Analysis Of Longitudinal Profiles Research Articles

Who needs What Support? Exploring the relationship between intergenerational support and digital media use among Chinese older adults: A latent profile analysis

Previous studies have suggested that intergenerational support can help mitigate the digital divide challenges faced by older adults. Guided by the framework of intergenerational solidarity and conflict, this study investigated the heterogeneity of intergenerational support among older individuals and their relationship with digital media usage patterns. Utilizing data from the China Longitudinal Aging and Social Survey (CLASS), which provides biennial data from 2018 to 2020 on 8703 older adults, the study employs longitudinal methods and latent profile analysis (LPA). The analysis identified five distinct intergenerational support profiles: Well Supported, Lack of Instrumental Support, Slight Lack of Emotional Support, Severe Lack of Emotional Support, and Doubly Disadvantaged. The findings indicate that lacking instrumental and emotional support to varying degrees was associated with lower frequency, constant use, and purposeful use of digital media. Additionally, the socioeconomic and demographic characteristics of both older adults and their adult children were also closely associated with the nature and effectiveness of intergenerational support. This research highlights the importance of understanding diverse intergenerational support profiles and their relationship with digital media engagement. Theoretically, it enriches the understanding of the heterogeneity of intergenerational relationships within the Chinese family context.

Morphometric and longitudinal profile analysis in the Cauvery River basin: a geospatial approach

Morphometric and longitudinal profile analysis in the Cauvery River basin: a geospatial approach

Longitudinal Profiles of Cultural Identity Processes and Associations with Psychosocial Outcomes Among Adolescents Participating in the Identity Project in Italy

Cultural identity formation is a complex developmental task that influences adolescents’ adjustment. However, less is known about individual variations in trajectories of cultural identity processes and how they relate to youth psychosocial outcomes. Using a person-centered approach, this study investigated patterns of change over a year in cultural identity exploration and resolution, respectively, among ethnically diverse adolescents in Italy. The sample included 173 high school students (Mage = 15 yrs, SD = 0.62, range = 14–17; 58.4% female; 26% immigrant background) who had participated in the Identity Project, a school-based intervention targeting ethnic-racial identity development. Longitudinal latent profile analysis revealed only one profile of change for exploration, whereas four unique profiles for resolution emerged (“stable low,” “stable average,” “increase low-to-average,” “increase high-to-higher”). Overall, youth in the resolution-increase profiles reported the best outcomes. The findings highlight the heterogeneity of adolescents’ resolution trajectories and the benefits of an increased sense of clarity concerning one’s cultural identity for positive psychosocial functioning.

Readjustment of fluvial systems to Quaternary tectonic disruption in the Central Afar (Ethiopia)

The Afar region constitutes the diffuse triple junction adjoining the Red Sea, Gulf of Aden, and Main Ethiopian Rifts. Extension in the Afar is distributed between on-axis, magmatic crustal spreading, and off-axis, amagmatic extension, such as in Dobe graben. The timing of initiation and development of these amagmatic grabens is key to understanding the final stages of continental extension/breakup in central Afar. All major graben-bounding faults in central Afar cut through the Quaternary Afar Stratoid Series, constraining the ages of initiation to younger than approximately 1 million years. The Afar Stratoid Series presents a widespread thick lava unit that smoothed and infilled the topography created by the prior 30 Ma of deformation. The ∼1 Ma top surface of the Afar Stratoid Series serves as a regional marker predating most Quaternary deformation. The initiation of a particular fault (or location along a graben-bounding fault) begins a process of local lowering of base level – this is recorded in the landscape as a knickpoint that incises the paleo drainage in the footwalls of the grabens, connecting it to the basin floor with a deep canyon. The rate at which knickpoints retreat upstream permits a space-for-time approach to assessing initiation. This study develops and applies a landscape evolution model to estimate relative maturity and age of drainage basins by measuring the long profile response to tectonic forcings over intermediate timescales in central Afar. This is applied under the assumption that faulting postdates Afar Stratoid Series emplacement. The model is calibrated by analysis of stream longitudinal profiles and terrestrial cosmogenic nuclide (TCN) analysis of samples collected in the field. Longitudinal stream valley profiles are mapped through remote sensing and photogrammetry, and TCN concentrations are assessed to calculate the uplift rate along the graben-bounding faults. Results indicate that faulting of Dobe Graben in the central Afar initiated in the southeast and propagated to the northwest. Along the southern margin of Dobe Graben, ages of 503 ± 116 ka were calculated for fault initiation at Hann Canyon in the southeast, and 339 ± 80 ka at Ishyilu Canyon to the northwest. These timing constraints have implications for competing tectonics models for central Afar. The general approach developed for modeling knickpoint retreat has broader utility beyond Afar, allowing for application to extensional tectonic regimes elsewhere where similar geological and surface constraints exist.

