Analgesic Activity Of Methanol Extract Research Articles

Evaluation of Anti-inflammatory and Analgesic Activity of Methanolic Extract of Cassia auriculata Leaves

Evaluation of Anti-inflammatory and Analgesic Activity of Methanolic Extract of Cassia auriculata Leaves

ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF IXORA COCCINEA FLOWER

The present study was an endeavor to evaluate anti-inflammatory and analgesic activity of methanolic extract of Ixora coccinea flowers (ICF-ME). The in vivo anti-inflammatory was evaluated in rats by using carageenan-induced paw edema, as an acute anti-inflammatory model. Quantitative estimation of total polyphenolic content of I. coccinea flowers was estimated by ICF-ME (100 mg/kg) significantly decreased paw volume, after oral administration of ICF-ME in carrageenan injection. ICF-ME also exhibit significant analgesic activity. The response of licking or jumping latency was recorded in seconds by using hotplate method. Presence of phytochemical like flavonoids, glycosides, and tannins in the ICF-ME might contribute to the observed analgesic and anti-inflammatory activity.

Involvement of opioid and monoaminergic pain pathways in Aegle marmelos induced analgesia in mice

Objective:To study analgesic activity and to evaluate the involvement of opioid and monoamines in the antinociceptive activity of methanol extract of leaves of Aegle marmelos.Materials and Methods:Analgesic activity of methanol extract (ME) of A. marmelos alone (75,150 and 300mg/kg orally) and in combination with morphine or venlafaxine (subanalgesic) were studied using tail flick test and acetic acid-induced writhing in mice. The effect of pre-treatment with opioid antagonist naltrexone 1mg/kg was also studied on antinociception induced due to ME.Result:ME produced a dose-dependent significant antinociceptive activity in the tail flick test and acetic acid-induced writhing in mice. (P<0.05) Administration of subanalgesic dose of ME with morphine or venlafaxine also resulted in significant (P<0.05) antinociceptive activity in both the pain models. Pre-treatment with naltrexone inhibited analgesic activity induced by ME alone and combination with morphine or venlafaxine.Conclusion:A.marmelos in induced antinociception is mediated through both opioid and monoaminergic pain pathways, suggest its possible use in chronic pain.

Analgesic and Anti-Inflammatory Activity of Methanolic Extract of Leaves of Quisqualis indica

The present study was designed to evaluate the analgesic and anti-inflammatory activity of methanolic extract of Quisqualis indica (MEQI) leaves in rodents. The peripheral analgesic activity of methanolic extract of Quisqualis indica leaves (MEQI; 200 and 400 mg/kg) was studied using acetic acid-induced writhing test and central analgesic activity of MEQI was studied using hot-plate method in mice. Anti-Inflammatory activity of MEQI (200 and 400 mg/kg) was studied in carragenin induced paw edema in rats. MEQI significantly decreased the writhing movements in acetic acid-induced writhing test and increased the reaction time in hot-plate test in mice. MEQI also showed significant anti-inflammatory activity in carragenin induced paw edema by reducing paw volume in rats. From our study, we concluded that MEQI has potential analgesic and anti-inflammatory activities.

Anti-edematogenic and analgesic activities of Ficus benghalensis

This work was done for the investigations of anti-inflammatory and analgesic activities of methanolic extract of dried leaves of Ficus benghalensis Linn. by oral administration at doses of 10, 20 and 100 mg/kg of body weight to healthy animals. The extract was studied for anti-inflammatory activity by using carrageenan-induced hind paw edema in rats. The mean increases in paw volume and % inhibition in the edema were measured plethysmometrically at different time intervals after carrageenan (1% w/v) injection. The extract was also evaluated for analgesic activity using acetic acid-induced writhing and Eddy's hot plate method in albino mice. The methanolic extract of F . benghalensis showed significant ( P F . benghalensis possesses significant ( P <0.05) anti-inflammatory and analgesic activities.

Evaluation of anti–inflammatory and analgesic potential of methanol extract of Tectona grandis flowers

To evaluate anti-inflammatory and analgesic activity of methanol extract of Tectona grandis ( T. grandis ) flowers (METGF) in animal models to support its traditional use. Acute toxicity study was performed to determine the toxicity level of METGF in mice and rats. Carrageenan (1% w/w) was administered and inflammation was induced in sub-plantar region of rat paw. Analgesia was induced by intraperitoneal injection of 0.6% v/v acetic acid in mice to assess peripheral analgesic action of METGF. Also, hot-plate was used to induce pain in mice to evaluate central analgesic action of METGF. Oral administration of METGF in rat and mice did not produce any toxicity at 2 000 mg/kg dose level. In carrageenan induced inflammation, administration of METGF (100 and 200 mg/kg) as well as indomethacin (10 mg/kg) reduced rat paw edema significantly at 3, 4 and 5 h. Both the doses of METGF showed significant inhibition in acetic acid induced writhing responses. In thermally induced analgesia models, administration of METG at dose of 100 and 200 mg/kg significantly increased reaction time compared to control animals. The preliminary phytochemical analysis revealed the presence of phenolic compounds and tannins in METGF. Present study, for the first time, confirms the anti-inflammatory and analgesic action of METGF and it supports the traditional use of T. grandis flowers.

