urticaria, both in adults and children. However, there are isolated reports that allow us to talk about individual restrictions in the use of this drug associated with adverse reactions. Anaphylactic reactions have been most commonly reported during the administration of omalizumab. There are reports that indicate itching and rashes on the skin as undesirable reactions. In children, dyspeptic disorders are a common complaint. Reliable data on the initiation of malignancy processes against the background of the use of omalizumab have not been established. Quite rarely, as adverse reactions, the authors note eosinophilic granulomatosis with polyangiitis and thromboembolic complications. The authors draw attention to the need for a thorough collection of allergic anamnesis in patients, a clear selection of the dose of the drug, and monitoring patients in the first hours after the administration of the drug. The analysis data are the theoretical basis for improving the system for ensuring the safety of medicines and notifying supervisory authorities of adverse reactions to the use of medicines.

Extrasystolic arrhythmia as an atrial fibrillation predictor

There is a number of conflicting data regarding electrocardiographic predictors of atrial fibrillation, among which extrasystoles (ES) stand out, but there is no reliable data on which extrasystoles variants may be considered as a risk factor. To identify the relationship between extrasystoles and atrial fibrillation, we have analyzed 3927 publications, from which we identified 46 works relevant for the topic. The data obtained allows us to consider extrasystole as one of the main predictors of the development of atrial fibrillation. An increase in the number of supraventricular and ventricular ES in the anamnesis of patients with atrial fibrillation indicates their relationship.

A Descriptive Study on Existing System in Medical Records Department and Its Gap Analysis in Multispecialty Hospital

The study goals are to assess the efficiency of the current medical record system and the current system for keeping medical records and to stipulate the advantages and downsides of completely linking computerized health databases with patient anamnesis. The study analyse the existing system of documentation of the medical record department, to identify bottlenecks in the existing system of medical records, and to provide recommendations to overcome the bottlenecks and implement the required changes in the required medical records department. And to discover user responses to computerized health databases, whether users are satisfied or not with computerized health databases, and what is users' perceptions of computerized health databases through a data collection process that includes direct observation and questionnaires for MRD staff, doctors, and nurses. Therefore, the medical records department has become an important department in every hospital, providing a variety of services not only to patients but also to the hospital& efficient operation, as well as playing a key role in health promotion and patient care quality.

From anamnesis, dedicated treatment and dental treatment of patients diagnosed with Alzheimer’s disease to the description of some historical truths

The present article focuses both on the standardized me­di­cal management, on the dental management of patients diag­nosed with Alzheimer’s disease, but also insists on the presentation of some historical aspects about the one who discovered and gave the name to the neu­ro­lo­gi­cal disease: Alois Alzheimer. Practically, many of the details presented in this material could clarify certain his­to­ri­cal curiosities regarding the background and life of Alois Alzheimer, both for students and practitioners in the field of general medicine (general medicine, general me­di­cine assistance etc.), as well as for students and prac­ti­tio­ners in the field of dentistry (dental medicine and den­tal technology).

СПОНТАННЫЕ РАЗРЫВЫ МОЧЕВОГО ПУЗЫРЯ

: Bladder ruptures are a serious injury to the abdomen and pelvis. The development of urinary leaks, peritonitis and septic complications cause a high mortality rate in this pathology. In the vast majority of cases, the cause of bladder rupture is trauma. Much less common are the so-called spontaneous ruptures of the bladder, in which the main cause is weakness of the muscle wall, against which a minimal increase in intravesical pressure leads to rupture of the organ according to a typical hydrodynamic mechanism. The rarity of this pathology, the variety of etiological factors, and the absence of any specific clinical manifestations in most cases lead to delayed diagnosis, which negatively affects the results of treatment. This paper summarizes the literature data and our own clinical experience in treating patients with spontaneous rupture of the bladder. The above analysis of clinical observations will allow practicing urological surgeons to be more attentive and purposeful in collecting anamnesis in patients with a clinical picture of an acute abdomen and, if there is a suspicion of spontaneous rupture of the bladder, to use a set of modern diagnostic capabilities. An accurate and timely diagnosis will allow patients to be operated on earlier, before the clinical manifestations of diffuse peritonitis develop, which will have a positive impact on the results of treatment.

