Levels Of Analysis Research Articles

Targeted High-Throughput Sequencing Enables the Detection of Single Nucleotide Variations in CRISPR/Cas9 Gene-Edited Organisms.

Similar to genetically modified organisms (GMOs) produced by classical genetic engineering, gene-edited (GE) organisms and their derived food/feed products commercialized on the European Union market fall within the scope of European Union Directive 2001/18/EC. Consequently, their control in the food/feed chain by GMO enforcement laboratories is required by the competent authorities to guarantee food/feed safety and traceability (2003/1829/EC; 2003/1830/EC). However, their detection is potentially challenging at both the analytical and interpretation levels since this requires methodological approaches that can target and detect a specific single nucleotide variation (SNV) introduced into a GE organism. In this study, we propose a targeted high-throughput sequencing approach, including (i) a prior PCR-based enrichment step to amplify regions of interest, (ii) a sequencing step, and (iii) a data analysis methodology to identify SNVs of interest. To investigate if the performance of this targeted high-throughput sequencing approach is compatible with the performance criteria used in the GMO detection field, several samples containing different percentages of a GE rice line carrying a single adenosine insertion in OsMADS26 were prepared and analyzed. The SNV of interest in samples containing the GE rice line could successfully be detected, both at high and low percentages. No impact related to food processing or to the presence of other crop species was observed. The present proof-of-concept study has allowed us to deliver the first experimental-based evidence indicating that the proposed targeted high-throughput sequencing approach may constitute, in the future, a specific and sensitive tool to support the safety and traceability of the food/feed chain regarding GE plants carrying SNVs.

A Rapid Method for Determination of Serum Methotrexate Using Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry and Its Application in Therapeutic Drug Monitoring.

Objectives Methotrexate (MTX) has anticancer therapeutic potential with multiple doses-related adverse effects and toxicities. Immunoassays for therapeutic monitoring of serum MTX have their own limitations. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is considered as the reference method; however, commercially availability of them is limited. We aimed to adapt/develop an in-house LC-MS/MS method for therapeutic monitoring of serum MTX. Materials and Methods Serum protein precipitation was performed using acetonitrile-water containing 250 μM solution of aminoacetophenone as internal standard (IS). Chromatographic separation was achieved on a C18 column with mobile phase of 0.1% solution of formic acid (solvent A) and acetonitrile (solvent B) at a flow rate of 0.4 mL/min. MS was performed under positive ion mode with mass transition for MTX and IS as m/z 455.1→308.1 and 136.2→94.1, respectively. The method was validated by following Bioanalytical Method Validation Guidance for Industry, 2018 and applied on leukemia patients' samples on MTX therapy. Results The correlation coefficient of eight serially diluted calibration standards of 0.09 to 12.5 μM was >0.99 and had linearity with > 95% precision and accuracy at analytical quality control levels. The lower limit of MTX quantification achieved was 0.09 μM with good intensity and sharp peak as compared with blank sample. The total run time of the assay was 5 minutes. The serum MTX levels obtained by this method in leukemia patients exhibited clinical correlation and an excellent agreement with commercial immunoassay used in parallel. Conclusion We were able to develop a rapid, sensitive, and cost-effective LC-MS/MS method suitable for therapeutic drug monitoring of MTX in routine clinical diagnostic laboratories.

A flexibilização do trabalho como regra no capitalismo: conceituação e proposições teórico-analíticas

Abstract This essay aims to explore flexible work in the context of flexible capitalism to propose a theoretical-analytical model of the different classifications of this phenomenon. From a critical literature review, we present fundamental problems - understanding the multiple manifestations of flexibility and how they affect workers and their productive practices. The proposed model comprises three interdependent analytical levels: contractual flexibility, functional flexibility, and workplace flexibility and flexitime. Each level has two subcategories that classify and analyze a work activity in terms of working arrangements, remuneration, tasks, autonomy, where work is accomplished, and work scheduling. Throughout this theoretical essay, we present an alternative definition to the concept of flexible work and argue that flexibilization is a phenomenon incompatible with the enhancement of the labor process in favor of workers and represents another movement of conflict between capital and labor. Therefore, flexibilization is configured in a mechanism of exploitation of workers and expansion of the labor force’s productivity in search of greater private accumulation of capital.

