Analysis Of Determinants Research Articles

Photovoltaic Power Plants with Horizontal Single-Axis Trackers: Influence of the Movement Limit on Incident Solar Irradiance

This paper presents an energy analysis of the influence of the movement limit of a horizontal single-axis tracker on the incident energy on the photovoltaic field. The procedure used comprises the following steps: (i) the determination of the periods of operation of a horizontal single-axis tracking; (ii) the analytical determination of the annual, daily, and hourly incident solar irradiance on the photovoltaic field; (iii) the validation of the model; and (iv) the definition of the evaluation indicators. The study focused on three photovoltaic power plants in Spain (Miraflores PV power plant, Basir PV power plant, and Canredondo PV power plant). Four evaluation indicators (annual energy loss, daily energy loss, beam component, and diffuse component) and ten movement limits, ranging from ±50 (°) to ±60 (°), were analysed. In Spain, photovoltaic power plants usually have a movement limit of ±60 (°), which is why it has been called the current scenario. According to this study, the following conclusions can be drawn: (i) It is necessary to calculate the optimal movement limit for each site under study at the design stage of the PV power plant. Although the energy loss per square metre for not using the optimal boundary movement is small, due to the large surface of the photovoltaic field, these energy losses cannot be neglected. For example, in the Canredondo photovoltaic power plant, the limit movement is not optimised and the annual energy loss is 18.49 (MWh). (ii) The higher the range of the limiting movement, the shorter the duration of the static operating period. Therefore, when the current scenario starts the normal tracking mode (where the beam component is maximised), the other scenarios remain in the static mode of operation in a horizontal position, which impairs the incidence of the beam component and favours the diffuse component. (iii) The type of day, in terms of cloudiness index, prevailing at a given location affects the choice of the movement limit. If the beam component is predominant, it favours the performance of the current scenario. In contrast, if the diffuse component is predominant, it favours scenarios other than the current scenario.

Facile synthesis of plasmonic BP@Au nanomatrix for sensitive detection of irinotecan and its active SN-38 metabolite via laser desorption/ionization mass spectrometry.

Anew methodology is presentedfor the rapid, specific, and sensitive detection of irinotecan (CPT-11), a chemotherapeutic agent utilized in the treatment of cancer, along with its metabolically active derivative, SN-38, via laser desorption/ionization mass spectrometry (LDI MS). Themethod includes the detection of camptothecin (CPT), which can be utilized as an internal standard for the quantitative assessment of both CPT-11 and SN-38 in mouse serum. The approach utilizes a plasmonic two-dimensional (2D) black phosphorus nanosheet (BPN)-gold nanomatrix (BP@Au) in LDI MS. The experimental results demonstrated that the BP@Au nanomatrix outperformed the standard organic matrices (SA, CHCA, and DHB) in detecting irinotecan and its active metabolite with improved specificity and sensitivity, crucial factorsfor applications in personalized medicine. Mass spectra obtained using organic matrices revealed interference from matrix peaks overlapping with analyte peaks. The coefficient of determination (R2) was 0.9806 for CPT-11 and 0.9932 for SN-38, indicating strong linearity suitable for quantification. Moreover, the method achieved a lower limit of detection (LOD) of 62.76ng/mL for CPT-11 and 189.87ng/mL for SN-38, significantly enhancing the detection sensitivity by approximately 2-8 times compared with previous matrix-assisted laser desorption/ionization (MALDI) methodologies. This method was subsequently applied tothe quantitative determination of analytes in mouse serum. The analyte recoveries for CPT-11 and SN-38 were 95.40% and 92.95%, respectively. Overall, this study offers potential insights and opens avenues for developing new nanomaterials as a MALDI nanomatrix, demonstrating enhanced capabilities for the rapid, specific, and sensitive detection of small biomolecules within the realms of analytical chemistry and personalized medicine.