THE RELEVANCE OF INTEGRAVASF IN SOCIAL DENTISTRY IN PROMOTING HEALTH IN THE SÃO FRANCISCO VALLEY

The IntegraVasf Social Project is relevant in promoting oral health in the São Francisco River Valley, highlighting the health area. This analysis is based on a study focused on dentistry. The social actions carried out totaled 160 patient anamnesis records between 2020 and 2023 in Juazeiro- BA and Petrolina- PE. The research reveals the prevalence of young patients, but with a significant number of children and elderly people, from whom data was collected on treatments carried out, treatments that need to be carried out and referrals for emergency cases. In view of this, the importance that integravasf plays in reducing factors that affect oral health in society, especially in vulnerable communities, is clear. The focus on promoting adequate oral health for the population that faces obstacles in accessing this sector due to socioeconomic problems. The role of integravasf is fundamental in the propagation, prevention and recovery of oral cavity health, making it accessible to everyone. This study contributes to understanding the oral health situation in the communities served, reinforcing the importance that the IntegraVasf project plays.

HISTORY OF PATIENTS WITH NEW CORONAVIRUS INFECTION AND PRETERM BIRTH

Purpose. To study the anamnesis of patients who have suffered a new coronavirus infection (NCI) and preterm birth (PB). Material and methods. A retrospective study of the anamnesis of patients who underwent NCI in the second half of pregnancy and PB was carried out in the period from May 2020 to December 2021. The division into groups was carried out taking into account the timing of delivery: Group 1 (n=104) – term birth at 37 weeks of gestation and later; Group 2 (n=44) – PB from 22 to 36+6 weeks of gestation. Results. The combination of diseases such as chronic bronchitis, maxillary sinusitis and bronchial asthma increased the risk of PB against the background of NCI by 3.4 times (95% confidence interval [CI] – 2.65–4.39). Among extragenital diseases, opisthorchiasis was detected 4.7 times more often in patients with PB (95% CI – 1.308–17.097). In group 2, compared with group 1, among pregnancy complications, moderate anemia was 6.5 times more likely to be observed (95% CI – 1.2–35.1). PB were due to the severe course of COVID pneumonia and its progression, the serious condition of the woman, which required the prescription of etiotropic therapy. In this regard, the probability of cesarean section in group 2 was 12.6 times higher (95% CI – 4.2–37.8) compared to group 1.

Rosacea is More than Just a Red Face: Microbotox's Role in Minimizing Enlarged Facial Pores for a Rosacea Patient

Enlarged facial pores are a cosmetic concern and a prominent feature of skin aging that impacts patient quality of life. Microbotox has emerged in multiple studies as a solution for reducing pore size and improving skin texture. A case of 29 years old female with papulopustular rosacea and enlarged skin pores was reported. From the patient's anamnesis, it was found that the patient has been complaining of a reddish patch with pimples on the nose and both cheeks for the past 4 years. The patient has also had enlarged pores on both cheeks for the past 3 years. On dermatologic state there were erythematous macule, erythematous papules and enlarged pores on both of the cheek. Global Flushing Severity Score (GFSS) was 3, Investigator’s Global Assessment (IGA) of Rosacea Severity for papules and pustules is grade 2 and erythema grade 2. Visual Assessment for Pore was 6. Patient received a single session of microbotox. Dermoscopy examination showed linear vessels (telangiectasia), a pustule, and also follicles filled with sebum. Follow up of the patient was done for 6 weeks. Patients reported a decrease in issues such as flushing, papules, pustules, and erythema. A noticeable improvement in pore size was also observed. This action can be repeated every 3 months to maintain clinical improvement and good skin texture. Botulinum toxin exhibits a satisfying level of efficacy and safety in rosacea treatment. A single microbotox session proves to be a safe and effective approach for reducing facial pore size, along with notable improvements in skin texture.

