Analysis Procedure Research Articles

Changes in blood biochemistry thrombosis parameters 24 hours after stent-assisted endovascular treatment of intracranial aneurysms.

This study aims to elucidate the early changes in blood biochemistry thrombosis parameters following stent-assisted endovascular treatment of intracranial aneurysms. Consecutive patients with unruptured aneurysms undergoing stent implantation during endovascular treatment were included in this prospective study with approval from the local ethics committee. Blood samples were collected immediately before and 24 h after the procedure for biochemical analysis, including basic thrombosis indicators, bleeding tests, and a complete blood count. The study included 80 patients (60 women, 20 men) with 134 aneurysms. A total of 135 stents (110 flow-diverting, 25 standard) were used. Additionally, intrasaccular coiling was utilized in 28 aneurysms among 27 patients. Following the procedure, there was a significant decrease in activated partial thromboplastin time, fibrinogen, hemoglobin, and platelet levels, and a significant increase in prothrombin time, D-dimer, von Willebrand factor (vWF) activity/antigen ratio, and leukocyte levels in all patients. Correlation analyses revealed significant positive associations between platelet and fibrinogen levels, and a negative association between D-dimer and fibrinogen levels in the coil (-) group. Additionally, there was a significant negative correlation between aneurysm volume and vWF activity/antigen ratio, and procedure duration and thrombocyte count, while a positive association was found between aneurysm number and leukocyte count in the coil (-) group. Analysis of blood chemistry alterations indicates that intravascular thrombosis occurs in the intracranial circulation following stent-assisted endovascular treatment of intracranial aneurysms. This thrombotic process is more pronounced in patients whose aneurysms were left open (i.e. flow-diverting stent alone).

Assessment of the bony resection margin distance in bone-invasive oral cancer using laser-induced breakdown spectroscopy

ObjectivesInadequate resection margins of less than 5 mm impair local tumor control. This weak point in oncological safety is exacerbated in bone-infiltrating tumors because rapid bone analysis procedures do not exist. This study aims to assess the bony resection margin status of bone-invasive oral cancer using laser-induced breakdown spectroscopy (LIBS).Materials and methodsLIBS experiments were performed on natively lasered, tumor-infiltrated mandibular cross-sections from 10 patients. In total, 5,336 spectra were recorded at defined distances from the tumor border. Resection margins < 1 mm were defined as very close, from 1–5 mm as close, and > 5 mm as clear. The spectra were histologically validated. Based on the LIBS spectra, the discriminatory power of potassium (K) and soluble calcium (Ca) between bone-infiltrating tumor tissue and very close, close, and clear resection margins was determined.ResultsLIBS-derived electrolyte emission values of K and soluble Ca as well as histological parameters for bone neogenesis/fibrosis and lymphocyte/macrophage infiltrates differ significantly between bone-infiltrating tumor tissue spectra and healthy bone spectra from very close, close, and clear resection margins (p < 0.0001). Using LIBS, the transition from very close resection margins to bone-infiltrating tumor tissue can be determined with a sensitivity of 95.0%, and the transition from clear to close resection margins can be determined with a sensitivity of 85.3%.ConclusionsLIBS can reliably determine the boundary of bone-infiltrating tumors and might provide an orientation for determining a clear resection margin.Clinical relevanceLIBS could facilitate intraoperative decision-making and avoid inadequate resection margins in bone-invasive oral cancer.

Nanoengineered Nonenzymatic Paper-Based Fluorescent Platform for Pre-Dilution-Free and Visual Real-Time Home Monitoring of Urea for Early Warning of Abnormal Nitrogen-Based Unhealthy Issues.

Distorted urea levels indicate several liver, kidney, or metabolic diseases; however, traditional clinical urea detection relies on urease-based methods enslaved to well-known limitations of high-price, unstable properties, complicated sample pretreatment and analysis procedures, and difficult visual real-time monitoring. Herein, nonenzymatic paper-based fluorescent materials (UFP-BP) are strategically integrated with an on-demand fluorescent-sensor (UFP) self-aggregated nanoparticle on commercial filter paper for pre-dilution-free and visual real-time urea monitoring. The UFP is synthesized and self-aggregated into the fluorescent nanoparticles for selective urea recognition. Then, the nanoparticles are interstitially loaded on filter paper to nanoengineer the UFP-BP, achieving selective quantitative urea detection in the normal concentration range (10-1000mm). UFP and UFP-BP can successfully monitor urea levels in real rat urine, artificial simulants, and milk. The proposed sensing platform, integrated with smartphones, offers accurate, quantitative, nonenzymatic, noninvasive, pre-dilution-free, on-site, rapid, low-cost, easy-to-operate, real-time visual urea detection in food samples and human body fluids. The designed sensing system can provide early warnings of abnormal nitrogen-based health issues.