Analytic Determination of the Roller Length of a Hydraulic Jump in an Open Channel Flow Using a Bouncing Ball

A hydraulic jump is a natural occurrence that occurs in spillways, rivers, and other open channel flows when water or other liquid flowing with a high velocity discharges into a region of lower velocity with an attendant abrupt rise in the liquid surface. Such a phenomenon, known as hydraulic jump, is normally accompanied by substantial dissipation of energy. Many researchers, in the past, focus attention in the numerical study of the hydraulic jump, under varied working situations. Few attempts are made to study the occurrence analytically. In this paper, the author studied the incident analytically using a bouncing ball to develop a model to examine the lengths of hydraulic jumps in a horizontal open channel flow. The model development is based on the laws of motion, the principles of impulse and momentum, and the classical hydraulic jump formula. The model was later verified with the roller length obtained from the series of experiments conducted in a large-size facility. The roller length that the new model estimated compared well with the experimental results conducted within the Froude number ranges of 2.00 and 16.00. The model is ease to use and its accuracy as determined by the Pearson correlation coefficient is between 0.93 and 1.00.

Chromic Electrospun Polymer Nanofibers: Preparation, Applications, and the Future.

Physical understanding and determination of different analytes without the need for advanced and additional equipment are highly important, which can be achieved by using stimuli-induced chromic materials. Physical and chemical incorporation of responsive chromophores into different polymers results in the fabrication of chromic polymers. Chromic electrospun nanofibers are prepared using the electrospinning technique, and their stimuli-responsivity is improved due to their high surface-to-volume ratio. This Perspective focuses on recent studies and developments on stimuli-induced chromic electrospun nanofibers. Within this Perspective, these nanofibers are divided into different classes of photochromic, thermochromic, electrochromic, mechanochromic, halochromic, solvatochromic, hydrochromic, and ionochromic according to the stimuli to which they respond. In addition, the preparation methods, chromic compounds, electrospinning conditions, response mechanisms, and different applications of chromic nanofibers will be discussed. The main applications of such chromic nanofibers are food packaging sensors, health monitoring sensors, anticounterfeiting materials, ink-free rewritable media, and smart clothing. Several new strategies are also proposed for different applications in future studies. The preparation of multiresponsive nanofibers that combine different chromic properties in a single system and also multifunctional nanofibers that merge stimuli-responsive chromic properties with other smart functionalities can be considered in the future. This Perspective aims to assist researchers and scientists in the preparation and development of new multifunctional chromic electrospun nanofibers for advanced applications, including multimode anticounterfeiting materials, multiresponsive sensors for food packaging, and shape memory-assisted dual-mode encryption of important data.

Protic Ionic Liquid as an Alternative Electrolyte for Simultaneous Electrochemical Determination of Caffeine and Nicotine in Environmental and Food Samples

Caffeine (CAF) and nicotine (NIC) are emerging contaminants and are among the most consumed substances in the world, making it crucial to monitor these contaminants. In this work, an alternative electrolyte, 2-hydroxyethylammonium acetate (2HEAA) was used for the development of an electroanalytical method for determination and quantification of CAF and NIC, simultaneously, using differential pulse voltammetry (DPV). The system with the 2HEAA electrolyte was characterized by cyclic voltammetry and electrochemical impedance spectroscopy, and the DPV parameters were optimized for the best conditions. The method was validated from a calibration curve obtained which showed limit of detection (LOD) of 0.82 and 6.26 μmol L-1 and limit of quantification (LOQ) of 2.73 and 20.8 μmol L-1 for CAF and NIC, respectively. In the precision analyses, values lower than 10% of relative standard deviation were obtained. In the presence of concomitant inorganic and organic species, the system proved to be selective in the determination of analytes. The method was used to determine the analytes in fortified samples (river water, synthetic urine and commercial milk), obtaining recoveries between 87.25 and 111.40%. The 2HEAA demonstrated high efficiency as an alternative electrolyte with good signal-to-noise ratio, increased analytical sensitivity of the method, in addition to presenting low cost and fast electrolyte preparation.

