Background: Launaea cornuta is a vegetable with therapeutic advantage for human diseases.Objective: Evaluate nutritive and non-nutritive components, antioxidant activity, and Fourier transform infrared spectroscopyprofile of L. cornuta leaves.Methods: Proximate, nutri, non-nutrient, percentage phenolic, flavonoid, alkaloid, and saponin contents were investigated usingstandard procedures. Total phenolic and flavonoids of the extracts were determined spectroscopically. Antioxidant activity andfunctional groups in the extracts were characterised by 2.2- diphenyl-2-picryl-hydrazyl radical and FTIR spectroscopy, respectively.Results: Carbohydrates were the most abundant (57.61±0.61 %), and crude lipids were the least abundant (4.26±0.20 %) in L.cornuta. Essential amino acids were present in varying concentrations, and histidine was the most abundant (251.20±2.00 mg/100g dw). Calcium was the most abundant mineral element (820.49±1.05 μg/g dw). High concentrations of phenols (13.07±0.60%) and low amounts of saponins (2.19±0.10 %) were recorded. Methanolic and aqueous leaf extracts revealed total phenols of 83.10±4.32 and 57.77 ±1.65 mgGAE/g dw, respectively, while total flavonoids were 8.00±0.01 and 7.99±0.03 mgCE/g of dryweight, respectively. Aqueous extract had significant DPPH radical scavenging efficacy (IC50 =72.96± 0.32 μg/ml) compared to681.57± 2.21 μg/ml for methanol extract.Conclusions: L. cornuta contain phytochemicals with health benefits for averting oxidative stress related diseases.