Life-Course Associations Between Smoking and Depressive Symptoms. A 30-Year Finnish Follow-up Study.

Relatively little is known about whether the association between smoking and depressive symptoms changes with age and how the trajectories of smoking and depressive symptoms are intertwined during the life course. In this population-based study, these associations were examined from young adulthood to middle age. Participants of a Finnish cohort study (N = 1955) were assessed at the ages of 22, 32, 42, and 52 using questionnaires covering daily smoking (yes/no) and the short 13-item Beck Depression Inventory. Longitudinal latent class and longitudinal latent profile analyses were used to identify life course trajectories of smoking and depressive symptoms. The proportions of daily smokers decreased, while levels of depressive symptoms increased among both females and males from age 22 to 52 years. Smoking was associated with higher levels of depressive symptoms from age 22 to 42 years, while not at 52. Associations among males prevailed when adjusting for education, marital status, and alcohol use. Four life course classes of daily smoking (nonsmokers, decreasing prevalence of smoking, persistent smokers, and increasing prevalence of smoking) and four trajectories of depressive symptoms (low, increasing/moderate, decreasing/moderate, and high) were identified. In males, persistent daily smokers (relative risk ratio (RRR) = 4.5, 95% confidence interval (CI): 2.2 to 9.2) and those in the class with increasing smoking prevalence (RRR = 3.2, 95% CI: 1.1 to 9.1) had an increased risk of belonging to the high depressive symptoms profile. In females these associations were nonsignificant. Compared to females, the relationship between smoking and depressive symptoms seems more robust among males during adulthood. Specifically, males smoking persistently from young adulthood to middle age have an increased risk of high depressive symptoms trajectory. This population-based cohort with 30 years of follow-up showed that the life course trajectories of daily smoking and depressive symptoms are associated. Persistent daily smokers and those starting late had an increased risk of belonging to the profile with constantly high levels of depressive symptoms during the life course. However, these associations were statistically significant only in males. Actions should be strengthened, especially in males, to prevent smoking initiation, to help smoking cessation, and to identify and treat depression in smokers with significant depressive symptoms.

Examining teacher transition pathways towards knowledge generation environments

ABSTRACT National standards that centre on the underpinning epistemic practices of the discipline has emphasised the need for teachers to focus much more on knowledge generation approaches to learning. Adopting a complexity perspective, we attempt to understand how teachers shift over time by examining their epistemic orientation to knowledge generation and their understanding of the nature of the epistemic tools of language, dialogue and argument that underpin these environments. Ninety-five teachers participated in a 2-year professional development programme to implement the Science Writing Heuristic (SWH) approach – a recognised generative learning approach. Using a longitudinal latent profile analysis of four waves of data, three different teacher profiles emerged (low, medium and high). Teacher transition to higher profiles was not uniform, took time, and required them to engage with the epistemic systems of orientation and tools. The results highlight that teacher PD needs to be tailored to promote richer transitions to implementing generative learning environments.