Protective procedures in functional analysis of self-injurious behavior: An updated scoping review.

Despite the efficacy of functional analyses in identifying the function of challenging behavior, clinicians report not always using them, partly due to safety concerns. Understanding how researchers employ safeguards to mitigate risks, particularly with dangerous topographies like self-injurious behavior (SIB), is important to guide research and practice. However, the results of a scoping review of functional analyses of self-injurious behavior conducted by Weeden et al. (2010) revealed that only 19.83% of publications included protections. We extended the work of Weeden et al. to determine whether reporting has improved. We observed increases in all but two types of protections reviewed by Weeden et al. Additionally, we included new protections not reported by Weeden et al. In total, 69.52% of the studies included at least one protective procedure and 44.39% specified that the protections were used for safety. It appears that reporting has increased since Weeden et al. called for improved descriptions of participant protections.

Pengaruh Efikasi Diri Akademik terhadap Hasil Belajar Geografi Fase F SMA Negeri 1 Linggo Sari Baganti Kabupaten Pesisir Selatan

The purpose of this study was to analyze whether there is a positive and significant influence of academic self-efficacy on the learning outcomes of geography phase F of SMA Negeri 1 Linggo Sari Baganti, Pesisir Selatan Regency. The type of research used is quantitative research with a correlational approach. The location of the study was at SMA Negeri 1 Linggo Sari Baganti, Pesisir Selatan Regency. The research period was April 22 to May 22. The population in this study were students of phase F who taught geography subjects at SMA Negeri 1 Linggo Sari Baganti, Pesisir Selatan Regency. The number of samples was 97 people using the total sampling technique. Data collection techniques used in this study were observation, surveys, and documentation records. The data analysis procedure technique in this study used validity tests, reliability tests, descriptive statistical analysis, normality tests, linearity tests and hypothesis tests. The results of this study concluded that 1) There is a significant relationship between academic self-efficacy and student learning outcomses at phase F of SMA Negeri 1 Linggo Sari Baganti, Pesisir Selatan Regency as indicated by a significant correlation level value of 0.000 which is smaller than 0.05. This means that the academic self-efficacy variable has an effect on the learning outcome variable. 2) The academic self-efficacy of students in phase F of SMA Negeri 1 Linggo Sari Baganti Pesisir Selatan as a whole is in the low classification, which can be seen from the pie chart and the academic self- efficacy percentage table. 3) The learning outcomes of students in phase F of SMA Negeri 1 Linggo Sari Baganti as a whole are in the context of the less group, based on the calculation of the pie chart and the Learning Outcome Criteria (KKTP) table set by the school.

Recent Advances in Aptamer‐Based Sensors for In Vitro Detection of Small Molecules

AbstractSensitive and accurate detection of small molecules from complex matrix has aroused increasing interest in many fields, yet remains an open challenge. Recent years have witnessed a considerable advance of aptasensors for diagnostic assay development towards diverse small molecules because aptamer is one of the most powerful classes of molecular receptors with advanced affinity and specificity. Herein, we reviewed the small‐molecule aptasensors in the past five years, focusing on the principles to specific applications in clinical diagnosis, food safety, and environmental monitoring. The first introductory section on the development of aptasensors in historical view and its analytical features contextualizes essential health‐related small molecules. The second part highlights the basic components of aptasensor and the detection principles of different sensors based on signal output modes. The subsequent part systematically discusses various small‐molecule sensing platforms by interfacing aptamers with diverse signal amplification strategies. Finally, challenges and perspectives for improving the aptasensor performance are also discussed. By describing biochemical and analytical procedures, this review highlights the optimal use of aptamers in the detection, quantification, and imaging of important health‐related small molecules and presents new insights, technical advances, and engineering strategies for practical applications.

The effect of an acute bout of exercise on circulating vitamin D metabolite concentrations: a randomised crossover study in healthy adults.