A double probe-based fluorescence sensor array to detect rare earth element ions.

There is a persistent need for effective sensors to detect rare earth element ions (REEIs) due to their effects on human health and the environment. Thus, a simple and efficient fluorescence-based detection method for REEIs that offers convenience, flexibility, versatility, and efficiency is essential for ensuring environmental safety, food quality, and biomedical applications. In this study, 6-aza-2-thiothymine-gold nanoclusters (ATT-AuNCs) and bovine serum albumin/3-mercaptopropionic acid-AuNCs (BSA/MPA-AuNCs) were utilized to detect 14 REEIs (Sc3+, Gd3+, Lu3+, Y3+, Ce3+, Pr3+, Yb3+, Dy3+, Tm3+, Sm3+, Ho3+, Tb3+, La3+, and Eu3+), resulting in the creation of a simple, sensitive, and multi-target fluorescence sensor array detection platform. We observed that REEIs exert various enhancement or quenching effects on ATT-AuNCs and BSA/MPA-AuNCs. Thus, these two probes function as double signal channels, with the different effects of REEIs serving as signal inputs. Pattern recognition methods, including hierarchical cluster analysis (HCA) and linear discriminant analysis (LDA), were used to assess the recognition performance of the constructed sensing system. Beyond the excellent ability to recognize individual REEIs, the platform is also capable of distinguishing mixed REEIs. Also, this approach was validated by applying it to detect REEIs in purified water samples. This method not only minimizes the need for synthesizing and optimizing new probes but also offers a novel approach for the determination and identification of diverse analytes, filling a gap in the detection of a large number of REEIs simultaneously.

НЕКОТОРЫЕ ВОПРОСЫ О ТЕПЛООБЕСПЕЧЕННОСТИ В СИСТЕМЕ «ПОЧВА - РАСТЕНИЕ - ВОЗДУХ»

During the growing season, cultivated plants are subject to bifurcation effects such as drought, frost, ice, hail, heavy rains, etc. The dependence of mankind on the weather is quite large. The purpose of this work is to study artificial bifurcation by heat supply of plants in laboratory conditions. The thermophysical characteristics of the interaction of the plant-soil-air system are due to radiation heat exchange, which includes the arrival of long-wave radiation from the atmosphere - plants and reflected radiation from plants into the atmosphere; the arrival of short-wave radiation from solar radiation used by plant leaves for photosynthesis and reflection of part of this photoactive radiation; turbulent heat exchange of the soil surface with the surrounding surface air; transpiration heat exchange of the soil surface with the surrounding surface air; heat exchange in the soil. In addition, solar radiation reaching the slope surface has a different scattering effect on the functioning of the plant-soil-air system. Note that the vegetation cover performs the function of thermal insulation between the atmosphere and the soil. The analytical determination of the heat supply of plants is quite difficult, especially on slopes of different steepness and exposure, due to both the insufficiency of the data included in these analytical expressions, as well as the uncertainty (impossibility) of determining experimentally appropriate coefficients. Therefore, the technique of the bifurcation approach allows, as a first approximation, to design certain technologies for cultivating crops for a specific catchment area, both in terms of frost resistance, and to apply measures to protect against frost. The stability of plant seedlings to frost was checked in laboratory conditions: sowing and germination of barley seeds under the same conditions (according to ambient temperature and soil moisture) for seven days; placing in a refrigerator at -18°C; extraction from the refrigerator at intervals of 5 minutes, maximum duration of 50 minutes; visual monitoring of the condition of plants. Experimental studies have shown that the death of a plant from frost is described by the regression equation y = 0,0268x2 – 0,3701x + 17,232. As a result of the research, a bifurcation function has been proposed, confirmed by laboratory experiments.