Analytic solutions to the two-dimensional solute advection-dispersion equation coupled with heat diffusion equation in a vertical aquifer section

Analytical and semi-analytical solutions to solute transport equations are not only used to predict the fate and transport of contaminants in soil or groundwater systems, but also to provide reference standards for validation of numerical models. However, when the solute transport equation is coupled with heat, the corresponding analytical solutions are rarely reported, perhaps due to the complexity of the coupled models. The main purpose of this paper is to present an analytical solution to the solute transport equation coupled with heat for the case of modeling solute transport in a vertical section of a homogenous infinite aquifer with steady uniform groundwater flow under constant-flux solute source. In earlier work (Shan and Javandel, 1997), analytical solutions to the solute transport equation in both finite and infinite aquifer thickness were presented, influence of heat (Soret effect) was generally not considered. Heat can, however, have a significant impact on movement of concentration front. In the present work, we first couple the solute equation with a generalized classic heat diffusion equation. To do this, we assume that the heat is not influenced by the solute (Dufour effect) such that only a one-way coupled model is considered. The repeated integral transformation method (RITM) is utilized to obtain the analytical solutions to the proposed coupled model. As a limiting case, a comparison with analytical solution (Shan and Javandel, 1997), equation (21) and other literature findings is done verify the new proposed solutions and validate our results. The influences of the thermopheresis effect and other model parameters are pictured graphically by the use of MATLAB R2015a. In comparison with the earlier work, the present results show that movement of contaminant in the medium is affected by the presence of heat, in particular along the direction of flow, consistent with the literature. The analysis of longitudinal and transverse concentration profiles suggest that the proposed solutions are applicable for monitoring of groundwater contaminants and risk assessment. Also, the solutions should be useful for comparison with numerical models.

Longitudinal profiles of neighborhood socioeconomic vulnerability influence blood pressure changes across the female midlife period.

To examine whether longitudinal exposure to neighborhood socioeconomic vulnerability influences blood pressure changes throughout midlife in a racially, ethnically, and geographically-diverse cohort of women transitioning through menopause. We used longitudinal data on 2738 women (age 42-52at baseline) living in six United States cities from The Study of Women's Health Across the Nation. Residential histories, systolic blood pressures (SBP), and diastolic blood pressures (DBP) were collected annually for ten years. We used longitudinal latent profile analysis to identify patterns of neighborhood socioeconomic vulnerability occurring from 1996 to 2007 in participant neighborhoods. We used linear mixed-effect models to determine if a woman's neighborhood profile throughout midlife was associated with blood pressure changes. We identified four unique profiles of neighborhood socioeconomic vulnerability - differentiated by residential socioeconomic status, population density, and vacant housing conditions - which remained stable across time. Women residing in the most socioeconomically vulnerable neighborhoods experienced the steepest increase in annual SBP growth by 0.93mmHg/year (95% CI: 0.65-1.21) across ten-year follow-up. Neighborhood socioeconomic vulnerability was significantly associated with accelerated SBP increases throughout midlife among women.

A new approach to stress of conscience's dimensionality: Hindrance and violation stressors and their role in experiencing burnout and turnover intentions in healthcare.

To identify a valid, longitudinally invariant factor model for stress of conscience and to investigate how stress of conscience dimensions associate with burnout and turnover intentions. There has been a lack of consensus about the number and content of stress of conscience dimensions, and a lack of longitudinal studies on its development and outcomes. A longitudinal, person-centred survey study using the STROBE checklist. Healthcare personnel (n = 306) rated their stress of conscience in 2019 and 2021. Longitudinal latent profile analysis was used to identify different subgroups based on the employees' experiences. These subgroups were then compared in terms of burnout and organisational/professional turnover. Five subgroups were identified, where participants experienced: (1) hindrance-related stress (14%), (2) violation-related stress (2%), (3) both stress dimensions increasing over time (13%), (4) both high yet decreasing over time (7%), and (5) stable levels of low stress (64%). When both hindrance- and violated-related stress were high, it was a significant risk for burnout and turnover. Shortened, 6-item, two-dimensional scale for stress of conscience was found to be reliable, valid, and longitudinally invariant. On its own, hindrance-related stress (e.g. lowering one's aspirations for high-quality work) is less detrimental to well-being than when it is combined with violation-related stress (e.g. being forced to do something that feels wrong). To prevent burnout and staff turnover in healthcare, different risk factors for stress of conscience need to be identified and addressed. Data were collected among public sector healthcare workers. If healthcare workers are forced to ignore their personal values at work, it poses a significant risk for their well-being and retention.