Electroencephalographic differences in patients with paranoid schizophrenia with or without a history of suicide attempts

To identify differences in electroencephalographic parameters in schizophrenia patients with and without a history of suicide attempts. Eighty-seven inpatients (50 men and 37 women) with paranoid schizophrenia were examined. Suicidal attempts in the anamnesis of patients were verified by a psychiatrist on the basis of clinical interviewing. The severity of psychopathological symptoms was assessed using The Positive and Negative Syndrome Scale (PANSS) based on a five-factor model. Electroencephalogram (EEG) parameters were recorded and evaluated using a 16-channel encephalograph. A clinical and quantitative analysis of the recordings was carried out with the calculation of absolute spectral power indicators for theta, alpha and beta rhythms, as well as the severity of the activation reaction (Berger effect). Significantly higher rates of the PANSS depression factor were revealed in patients with a history of suicide attempts (p=0.016). Clinical analysis of EEG changes did not reveal any significant differences between the groups (p>0.05). The spectral analysis of the EEG showed significant differences only in the spectral power of the beta rhythm in the central (p=0.048) and occipital (p=0.021) leads with closed eyes, which was lower in the group with a history of suicide attempts. The degree of alpha rhythm depression in the occipital leads was also significantly lower in this group (p=0.016). The regression analysis showed that significant correlates of suicidal attempts in patients with paranoid schizophrenia are the PANSS depressive factor (t=2.784; p=0.016) and a deficiency in the activation response to EEG (t=-2.035; p=0.045). The results complement previous studies on the relationship between suicidal attempts, clinical symptoms and neurophysiological features of the functioning of the brain of patients with paranoid schizophrenia.

Gender-age and clinical-dynamic aspects of the course of depressive disorders in obese patients

Obesity and depression are global health problems. According to WHO estimates, depression is experienced by 3.8% of the population, including 5.0% of adults (4.0% of men and 6.0% of women) and 5.7% of people over the age of 60. About 60.0% of the population of economically developed countries is overweight, 25.0–30.0% are suffering from obesity. Taking into account the great medical and social importance and the insufficient study of the peculiarities of the structure, clinical course, and management of depression in patients with abdominal obesity, the purpose of the study is to analyse and compare the structure, gender-age, and clinical-dynamic features of the course of depressive disorders in obese patients. 140 people were examined. Patients were divided into two clinical groups. The 1st group included 70 women with abdominal obesity and average BMI (34.6±1.42) kg/m2, the 2nd group – 70 men with abdominal obesity and average BMI (34.6±1.42) kg/m2. Examination of patients included: a detailed collection of complaints and anamnesis of patients; a questionnaire to identify depressive disorders according to Beck’s Depression Inventory; clinical and objective examination; measurement of anthropometric and physiological indicators; and laboratory and statistical research. The results of the study established that in young people (25–44 years old), depression was recorded 3.80 times (χ2=24.86, p=0.00001) more often in women than in men, while the number of depressive disorders at the age of 45–59 among men was 2.42 times (χ2=20.94, p=0.00001) more often than among women. The emotional type with an episodic and more severe course of depression prevailed in women, while physical manifestations of depression were characteristic of men. In particular, aggression, which was registered 2.00 times (χ2=4.54, p=0.00001) more often than in women. In order to effectively provide treatment to patients with abdominal obesity and depression, not only the course and type of depressive disorders but also the gender and age characteristics of the patients must be taken into account. Keywords: obesity, depression, gender-age characteristics, body mass index.

The influence of a transferred infection of COVID-19 on the development of atrial fibrillation and changes in its course depending on clinical and anamnestic data

