Anemia In Pregnancy Research Articles

Risk Factors for Anemia in Adolescent Pregnancies: Evidence From the Lembah Pantai Urban Health District in Malaysia.

Introduction Adolescent pregnant mothers are at higher risk of acquiring anemia during pregnancy, which has detrimental consequences for the mother and baby. Untreated and prolonged anemia can lead toperinatal morbidity and mortality and antepartum, intrapartum, and postpartum maternal morbidity.Anemia among adolescent pregnant mothers can be attributed to many factors, such as poor nutrition and the physiological demands of pregnancy. Hence, this study aimed to determine the prevalence and characteristics of anemia among adolescent pregnancies in Lembah Pantai Health District in an urban setting. Materials and methods This cross-sectional study utilized secondary data from registry records of adolescentpregnant mothers in the Lembah Pantai District Health Office in Kuala Lumpur,Malaysia from 2019 to 2022. All adolescent pregnancies aged 10 to 19 years were included in this study. Those with a prior diagnosis of thalassemia or other hematological disorders, as indicated in their medical records, were excluded from the study. The chi-square (χ2) test was applied to elicit the association at a univariate level, and those variables with a p-value of <0.25 were included in a multiple logistic regression model. Results A total of 307 records were reviewed, and 272 pregnant adolescent cases were eligible for the analyses. The prevalence of anemia among teenage pregnancies from 2019 to 2022 was 28.7% (95% CI: 23.0-33.6). This prevalence was lower than in many lower-income countries and developing countries.Factors that were significant on using multiple logistic regression analysis included marital status (unmarried) (AOR: 1.87, 95% CI: 1.01-3.45, p=0.046), residing area Seputeh (AOR: 0.29, 95% CI: 0.14-0.61, p=0.001), and third trimester of first antenatal visit/booking (AOR: 5.08, 95% CI: 2.02-12.70, p<0.001).The population in the Seputeh area has a higher overall household income in comparison toLembah Pantai. Conclusions According to the WHO classification, the prevalence of anemia among adolescent pregnant women at the Lembah Pantai District Health Office reflects amoderate public health issue. Consequently, anemia may exacerbate the impact of other health conditions in this population.Hence, local health authorities should ensure that anemia is adequately addressed without ignoring other crucial health issues. A multidisciplinary, comprehensive, holistic strategy involving healthcare providers, school health teams, and community assets offers a potential solution. Strategies that can be employed include providing targeted health and nutrition education in schools through school health teams. Additionally, establishing adolescent-friendly health clinics tailored to the specific needs of pregnant adolescents and enhancing antenatal services to ensure comprehensive screening and management of anemia should also be implemented.Hence, this will ensure achieving safe motherhood goals through an effective healthcare response.

Effect of consumption of millets on prevalence and severity of anaemia during pregnancy

Background: Anaemia is the commonest medical disorder in pregnancy. Methods: A cross-sectional study was performed on 430 pregnant women in second and third trimester of pregnancy to know the effect of consumption of millets on prevalence of anaemia. Results: A total of 42 (9.77%) women (group one) consumed millets in pregnancy while 388 (90.33%) didn’t consume millets (group 2). Mean age, parity, body mass index (BMI), and gestation were 26.4±4.3 years, 1.9±0.8, 22.6±2.6 kg/m2 and 29.3±2.8 weeks in group 1 and 26.8±4.4 years, 2.1±0.9, 23.1±2.7 kg/m2 and 28.2±2.7 weeks in group 2 respectively, and were similar. Patients education, occupation and mean family income were similar in two groups. Out of 42 patients consuming millets in pregnancy, pearl millet, sorghum, finger millet and barley were consumed by 47.62%, 11.90%, 14.28% and 14.28% patients respectively. Mean calories were equal in the two groups, but mean proteins and iron were significantly higher in group 1 than in group 2 (61.28±6.2 gm and 31.4±3.42 mg versus 56.75±5.7 gm and 22.5±2.51 mg). The prevalence of anaemia was significantly less (40.48%) in group 1 (millets group) than in group 2 (49.74%) (p=0.04). Mild, moderate, and severe anaemia were all less common in the millets group than in non-millet group. Conclusions: The prevalence of anaemia in pregnancy was significantly less common in women consuming millets. There is need to encourage consumption of millets in pregnancy to reduce prevalence of anaemia in pregnancy.

