Open biomass burning has significant adverse effects on regional air quality, climate change, and human health. Extensive open biomass burning is detected in most regions of China, and capturing the characteristics of open biomass burning and understanding its influencing factors are important prerequisites for regulating open biomass burning. The characteristics of open biomass burning have been widely investigated at the national scale, with regional studies often focusing on northeast China, but few studies have examined regional discrepancies in spatiotemporal variations over a long timescale in Guangxi province. In this study, we used the Visible Infrared Imaging Radiometer Suite (VIIRS) 375 m active fire product (VNP14IMG), combined with land cover data and high-resolution remote sensing images, to extract open biomass burning (crop residue burning and forest fire) fire points in Guangxi province from 2012 to 2023. We explored the spatial density distribution and temporal variation of open biomass burning using spatial analysis methods and statistical methods, respectively. Furthermore, we analyzed the driving forces of open biomass burning in Guangxi province from natural (topography, climate, and plant schedule), policy, and social (crop production and cultural customs) perspectives. The results show that open biomass burning is concentrated in the central, eastern, and southern parts of the study area, where there are frequent agricultural activities and abundant forests. At the city level, the highest numbers of fire points were found in Baise, Yulin, Wuzhou, and Nanning. The open biomass burning fire points exhibited large annual variation, with high levels from 2013 to 2015 and a remarkable decrease from 2016 to 2020 under strict control measures; however, inconsistent enforcement led to a significant rebound in fire points from 2021 to 2023. Forest fires are the predominant type of open biomass burning in the region, with forest fires and crop residue burning accounting for 76.82% and 23.18% of the total, respectively. The peak period for crop residue burning occurs in the winter, influenced mainly by topography, planting schedules, crop production, and policies, while forest fires predominantly occur in the winter and spring, primarily influenced by topography, climate, and cultural customs. The results indicate that identifying the driving forces behind spatiotemporal variations is essential for the effective management of open biomass burning.