The aim – to study the influence of clinical and anamnestic characteristics, namely: arterial hypertension, coronary heart disease, diabetes, previous myocardial infarction, acute cerebrovascular accident, metabolic cardiomyopathy, of myocarditis in the anamnesis and chronic heart failure on the development of atrial fibrillation (AF) de novo or the deterioration of the course of an already existing arrhythmia in patients after suffering a coronavirus infection (CI).Materials and methods. The study involved 116 patients with AF who were hospitalized in the department of clinical arrhythmology and electrophysiology from September 20.09.2020 to 21.12.2021 and had a history of coronavirus infection (CI). The 1st group – 36 people (31 %) in whom AF occurred after CI. The 2nd group – 25 patients in whom the form of AF has changed. The 3rd group – 55 patients in whom the form of AF did not change. In the 3rd group, two subgroups were formed: 3A – 35 patients in whom, although the form of AF did not change, the frequency or duration of arrhythmia paroxysms increased, and 3B – 20 patients without significant changes in the course of AF. As the first control group (C1), 49 patients with AF without a history of CI were examined. The second control group (C2) was formed by 22 patients after a CI in whom AF did not develop.Results and discussion. In patients of the 1st group, hypertension occurred 1.4 times more often (p<0.001) than in the subjects of the 2С comparison group. The presence of hypertension, especially of the 3rd stage, increased the probability of the appearance of AF after a previous CI, which probably contributed to the emergence of a new, more serious form of AF and worsened the course of this arrhythmia. CHD was probably more common in patients of group 2, compared to group 3. Coronary heart disease was also statistically more frequent in patients of subgroup 3A – in patients in whom the form of AF did not change, but the course of the arrhythmia worsened – the frequency and duration of paroxysms increased, in contrast to the subgroup 3B, in whose patients the course of AF did not fundamentally change. In patients with AF who underwent CI and had a history of аcute violation of cerebral circulation, its course worsened, compared to group 3B, in which the course of this arrhythmia did not change (p<0.001). Myocarditis in the anamnesis was probably much more common in patients of the 1st group, in comparison with the C2 group. There was a significant difference between the frequency of myocarditis in the anamnesis in patients of the 2nd group, in which the form of AF after CI changed to a more severe one, and in the patients of the 3rd group, in which the form of this arrhythmia did not change. Diabetes significantly and reliably affected the deterioration of the course of AF in patients who had this arrhythmia before CI, and contributed to a change in the form of AF to a more unpleasant one (2nd group) in comparison with patients without a change in the form of this arrhythmia (3rd group). Metabolic cardiomyopathy was reliably significantly more common in patients of the 1st group compared to the C2 group. There is a big difference between the frequency of metabolic cardiomyopathy in patients of the 2nd group in comparison with the patients of the 3rd group. In the patients of the 2nd group, in whom the form of AF changed to a more threatening one. There were statistically more people with heart failure IIA, and a higher stage of HF in the digital form in equal to persons of the 3rd group, which included patients in whom the form of AF did not change.Conclusions. In patients with atrial fibrillation who suffered a coronavirus infection, the most common concomitant diseases were found to be: HF I–IIA stage – 92 % (in more than half of the cases – in 51.4 % it was HF IIA stage), arterial hypertension – 83 %, coronary heart disease – 60 %, myocarditis – 28 %, diabetes was recorded in 12 % of patients. Arterial hypertension, especially of the 3rd stage, myocarditis in the anamnesis, heart failure of the II A stage caused the appearance of paroxysms of AF de novo after the transferred coronavirus infection in the cohort of patients studied by us. The aforementioned factors, as well as ischemic heart disease, myocardial infarction, and acute cerebrovascular accident in the anamnesis, have been established as markers of the transformation of the paroxysmal form of atrial fibrillation into persistent, or persistent atrial fibrillation into a permanent form of this arrhythmia after being infected with COVID-19.

User Perspectives of Geriatric German Patients on Smart Sensor Technology in Healthcare.

With consideration of the progressing aging of our societies, the introduction of smart sensor technology can contribute to the improvement of healthcare for older patients and to reductions of the costs of care. From the clinical and medico-ethical points of view, the advantages of smart sensor technology are copious. However, any ethical evaluation of an introduction of a new technology in medical practice requires an inclusion of patients' perspectives and their assessments. We have conducted qualitative, semi-structured, exploratory interviews with 11 older patients in order to gain their subjective opinions on the use of smart sensor devices for rehabilitation purposes. The interviews were analyzed using methods of qualitative content and thematic analyses. In our analysis, we have focused on ethical aspects of adoption of this technology in clinical practice. Most of the interviewees expressed their trust in this technology, foremost because of its accuracy. Several respondents stated apprehension that the use of smart sensors will lead to a change in the patient-healthcare professional relationship. Regarding costs of introduction of smart sensors into healthcare, interviewees were divided between health insurance bearing the costs and individual participation in corresponding costs. Most interviewees had no concerns about the protection of their privacy or personal information. Considering these results, improvement of users' technology literacy regarding possible threats connected with putting smart sensors into clinical practice is a precondition to any individual application of smart sensors. This should occur in the form of extended and well-designed patient information adapted to individual levels of understanding. Moreover, application of smart sensors needs to be accompanied with careful anamnesis of patient's needs, life goals, capabilities, and concerns.

