Anaerobic Exercise Capacity Research Articles

무용수 체력과 웰니스 영역과의 회귀분석

This study aims to analyze the relationship between dancers’ fitness and their wellness dimensions using regression analysis. Data were collected by surveying 110 dancers from middle and high schools, universities, and graduate schools after identifying the sample. One Gate, a TestWell survey, measures anaerobic exercise capacity using Wingate Anaerobic peak power[PP], Average Power[AP], Fatigue Index[FI]), cardiovascular endurance(PEI), flexibility, body composition, body fat mass(BFM), body mass index (BMI), percentage body fat(PBF), lean body mass(LBM), and cellular water. For statistical analysis, the study used t-test, one-way ANOVA, Fishers Least Significant Difference(LSD) test, Simple Linear Regression, and Multiple Linear Regression. The results revealed that the variables affecting the spiritual and emotional dimensions of wellness showed a significance difference in intra/extra cellular water, skeletal mass, and career (p＜.05). The variables affecting the intellectual dimension of wellness showed a significant difference in body mass index(BMI)(p＜.05). The variables affecting the physical dimension of wellness showed a significant difference in physical efficiency index(PEI), percentage body fat(PBF), and career (p＜.05). Ultimately, dancers’ perception of wellness affects their physical dimensions.

Non-combative taekwondo evokes highly anaerobic physiological responses in elite-level athletes: potential evidence for a new training modality.

Despite the increasing international popularity of taekwondo (TKD) poomsae, there is a lack of physiological characterizations of elite-level competitors in the sport. Thus, the aim of the present study was to investigate the physiological demands associated with various types of TKD poomsae. Eight male international TKD poomsae competitors carried out tae-geuk (TG) and professional (PF) poomsaes (in accordance with international competition standards), and consecutive TG (CTG) poomsae (a previously identified poomsae-specific training method). During each poomsae performance, oxygen uptake, heart rate, respiratory exchange ratio, and blood lactate were measured. The physiological responses were normalized and compared to maximal aerobic exercise tests such as a graded treadmill exercise (GXT) and maximal graded arm-crank ergometer exercise (ACE) to analyze the relative exercise intensity of each TKD poomsae. The results showed the relative exercise intensity of TG and PF poomsaes elicit moderate to high intensity physiological proportions of the maximal responses found during the GXT and ACE tests. Interestingly, CTG poomsae responses resulted in similar exercise intensities as those reported during high intensity interval training, indicating that CTG may be an effective training modality to improve aerobic and anaerobic exercise capacity while also utilizing and developing sport specific techniques and skills. This indicates the need for poomsae athletes to develop and maintain both aerobic and anaerobic capacity to enhance performance. Therefore, these physiological findings will help elite poomsae competitors and coaches to develop exercise programs of substantial duration and intensity to elicit beneficial performance adaptations.

Gene expression profile of muscle adaptation to high-intensity intermittent exercise training in young men

High-intensity intermittent exercise training (HIIT) has been proposed as an effective approach for improving both, the aerobic and anaerobic exercise capacity. However, the detailed molecular response of the skeletal muscle to HIIT remains unknown. We examined the effects of the HIIT on the global gene expression in the human skeletal muscle. Eleven young healthy men participated in the study and completed a 6-week HIIT program involving exhaustive 6–7 sets of 20-s cycling periods with 10-s rests. In addition to determining the maximal oxygen uptake ({dot{{rm{V}}}{rm{O}}}_{2{rm{max }}}), maximal accumulated oxygen deficit, and thigh muscle cross-sectional area (CSA), muscle biopsy samples were obtained from the vastus lateralis before and after the training to analyse the skeletal muscle transcriptome. The HIIT program significantly increased the {dot{{rm{V}}}{rm{O}}}_{2{rm{max }}}, maximal accumulated oxygen deficit, and thigh muscle CSA. The expression of 79 genes was significantly elevated (fold-change >1.2), and that of 73 genes was significantly reduced (fold-change <0.8) after HIIT. Gene ontology analysis of the up-regulated genes revealed that the significantly enriched categories were “glucose metabolism”, “extracellular matrix”, “angiogenesis”, and “mitochondrial membrane”. By providing information about a set of genes in the human skeletal muscle that responds to the HIIT, the study provided insight into the mechanism of skeletal muscle adaptation to HIIT.

