In the past decade, governments and development agencies have contributed significantly to society through anaerobic digestion technology (ADT). Anaerobic digestion technology (ADT) has become an important tool in the fight against global poverty and environmental issues, leading to positive change in communities around the world. The technology works as a wet or dry process, depending on its classification. The process is complex and yields multiple benefits, such as creating a natural fertilizer that can be used to help crops grow, as well as generating renewable energy sources. It is common knowledge that many household-sized digesters installed in different areas are one-stage digesters. One-stage digesters do not require a separate pre-treatment stage before the digestion process. This makes them simpler and more cost-effective to install and operate than traditional two-stage digesters. Thus, some drawbacks are associated with these systems since they feed on just one type of feedstock. Many researchers fail to adequately address interactions critical to ADT’s operation, including interactions among growth factors and operating parameters. In a single-stage and one-substrate digester, researchers commonly neglect to study the digester feeding and operational conditions. Anaerobic digestion was the subject of this review, covering research conducted between 2001 and 2022. The study identified a significant drawback associated with mono-digestion and single-stage digestion. The findings illustrate that mono-substrate and single-stage digestion are worthwhile approaches, even though they have their challenges. However, adding a further digestion stage can significantly improve biogas production.