Instability of the Knee Joint Before and After Reconstruction of the Anterior Cruciate Ligament According to the Questionnaire

Background: The instability of the knee joint after a rupture of the anterior cruciate ligament in recent decades has acquired the character of a meme among Russian orthopedists with a very wide use and meaning. Aim: In this study, we tried to find out how often the phenomenon of instability occurs and how it can be associated with joint injury. Methods: The method of questioning, collecting anamnesis in patients at the primary orthopedic appointment and in patients after surgical reconstruction by the method of questioning was used. Results: The data collected in 433 patients with a verified rupture of the anterior cruciate ligament showed that 77% experienced a feeling of instability in the knee joint, and 19% did not experience them at all. Arthroscopic reconstruction was performed in 297 patients, 71 of them were surveyed. The period of time from surgery to questioning was 6.5 years on average. Not all patients can note the moment of injury. Even if there was an injury to the knee joint, 10% of patients do not note the development of instability immediately after injury. The duration of the sensation of instability in the knee joint after injury varies from one week to a year or more. The very moment of joint instability is accompanied by pain in more than half of the cases. At the same time, 12% of the respondents had no pain. A third of the respondents had never noted episodes of instability in the knee joint before surgical reconstruction. But 11% had such episodes daily. In the postoperative period, 27% note the recurrence of joint instability at different times. Conclusions: Thus, an ACL tear does not equal knee instability. Instability is not a condition, but a short-term episode that occurs during the period of support and leads to buckling of the limb.

Medical Support of Adaptation to Refractive Errors with Age

Aim: to evaluate the effectiveness of treatment with Optinol on the condition of the ocular surface in people over 35 years of age with refractive error. Patients and methods. The study was carried out in two clinical and in the control group. The first group included 74 patients (148 eyes) with moderate (group 1a) and high (group 1b) myopia, mean age 38.3 ± 0.4 years. The second group consisted of 49 patients (98 eyes) with moderate (group 2a) and high (group 2b) hypermetropia, mean age 42.3 ± 0.5 years. The control group included 25 healthy individuals (50 eyes), mean age 38.2 ± 1.4 years. The anamnesis of patients, complaints and concomitant diseases were assessed by the questionnaire method. Conclusion. The results of the study proved the influence of moderate and high hypermetropia on the likelihood of dry eye syndrome (DES).

Identification of Respondent Characteristics and Relationship of Clinical Manifestations with Chest Radiograph Lesion in Pulmonary Tuberculosis Patients at Aloei Saboe Hospital

Introduction: Tuberculosis (TB) is an infectious infectious disease caused by Mycobacterium tuberculosis. This study aimed to determine the relationship between clinical manifestations and the results of chest radiographs in adult pulmonary TB patients at Aloei Saboe Hospital.Method: The research design used in this study was cross-sectional by examining the relationship between clinical manifestations and chest radiography results in adult pulmonary TB patients at Aloei Saboe Hospital from October to November 2022. The population of this study was adult pulmonary TB patients using accidental sampling as a sampling technique. The research instrument used was the medical record which contained the patient's anamnesis status and the results of the chest radiography examination. The relationship between variables was then analyzed using the Kolmogorov-Smirnov test.Results: Of the 44 samples, the most common clinical manifestations were dyspnea and chest pain in 12 patients (26.67%). The most chest radiographic results were fibrotic in 21 patients (47.7%). According to the American Thoracic Association (ATA) classification, extensive lesions were predominantly found in 21 patients (47.7%). There was an association between productive cough and chest radiography results (p=0.012). Meanwhile, chest radiographs were not associated with productive cough, hemoptoe, and dyspnea.Conclusion: There is a relationship between productive cough and chest radiography lesions. Further study may determine samples for research that are minimally biased so that the results obtained are more representative of the population.