Capacité physique de l’enfant présentant un syndrome d’apnée du sommeil léger

While the association between sleep-disordered breathing (SDB) and low physical activity has been reported in children, little information is available on the impact of SDB on exercise capacity. The aim of this study was to assess exercise capacity in children with SDB in order to estimate the relevance of exercise training intervention. Twelve young patients with suspected SDB matched with 11 presumably healthy subjects of same age range (aged 13±0.5yr) were investigated. Both groups underwent physical activity assessment, full night polysomnography, incremental and all-out exercise tests. The respiratory disturbance index was higher in the patient group (4.6±4.7 vs 0.8±0.6; P=0.02). Children with SDB had lower VO2max (32.0±9.9 vs 42.3±5.7mL.kg-1.min-1, P=0.007) and lower peak power (8.6±3.4 vs 11.8±1.9W.kg-1, P=0.009). A significant correlation between VO2max and weekly physical activity only was found in the SDB group (P=0.005). Mild SDB may be associated with impairment of both aerobic and anaerobic exercise capacity in children, related to poor physical activity. Exercise training could bring clinical benefit in this population.

Chlorella Intake Further Enhances Anaerobic And Aerobic Capacities Increased By High Intensity Intermittent Training

High intensity intermittent training (HIIT) enhances anaerobic and aerobic capacities. Our recent study have demonstrated in animal study that the 6-week combination of chlorella intake and HIIT further elevated glycolytic and oxidative phosphorylation as ATP supply in skeletal muscle as compared with chlorella alone and HIIT alone, resulting in enhancement of anaerobic and aerobic exercise capacities. However, the combined effects of chlorella intake and HIIT on anaerobic and aerobic capacities in human remain unclear. PURPOSE: The aim of this study was to investigate whether the combination of chlorella intake and HIIT further enhanced anaerobic and aerobic capacities as compared with HIIT alone in human. METHODS: Twelve healthy young male subjects (21 ± 1 years) were participated in this study. Subjects completed 3-week of exhaustive HIIT, consisting of 6-7 bouts of 20-second cycling on a leg ergometer at an intensity of 170% maximal oxygen uptake (VO2max) with a 10-second rest between each bout, 3 days/week. They orally took chlorella or placebo (10 tablets) after the breakfast and dinner between the 3-week in a double-blind, randomized, crossover design with 4 weeks between each intervention. We measured VO2max as an indicator of aerobic capacity and maximal oxygen deficit (MOD) as an indicator of anaerobic capacity. RESULTS: After each HIIT intervention, VO2max was significantly increased in both chlorella and placebo groups (P<0.05). However, the amount of change in VO2max after the intervention was significantly higher in chlorella intake than placebo intake (P<0.05). After each HIIT intervention, MOD was significantly increased in both chlorella and placebo groups (P<0.05). However, the amount of change in MOD after the intervention was significantly higher in chlorella intake than placebo intake (P<0.05). CONCLUSIONS: These results suggest that the combination of chlorella intake and HIIT may further enhance anaerobic and aerobic capacities in human. Supported by Grants-in-Aid for Scientific Research (#17H02183, #16K13059, M. Iemitsu)

Effects of nicotinamide N-methyltransferase (NNMT) inhibition on the aerobic and the anaerobic endurance exercise capacity

Summary Introduction Numerous reports showed that nicotinamide N-methyltransferase (NNMT) plays important roles in the regulation of energy metabolism and in the synthesis of ATP, which indicates that the activity of NNMT may be associated with sport performance. Methods and results To test this speculation, we inhibited NNMT activity of the rats with N-methylnicotinamide (MNA) (MNA group), and observed the effects on the lactate threshold and the maximal blood lactate concentration, and on the performance in the competitions of anaerobic and aerobic endurance exercise, respectively. The results showed: (1) the workloads (% body weight) of the rats in the swimming have no significant differences between MNA group and control group when the lactate threshold appeared (4.54 ± 0.90 vs. 4.60 ± 1.06), and when the maximal exercise intensity (exhaustion) appeared (6.00 ± 0.54 vs. 6.00 ± 0.81); (2) the rats of MNA group showed highly significantly lowered blood lactate concentrations than those of the control group immediately after the swimming with the maximal workload (10.40 ± 1.39 vs. 11.67 ± 1.71 mmol/L), 2 min post-exercise (11.49 ± 1.38 vs. 12.82 ± 1.63 mmol/L) and 4 min post-exercise (12.84 ± 1.36 vs. 14.3 ± 1.54 mmol/L); (3) in the anaerobic endurance exercise competition, 8 rats of the MNA group while 16 of the control group entered the top 24 places in the rank; (4) in the anaerobic endurance exercise competition, the swimming durations from the beginning until exhaustion were not significantly different between the MNA group and the control group (345.37 ± 71.69 vs. 345.30 ± 72.02 min). Conclusion These results suggest that NNMT inhibition significantly impairs the performance in anaerobic endurance exercise but not in aerobic endurance exercise.