Phytochemical screening and analgesic activity of methanolic extract of Ximenia americana

Phytochemical screening and analgesic activity of methanolic extract of Ximenia americana

Pain management in mice using methanol extracts of three plants belongs to family Amaranthaceae

Objective To investigate the analgesic activity of methanolic extract of Amaranthus viridis (A. viridis), Amaranthus caudatus (A. caudatus) and Amaranthus spinosus (A. spinosus). Methods In this study, the analgesic activity of methanol extracts of all three plants at doses of 200 and 400 mg/kg were investigated by acetic acid-induced writhings test, hot plate test and tail immersion test for mice. Results It was found that all the three plants showed significant pain management effect (P<0.01) at a dose of 400 mg/kg, but showed a less significant effect at a dose of 20 mg/kg in the entire tests used for evaluation of analgesic activities (P<0.05). Conclusions Methanol extracts of A. viridis, A. caudatus and A. spinosus show potent analgesic activities, and this study provides the scientific proof for their traditional claims.

Anti-inflammatory and analgesic activities of methanolic extract of Kigelia pinnata DC flower

Ethnopharmacological relevance Kigelia pinnata DC is extensively used in Indian traditional medicine for several diseases including inflammatory and painful disorders. Aim of the study The aim of the present study is to investigate the possible anti-inflammatory and analgesic activities of methanolic extract of Kigelia pinnata flower (MKFL) to support the medicinal uses claimed by folklore practitioners. Materials and methods MKFL is evaluated for its anti-inflammatory activity in carrageenan-induced paw edema model in rats and analgesic activity in acetic acid-induced writhing, hot plate and formalin-induced paw licking models in mice. Results MKFL exhibited a significant ( P < 0.01) anti-inflammatory and analgesic activities with the doses of 100, 200 and 400 mg/kg b.w. in rats and mice respectively. Conclusions The results of the experimental study thus strongly support the traditional use of this plant for inflammatory and pain disorders.

Anti-inflammatory and analgesic activities of methanol extract of Triphala - a poly herbal formulation

Ayurveda, an ancient System of Indian Medicine, has recommended a number of drugs from indigenous plant sources for the treatment of inflammation. To evaluate the anti-inflammatory and analgesic activities of methanol extract of Triphala were investigated in Wister albino rats and mice. The methanol extract of Triphala were found to encompass substantial anti-inflammatory effect in acute and sub-acute models and analgesic effect. Animal models of carrageenan induced edema and cotton pellet induced granuloma in albino rats were used. Extract of 200 mg/kg shows significantly reduced paw edema. Analgesics activity of Triphala with 200 mg/kg shown by significant reduction of writhing. These report shows to support the use methanol extract of Triphala in relieving inflammation and pain.

Analgesic activity of methanol extract of Aegle marmelos leaves

The methanol extract of leaves of Aegle marmelos at a dose level of 200 and 300 mg/kg showed significant analgesic activity on acetic acid-induced writhing and tail flick test in mice.

Anti-inflammatory and analgesic effects of Careya arborea stem bark in experimental animal models

The present study was carried out to evaluate the anti-inflammatory and analgesic activities of methanol extract of Careya arborea (MECA). The effects of MECA on the acute and chronic phases of inflammation were studied in carrageenan, dextran and mediators (histamine and serotonin) induced paw oedema and cotton pellet induced granuloma respectively. Analgesic effect of MECA was evaluated in acetic acid induced writhing and hotplate tests. The anti-oedema effect of MECA was compared with indomethacin 10 mg/kg orally. In acute phase of inflammation a maximum inhibition of 50.56, 48.86, 47.12 and 48.23% (p

Studies on analgesic activity of Cleome viscosa in mice

The analgesic activity of methanol extract of Cleome viscosa, given orally at the doses of 100, 200, 400 mg/kg was evaluated for its analgesic activity in mice using the acetic acid-induced writhing and the tail flick, tail clip, tail immersion methods. The extract showed promising activity in all the tests.