PENCEGAHAN ANEMIA PADA IBU HAMIL MELAUI “PEDIKUR“ (PENDEKATAN EDUKASI DAN PUDING KURMA) DI DESA WONOSARI – NGORO

Anemia in pregnancy is still a major problem experienced by almost half of pregnant women in all countries in the world including Indonesia. Many pregnant women refuse and do not comply with taking FE tablets for various reasons so that the prevalence of anemia in pregnant women is still high. A mother is said to be compliant with taking FE tablets if ≥ 90 % of the amount should have been taken. Anemia in pregnancy is a national problem because it reflects the value of the socio-economic welfare of the community, and has a very large impact on the quality of human resources, which is called "potential danger to mother and child". The purpose of the service is to provide education on the addition of nutrients to reduce anemia. Based on the results of the activity, the delivery of material. The results of this activity are the participation of pregnant women during educational and simulation activities running smoothly, indicated by the activeness of pregnant women and attended by all pregnant women class participants and there is an increase in understanding of anemia by 50 %. The service was carried out on 23 June 2023 at Waonosari Polindes in the class of pregnant women. The method used was education and simulation in making soy milk and date pudding. Indonesia itself has an anemia prevention program for pregnant women by providing a minimum FE supplement of 90 tablets during pregnancy.

Edukasi Anemia melalui Kelas Ibu Hamil Menggunakan Buku Saku Cegah Anemia pada Kehamilan sebagai Upaya Pencegahan Anemia pada Ibu Hamil

Anemia is one of the most frequent complications associated with pregnancy. Normal physiological changes in pregnancy affect hemoglobin (Hb) and there is a relative or absolute decrease in Hb concentration. Anemia adversely affects maternal and fetal well-being and is associated with increased fetal morbidity and mortality. Adverse perinatal outcomes includeintrauterine growth retardation (IUGR), prematurity and low birth weight are significant risks of death, especially in developing countries. This service to society is of a natureeducational persuasive by providing health education in the form of health education about anemia in pregnancy through classes for pregnant women using media in the form of a pocket book to prevent anemia in pregnancy. The characteristics of pregnant women who took part in this community service activity included an average age of 29.13 years, most of them had low and middle education, did not work, were multigravida and most were in the third trimester of pregnancy. The average knowledge score of pregnant women before receiving health education using a pocket book to prevent anemia in pregnancy was 56 and after the education was carried out there was an increase in the knowledge score of 86 so that the pocket book could be an alternative use of health education media to increase the knowledge of pregnant women.

Implementation fidelity of intravenous ferric carboxymaltose administration for iron deficiency anaemia in pregnancy: a mixed-methods study nested in a clinical trial in Nigeria

BackgroundIron deficiency anaemia is common among pregnant women in Nigeria. The standard treatment is oral iron therapy, which can be sub-optimal due to side effects. Intravenous ferric carboxymaltose (FCM) is an evidenced-based alternative treatment with a more favourable side effect profile requiring administration according to a standardized protocol. In this study, we assessed the fidelity of administering a single dose of FCM according to protocol and identified factors influencing implementation fidelity.MethodsWe used a mixed-method approach with a sequential explanatory design nested in a clinical trial across 11 facilities in Lagos and Kano States, Nigeria. Guided by a conceptual framework of implementation fidelity, we quantitatively assessed adherence to protocol by directly observing every alternate FCM administration, using an intervention procedure checklist, and compared median adherence by facility and state. Qualitative fidelity assessment was conducted via in-depth interviews with 14 skilled health personnel (SHP) from nine purposively selected health facilities, using a semi-structured interview guide. We analyzed quantitative data using descriptive and inferential statistics in Stata and used thematic analysis to analyze the transcribed interviews in NVivo.ResultsA total of 254 FCM administrations were observed across the 11 study sites, with the majority in secondary (63%), followed by primary healthcare facilities (PHCs) (30%). Overall, adherence to FCM administration as per protocol was moderate (63%) and varied depending on facility level. The lowest level of adherence was observed in PHCs (36%). Median, adherence level showed significant differences by facility level (p = 0.001) but not by state (p = 0.889). Teamwork and availability of protocols are facilitation strategies that contributed to high fidelity. However, institutional/ logistical barriers are contextual factors that influenced the varied fidelity levels observed in some facilities.ConclusionsCollaborative teams and access to operating protocols resulted in high fidelity in some facilities. However, in some PHCs, fidelity to FCM was low due to contextual factors and intervention complexities, thereby influencing the quality of delivery. In Nigeria, scale-up of FCM will require attention to staff strength, teamwork and availability of administration protocols, in order to optimize its impact on anaemia in pregnancy.

Pengaruh Konsumsi Buah Kurma terhadap Kadar Hemoglobin Ibu Hamil dengan Anemia

Globally, the prevalence of anemia in pregnant women in developed countries is 49% and in developing countries it is 53%. In Indonesia, the rate of anemia in pregnant women is quite high, namely 48.9%. Anemia in pregnant women can increase the risk of premature birth and bleeding. One effort that can help prevent and treat anemia in pregnant women is to consume foods that are sources of iron, for example dates. The aim of the research was to determine the effect of consuming dates on hemoglobin levels in pregnant women with anemia. The research design used a quasi-experimental one group with control group. The experimental group was the group that consumed dates and Fe tablets, while the control group only consumed Fe tablets. The population is all third trimester pregnant women at PMB Lina in May 2024, totaling 24 respondents where each group consists of 12 respondents. The sampling technique used is total sampling. Based on the results of the normality test, sig. &gt;0.05, then the statistical test used is the Paired Sample T Test. The average hemoglobin level in the experimental group before being given dates and Fe tablets was 10.2 gr/dl and the average hemoglobin level after being given date palm juice was 11.4 gr/dl. The results of the Wilcoxon test obtained a p value of 0.001, meaning that there was an effect of giving dates on hemoglobin levels in pregnant women. It is hoped that health workers can increase public knowledge, especially pregnant women, about food sources high in iron so that they can prevent and reduce the incidence of pregnancy anemia. Key words: , ,