Reduced anaerobic and aerobic performance in children with primary ciliary dyskinesia.

Anaerobic and aerobic performance is impaired in PCD from the early stages. Age determines anaerobic performance. Gender is the determinant of aerobic performance. Whether skeletal muscle characteristics and sex-related changes in body composition affect anaerobic and aerobic capacity in PCD children warrants further study. What is Known: • Exercise performance is determined by anaerobic and aerobic power. • Few studies have shown that PCD patients have lower aerobic performance which is associated with impaired lung function. What is New: • The present research indicated that both anaerobic and aerobic exercise capacity determined using field testing is impaired in PCD from the early stages. • Anaerobic capacity was found to be independently associated with age in PCD. Higher aerobic performance is independently associated with male gender.

High Intensity Intermittent Training And Chlorella Intake Enhance Muscle Glycolytic And Oxidative Metabolism In Rats.

Chronic chlorella intake enhances aerobic exercise capacities, i.e. exercise tolerance. High intensity intermittent exercise (HIIE) training enhances aerobic and anaerobic exercise capacities via elevation of muscle glycolytic and oxidative metabolism. However, the additive effects of combination of HIIE training and chlorella intake on exercise performance and muscle glycolytic and oxidative metabolism remain unclear. PURPOSE: The purpose of this study was to investigate the effect of chronic chlorella intake alone or in combination with HIIE training on exercise performance and muscle glycolytic and oxidative metabolism in rats. METHODS: Male 12-week-old Sprague-Dawley rats were randomly assigned to the four groups; sedentary control, chlorella intake (0.5% chlorella powder in normal feed), HIIE training, and combination of HIIE training and chlorella intake for 6 weeks (n = 10 each group). HIIE training comprised 14 repeats of a 20-s swimming session with a 10-s pause between sessions, while bearing a weight equivalent to 16% of body weight, 4 days/week. Exercise performance was tested after the interventions by measuring the maximal number of HIIE sessions that could be completed. RESULTS: Chlorella intake and HIIE training significantly increased the maximal number of HIIE, and enhanced the expression of monocarboxylate transporter (MCT)1, MCT4, and peroxisome proliferator activated receptor γ coactivator-1α concomitantly with the activities of lactate dehydrogenase (LDH), phosphofructokinase, citrate synthase (CS), and cytochrome oxidase (COX) in the red region of the gastrocnemius muscle (p<0.05). Furthermore, the combination further augmented the increased exercise performance and the enhanced expressions and activities (p<0.05). By contrast, in the white region of the gastrocnemius muscle, MCT1 expression and LDH, CS, and COX activities did not change. CONCLUSIONS: These results showed that compared to only chlorella intake and only HIIE training, chlorella intake combined with HIIE training has a more pronounced effect on exercise performance and muscle glycolytic and oxidative metabolism, in particular lactate metabolism. Supported by Grants-in-Aid for Scientific Research (#26282199, M. Iemitsu)

The Effect of High-Intensity Aerobic Continuous and Anaerobic Interval Training at 3,000 m Hypobaric Hypoxic Condition for Six-weeks on Aerobic and Anaerobic Exercise Capacity in Competitive Swimmers

The Effect of High-Intensity Aerobic Continuous and Anaerobic Interval Training at 3,000 m Hypobaric Hypoxic Condition for Six-weeks on Aerobic and Anaerobic Exercise Capacity in Competitive Swimmers

Effects of lower extremity injuries on aerobic exercise capacity, anaerobic power, and knee isokinetic muscular function in high school soccer players.