Reflexive and Metacognitive Determinants of Professional Activity of IT Specialists

The article presents the results of a study of reflexive and metacognitive regulation of professional activity of IT specialists: analysts and programmers. It is shown that these types of information activities have a structural rather than analytical determination in relation to the main reflexive and metacognitive parameters. Patterns have been established according to which the structural organization of the main reflexive and metacognitive determinants differs both relative to the indices of the structural organization and in comparison with each other according to the criterion of homogeneity-heterogeneity, revealing qualitative differences among themselves due to the peculiarities of professional activity of each of the groups. They are differentiated according to professional affiliation and gender criterion. The ideas about the specifics of the relationship between antireflexion and other reflexive and metacognitive characteristics, mainly reflection, are formulated. It is negative with an equally high level of severity of each of them, which indicates the “suppression” of a high measure of development of one parameter by an equally high level of severity of the second, which does not reduce the overall potential of the structure, but on the contrary, strengthens it. Thus, a new type of connection in the structure is explicated – “inhibitory”, which reflects not synergistic effects, but also non-compensatory tendencies. The obtained results are based on the characteristics of a new subject-information class of activity.

Impact of Addition of a Newtonian Solvent to a Giesekus Fluid: Analytical Determination of Flow Rate in Plane Laminar Motion

In this study, the influence of the presence of a Newtonian solvent on the flow of a Giesekus fluid in a plane channel or fracture is investigated with a focus on the determination of the flow rate for an assigned external pressure gradient. The pressure field is nonlinear due to the presence of the normal transverse stress component. As expected, the flow rate per unit width Q′ is larger than for a Newtonian fluid and decreases as the solvent increases. It is strongly dependent on the viscosity ratio ε (0≤ε≤1), the dimensionless mobility parameter β (0≤β≤1) and the Deborah number De, the dimensionless driving pressure gradient. The degree of dependency is notably strong in the low range of ε. Furthermore, Q′ increases with De and tends to a constant asymptotic value for large De, subject to the limitation of laminar flow. When the mobility factor β is in the range 0.5÷1, there is a minimum value of ε to obtain an assigned value of De. The ratio UN/U between Newtonian and actual mean velocity depends only on the product βDe, as for other non-Newtonian fluids.

A Graphene-Based Bioactive Product with a Non-Immunological Impact on Mononuclear Cell Populations from Healthy Volunteers.

We previously described GMC, a graphene-based nanomaterial obtained from carbon nanofibers (CNFs), to be biologically compatible and functional for therapeutic purposes. GMC can reduce triglycerides' content in vitro and in vivo and has other potential bio-functional effects on systemic cells and the potential utility to be used in living systems. Here, immunoreactivity was evaluated by adding GMC in suspension at the biologically functional concentrations, ranging from 10 to 60 µg/mL, for one or several days, to cultured lymphocytes (T, B, NK), either in basal or under stimulating conditions, and monocytes that were derived under culture conditions to pro-inflammatory (GM-MØ) or anti-inflammatory (M-MØ) macrophages. All stirpes were obtained from human peripheral mononuclear cells (PBMCs) from anonymized healthy donors. The viability (necrosis, apoptosis) and immunological activity of each progeny was analyzed using either flow cytometry and/or other analytical determinations. A concentration of 10 to 60 µg/mL GMC did not affect lymphocytes' viability, either in basal or active conditions, during one or more days of treatment. The viability and expression of the inflammatory interleukin IL-1β in the monocyte cell line THP-1 were not affected. Treatments with 10 or 20 µg/mL GMC on GM-MØ or M-MØ during or after their differentiation process promoted phagocytosis, but their viability and the release of the inflammatory marker activin A by GM-MØ were not affected. A concentration of 60 µg/mL GMC slightly increased macrophages' death and activity in some culture conditions. The present work demonstrates that GMC is safe or has minimal immunological activity when used in suspension at low concentrations for pre-clinical or clinical settings. Its biocompatibility will depend on the dose, formulation or way of administration and opens up the possibility to consider GMC or other CNF-based biomaterials for innovative therapeutic strategies.