The effect of acute exercise on circulating concentrations of vitamin D metabolites is unclear. To address this knowledge gap, we examined the effect of a bout of treadmill-based exercise versus rest on circulating concentrations of 25(OH)D3, 25(OH)D2, 3-epi-25(OH)D3, 24,25(OH)2D3, 1,25(OH)2D3, and vitamin D2 and D3 in healthy men and women. Thirty-three healthy adults (14 females, 41 (15) years, body mass index 26.2 (3.7) kg/m2, 36.2 (9.2) ml/kg/min; mean (SD)) completed two laboratory visits involving 60min of moderate-intensity treadmill exercise (60% ) versus 60min of seated rest, both in an overnight fasted-state, as part of a randomised crossover design. Venous blood samples were drawn at baseline, immediately (0h), 1h and 24h after the exercise or rest-period. There was a significant time × trial interaction effect for total circulating 25(OH)D (P=0.0148), 25(OH)D3 (P=0.0127) and 1,25(OH)2D3 (P=0.0226). Immediately post-exercise, 25(OH)D, 25(OH)D3 and 1,25(OH)2D3 concentrations were significantly elevated compared to the control resting condition, and 1,25(OH) 2D3 remained significantly elevated 1 h later. Circulating albumin, vitamin D binding protein, calcium and parathyroid hormone were elevated immediately post-exercise. Thus, an acute bout of moderate intensity exercise transiently increases concentrations of circulating 25(OH)D and 1,25(OH)2D3 compared to resting conditions. KEY POINTS: Observational studies suggest that acute exercise might change circulating concentrations of vitamin D metabolites, but this has not been investigated using randomised crossover studies and using robust analytical procedures. In this study, we used a randomised crossover design to examine the effect of a bout of treadmill-based exercise (vs. rest) on circulating concentrations of a wide range of vitamin D metabolites in healthy humans. We show that an acute bout of moderate intensity exercise transiently increases concentrations of circulating 25(OH)D and 1,25(OH)2D3 compared to resting conditions. These findings indicate that regular exercise could lead to transient but regular windows of enhanced vitamin D biological action.

АНАЛИТИКА И КОНТРОЛЬ ФИНАНСОВОЙ БЕЗОПАСНОСТИ В УСЛОВИЯХ ЦИФРОВОЙ СРЕДЫ: МЕТОДЫ АНАЛИТИЧЕСКИХ ПРОЦЕДУР И ИСКУССТВЕННОГО ИНТЕЛЛЕКТА

The article presents a generalized approach to the content of analytical procedures that provide diagnostics and control of the financial security of a company from the perspective of corporate fraud risks. Modern methods of empirical diagnostics of financial security using information resources and artificial intelligence, based on the concepts of professional auditing standards and preparation of financial statements, are disclosed.

Examining the mediating and moderating roles of social marketing behavioural enhancers regarding consistent condom use.

Since their importance was highlighted by Ayikwa and De Jager, social marketing behavioural enhancers (SMBEs) have been investigated in terms of their causal and correlational relationships with the intention to use condoms (IUC) and consistent condom use (CCU), as people often fail to act on their intentions. However, scrutiny of their mediating and moderating roles could provide insights pertinent to the design of effective HIV and AIDS preventative programmes. This study examined whether perceived behavioural control (PBC) and IUC interact with exposure to HIV and AIDS information (EI), ease of access to condoms (EAC) and level of related knowledge (KN) in determining CCU. It also investigated whether PBC and IUC predict CCU through increasing EI, EAC, and KN. A quantitative approach was adopted and data were collected from 607 participants, aged at least 18, living in Gauteng Province, South Africa. The questionnaire administered included pre-existing items, validated through exploratory and confirmatory factor analysis procedures. Regression analyses of the data for mediation and moderation testing were performed using PROCESS macro software for SPSS. The results indicated that none of the SMBEs mediated the non-significant PBC-CCU relationship: B = -0.0258, SE = 0.0199, p = 0.195. Nor did they mediate the significant IUC-CCU relationship: B = 0.0395, SE = 0.0195, p = 0.043. Similarly, none of the SMBEs were found to moderate the PBC-CCU relationship (EI*PBC: B = 0.0034, SE = 0.0056, p = 0.540; KN*PBC: B = -0.0006, SE = 0.0064, p = 0.931; EAC*PBC: B = 0.0011, SE = 0.0059, p = 0.854) as IUC-CCU relationship (EI*IUC: B = 0.0036, SE = 0.0054, p = 0.513; KN*IUC: B = -0.0096, SE = 0.0060, p = 0.111; EAC*IUC: B = 0.0044, SE = 0.0061, p = 0.469). A recommendation is made to scrutinise the mediating and moderating roles of SMBEs in the context of health behavioural models other than the theory of planned behaviour, which was considered in this study.