[Purpose] The study investigated the effects of lower extremity injuries on aerobic exercise capacity, anaerobic power, and knee isokinetic muscular function in high school soccer players. [Subjects and Methods] The study assessed U High School soccer players (n=40) in S area, South Korea, divided into 2 groups: a lower extremity injury group (n=16) comprising those with knee and ankle injuries and a control group (n=24) without injury. Aerobic exercise capacity, anaerobic power, and knee isokinetic muscular function were compared and analyzed. [Results] Regarding the aerobic exercise capacity test, significant differences were observed in maximal oxygen uptake and anaerobic threshold between both groups. For the anaerobic power test, no significant difference was observed in peak power and average power between the groups; however, a significant difference in fatigue index was noted. Regarding the knee isokinetic muscular test, no significant difference was noted in knee flexion, extension, and flexion/extension ratio between both groups. [Conclusion] Lower extremity injury was associated with reduced aerobic exercise capacity and a higher fatigue index with respect to anaerobic exercise capacity. Therefore, it seems necessary to establish post-injury training programs that improve aerobic and anaerobic exercise capacity for soccer players who experience lower extremity injury.

The Effects of Quadriceps Kinesio Taping on Aerobic and Anaerobic Exercise Performance in Healthy Participants: A Randomized Controlled Study

Objective:Aerobic and anaerobic exercise capacities are important components of athletic performance. The use of Kinesio Taping® (KT) as a supplementary treatment in athletic settings has increased in the recent years. KT can facilitate muscle contraction, which may be useful for improving performance. The purpose of this study was to determine whether the application of KT to the quadriceps muscle has any effect on anaerobic and aerobic performance in young healthy individuals.Design:Randomized, controlled, double-blind clinical study.Setting:Baskent University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation.Patients:Thirty-two healthy male participants were randomly assigned to either the KT group or a sham KT (SKT) group.Interventions:The KT muscle facilitation technique was applied to the quadriceps muscle bilaterally and measurements were taken 45 min later to ensure full adhesion.Main Outcome Measures:The Wingate cycle ergometer test was used to assess peak anaerobic power (peak AnP, in Watts) and exercise capacity (Watt/kg), while the 6-minute walk test (6MWT) was used to assess aerobic exercise capacity of the participants. Comparisons between groups were performed using the nonparametric Mann-Whitney U test, while those between baseline and posttaping used the nonparametric Wilcoxon test.Results:No significant difference was found between the two groups in the aerobic or anaerobic test parameters (p &gt; .05). Within the groups, a significant improvement in time factors in peak AnP (929.7 2 ± 184.37 W to 1043.49 ± 224.42 W) was found only in the KT group (p = .028) and no other parameter was significantly different (p &gt; .05).Conclusions:KT applied to the quadriceps muscle can positively improve anaerobic exercise performance and athletic performance capacity. However, KT did not affect aerobic capacity. Further research is needed to show that KT can improve and support anaerobic and aerobic exercise capacity in healthy participants or athletes.

The Study on the Isokinetic Muscular Strength and Anaerobic Exercise Capacity of Visually Impaired and Non-Disabled National Judo Athletes.

The Study on the Isokinetic Muscular Strength and Anaerobic Exercise Capacity of Visually Impaired and Non-Disabled National Judo Athletes.

Increased consumption and vasodilatory effect of nitrite during exercise.

This study investigated the effects of aerobic-to-anaerobic exercise on nitrite stores in the human circulation and evaluated the effects of systemic nitrite infusion on aerobic and anaerobic exercise capacity and hemodynamics. Six healthy volunteers were randomized to receive sodium nitrite or saline for 70 min in two separate occasions in an exercise study. Subjects cycled on an upright electronically braked cycle ergometer 30 min into the infusion according to a ramp protocol designed to attain exhaustion in 10 min. They were allowed to recover for 30 min thereafter. The changes of whole blood nitrite concentrations over the 70-min study period were analyzed by pharmacokinetic modeling. Longitudinal measurements of hemodynamic and clinical variables were analyzed by fitting nonparametric regression spline models. During exercise, nitrite consumption/elimination rate was increased by ∼137%. Cardiac output (CO), mean arterial pressure (MAP), and pulmonary artery pressure (PAP) were increased, but smaller elevation of MAP and larger increases of CO and PAP were found during nitrite infusion compared with placebo control. The higher CO and lower MAP during nitrite infusion were likely attributed to vasodilation and a trend toward decrease in systemic vascular resistance. In contrast, there were no significant changes in mean pulmonary artery pressures and pulmonary vascular resistance. These findings, together with the increased consumption of nitrite and production of iron-nitrosyl-hemoglobin during exercise, support the notion of nitrite conversion to release NO resulting in systemic vasodilatation. However, at the dosing used in this protocol achieving micromolar plasma concentrations of nitrite, exercise capacity was not enhanced, as opposed to other reports using lower dosing.