“Two choruses on H. Skovoroda’s poems” by Vitalii Kyreiko: conductor’s concept

The purpose of the study provides a conductor’s concept of “Two choruses on H. Skovoroda’s poems” by Vitalii Kyreiko creating process coverage.
 The methodology. Methodological principles are based on the historicism, genre-stylistic, intonation-dramaturgical and interpretive types of analysis, that are used to create a conductor’s concept of “Two choruses on H. Skovoroda’s poems” by Vitalii Kyreiko.
 The results. The development of the conductor’s concept is a process that covers worldview, analytical and creative-executive systemic levels. A conductor-choirmaster, first of all, must understand the artistic idea due to which V. Kyreiko combined the national philosopher’s poems into a choral diptych. In the first chorus “Ah, the fields” (“Akh, polia”), the essence of H. Skovoroda’s pantheistic doctrine is revealed, enriched with choral means of expression: sound imagery, antiphons between female and male choirs, nominal “dialogues”, a combination of diatonicism and tart, rich harmonies with a dynamic pastel palette. As a result, it creates an image of the Eden Garden, where the hero finds peace and happiness. The second chorus of the diptych “Seeing this life’s woes” (“Vydia zhytiya seho ya hore”) represents the hero’s difficult path to God and to understanding His mercy. The composer creates an artistic sound image due to monody, ostinato, sound imagery, multi-layer character, symbolism, textural and stroke diversity, contrasting dynamics and pleading intonations, the origins of which are found in a national folklore. Two choruses by V. Kyreiko on the H. Skovoroda’s texts, while revealing the spiritual meaning of the brilliant Ukrainian philosopher’s poems, receive features of the neo-baroque style due to the introduction into the XX century’s sound-space of the XVIII century’s poetic heritage, and rhetorical figures (symbols of the Baroque era) introduction into the musical canvas of the choral works. The chorus “Seeing this life’s woes” contains a Renaissance opposition: despair — hope, and chorus “Ah, the fields” represents the beauty cult, which gives the choral diptych Neo-Renaissance features.
 Despite the genre and figurative contrasts of these compositions (choral miniature-scenery and dramatic monologue), let’s emphasize the common features between the choral work by V. Kyreiko and the poetic primary source, which directs the development of choral dramaturgy. The use of couplets as a song carrier, which follows the structure of H. Skovoroda’s poems-songs, appears developed and enriched. The movement acceleration is facilitated by the comparison of sections in chorus “Seeing this life’s woes”, which are built according to the contrast principle, and concert baroque style in chorus “Ah, the fields”. In the choral compositions’ finales, the rhythmic and harmonic unity of the choral array reaches the highest culmination and provides “Two choruses on H. Skovoroda’s poems” with a logical completion in the disclosure of the artistic content. A conductor’s concept of Skovoroda’s diptych by V. Kyreiko represents two Worlds: Eearthly and Heavenly, where the renewal of the hero’s soul, the search for a path to happiness in harmony with nature and hope for God’s mercy and salvation in the highest world take place. This concept must be realized in the choir performance interpretation under the choirmaster’s direction.
 The scientific novelty. The scientific novelty lies in the conductor’s concept of “Two choruses on H. Skovoroda’s poems” by V. Kyreiko development, which will contribute to its realization in choral reproduction.
 The practical significance. The obtained results’ practical significance is determined by the need to find a conductor’s concept for an adequate composer’s intention interpretation.

Reprint of: Capturing conversations in entrepreneurial ecosystems

This paper examines a novel and innovative methodological approach and dataset for measuring the complex relational dynamics underpinning entrepreneurial ecosystems (EEs). Existing measurement techniques have largely failed to yield sufficiently nuanced data or insights to inform robust policy recommendations within this research field. To rectify this situation, this paper sets out a novel approach to assessing the relational connectivity within EEs by capturing entrepreneurial "conversations". Drawing on real-time data extracted from an event-based social media platform, in combination with social network analysis and qualitative interview data, we provide an in-depth assessment of the relational connections within the city of Edinburgh at three analytical levels. Overall, the paper demonstrates that the analysis of conversations and conversational spaces is an important mechanism for exploring and mapping the relational connectivity within EEs. As well as producing novel empirical insights, this approach provides policy makers with vital strategic policy intelligence to help better inform public policy frameworks and associated interventions. • Existing measurement techniques examining entrepreneurial ecosystems (EEs) have largely failed to yield sufficiently nuanced insights. • This paper offers a novel data-driven methodological framework for examining EEs. • It draws on “real-time” data extracted from a digital meetup platform to undertake social network analysis within the Edinburgh EE. • This methodological approach provides policy makers with vital “strategic policy intelligence” to help inform public policy frameworks.

