This study investigates the differential impacts of Propofol, Sevoflurane, and Desflurane on stress responses in 150 elective surgery patients, emphasizing the importance of anesthetic choice in patient care. Utilizing a prospective observational design at a tertiary care center, we measured physiological stress markers (cortisol levels, heart rate, blood pressure) and psychological stress (via the State-Trait Anxiety Inventory) before and after anesthesia administration. Results highlighted Propofol's superior efficacy in significantly reducing both physiological and psychological stress markers compared to Sevoflurane and Desflurane. This suggests that Propofol not only ensures patient comfort during surgeries but also enhances postoperative recovery by mitigating stress responses. Our findings advocate for a strategic selection of anesthetics to optimize patient outcomes and satisfaction, positioning Propofol as a preferred choice for minimizing stress in surgical settings. This research underscores the nuanced role of anesthetics in stress modulation, contributing valuable insights into anesthetic practices aimed at improving surgical experiences and patient well-being.