Influence of passive hyperthermia and diurnal variation on exercise performance and cognitive function in the heat

Both aerobic and anaerobic exercise performances have a diurnal variation. As commonly reported in previous studies, circadian rhythm in exercise performance is low in the morning and peaks in the evening. It has been demonstrated that hyperthermia before exercise attenuates subsequent exercise performance in the heat. However, combined effects of passive hyperthermia and the time-of-day on both aerobic and anaerobic exercise capacity and cognitive function in the heat have not been evaluated. Therefore, the aim of this study was to examine the effects of passive hyperthermia and circadian rhythm on aerobic and anaerobic exercise performances and cognitive function after exercise in the heat.

Doping in sport: effects, harm and misconceptions.

Doping in sport is a widespread problem not just among elite athletes, but even more so in recreational sports. In scientific literature, major emphasis is placed on doping detection, whereas detrimental effects of doping agents on athletes' health are seldom discussed. Androgenic anabolic steroids are well known for their positive effects on muscle mass and strength. Human growth hormone also increases muscle mass, although the majority of that is an increase in extracellular fluid and not the functional muscle mass. In recreational athletes, growth hormone does not have major effect on muscle strength, power or aerobic capacity, but stimulates anaerobic exercise capacity. Erythropoietin administration increases oxygen-carrying capacity of blood improving endurance measures, whereas systemic administration of beta-adrenergic agonists may have positive effect on sprint capacity, and beta-adrenergic antagonists reduce muscle tremor. Thus, there are certain drugs that can improve selective aspects of physical performance. However, most of the doping agents exert serious side-effects, especially when used in combination, at high doses and for a long duration. The extent of long-term health consequences is difficult to predict, but likely to be substantial, especially when gene doping is considered. This review summarises the main groups of doping agents used by athletes, with the main focus on their effects on athletic performance and adverse effects.

Physiological Characteristics of an Aging Olympic Athlete

To investigate the physiological basis of continued world-class performance of a world-class rower who won medals (three gold and two bronze) at five consecutive Olympic Games. From the age of 19 to 40 yr, maximal oxygen uptake (VO2 max), peak HR, blood lactate, and rowing ergometer performance were assessed annually. During the first years of his elite career (from age 19 to 24), VO2 max increased from 5.5 to approximately 5.9 L · min(-1) (78 mL · min(-1) · kg(-1)) and his average power during 6-min maximal rowing increased from 420 to approximately 460 W. Although his HRmax declined by approximately 20 bpm during the 20-yr period, maximal aerobic power, evaluated both as VO2 max and 6-min test performance, was maintained until the age of 40. Furthermore, peak lactate levels remained unchanged and average power outputs during 10-s, 60-s, and 60-min ergometer tests were all maintained at approximately 800 W, approximately 700 W, and approximately 350 W, respectively, indicating that he was able to preserve both aerobic and anaerobic exercise performances. Echocardiographic analyses revealed a left ventricular mass of 198 g and left ventricular end-diastolic diameter of 5.8 cm. This longitudinal case indicates that until the age of 40 yr, a steady increase in the oxygen pulse may have compensated for the significant decline in the maximal heart frequency. Furthermore, the maintenance of aerobic and anaerobic exercise capacities allowed this Olympic athlete to compete at the highest level for almost two decades.

Effects on Electro-Chemical Screen and Anaerobic Exercise Capacity Caused by Short-Term Weight Loss in Amateur Boxing Players

Effects on Electro-Chemical Screen and Anaerobic Exercise Capacity Caused by Short-Term Weight Loss in Amateur Boxing Players

