This article examines research related to determining the economic selling prices for concrete brick products at Karunia MSMEs, with the aim of optimization for production cost while still maintaining process quality. The method used in this research is Design of Experiment (DoE) based, namely Taguchi with regression, then continued with cost analysis to determine the optimal cost of production for efficiency. The technique in this method uses 3 variables, there are sand, cement and the length of time for mixing the concrete mixture with the quality parameters and production costs of the concrete bricks. Based on the experimental results, in achieving the goal of increasing cost efficiency, through sensitivity analysis it was obtained that the optimal composition of the cost of production was IDR 5,000 per piece of concrete brick, while maintaining SNI quality standards in optimal results of compressive strength is 117.37 kg/cm2, water permeability is 7.77% and roughness is 52.42 µm. The cost of production is the same as the initial cost of production before composition optimization efforts are carried out, where the initial concrete brick product is indicated as not meeting SNI quality standards because it has a compressive strength value below standard. The results of this research are expected to be able to provide recommendations for economic selling price for concrete brick by production costs optimizing while maintain the SNI standard quality of concrete brick products.