Thyroid Dysfunction in Pregnancy and its Outcome

Objective: To identify the thyroid dysfunction in pregnancy and its outcomes. Study Design: Prospective study Place and Duration of Study: Department of Obstetrics & Gynaecology, Sheikh Khalifa Bin Zayed Al-Nahyan Hospital/CMH Muzaffarabad Azad Kashmir from 1st October 2021 to 31st March 2022. Methodology: Seventeen hundred pregnant women in third trimester were screened. Out of them, 50 were identified to be suffering from thyroid dysfunction. The pregnant women in their third trimester and within the age group of 18-40 years were recruited. By using enzyme linked sorbent assay the serum levels of TSH, Free T3 and Free T4 were determined for each woman as a routine clinical health check-up practice. The women who had raised analytical levels as well as correlated clinical history were identified as suffering from thyroid dysfunction. These women were further followed for the outcomes of their pregnancy. Results: The prevalence of thyroid dysfunction was 2.9%. There were 42% pregnant women suffering from subclinical hypothyroidism while 36% were having overt hypothyroidism and 12% had subclinical hyperthyroidism. Conclusion: The major outcome of thyroid dysfunction in pregnancy in terms of maternal and fetal outcomes was presence of anemia in women and was 4.89%. In women considering fetal outcomes, low birth weight was observed in 32% neonates with a need of neonatal intensive care for 42% of newborns were seen. Keywords: Thyroid dysfunction, Pregnancy, Outcome

Food systems transformations in South America: Insights from a transdisciplinary process rooted in Uruguay

The wicked nature of sustainability challenges facing food systems demands intentional and synergistic actions at multiple scales and sectors. The Southern Cone of Latin America, with its historical legacy of “feeding the world,” presents interesting opportunities for generating insights into potential trajectories and processes for food system transformation. To foster such changes would require the development of collective understanding and agency to effectively realize purposeful and well-informed action toward desirable and sustainable food futures. This in turn demands the transdisciplinary engagement of academia, the private sector, government/policy-makers, community groups, and other institutions, as well as the broader society as food consumers. While the need for contextualized knowledge, priorities and definitions of what sustainable food systems change means is recognized, there is limited literature reporting these differences and critically reflecting on the role of knowledge brokers in knowledge co-production processes. The political nature of these issues requires arenas for dialogue and learning that are cross-sectoral and transcend knowledge generation. This paper presents a case study developed by SARAS Institute, a bridging organization based in Uruguay. This international community of practice co-designed a 3-year multi-stakeholder transdisciplinary process entitled “Knowledges on the Table.” We describe how the process was designed, structured, and facilitated around three phases, two analytical levels and through principles of knowledge co-production. The case study and its insights offer a model that could be useful to inform similar processes led by transdisciplinary communities of practice or bridging institutions in the early stages of transformative work. In itself, it also represents a unique approach to generate a language of collaboration, dialogue, and imagination informed by design skills and methods. While this is part of a longer-term process toward capitalizing on still-unfolding insights and coalitions, we hope that this example helps inspire similar initiatives to imagine, support, and realize contextualized sustainable food system transformations.

Developing a framework for investigating citizen science through a combination of web analytics and social science methods-The CS Track perspective.

Over the past decade, Citizen Science (CS) has shown great potential to transform the power of the crowd into knowledge of societal value. Many projects and initiatives have produced high quality scientific results by mobilizing peoples' interest in science to volunteer for the public good. Few studies have attempted to map citizen science as a field, and assess its impact on science, society and ways to sustain its future practice. To better understand CS activities and characteristics, CS Track employs an analytics and analysis framework for monitoring the citizen science landscape. Within this framework, CS Track collates and processes information from project websites, platforms and social media and generates insights on key issues of concern to the CS community, such as participation patterns or impact on science learning. In this paper, we present the operationalization of the CS Track framework and its three-level analysis approach (micro-meso-macro) for applying analytics techniques to external data sources. We present three case studies investigating the CS landscape using these analytical levels and discuss the strengths and limitations of combining web-analytics with quantitative and qualitative research methods. This framework aims to complement existing methods for evaluating CS, address gaps in current observations of the citizen science landscape and integrate findings from multiple studies and methodologies. Through this work, CS Track intends to contribute to the creation of a measurement and evaluation scheme for CS and improve our understanding about the potential of analytics for the evaluation of CS.