Comparing the Efficacy and Efficiency of Human and Generative AI: Qualitative Thematic Analyses.

Qualitative methods are incredibly beneficial to the dissemination and implementation of new digital health interventions; however, these methods can be time intensive and slow down dissemination when timely knowledge from the data sources is needed in ever-changing health systems. Recent advancements in generative artificial intelligence (GenAI) and their underlying large language models (LLMs) may provide a promising opportunity to expedite the qualitative analysis of textual data, but their efficacy and reliability remain unknown. The primary objectives of our study were to evaluate the consistency in themes, reliability of coding, and time needed for inductive and deductive thematic analyses between GenAI (ie, ChatGPT and Bard) and human coders. The qualitative data for this study consisted of 40 brief SMS text message reminder prompts used in a digital health intervention for promoting antiretroviral medication adherence among people with HIV who use methamphetamine. Inductive and deductive thematic analyses of these SMS text messages were conducted by 2 independent teams of human coders. An independent human analyst conducted analyses following both approaches using ChatGPT and Bard. The consistency in themes (or the extent to which the themes were the same) and reliability (or agreement in coding of themes) between methods were compared. The themes generated by GenAI (both ChatGPT and Bard) were consistent with 71% (5/7) of the themes identified by human analysts following inductive thematic analysis. The consistency in themes was lower between humans and GenAI following a deductive thematic analysis procedure (ChatGPT: 6/12, 50%; Bard: 7/12, 58%). The percentage agreement (or intercoder reliability) for these congruent themes between human coders and GenAI ranged from fair to moderate (ChatGPT, inductive: 31/66, 47%; ChatGPT, deductive: 22/59, 37%; Bard, inductive: 20/54, 37%; Bard, deductive: 21/58, 36%). In general, ChatGPT and Bard performed similarly to each other across both types of qualitative analyses in terms of consistency of themes (inductive: 6/6, 100%; deductive: 5/6, 83%) and reliability of coding (inductive: 23/62, 37%; deductive: 22/47, 47%). On average, GenAI required significantly less overall time than human coders when conducting qualitative analysis (20, SD 3.5 min vs 567, SD 106.5 min). The promising consistency in the themes generated by human coders and GenAI suggests that these technologies hold promise in reducing the resource intensiveness of qualitative thematic analysis; however, the relatively lower reliability in coding between them suggests that hybrid approaches are necessary. Human coders appeared to be better than GenAI at identifying nuanced and interpretative themes. Future studies should consider how these powerful technologies can be best used in collaboration with human coders to improve the efficiency of qualitative research in hybrid approaches while also mitigating potential ethical risks that they may pose.

Rescuing error control in crosslinking mass spectrometry.

Crosslinking mass spectrometry is a powerful tool to study protein-protein interactions under native or near-native conditions in complex mixtures. Through novel search controls, we show how biassing results towards likely correct proteins can subtly undermine error estimation of crosslinks, with significant consequences. Without adjustments to address this issue, we have misidentified an average of 260 interspecies protein-protein interactions across 16 analyses in which we synthetically mixed data of different species, misleadingly suggesting profound biological connections that do not exist. We also demonstrate how data analysis procedures can be tested and refined to restore the integrity of the decoy-false positive relationship, a crucial element for reliably identifying protein-protein interactions.