Patterns of demoralization and anhedonia during early substance use disorder treatment and associations with treatment attrition

BackgroundAlthough depressive symptoms represent a promising therapeutic target to promote recovery from substance use disorders (SUD), heterogeneity in their diagnostic presentation often hinders the ability to effectively tailor treatment. We sought to identify subgroups of individuals varying in depressive symptom phenotypes (i.e., demoralization, anhedonia), and examined whether these subgroups were associated with patient demographics, psychosocial health, and treatment attrition. MethodsPatients (N = 10,103, 69.2 % male) were drawn from a dataset of individuals who presented for admission to SUD treatment in the US. Participants reported on their demoralization and anhedonia approximately weekly for the first month of treatment, and on their demographics, psychosocial health, and primary substance at intake. Longitudinal latent profile analysis examined patterns of demoralization and anhedonia with treatment attrition as a distal outcome. ResultsFour subgroups of individuals emerged: (1) High demoralization and anhedonia, (2) Remitting demoralization and anhedonia, (3) High demoralization, low anhedonia, and (4) Low demoralization and anhedonia. Relative to the Low demoralization and anhedonia subgroup, all the other profiles were more likely to discontinue treatment. Numerous between-profile differences were observed with regard to demographics, psychosocial health, and primary substance. LimitationsThe racial and ethnic background of the sample was skewed towards White individuals; future research is needed to determine the generalizability of our findings to minoritized racial and ethnic groups. ConclusionsWe identified four clinical profiles that varied in the joint course of demoralization and anhedonia. Findings suggest specific subgroups might benefit from additional interventions and treatments that address their unique mental health needs during SUD recovery.

Latent patterns of sleep disturbance, pain impact, and depressive symptoms in residential substance use treatment

AimSleep disturbance, clinically significant pain, and depressive symptoms commonly occur together among individuals with substance use disorders. The purposes of the present study were to 1) identify subgroups of individuals with heterogenous patterns of pain, sleep disturbance, and depressive symptoms, and 2) identify demographic and clinical correlates of profile membership. Material and methodsThe present study assessed a sample (N = 8621) of individuals seeking residential substance use treatment in 2020 and 2021 in the United States. We examined whether unique sub-groups could be identified based on patterns of sleep disturbance, pain impact, and depressive symptoms during the first four weeks of treatment, using longitudinal latent profile analysis. Next, we explored demographic, substance use, and clinical correlates (i.e., distress intolerance) of profile membership, as well as whether profile membership was associated with treatment attrition. ResultsThe identified classes were: 1) Low sleep disturbance, pain impact, and depressive symptoms, 2) High pain, remitting depressive symptoms, and mild sleep disturbance, 3) High depressive symptoms, low pain, and remitting sleep disturbance, and 4) High sleep disturbance, pain impact, and depressive symptoms. Individuals with high pain, depressive symptoms, and sleep disturbance were more likely to be older, use opioids as their primary substance, have high distress intolerance, and discontinue treatment. ConclusionResults highlight the importance of comprehensive care and management of physical health conditions, particularly among older adults. Further, results highlight that distress intolerance may be a modifiable risk factor for co-occurring sleep disturbance, pain impact, and depressive symptoms.

