Analysis Of Above Data Research Articles

New modes of converting chemical information with colloidal photonic crystal sensing units

Photonic crystal is a kind of device which can convert a chemical signal into an optical signal and is commonly used in sensing and detection. The maximum reflection wavelength representing the photonic band gap has been the most common converting mode in analytical usage which however discard too much valuable chemical information. In this work, we established two additional modes for mining chemical information more deeply in time and space as the sensing information to distinguish analytes. They are respectively based on dynamic analysis of the spectrum shift and the distinction of the RGB partition block value information of optical image. The molecular imprinting sensing mechanism worked well on three organophosphorus compounds to the detection limit of 10−4 M. The principle component analysis of above data did present a good discrimination of organophosphorus analytes from interfering counter anions to a low detection limit of 10−6 M. To make the detection more convenient and to achieve real-time on-site detection, we have designed the portable photonic crystal signal acquisition kit. Together with the mobile terminal, the kit connects the optical image collected on site, the algorithm working on the cloud and the input/output interactive interface of users in detection. The methods were constructed on an example made of a three-dimensional molecularly imprinted photonic crystal hydrogels sensing unit targeting on organo-phosphides.

Applications of international blood smear review criteria for improvement on Beckman-Coulter hematology analyzers

Objective To evaluate the international blood smear review criteria for improvement using Beckman-Coulter hematology analyzers and find out proper slide review criteria suitable for Chinese population. Methods 3 600 random-selected blood samples were tested in three hospitals using MAXM, GENS and LH750 5-diff automated analyzers and a manual differential with a smear review was performed on all samples in the study. True positive rate, true negative rate, false positive rate and false negative rate were calculated according to the international blood smear review criteria. We have set up smear review criteria for Chinese population by analyzing false positive and false negative cases according to Chinese clinical conditions. Another 240 blood samples were tested in three hospitals using the same analyzers to verify the new slide review rules. Results According to international blood smear criteria, the true positive rate was 4.9%, false positive rate was 24.2%, true negative rate was 70.4% and false negative rate was 0.5%. The international smear review criteria were modified into 23 criteria by analysis of above statistical data. In addition, we added four WBC differential ratio rules in positive smear criteria. After modification, the true positive rate was 9.9% (355/3 600) ,false positive rate was 17.1% (617/3 600), true negative rate was 71.2 % (2 563/3 600) and false negative rate was 1.8% (65/3 600). No blast cell was missed using both smear review criteria. A little higher false negative rate after modification was caused by supplemented differential ratio roles in positive smear criteria. Verification results were satisfactory;The tree positive rate was 13.7% (33/240) ;false positive rate was 15.8% (38/240) ;false negative rate was 2.5% (6/240) and true negative rate was 68.0% (163/240). Conclusions Although the smear review criteria suggested by the International Consensus Group is clinically important, the false positive rate increases when they are used in Chinese population. The modified slide review criteria used on Beckman-Coulter hematology analyzers in this study are more suitable for Chinese laboratories. Key words: Blood cell count; Hematologic tests; Diagnostic equipment ; Autoanalysis; Evaluation studies