Analytical determination of internal stresses in galvanic coatings during restoration of parts

The flexible cathode method is considered, recommended for the analytical determination of internal stresses in galvanic coatings when restoring worn machine parts. To determine the absolute values of internal stresses in coatings, formulas are proposed that take into account the thickness of the cathode, coating, and radius of curvature of the cathode-coating system. The proposed method is simple and free from many of the disadvantages inherent in many common mechanical methods for measuring and calculating internal stresses in electroplated coatings.

A simple lable-free aptasensor based on liquid exfoliated graphene modified electrode for chloramphenicol detection in milk

Antibiotic residues in animal derived foods considered as one of the most serious food contamination poses significant risks to human health. Conventional methods for antibiotic residue detection rely on expensive and bulky instruments, complicated sample pretreatment and time-consuming, thus limiting their applications. Consequently, developing miniaturized and low-cost analytical technology for ultrasensitive monitoring and accurate evaluation of antibiotic residues in foods is of great significance. Herein, a simple and label-free electrochemical sensing platform for the highly sensitive detection of chloramphenicol (CAP) in milk was demonstrated by employing aptamer specific for CAP as a biological recognition element and liquid exfoliated graphene (LEG) modified indium tin oxide electrode (LEG/ITO) as substrate. LEG is believed to be the most economic few-layer graphene with remarkable electrical properties and larger specific surface area not only promotes electron transfer but also provides a large number of binding sites for aptamers to be assembly immobilized via the π–π stacking of DNA bases. Under optimal experimental factors, the aptasensor displayed a wider linear range for detecting CAP (1 fM ∼ 100 nM), accompanied by a limit of detection (LOD) (1 fM), as well as satisfactory performance with specificity, reproducibility, and stability. In addition, the designed strategy allowed the direct analysis of actual milk samples and the recovery rates were from 97.92 % to 103.34 %, rendering a ideal sensing strategy for quantitative determination of various analytes in food by adapting the specific aptamer.

Atomic absorption and inductively coupled plasma atomic emission determination of iron and manganese in medicinal salt mixtures

Complete extraction of analytes from samples and the homogeneity of analyzed solutions were achieved using ultrasonic treatment (20 minutes). The sensitivity, precision, and accuracy of atomic absorption determination of analytes were improved by using Triton X-100 (4%) and calibration solutions based on iron and manganese acetylacetonates. It was demonstrated that sensitivity increased by 1.7 times for manganese and 1.5 times for iron. The iron and manganese content in medicinal salt mixtures was determined using both atomic absorption and inductively coupled plasma atomic emission methods. The results obtained by these two independent methods were compared, showing that the dispersions are homogeneous and the variation in results is minor, attributed to random error. The accuracy of the atomic absorption results was verified using the standard addition method and by varying the sample weight, confirming that systematic error is negligible. The detection limits established by the atomic absorption method were Cmin=0.009 g/mL for iron (Cmin, lit=0.015 g/mL) and Cmin=0.003 g/mL for manganese (Cmin, lit=0.004 g/mL).

Analytical Determination of Majority Carrier Diode Losses in Power Switching and Perspective for Ultrawide Bandgap Semiconductors

Analytical Determination of Majority Carrier Diode Losses in Power Switching and Perspective for Ultrawide Bandgap Semiconductors

An effective path planning approach for robot welding considering redundant kinematics