Assessment of basin-scale geomorphic processes based on the analysis of longitudinal profiles: A case study of the Dwarkeswar river, Eastern India

ABSTRACT The longitudinal profile of the river bears geomorphic signature of long-term fluvial adjustment to tectonic, structure, lithology, and climate. Therefore, analysis of the longitudinal profile can be helpful in understanding the fluvial process and the response of the river to regional geodynamics. The present study uses longitudinal profiles and related geomorphic indices, including the Stream Length-Gradient Index (SL Index) of the Dwarkeswar river and its nine major tributaries, to understand the role of regional geological structure and lithology on the landscape evolution of the basin and the stage of river-valley development. Four mathematical functions were used in the present study to fit the curves of the profiles, on the basis of which the sequence of evolution was estimated. The exponential function is the best fit, followed by the linear function for each river, indicating a dynamic equilibrium condition. Moreover, profile concavity and hypsometric integral were used in the present study to understand sediment generation and transportation dynamics. The lower concavity index in Arkasa, Beko river, and Debkhal rivers indicate that sediment production and transportation balance each other. All the indices and the shape of Hack’s profile indicate that the rivers are in non-graded condition. The concavity of the profile reveals that Dwarkeswar rivers is an energy-limited river with a lower sediment delivery ratio (SDR)(0.47). Other rivers of the basin have moderate to high SDR (0.61–0.78). The integration of the results with the geological data indicates that the segments with anomalously high values of the SL index correspond to the fault lines, lineaments, and lithological discontinuities.

Profiles of teacher’s professional agency in the classroom across time

ABSTRACT Teachers with strong professional agency (TPA) in the classroom make efforts to constantly learn and develop their teaching practices. The aim of the present study is to identify teachers’ different TPA development profiles and their association with experiencing burnout symptoms and abilities to use proactive strategies in regulating well-being. A total of 1920 Finnish primary school teachers responded during the two-year follow-up study. The data were analysed using longitudinal latent profile analysis. Four profiles were found: (1) High and stable professional agency; (2) Moderately high professional agency; (3) Increasing professional agency; and (4) Decreasing professional agency. Most teachers experienced strong and stable professional agency and only few changes in their sense of professional agency over time. Socio-contextual burnout symptoms and proactive strategy use differentiated the profiles well. Teachers with lower professional agency profiles experienced more burnout symptoms and less ability to use proactive strategies.

Alterations in Abundance and Compartmentalization of miRNAs in Blood Plasma Extracellular Vesicles and Extracellular Condensates during HIV/SIV Infection and Its Modulation by Antiretroviral Therapy (ART) and Delta-9-Tetrahydrocannabinol (Δ9-THC).

Alterations in Abundance and Compartmentalization of miRNAs in Blood Plasma Extracellular Vesicles and Extracellular Condensates during HIV/SIV Infection and Its Modulation by Antiretroviral Therapy (ART) and Delta-9-Tetrahydrocannabinol (Δ9-THC).

Morphology, flow dynamics and evolution of englacial conduits in cold ice

AbstractMeltwater routing through ice masses exerts a fundamental control over glacier dynamics and mass balance, and proglacial hydrology. However, despite recent advances in mapping drainage systems in cold, Arctic glaciers, direct observations of englacial channels and their flow conditions remain sparse. Here, using terrestrial laser scanning (TLS) surveys of the main englacial channel of cold‐based Austre Brøggerbreen (Svalbard), we map and compare an entrance moulin reach (122 m long) and exit portal reach (273 m long). Analysis of channel planforms, longitudinal profiles, cross‐sections and morphological features reveals evidence of spatial variations in water flow conditions and channel incision mechanisms, and the presence of vadose, epiphreatic and phreatic conditions. The entrance reach, located at the base of a perennial moulin, was characterized by vadose, uniform, channel lowering at annual timescales, evidenced by longitudinal grooves, whereas the exit portal reach showed both epiphreatic and vadose conditions, along with upstream knickpoint migration at intra‐annual timescales. Fine‐scale features, including grooves and scallops, were readily quantified from the TLS point cloud, highlighting the capacity of the technique to inform palaeoflow conditions, and reveal how pulses of meltwater from rainfall events may adjust englacial conduit behaviour. With forecasts of increasing Arctic precipitation in the coming decades, and a progressively greater proportion of glaciers comprising cold ice, augmenting the current knowledge of englacial channel morphology is essential to constrain future glacier hydrological system change.

