When exposed to light sources, photochromic (PC) materials change their optical properties and can lessen the transmission of UV and infrared radiation. This results in optimal thermal comfort and a pleasing visual contrast between the internal and external settings. This study uses computer modeling to analyze the annual energy usage in a home with natural ventilation in order to compare the effectiveness of photochromic films with commercial glass. The study is carried out using the EnergyPlus program in the cities of São Carlos and Cuiabá ‐ Brazil. Experiments and numerical simulations with data from doped and undoped tungsten trioxide (WO3) PC films are used in the study. Given the rise in energy usage and the pursuit of thermal comfort, this method is essential for assessing the thermal performance of buildings. Evaluations included a comparison of air conditioner performance and energy savings analysis, which leads to a noteworthy annual reduction in energy usage of up to 216.55 kWh and a 40% improvement in visual comfort. It is determined that PC film's dynamic behavior is the best option for comfort in terms of heat, illumination, and visual comfort.