An Analytical Study in The Arabic-English Translation of Al-Tin Surah

The religious translation is one of the important types of translation. The translation of it is not easy. It has a number of difficulties that the translator may face during translation. This leads him/her to use a number of strategies that enable him/ her to translate the religious texts efficiently. This research comprises three sections. Section one presents definitions of translation. Section two deals with the analytical levels of translation (lexical, syntactic, semantic, phonological and stylistic levels). Section three investigates such levels in the translation of Surah Al-Tin l and analyse their implications in translation. Finally, the conclusions have been drawn.

Changes in the Bone Mineral Density after Sleeve Gastrectomy vs. Roux-En-Y Gastric Bypass 2 Years after Surgery.

The aim of this study was to compare the analytical and densitometric changes 2 years after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). A retrospective study of a prospectively collected database was performed. Morbidly obese patients undergoing RYGB or SG, as primary bariatric procedures, were included. Weight loss; analytical levels of parathormone (PTH), vitamin D, and calcium; and densitometric parameters were investigated. In total, 650 patients were included in the study, and 523 patients (80.5%) underwent RYGB and 127 (19.5%) SG. There were no significant differences in excess weight loss at 24 months between both groups. When comparing preoperative and postoperative values, a significantly greater increase in PTH values was observed in the RYGB group, whereas there were no significant differences in calcium and vitamin D levels. The mean t-score values decreased after surgery at all the locations and in both groups. The reduction in the t-score was significantly greater in the RYGB group at the femoral trochanter and lumbar spine. A decrease in bone mineral density (BMD) was observed after both techniques. The mean BMD decrease was significantly greater in the femoral trochanter and lumbar spine after RYGB.

Toward a micro‐level perspective of organizational publicness: Felt organizational publicness in the eyes of state government employees

AbstractOrganizational publicness is a foundational construct for public administration. It has largely been conceptualized deductively and focuses mostly on the macro‐ and meso‐levels of analysis, leaving under‐explored how public employees perceive it at the micro‐level. Through a grounded theory analysis of state government employees' interview data, this study aims to uncover public officials' perceptions about organizational publicness. We find that participants' perception of organizational publicness is a composite of five themes: four represent the core meanings of felt organizational publicness, essentially reflecting a cultural/ethical perspective (purpose, value, behavior, and outcome), and one represents the context of the meanings (external environment). Linking the dimensions with the literature and publicness at other analytical levels, we discuss the findings' implications. We emphasize that employee perceptions of organizational publicness play an important role in achieving realized publicness.

Public project success? Measuring the nuances of success through ex post evaluation

Public projects are conducted on behalf of citizens and taxpayers, who may have different views of what success looks like. The authors argue that the definition of success needs to be broad and multifaceted, even more in public than private projects. A generic six-criteria model is suggested, which covers project success on three analytical levels, from various valuation perspectives, and intended and unintended impacts alike. The model is used to evaluate 34 projects some years into their operational phases. The findings suggest that public projects are often more successful than people think. For example, cost performance is largely acceptable, contrary to the impression presented by the media and some academic studies. We also demonstrate how projects can be successful in some respects yet unsuccessful in others. We argue that the media, the most important source of information for members of the public, has a narrow definition of success and is negatively biased. It seems that ex post evaluation applying a standardized and multifaceted framework, provides a good basis for learning and improvement, to enhance the success of future projects on all levels.

Social interactions at work: why interactive work should be an analytical category in its own right

PurposeThe purpose of this paper is to make a conceptual argument for considering interactive work – i.e. work made up of micro-level exchanges or social interactions with third parties such as customers, patients or citizens – as a distinct analytical category in employment-related research. The argument is underpinned by the core role played by interactive work in valorisation.Design/methodology/approachThis is a conceptual paper, with its argument based on key findings from the debates on symbolic interactionism, service work and interaction work. These are merged and combined with a valorisation perspective.Findings“Social interactions” and “work” have mostly been considered separately by theoretical sociology and the sociology of work. The author contends however that the two concepts should be viewed together, as social interactions at work are a constitutive feature of many occupations, jobs and tasks. This implies studying both exchange and social relationships between the different parties and their embeddedness in specific (multi-level) contexts. Moreover, there are two reasons why interactive work relates to specific working conditions: first, it involves customers or similar groups as third parties; second, it is key to valorisation. To systematically study interactive work, context-sensitive approaches spanning multiple (analytical) levels are recommended.Originality/valueThe article contributes to advancing the understanding of interactive work as a distinct form of work as yet under-theorised but deserving to be considered as a separate analytical category.