Morphometric Analysis of Mount Ararat (Eastern Anatolia, Türkiye)

In this study, the morphometric characteristics of Mount Ararat which is a strato-volcano are analyzed. Türkiye’s highest Mountain, Mount Ararat, is located in Eastern Anatolia. The Mountain takes the shape of two major volcanic cones after 2500 m height; these volcanic cones are named Greater Mount Ararat (5137 m) and Little Mount Ararat (3896 m). In this study, relief morphometry, basin morphometry, and drainage characteristics are morphometrically analyzed with Geographic Information Systems (GIS) using 10x10 m resolution Digital Elevation Model (DEM). According to the analysis results, there is an increase in the elevation on the high and steep slopes of the main cone and the slope values increase up to 56° in some locations towards the summit. On the other hand, according to the aspect analyses, 19.9% of slope faces are north-east direction, 14.7% of the slopes are north-direction, 9.4% are northwest, 9.8% are west, 10.7% are southeast, and 16.4% of the slopes are east direction. These results support the fact that Mount Ararat extends in NW-SE direction and is formed on the basis of a fault line in this direction. According to the grouping made by the altitude ranges analysis, the decrease in the rate of elevation belts starting from the slopes of the mountain towards the top confirms the structure of volcanic cone. Elevation differences in relative relief analyses range between 0 and 1141 m and this value increases to 1141 m on the slopes surrounding the summit. The cone structure of Mount Ararat was prominent in transverse and longitudinal profile analyses.

Analysis and Modeling of Longitudinal Deformation Profiles Considering the Reinforcement Effect of Tunnel Face in Weak Rocks

Convergence-confinement method (CCM) has become a common method for tunnel design due to its simplicity and practicality. The ground reaction curve (GRC), the support characteristic curve (SCC) and the longitudinal deformation profile (LDP) are all considered in this method. One of these is the LDP which serves as a unique identifier for the location of the tunnel support. The installation point of the tunnel support is one of the most important outcomes of the method. LDP is more impacted by the reinforcement of the tunnel face. However, more existing LDP calculation methods do not consider the reinforcement of the tunnel face. A study on methods for calculating LDP considering the tunnel face reinforcement was carried out to address this constraint of CCM. Firstly, the transformation of tunnel face extrusion deformation and pre-convergence deformation at the tunnel face is realized in accordance with equivalent volume. Then a model of LDP with the tunnel face extrusion deformation as the variable was established considering the tunnel face reinforcement effect. The proposed model's accuracy is assessed in comparison with other typical models. We conclude with parametric analyses concerning the tunnel face reinforcement's effects on the point of support installation, as well as convergence deformation of the tunnel. By taking into account tunnel faces' reinforcement effects, tunnel support design can be more accurate, and the construction costs can be reduced.

Estimating the long-term slip rate of active normal faults: The case of the Paganica Fault (Central Apennines, Italy)