A rapid and automated analysis procedure for seismic response of arch dams

The seismic safety of arch dams has long been a focal point of research. Due to the complexity of modeling and computation, analyzing the seismic response of arch dams using traditional finite element methods requires a considerable amount of time. In the event of a sudden earthquake, it is challenging to quickly obtain stress analysis results or conduct a safety assessment. To address these issues, a rapid and automated analysis procedure is proposed in this paper, providing seismic response of arch dams within hours after an earthquake. The procedure includes a pre-processing program, a computing program EACD-3D-2008, and a post-processing program, achieving a fully automated process from generating non-uniform earthquakes to analyzing dam dynamic responses and visualizing computation results. As a case study, the 294.5 m high Xiaowan arch dam in southwest China is analyzed, which is equipped with strong motion instruments that have recorded several small earthquakes. The case study revealed that accounting for the non-uniformity of the earthquake significantly improves simulation results, with maximum principal stresses typically occurring near the dam-foundation rock interface. Additionally, the procedure effectively compensates for missing data, allowing for the successful supplementation of the missing acceleration records. For stronger earthquakes, high-stress regions are clearly displayed in the result visualization, providing an effective reference for safety assessment. The case study validated the accuracy and wide applicability of the procedure, demonstrating its potential to offer valuable insights for similar analyses in various engineering projects.

Analytical procedure development and proposed established conditions: A case study of a mass spectrometry based NDSRI analytical procedure

With the finalization of the ICH Q14 Analytical Procedure Development guideline, how to apply enhanced approaches (such as analytical quality by design (AQbD)) to develop an analytical procedure, and to propose Established Conditions (ECs) and corresponding reporting categories, is increasingly being discussed. To gain practical experience in applying an enhanced approach for method development and identifying ECs, we developed, validated, and implemented an analytical procedure for a nitrosamine drug substance-related impurity (NDSRI). Here, as an example of the application of Q12 Lifecycle Management guideline principles in regards to analytical procedures, we briefly elaborate how: 1) the principles documented in the ICH Q14 guideline for analytical procedure development were applied, with the focus on identifying an Analytical Target Profile (ATP), knowledge management and risk assessment; 2) analytical procedure robustness according to the recommendations in ICH Q2(R2) Validation of Analytical Procedure guideline and Q14, were evaluated; and 3) mass spectrometry ECs and associated proposed reporting categories were proposed.

Strategies for coping with citizenship pressure: development of a context-specific scale

ABSTRACT Accumulating empirical evidence suggests that citizenship pressure (CP) in the workplace, the pressure to engage involuntarily in citizenship behaviour, has a detrimental effect on both the individual employee and the organisation. Personal coping strategies for dealing with CP can alleviate the negative effects. The purpose of this study was to develop a context-specific, reliable, and valid measure that could assess specific coping strategies individuals use to deal with CP in the workplace. We conducted a comprehensive inductive and deductive methods that included, firstly, a qualitative procedure of interviews, data analysis, and initial scale generation, and secondly, a quantitative process of construct validation of the measure. The factor structure yielded a 16-item measure, based on EFA and CFA, providing initial support for the utility of the measure as a self-report instrument of coping strategies to deal with CP. The analysis revealed a two-factor structure that describes conceptually meaningful patterns of coping: self-reliance vs. reliance on others. The former depicts nine strategies in which employees solely rely on themselves when coping with CP; and the latter depicts seven strategies in which employees rely on others’ advice, support, or empathy to deal with CP. Applications, limitations, and implications for future research are discussed.

Efficient application of Pyrosin B for nano-gram level assay of antiparkinsonian medication, rasagiline: Evaluation of tablets and content uniformity.

Rasagiline (RAS) is a medication for Parkinson's disease that increases dopamine levels in the brain by inhibiting monoamine oxidase, helping to alleviate symptoms. The proposed study aims to develop an efficient, feasible, and sensitive method for RAS assay, utilizing Pyrosin B dye, a convenient fluorescent ligand. Combining the RAS analyte with Pyrosin B ligand in a mildly acidic buffered solution rapidly quenches the native fluorescence of the ligand. This quenching results from the formation of a specific ion-dipole association complex between the lone pair-bearing atoms of the ligand and the protonated amine moiety of RAS, highlighting their interactive chemistry under these conditions. The degree of this interaction demonstrated superior sensitivity compared with reported alternatives, exhibiting a linear range of 50.0 to 1000.0ng/mL. The method is characterized by a limit of detection (LOD) of 16.0ng/mL and a limit of quantification (LOQ) of 48.0ng/mL. By optimizing the RAS-Pyrosin B system, the variable parameters were finely tuned, ensuring the assay method's reliability. The method's accuracy, precision, selectivity, and robustness were validated according to International Council for Harmonization (ICH) guidelines, enabling precise and efficient analysis of RAS in the nanogram range. This method streamlines the analysis procedure and reduces environmental impact, making it a promising approach for the quality control of ParkintreatR tablets (1mg) and other analytical applications.