THE AMYOTROPIC LATERAL SCLEROSIS AND FUNCTIONAL RATING SCALE (ALSFRS)

Research material and methods: During the last five years, 60 patients from different parts of Georgia, including Samegrolo, Kartli, Adjara, Abkhazia, Guria, Kakheti regions have been studied, searched and examined by us. The Georgian Neurologists Corps participated and helped us in finding patients. With the consent of the individual patient, which is confirmed in writing, the study was conducted in accordance with the modern requirements of research. We studied patient's anamnesis, physical data, evaluated their mental, cognitive functions and neurological status. We have also interviewed family members, as it was often difficult for the patient to accurately describe the symptoms. Brain MRI and electromyography were also performed. 60 patients with different forms of ALS participated in the study, including 34 (56.66%) men and 26 (43.33%) women. Their age ranges from 30 to 81 years. Patients were included in the study according to the El Escorial criteria. Among those examined by us, the disease began mainly with muscle numbness, weakness of the limbs, fasciculations, in 36 (60%) patients with speech difficulties. According to our research, the diagnosis of ALS is difficult until muscle atrophy and tremors are detected. There are relatively less cases of ALS (23 (38.33%) patients) with symptoms of one or both legs. At this time, the patients felt uncomfortable while walking, the ankle lost its flexibility, its range of motion was limited. muscle weakness is expressed; muscle spasms; increase of deep reflexes or expansion of the reflexogenic zone; pathological reflexes; pronounced muscle atrophy; increased spasticity; At this time, the upper limbs were less damaged, although the flexibility of the fingers in the upper limbs is limited. ALS with bulbar events was detected in 24 (40%) patients with difficulty speaking, the patient spoke "through the nose", later had difficulty swallowing. Disturbance of speech (dysarthria, anarthria), voice production disorder (dysphonia, aphonia). Disappearance of soft palate and throat reflexes, salivation, breathing disorders were soon added to the symptoms; While in the 11 (18.33%) patients with ALS confirmed by us, the symptoms included signs of both lower and upper motor neuron damage, the upper motor neuron showed: muscle hypertonia, hyperreflexia, pathological Babinski reflex; and in case of damage to the lower motoneurons: muscle weakness and atrophy, involuntary fasciculations. Thus, for the first time in Georgia, we determined the structure and characteristics of the most common syndromes of amyotrophic lateral sclerosis in over the last 5 years, and the prevalence of patients with this disease, taking into account age, sex, disease anamnesis, and other symptoms.

Mortality Risk Factors in Neonates Requiring Interhospital Transport

Objective. To identify predictors of newborn infants mortality before medical evacuation.Materials and methods. The observational, cohort, retrospective study included 564 newborns: 526 patients survived and 38 died after 604 visits of the resuscitation-consultation Center transport team (critical care transport — CCT team). Patient's anamnesis, objective data of a patient at the time of examination by CCT team, the volume of intensive care provided and treatment adjustments during preparation for the transfer, records of patient's monitored parameters and indicators of prognosis were analyzed.Results. Compared to survivors, non-survivors neonates exhibited significant increases in premature new-borns (gestation period <29 weeks in 55.26% vs 10.27% in survivors, P<0.001) and significantly increased need in a high-frequency ventilation (7.89% [1.66-21.38] vs 0.57% [0.12-1.66] in survivors, P=0.005), and in cate-cholamines support (use of adrenaline was 13.51% [4.54-28.77] in non-survivors vs 0.76% [0.21-1.94] in survivors, P<0.001). Both early and late neonatal infections predominated in non-survivors: ([26.32% [13.40-43.10] vs 8,75% [6,47-11,49, early infection, non-survivors vs. survivors, respectively, P=0.002) and (23.6% 8 [11.44-40.24] vs 10.46% [7.97-13.39], late infection, non-survivors vs. survivors, respectively, P=0.028). Significant differences in the fraction of inspired oxygen (30% [30-30] vs 45% [30-60], P<0.001), oxygenation saturation index (2.71 [2.54-3.03] vs 4.48 [2.55-7.67], P<0.001), and SpO2/FiO2 ratio (316.67 [313.33-320] vs 207.25 [151.67-313.33] P<0.001) were found between the groups of survived vs. non-survived neonates, respectively. Logistic regression model revealed following markers of neonatal mortality: birth weight, development of early and late neonatal infection, and the oxygenation saturation index.Conclusion. Low birth weight, development of early or late neonatal infection and an increase in the oxygenation saturation index are the risk factors of death in newborns requiring medical evacuation.