Dynamics and disruption: Structural and individual changes in two Dutch Jihadi networks after police interventions

Longitudinal studies of criminal networks are rare yet necessary to assess the adaptation and recovery of criminal networks after disruptions. We study the structural and individual effects of law enforcement disruption on criminal networks using longitudinal data on two Dutch jihadi networks (n1 = 57; n2 = 26). We expect that actors in criminal networks under disruption seek security and to remain concealed as much as possible. We argue how the structural properties of networks as well as mechanisms operating at the actor level might change after a disruption. We used descriptive measures of network cohesion together with core-periphery model fit and modularity to analyse the structural changes in the networks. To obtain the actor-level tendencies, we used undirected stochastic actor oriented models. At the structural level, both networks display opposite tendencies – the larger one is becoming less cohesive after the disruption, whereas the smaller network counter-intuitively becomes structurally more cohesive. Despite the structural differences, the actor-level mechanisms are similar in both studied networks with actors being inclined towards triadic closure and reliance on pre-existing ties. Our study demonstrates the importance of considering the analytical levels of networks and actors by showing that a disruption may disrupt the network at the structural level, while triggering contradictory unintended consequences by increasing individual-level connectivity as in the case of our second network.

Mindfulness in Intercultural Communication: A Qualitative Analysis Experience

The study of intercultural communication has recently become one of the topical issues in the psychology of intergroup relations, intercultural communication and social psychology. Intercultural communication is considered within the framework of communication theory and describes the features and mechanisms underlying effective communication. The integrative communication model, previously described by the authors of this article, made it necessary to test the role of mindfulness in intercultural communication. The aim of this research is to analyze the contribution of mindfulness to the situation of intercultural interaction using qualitative research methods. The research was carried out based on the theoretical model of interpersonal mindfulness described at the following levels: (1) concentration on the present, presence; (2) attentive awareness of both oneself and the other; (3) acceptance of the other without condemnation, and (4) inhibition of automatic responses. Using the method of in-depth interviews and subsequent thematic and phenomenological data analysis, the authors were able to describe the mechanisms of mindfulness in intercultural communication in general and at each of the four analytical levels separately. The data obtained as a result of the analysis made it possible to reveal the content of each of the levels of mindfulness. Conclusions were also made about the content of the goals and values of intercultural communication, the motives for specific practices in the life and communication of informants. Methods for controlling reactivity in a situation of uncertainty in intercultural communication were analyzed and the roles of attitudes towards accepting the other without condemnation were described. The results of this study can serve as a basis for the development of an integrative model that will describe the role of anxiety and uncertainty in intercultural communication and allow the data to be operationalized into measuring scales for quantitative research in the field of assessing the role of mindfulness in intercultural communication.

What Makes International Business Unique and Important as a Field? The Three Cs of IB

We propose a framework for what makes international business important and relevant as a field, based on three attributes that are critical in our research and teaching: context, connection, and complexity. Context refers to examining firms in their environment and not in a vacuum. Connection captures how the field bridges disciplines, nations, and analytical levels. Complexity denotes the systemic nature of the field. We apply this framework to the multinational enterprise and discuss applied insights for various key stakeholders.

Multifunctional Web-system to register and control intellectual products in scientific research

The authors present the web-system providing services of acquiring and accessing multiaspect information on science and research products (publications and papers delivered at scientific events) generated by researchers at an organization or a group of organizations. The system is designed at the Interdepartmental Supercomputer Center of the Russian Academy of Sciences. The System is targeted at both end users interested in obtaining specific data and at administrators and librarians who are to report to their parent organizations. The System’s information base comprises linked data on the following categories: personalia (authors of publications and papers); organizations with their divisions; publications at analytical, monographic and union levels; inventor certificates; scientific events (conferences, symposia, seminars); papers. The system is structured in two modules, the administrative (for data loading and editing) and user module – retrieval system for information search, visualization, navigation through linked resources and data exporting. The System specific feature is that it introduces the concept of “equivalent” objects, i. e. the objects represented by different metadata though related to the same physical entity. In compliance with current reporting standards, the entries also comprise funding resources of the publications, as well as the authors’ affiliation as specified in the articles. While accentuating the friendliness of the system user interface, the authors recommend to use the System in research and academic libraries as an instrument of publication activity assessment.

