This study investigates seasonal variations in water quality at Laguna Mar Chiquita Lake, Argentina, by employing remote sensing techniques to analyze Suspended Particulate Matter (SPM) which offers valuable insights into the lake's environmental health. Landsat 8-9 OLI/TIRS data from 2014-2023 was utilized for spectral analysis of water quality, processed using ACOLITE software for accurate quantitative data. Results show SPM concentrations ranging from 0.823 to 44.172mg/l, with significant seasonal variations. Higher SPM concentrations post-monsoon indicate increased anthropogenic influence, particularly in the northern area. Pollution from tourism and industrial activities is lower pre-monsoon but spikes post-monsoon and during monsoon, suggesting unfavorable conditions. Effective management and continuous monitoring are crucial for maintaining lake quality and ecosystem health.