Robot welding with redundant kinematics demands precise coordination of the welding path and redundant axis motion for stable operation. This paper introduces an effective G3 continuous path planning approach for a 6-DOF friction stir welding robot, integrating redundant axis motion to enhance welding stability and quality. The method encompasses a two-pronged strategy: a five-axis path corner smoothing technique and a motion synchronization strategy. Initially, a robust toolpath preprocessing algorithm is presented to mitigate curvature extremities of the inserted smoothing curves within predefined error limits. Subsequently, leveraging G3 continuity criteria, a B-spline-based smoothing method is advanced for refining tool position and orientation paths, with an analytical determination of spline control points facilitated by an explicit smoothing error expression. An effective motion synchronization technique is then proposed, which formulates the tool position, tool orientation, and redundant axis path as explicit functions of the position path arc length. The effectiveness of the proposed method is demonstrated through simulations and experiments on a robot welding platform, with the integration of a jerk-continuous feedrate profile for smooth motion execution. The findings indicate a significant improvement in robotic welding quality by integrating the proposed path planning method with existing workpiece posture optimization techniques.

Matrix Solid-Phase Dispersion Procedure for Determination of Antibiotics and Metabolites in Mussels: Application in Exposure Bioassays.

The presence of antibiotics in seafood for human consumption may pose a risk for consumers. Furthermore, some marine organisms, such as mussels, can result in appropriate bioindicators of marine contamination. In this work, a multiresidue analytical methodology suitable for the determination of antibiotics and metabolites in mussels is proposed. The target compounds include three sulphonamides and trimethoprim (TMP) and six of their main metabolites. Sample treatment involves extraction and clean-up in a single step using matrix solid-phase dispersion with acetonitrile. Analytical determination was carried out by liquid chromatography-tandem mass spectrometry. Good linearity (R2 > 0.99), accuracy (from 80.8 to 118%), and limits of quantification (lower than 5 ng g-1 (dry matter, dm)) were obtained for all selected compounds. The method was applied to the determination of antibiotics in mussel samples from an exposure assay with contaminated seawater with TMP and sulfamethoxazole (SMX). Both antibiotics were detected in the analysed samples with concentrations up to 77.5 ng g-1 dm. TMP was bioconcentrated to a higher extent than SMX, attributable to its higher hydrophobicity. None of the metabolites were detected. These results demonstrate that Mytilus galloprovincialis is a suitable bioindicator to assess marine pollution.

Highly sensitive SERS-based lateral flow immunoassay of fipronil using bimetallic Au@Ag@Ag nanorods.

Abimetallic core-shell-shell nanorods structure with gap-embedded Raman reporter 5,5'-dithio-bis-(2-nitrobenzoic acid) (DTNB) was developed and applied as a SERS-active nanotag in surface-enhanced Raman scatteringlateral flow immunoassay (SERS-LFIA) of theinsecticide fipronil. Due to the strong SERS signal of the AuDTNB@AgDTNB@AgNRods, fipronil is detected with extremely low detection limit of 4.6pg/mL. To the best of our knowledge, the proposed technique is the first SERS-LFIA of fipronil, proven to be effective in the selective determination of the target analyte and capable of detecting fipronil in a matrix of food samples (cucumber and apple juice) with recoveries of 97.0-117.0%. Moreover, the applied functionalization of the SERS nanotag with anti-species antibodies has provided a versatile immunoprobe that could improve performance of different LFIAs.

Optimization of the Combined Use of Z-Sep Plus and EMR-Lipid in QuEChERS Procedure for the Analysis of Eight Pesticides in Real Milk Samples

