With the development of modern methods of examination in urology, it will be found, in the examination and treatment of any group of urologic patients, that a certain percentage will require complete anesthesia of the urethra and bladder. Regional anesthesia in some form is particularly applicable in these patients. Urologic surgeons generally have adapted some form of regional anesthesia for urologic surgery; the benefits that their debilitated, septic and elderly patients have received from regional anesthesia have been manifold. Before the introduction of epidural caudal and sacral anesthesia, the urologist had his choice of local anesthesia, by means of the topical application of cocaine and other anesthetic agents to the urethra, or some method of general anesthesia. The use of local anesthesia in the urethra is successful to a certain degree, permitting satisfactory cystoscopic and other manipulations in some cases. Cocaine is the only drug that will produce satisfactory anesthesia