Evaluation of physical fitness parameters in patients with schizophrenia

The aims of this study were to compare aerobic and anaerobic exercise capacities, pulmonary functions, body composition and fat distribution parameters in patients with schizophrenia and healthy controls and to investigate the associations among these parameters. Sixty (30 male, 30 female) patients with schizophrenia and 60 (30 male, 30 female) healthy controls were included in the study. Maximal aerobic capacity was estimated with the Astrand submaximal exercise protocol, and anaerobic performance was determined with a Wingate test. Body composition was established with a bioelectrical impedance analyzer. Pulmonary function tests, skinfold thickness and body circumference measurements were also carried out. Maximal aerobic capacity, maximal anaerobic power, anaerobic capacity and pulmonary function tests (forced vital capacity and maximal voluntary ventilation) were found to be lower in male and female schizophrenic groups as compared to the controls. Body fat percentage, waist and abdomen circumferences, and waist to hip ratio were found to be higher in female schizophrenic patients than in controls. We suggest that maximal aerobic capacity, maximal anaerobic power, and anaerobic capacity are poor in the schizophrenia patients as compared to healthy controls. Low cardiorespiratory fitness is related to reduced pulmonary function and impaired body composition in schizophrenia patients.

Differences of aerobic·anaerobic exercise capacity according to performance level in male wheelchair tennis players

Differences of aerobic·anaerobic exercise capacity according to performance level in male wheelchair tennis players

Growth Hormone and Muscle Strength in Children

When I was asked to write an editorial to comment on the article by Simon et al (1) in this issue of the Journal, I felt it would be a real challenge. The use of GH therapy in children has provoked more discussion in the last few years from a legal, journalistic, economical, and even political point of view than from medical and scientific perspectives. I decided to take the challenge and to comment on the facts as I perceive them. An impact of recombinant human GH (rhGH) on muscle strength is controversial. As physicians, we are essentially warned about rhGH doping in professional and Olympic athletics, with the presumption that it has a beneficial effect on muscle strength. This is despite the fact that there appears to be no evidence that rhGH enhances muscle strength, power, or aerobic capacity in trained adult athletes. However, rhGH does increase modestly anaerobic exercise capacity when administered alone and to a greater extent when combined with testosterone (2). Thus, despite the abuse of rhGH by athletes, there is little support of performance benefit except for an effect on anaerobic exercise capacity (2). In GH-deficient patients, replacement of rhGH improves aerobic exercise capacity, although it remains to be elucidated whether this is due to the direct effect on muscle function or on other factors influencing cardiovascular function, well-being, and motivation. Long-term rhGH replacement in excess of 12 months seems to be required for improved muscle strength to take place in GH-deficient adult subjects (2). It has been reported that 10 years of rhGH replacement therapy in GH-deficient adults increased muscle strength during the first half of the study and then protected partly against the normal decline withage inmusclestrength,resulting inapproximatelynormalized muscle strength after 10 years (3). Even fewerdataareavailable inchildren,with theexception of data gathered from children affected with Prader-Willi syndrome(PWS),araregenetic formofobesitywithhypothalamic involvement that leads to GH deficiency. One group assessed the impact of rhGH therapy begun early in life on the natural history of PWS and compared height, body composition, and strength in similar-age children with PWS naive to rhGH with those treated with hGH for 6 years (4). Motor strength testing included broad jump, agility run, sit-ups, and upper arm strength assessments. The evaluator of motor strength testing was blinded to the treatment status of each child. PWS children treated with rhGH demonstrated greater motor strength (increased standing broad jump 22.9 2.1 vs 14.6 1.9 inches (P .001) and sit-ups 12.4 0.9 vs 7.1 0.7 repetitions in 30 seconds; P .001). Clear trends were seen in the 2 other areas of the testing, including improved agility run and weight-lift repetitions, although these did not reach statistical significance. Thus, thisnonrandomizedstudysuggestedabeneficialeffecton muscle strength in children affected by PWS. However, these few reports on young active adults, on GH-deficient adults, and on children affected by PWS may not be relevant to the chronically ill and less active children included in the study of Simon et al (1). In this study, the authors evaluated the effects of rhGH on muscle strength in children receiving long-term glucocorticoid therapy. Expected effects of growth hormone on height and body composition were assessed and confirmed, but those will not be commented upon here. This was a pilot study, randomized and controlled, with a delayed-start of rhGH for 12 months. rhGH was started after randomization (month 0) or 6 months later (month 6). A total of 30 children with various diagnoses, on glucocorticoid therapy for a chronic disease, startedat least1year earlierwithheight1SDorat2SDscore (SDS) below and bone age 15 years in boys and 13 years in girls. rhGH was administered at a dose of 0.065 mg/kg/d for 6monthsandtheninthedosagemaintainingserumIGF-1levels