The Rhetorical Structure of Method Section of Research Articles in Reputable International Journal of ELT Published in Indonesia

This study investigated the rhetorical structure of method section in English language teaching articles. A corpus consisting of 80 research articles in reputable international journal of English language teaching published in Indonesia was systematically sampled to serve as data input for analysis. The results showed that the method section of English language teaching articles were characterized by structural complexity and rich, nuanced descriptions. English language teaching researchers generally used three rhetorical moves to realize the overall communication goal of the methods section: 1) Describing the research design, 2) Describing the data collection procedures, and 3) Describing the data analysis procedures. While Move-1 was a Conventional move and did not have constituent steps, the second and third Move have a series of constituent steps, with Move-2 was an Obligatory move and the Move-3 was a Conventional. The most hypothetical model of method section in the results of this research were Describing research design (M1), Describing the Data Collection Procedure (M2): Describing the Samples (Move 2- Step B), Describing Research Instruments (Move 2- Step C), Elaborating on Data Collection Procedure (Move 2-Step D), and Describing the Data Analysis Procedure (Move 3): Relating (or recounting) data analysis procedure/s (Move 3- Step A). These Moves and Steps provide very detailed information on various aspects of the methodology. Pedagogically, the results can provide input for lecturers and students in writing research method section of English education field.Keywords: Academic writing, Rhetorical structure, Research method, Reputable international journal

Evaluating financial risk management in corporation financial security systems

Systemic risks are relevant to most segments of financial and economic activity, which creates the threat of financial instability of enterprises. Financial security, in this case, implies the state of financial soundness; it is expressed through various parameters including the level of solvency, financial stability, business activity, and efficiency of management. These questions are specific to each indicator, and this paper aims to understand their relations and how changes in them can result in risks. It elaborates the risk analysis and assessment procedure that uses a set of common financial analysis tools and determines key financial coefficients. Liquidity ratios, solvency ratios, profitability ratios, and the risk exposure metrics are the key areas that the research is based on. Correlating the financial indicators from a rich dataset from Yahoo’s Stock market data, regression analysis is used to determine these relationships between these indicators and risk management factors. A positive relationship between liquidity ratios and profitability is detected points to the fact that, firms with high liquidity levels are more capable of attaining good financial health and returns. It establishes the need for the development of a credible risk management structure that would lower threats to fiscal and economic activities. In light of this, the research shows that the liquidity and solvency management lowers financial risk and improves return for companies. The regression analysis was conducted to ascertain the degree of predictability of each independent variable to the dependent variable and the findings revealed that approximately 94 percent of each independent variable is predictable of the dependent variable that able to establish as much as 5% of the total variability in profitability, with the PE ratios being an indication of this aspect, was attributed to stock prices, as a result, the firm must be keen on its financials. This paper explores the employability of the proposed methods and models to assess the risks with high accuracy and supports optimum decision making in regard with the needed security of the enterprises. By adopting these methodologies, the businesses can observe and estimate risks which exist in the future which would help them to avoid certain issues or dangers and also pave the way for the improvements of the financial stability of the businesses. On this note, the study establishes the fact that incorporating the notion of total risk management into the framework of analyzing business and making financial decisions is inevitable in maintaining corporate financial stability and realizing perpetual economic solidity. This research enriches the literature on financial risk management, as it outlines viable strategies for the protection of enterprise financial sustainability.

A 10 µH Inductance Standard in PCB Technology with Enhanced Protection against Magnetic Fields

Low-frequency working standards of inductance are generally uniformly wound toroids on a ceramic core. Planar inductors made using printed circuit board (PCB) technology are simple and cheap to manufacture in comparison to inductors wound on toroid cores, but they are significantly prone to the influence of external magnetic fields. In this paper, we propose the design of a PCB inductance working standard of 10 μH, consisting of a duplex system of planar PCB coils, electrostatic shielding, and an enclosure. Alongside an electromagnetic analysis and design procedure, the measurements on the manufactured prototype included the generated magnetic field, the thermal time constant of the enclosure, temperature coefficients, and its error analysis. The measurements show negligible generated magnetic fields (, 49 mA, 10 kHz). The minimum thermal time constant of the enclosure is 1270 s and the temperature coefficient of resistance is . The presented method of temperature coefficient measurement using a climate chamber allows for measurements in the temperature range of 10 °C to 40 °C. In this temperature range, the results show an inductance variation of 0.05 µH at 50 kHz, while the uncertainty of inductance measurement at this frequency was 0.03 µH (k = 2).