English

Effect of smoking technologies on nutritional quality and concentration levels of polycyclic aromatic hydrocarbons (PAHs) in Mormyrus caschive and Oreochromis niloticus were determined to enable adoption and utilization of suitable facility that maintains good quality for sustainable supply of nutritious fish products in South Sudan. A total of 72 fresh M. caschive and O. niloticus were purchased, of which 24 were iced for reference and the other 48 were divided into two groups for pit and chorkor smoking. Experimental smoking of fish samples was conducted twice in a randomized design. Fish samples were analyzed for nutritional values using standard methods of the association of official analytical chemists and levels of PAHs using gas chromatography-mass spectrometry. Results revealed; the two smoking methods concentrated crude protein, fat and ash contents. However, fish smoked using chorkor had significantly higher nutritional values than fish smoked using pit kiln. About seven types of PAHs comprising of low and medium molecular weight were recorded from the two smoked fish species. Naphthalene and fluorene were the two dominant PAHs with fish smoked using pit kiln having significantly higher concentration levels of naphthalene (5.86±4.16 µg/kg) and fluorene (3.83±0.10 µg/kg) than fish smoked using chorkor oven. The study concluded that chorkor oven has better quality smoked fish than pit. Hence, its utilization and adoption for artisanal fisheries in South Sudan is recommended.   Key words: Nutritional values, food quality and safety, smoking techniques, polycyclic aromatic hydrocarbons (PAHs).

Gestión de costos de la logística verde en la región sur de Brasil

This study analyses the practices of green logistic and costs management in an agroindustry in the southern region of Brazil. Interviews with a semi-structured script, follow-up of internal processes and inquiries on websites, in management reports and account plans were conducted, for analyze the company's adherence to the 84 practices identified in the literature and organized into nine components, identify other practices not listed, verify the cost elements linked to these practices and how the company manages these costs. The results indicate that the company uses about 83% of the analyzed practices, with the inclusion of six not mentioned in the literature. For practices not introduced or partially used, potentialities and ways of improvement have been verified. The component with the lowest adherence is green marketing. The loading and unloading, packaging, storage and green production have 100% of the practices used by the company, even if partially. However, for the green transport has an adherence of 95.8% (23 of the 24 analyzed). We identified 70 cost elements, many of which exist regardless of ecological practices, but are affected by them. To manage them, the company performs comparative analysis through an integrated information system that tracks data at analytical levels. Some information is entered into the system in isolation and others can be computed from the following accounting period. Many practices are carried out without the perception that they are socio-environmental actions, but their analysis and monitoring can serve as a basis for strategic decision-making and for the realization of sustainable marketing, including the preparation of the Sustainability Report, which the company intends to disclose in the future. In addition, the results serve as a guide to other companies, even if from different segments, by favoring the understanding of the theme and the existing possibilities and providing indications of how to execute them.

РОЛЬ ЕКОНОМІЧНОГО РИЗИКУ У КОНТЕКСТІ РОЗВИТКУ ПРОМИСЛОВОГО ПІДПРИЄМСТВА ЯК ВІДКРИТОЇ СОЦІАЛЬНО-ЕКОНОМІЧНОЇ СИСТЕМИ

The analysis of macro- and microeconomic theories of development, sustainability and risk, their essential foundations, genesis and terminological apparatus allows establishing the existence of interrelationships and interdependencies between the categories of "risk", "sustainability" and "development" at different analytical levels, which determine their relevance research in a single context – to create a mechanism for managing the sustainability of an industrial enterprise during the implementation of innovative strategies. There is a high level of correlation between efficiency and riskiness. The main drivers of economic development are risk and competition. Economic progress is ensured by various "risk stratification". Risk is a regulator of the economy, performing a protective (analytical) function. With the help of risk accounting, the most rational development of microeconomic objects, which is the basis of the market, is achieved, and the entire system achieves the necessary balance, stability of functioning and exclusion of crises. Sustainability of an industrial enterprise as an open socioeconomic system: stability as a characteristic of the system in the processes of functioning and development, which can occur only if the system is stable; resilience is the system's ability to: maintain the planned mode of operation in the conditions of external and internal disturbances, restoring its parameters after their deviation due to the influence of various factors; to adapt to the changing conditions of activity, keeping within permissible limits the movement along the target trajectory of development; to preserve oneself, to exist, to realize one's own target function under various changes in the external and internal environment; to return to a state of equilibrium under influences that upset it. Dynamic stability is ensured by the implementation of innovative strategies that contribute to the qualitative and quantitative increase of potential, as well as the adaptive capabilities of the enterprise management system, preventive accounting of risk factors of various genesis that deflect the influence of factors.