In order to predict the settlement of self-compacting solidified soil in foundation pit backfilling, finite element software is used to study the influence of soil properties and the surrounding structural properties of the foundation pit on the settlement of backfilled self-compacting solidified soil based on a foundation pit project in the city of Nanjing. The degree of influence of various factors influencing settlement is considered, a grey relational grade analysis is conducted, and input layer parameters of the neural network are determined based on the results of the grey relational grade analysis. Based on the GA-BP neural network model, the settlement of soil is predicted using numerical simulation results. The results reveal that the settlement and structural disturbance of self-compacting solidified soil after backfilling are smaller than those of fine silty sand; self-compacting solidified soil significantly improves the engineering performance of excavated soil. In the grey relational grade analysis, the six influencing factors that have high correlation with soil settlement can be used as input layer parameters for the neural network model. Among them, the correlation degree between elastic modulus and soil settlement is the highest, reaching 0.8402. The correlation degrees of the remaining five influencing factors are above 0.5, and the values are close. The GA-BP neural network can improve the overfitting situation of a BP neural network trapped in local optima, with R2 reaching 0.9999 and RMSE only 0.0018 mm, achieving high-precision prediction of settlement of self-compacting solidified soil.