The Influence of Thrombocytopenia in Covid-19 Patients on Dengue Hemorrhagic Fever Cases

The increasing cases of Dengue Hemorrhagic Fever in all regions of Indonesia are a disease transmitted through a vector amid the ongoing COVID-19 Pandemic, which can seriously threaten public health. This study aims to analyze the relationship between thrombocytopenia in patients with COVID-19 and cases of dengue hemorrhagic fever. This research was conducted from February to March 2022. The tools used in this study were the Abbot Cell-Dyn Ruby Hematology Autoanalyzer and questionnaires as well as PCR secondary data. Anas used Pearson's Correlation Test statistic and used a cross-sectional study design with 389 respondents who came to check blood at the laboratory. Based on the data obtained, 128 respondents had thrombocytopenia (32.9%) diagnosed with Dengue Hemorrhagic Fever, and as many as 70 out of 128 respondents had been exposed to COVID-19 (54.7%). The analysis results show a relationship between the influence of thrombocytopenia in patients with COVID-19 and cases of Dengue Hemorrhagic Fever. It is necessary to improve anamnesis in patients suspected of Dengue Hemorrhagic Fever, it is hoped that they will carry out investigations related to previous exposure to COVID-19, so that they can provide, fast, precise and accurate treatment and treatment.

Анализ биохимических показателей сыворотки крови у больных с ревизионным эндопротезированием тазобедренного сустава и нарушением углеводного обмена

INTRODUCTION: Along with increase in the number of hip arthroplasty surgeries, the number of complications after them also increases. Laboratory diagnostics, being a unified method for determining the risks of complications and relapses, indicates the need for a comparative analysis of standard laboratory parameters in patients with carbohydrate metabolism disorders (CMD) before revision arthroplasty. AIM: To evaluate changes in the biochemical parameters of blood serum of patients with impaired carbohydrate metabolism before revision arthroplasty. MATERIALS AND METHODS: The data of anamnesis, morphometry and main blood parameters of patients who underwent treatment for osteoarticular pathology and purulent osteology in inpatient facility from 2011 to 2019 were processed and analyzed. The first group included 115 patients (33% of the total amount of examined patients) with revision hip arthroplasty having no disorders in carbohydrate metabolism in history. The second group included 103 patients (30%) who underwent revision hip arthroplasty and had diabetes mellitus, impaired glucose tolerance, and early forms of carbohydrate metabolism disorders as comorbidities. The third group included 73 patients (21%) with periprosthetic infection of the hip joint without history of carbohydrate metabolism disorders. The fourth group included 56 patients (16%) with periprosthetic infection, with disorders of carbohydrate metabolism. RESULTS: The results obtained in the study groups were intercompared and compared with the reference intervals established by the reagent manufacturers for each study method. In the studies, no statistically significant differences were found in the biochemical parameters of blood of patients with aseptic revision arthroplasty, depending on the existing disorders of carbohydrate metabolism. When comparing biochemical parameters of blood of patients with periprosthetic infection, statistically significant differences depending on the presence of CMD, were found in three parameters. Patients with disorders of carbohydrate metabolism had higher blood levels of glucose, creatinine and urea, which, however, remained within the normal range. Two biochemical parameters of the blood of patients of all four groups were beyond the standard limits — C-reactive protein and albumin-globulin ratio. In patients with endoprosthesis instability, bilirubin, creatinine, and albumin values changed depending on the presence of an infectious process in the joint, and creatinine and urea, depending on carbohydrate metabolism disorders. CONCLUSIONS: Depending on the presence of an infectious process or disorders of carbohydrate metabolism, these parameters require closer attention in the preoperative period in patients with endoprosthesis instability. Patients with periprosthetic infection of the hip joint with carbohydrate metabolism disorders require laboratory monitoring of kidney function, protein fractions, and C-reactive protein even with normal results of biochemical blood tests.