The footwall of the surface rupturing Paganica normal fault, the source of the 2009 L’Aquila earthquake (Mw 6.1) in the Central Apennines (Italy), was investigated using integrated geological and geomorphological approaches. The aim was to constrain the active tectonics by studying the Raiale River that orthogonally crosscuts the fault trace, where it provides a useful geomorphological marker of long-term fluvial incision and footwall uplift. Using morphostratigraphy and paleomagnetic analysis, the Plio–Pleistocene morphotectonic evolution of the area was reconstructed, comprising an ancient continental basin and paleolandforms that predate the footwall incision. Starting from the Late Early Pleistocene–Middle Pleistocene, fluvial dissection was mainly due to marked river downcutting triggered by significant activity of the Paganica Fault, which caused progressive base-level lowering. The Raiale River downcutting formed five Middle–Late Pleistocene fluvial terraces, that, along with absolute Optically Stimulated Luminescence (OSL) dating, allowed the identification of paleolongitudinal profiles with a diverging downstream configuration. Terrace dating yielded a minimum incision rate of 0.25 ± 0.02 mm/a, which only partially compensates the footwall uplift and can thus be considered as a minimum value for the Paganica Fault throw rate, which could reach up to ~0.45 mm/a. In parallel, using terrestrial cosmogenic nuclides, a denudation rate of 0.02–0.04 mm/a was measured on the summit of the footwall block. This denudation is in keeping with the drainage incision, suggesting a non-steady state for the fault footwall topography and a dominance of relief growth. Last, the analysis of the modern Raiale River longitudinal profile denoted an ungraded status, with two main knickzones that we interpret as transient forms due to tectonic perturbations, likely triggered by activity of the Paganica Fault during the end Early Pleistocene and the Late Pleistocene. Considering the 2009 L’Aquila earthquake coseismic rupture, we observe that the younger transience on the Raiale River longitudinal profile, if it is of tectonic origin, could have only been produced by much larger seismic events (i.e., Mw > 6.5) than those documented in the area by paleoseismological investigations. The collective results confirmed that in the Central Apennines, conditions of dynamic equilibrium are often not met, and that the persistence of transient perturbations induced by tectonics should be accounted for.

The methods and program implementation for river longitudinal profile analysis—RiverProAnalysis, a set of open-source functions based on the Matlab platform

The methods and program implementation for river longitudinal profile analysis—RiverProAnalysis, a set of open-source functions based on the Matlab platform

Latent class trajectories of biochemical parameters and their relationship with risk of mortality in ICU among acute organophosphorus poisoning patients

Acute poisoning is a global public health challenge. Several factors played role in high mortality among acute organophosphorus poisoning (OP) poisoning patients including clinical, vitals, and biochemical properties. The traditional analysis techniques use baseline measurements whereas latent profile analysis is a person-centered approach using repeated measurements. To determine varying biochemical parameters and their relationship with intensive care unit (ICU) mortality among acute organophosphorus poisoning patients through a latent class trajectory analysis. The study design was a retrospective cohort and we enrolled data of 299 patients admitted between Aug’10 to Sep’16 to ICU of Dr. Ruth K. M. Pfau, Civil Hospital, Karachi. The dependent variable was ICU-mortality among OP poisoning patients accounting for ICU stay, elapsed time since poison ingestion, age, gender, and biochemical parameters (including electrolytes (potassium, chloride, sodium), creatinine, urea, and random blood sugar). Longitudinal latent profile analysis is used to form the trajectories of parameters. In determining and comparing the risk of ICU-mortality we used Cox-Proportional-Hazards models, repeated measures and trajectories were used as independent variables. The patients’ mean age was 25.4 ± 9.7 years and ICU-mortality was (13.7%, n = 41). In trajectory analysis, patients with trajectories (normal-increasing and high-declining creatinine, high-remitting sodium, normal-increasing, and high-remitting urea) observed the highest ICU-mortality i.e. 75% (6/8), 67% (2/3), 80% (4/5), 75% (6/8), and 67% (2/3) respectively compared with other trajectories. On multivariable analysis, compared with patients who had normal consistent creatinine levels, patients in normal-increasing creatinine class were 15 times [HR:15.2, 95% CI 4.2–54.6], and the high-declining class was 16-times [HR 15.7, 95% CI 3.4–71.6], more likely to die. Patients in with high-remitting sodium, the trajectory was six-times [HR 5.6, 95% CI 2.0–15.8], normal-increasing urea trajectory was four times [HR 3.9, 95% CI 1.4–11.5], and in extremely high-remitting urea trajectory was 15-times [HR 15.4, 95% CI 3.4–69.7], more likely to die compared with those who were in normal-consistent trajectories of sodium and urea respectively. Among OP poisoning patients an increased risk of ICU-mortality were significantly associated with biochemical parameters (sodium, urea, creatinine levels) using latent profile technique.