AbstractOne of the most applied procedures for the determination of trace analytes in complex matrices is QuEChERS (an acronym for Quick, Easy, Cheap, Effective, Rugged, and Safe). QuEChERS procedures include an extraction step followed by a dispersive solid-phase extraction (dSPE) for analytes cleaning-up from the matrix components. A challenging task in QuEChERS procedures is extracting and determining pesticides from samples of high fat such as milk samples. This challenge induced the innovation of new adsorbents for the clean-up step such as Z-Sep Plus® and EMR-Lipid® to enable removal of fatty matrix components without affecting the recovery of hydrophobic analytes. This work aims to apply experimental design to optimize the combined application of both QuEChERS clean-up adsorbents; Z-Sep Plus® and EMR-Lipid® in addition to other QuEChERS parameters in the determination of eight pesticides: hexachlorocyclohexane, dichlorodiphenyldichloroethane, dichlorodiphenyltrichloroethane, primiphos ethyl, diazinon, malathion, endrin, and dimethoate in milk matrix. This was augmented by optimization of GC–MS/MS and UPLC-MS/MS to detect and determine analytes in extracts. The experimental design of QuEChERS procedure enabled the optimization of Z-Sep Plus®- and EMR-Lipid®-added adsorbent amounts with other method parameters to enable the maximum recovery of analytes. Furthermore, the optimized methods enabled low detection limits of the studied pesticides within a short analysis time (28 min for GC and 12 min for LC methods, respectively). The procedure was validated according to European SANTE/11312/2021 Guideline. Quantitation limit ranged from 1.7 to 3.2 ng/mL for GC–MS/MS method and from 1.7 to 3 ng/mL for UPLC-MS/MS method. Greenness assessment of the methods followed four approaches indicating an excellent value of greenness for the proposed methods. Furthermore, 45 real milk samples collected from the Egyptian market were tested with the developed procedure for the presence of pesticides.

Simple and straightforward synthesis of magnetoplasmonic nanostars Fe3O4@Au NSs for enhanced SERS detection

This work introduces a simple and efficient protocol for synthesizing dual-functional magnetic gold nanostars Fe3O4@Au NSs, overcoming the challenges of previous complex synthesis protocols. By analyzing key synthetic variables and their impact on the structure and plasmonic properties, we optimized the production of these nanostars. The synthesized nanostructures exhibit significant surface-enhanced resonance Raman spectroscopy (SERRS) effects, with an enhancement factor of 1 × 105 using malachite green as a model analyte. The inherent magnetic properties enable efficient pre-concentration, leading to a 13-fold increase in Raman signal intensity and a low detection limit of 33 nM. Through the synergistic combination of magnetic separation and SERS/SERRS analysis, these nanostructures offer a robust tool for sensitive and selective analyte determination in complex matrices, making them valuable for applications in environmental monitoring, sensing, imaging, and biomedical research.

Methylated magnetic covalent organic framework for sample preparation and LC-MS/MS detection of 12 tadalafil analogs in dietary supplements

Tadalafil analogs are often illegally added to dietary supplements such as herbal beverages, protein powders and tablet foods. Due to the complexity of the matrices, effective extraction of tadalafil analogs is the key to achieve accurate quantification. Therefore, it is of great significance to establish a rapid and effective method for the analytical determination of tadalafil analogs in complex matrices. In this study, a novel methylated magnetic covalent organic framework, Fe3O4@TFPB-OT, was successfully synthesized under mild conditions. Fe3O4@TFPB-OT demonstrated robust adsorption capabilities, with capacities ranging from 52.4 to 90.9 mg/g for the tadalafil analogs. Several pre-enrichment parameters were optimized, including adsorbent dosage, extraction time, pH, shaking time, elution solvent, and desorption time. The applicability of Fe3O4@TFPB-OT was evaluated as effective adsorbents for the magnetic solid-phase extraction (MSPE) of 12 tadalafil analogs in dietary supplements. Combined with high-performance liquid chromatography-tandem mass spectrometry, the limits of detection (LODs) of this method ranged from 0.005 to 0.05 μg/L in liquid matrices and from 0.005 to 0.05 μg/kg in solid matrices, showing good sensitivity and recoveries ranged from 56.1 % to 90.9 %with relative standard deviations lower than 3.9 %, demonstrating good accuracy and precision. Additionally, the adsorbent retained its effectiveness after at least ten reuse cycles, indicating significant reusability. This study provides an effective method for the analysis and detection of tadalafil analogs in dietary supplements and has great potential for application.