Analysis of warpage and reliability of very thin profile fine pitch ball grid array

With the evolution of advanced integrated circuit (IC) packaging technology, the use of experiments to identify package performance and life expectation will take a significant amount of time and cost to finish the job. To reduce the cost of research and testing, predictive analyses of reliability and performance using simulation tools have become a feasible approach for the IC assembly industry. Therefore, this study utilized Moldex3D molding simulation software to analyze very thin profile fine pitch ball grid array (VFBGA) packages and established a numerical analysis procedure from the molding and curing process, the post-mold cure (PMC) process, to a thermal cycling test (TCT) to predict the amount of package warpage during processing and reliability after TCT.The results showed that the warpage trends of both experiments and simulations during the same temperature ramping process were similar. In the thermal cycling analysis, potential failure locations were found to be at the copper pillars and redistribution layer (RDL), where the maximum Von Mises stress occurred at the lowest temperature (−65 °C). The fatigue life model, Coffin–Manson model, was used to calculate the potential fatigue life at the two locations, resulting in 1689 cycles (copper pillars) and 9706 cycles (RDL L1).

Physiochemical and Microbial Quality of Melon and Bush Mango Seeds and Milled Products in Local Markets ln Rivers State,Nigeria.

Risk of food borne infection contamination of food, in Africa is increased due to environmental, agronomic and socio-economic factors. This study assesses the microbial quality of melon and bush mango displayed in the local markets, aiming to provide valuable insights into the safety and quality of these widely consumed food products. Standard procedure for microbiological and proximate analysis were employed. The heterotrophic bacteria count ranged from 8.5 x 10⁵ cfu/g to 1.35 x10⁶ cfu/g. The total staphylococcus count ranged from 1.2 x 10³ cfu/g to 4.35 x 10³ cfu/g. The coliform count ranged from 2.8 x 10⁴ to 7 x 10⁵, Total Samonella count ranged from 4 x 10² cfu/g to 1.5 x 10³ cfu/g and Fungi count 6.5 x 10² cfu/g to 2.5 x 10³ cfu/g. Morphological and Biochemical characterization of heterotrophic bacteria isolated from both melon and bush mango identified nine genera, including Staphylococcus (14.6%) Bacillus (20%), Corynebacterium (5.6%) Enterobacter (4.4%), Micrococcus ( 3.3%) Pseudomonas (12.2%), Escherichia coli (13.3%), Salmonella (11.1%) and Proteus (11.1%). Fungal species like Penicillium spp., Fusarium spp., Aspergillus flavus, Candida spp., Mucor spp., Saccharomyces sp., and Aspergillus niger were isolated from both seed and milled seeds samples of melon and bush mango. The frequency of occurrence revealed variations among bacterial isolates in melon and bush mango seeds. The most frequent fungal species included Candida spp. (9.4%) Aspergillus niger (20%) Mucor (9.4%), Fusarium (11.4%), Aspergillus flavus (9.4%), Penicillium (13.2%), Rhizopus spp (3.7%) and Saccharomyces (15%). Proximate and heavy metal analysis indicated variations in the composition of Carbohydrate (7.11%), Lipid (15.03%), Ash (1.89%), Moisture (7.31%), Protein (23.86%), Crude Fiber (12.66%), Lead (0.213 mg/kg), Copper (2.11mg/kg), calcium (0.49mg/kg) and Cadmium (0.0169mg/kg) in melon and bush mango, Carbohydrate (15.03%), Lipid (58.24%), Ash (1.74%), Moisture (10.48%), Protein (11.95%), Crude Fiber (2.64%), Lead (1.7903mg/kg), Copper (2.11mg/kg), calcium (0.148mg/kg) and Cadmium (0.000385mg/kg). The presence of heterotrophic bacteria in such ranges suggests potential differences in hygiene practices during cultivation, processing, and storage. Therefore; Implement stringent quality control measures during the production, processing, and storage of both melon and bush mango seed.