PENGARUH PEMBERIAN BUAH NAGA (Hylocerreus polyrhizus) TERHADAP PENINGKATKAN KADAR HEMOGLOBIN PADA IBU HAMIL DI PUSKESMAS NARAS

Anemia in pregnancy is a problem that requires special treatment because its prevalence is still high. According to WHO 2017, anemia in pregnancy is a condition in which a mother has a hemoglobin level of &lt;11 gr% in the first and third trimesters, while in the second trimester the hemoglobin level of pregnant women is &lt;10.5 gr. The purpose of the study was to determine the effect of giving dragon fruit (hylocerreus polyrhizus) on increasing hemoglobin levels in pregnant women in the Naras Health Center Work Area. This type of research uses an experimental method with a one group pre-test and post-test design. The sample in the study was 15 pregnant women who had anemia. Statistical tests using the Paired Sample Test. The results of the study were obtained before giving dragon fruit to pregnant women in the Naras Health Center Work Area, Pariaman City 2023 with a moderate anemia category, namely 8 respondents (53.0%). After giving dragon fruit with a mild anemia category, namely 11 respondents (73.3%). In conclusion, there is a significant effect on increasing hemoglobin (HB) levels in pregnant women with anemia after being given dragon fruit in the Naras Health Center work area, Pariaman City, with a P value of 0.001 (p&lt;0.05).

The association of umbilical cord blood oxidative stress with maternal iron deficiency anemia: A tertiary center experience.

To compare the levels of oxidative stress markers in the umbilical cord blood between pregnant women diagnosed with iron deficiency anemia (IDA) and low-risk controls. The sample consisted of 131 patients, including 55 pregnant women with IDA and 76 controls with similar demographic characteristics. Participants were selected from patients delivered at ≥37 weeks. We compared the two groups in terms of the native thiol, total thiol, disulfide, and ischemia-modified albumin (IMA) levels measured in pregnant women's umbilical cord venous blood. The native thiol and total thiol values were statistically significantly lower in the anemia group, and the disulfide and IMA values were statistically significantly higher in the IDA group (P < 0.001). Perinatal outcomes were similar between the groups. In the present study, pregnant women with IDA had lower native and total thiol values and higher disulfide and IMA values in umbilical cord blood. Iron deficiency anemia in pregnancy may be a potential cause of increased oxidative stress.

Prevalence of Iron Deficiency Anaemia Among Pregnant Women Attending Primary Health Care Center Malala Dukku Local Government Area of Gombe State, Nigeria

Iron deficiency anaemia in pregnancy is an important health issue resulting in high maternal morbidity and mortality. The purpose of the current study was to identify the prevalence of iron deficiency anaemia among pregnant women attending primary healthcare center malaladukku local government of Gombe state, the researcher pick interest on the topic as a result of high rate of anaemia in pregnancy in the research setting primary healthcare center malala, a cross sectional descriptive non-experimental design was adopted by the researcher. Questionnaire was used as a tool for data collection various literature were review which include conceptual review, theoretical review, and empirical review of prevalence, causes and preventive measures. The study assesses the prevalence iron deficiency anaemia among pregnant women, causes of iron deficiency anaemia, and the preventive measures of the condition. The result of the study shows that the prevalence of iron deficiency was high at (74.9%) many factors were considered responsible with the condition as revealed by the research work which includes previous history of the condition, imbalanced nutrition 66.6% () and malaria in pregnancy. Supplementary iron therapy during pregnancy 83.3% (), antenatal services as soon as pregnancy is confirmed, sleeping under mosquito treated net (58.3%) s and chief alternative of healthy diet (46.6%) are the preventive measures of iron deficiency anaemia as revealed by the study. There is also need for further studies on ways of preventing and reducing the rate of iron deficiency anaemia. The research work will help in enlightening the midwives, healthcare providers on the disease and its preventive measures wsith regards to clinical practice and it will also add to the body of knowledge in the medical field and the researcher’s knowledge on the condition.

CLASSİFİCATİON OF CLİNİCAL SYMPTOMS DEPENDİNG ON THE SEVERİTY OF ANEMİA İN PREGNANT WOMEN

The article provides information on the results of research conducted to study the changes in clinical signs during pregnancy in women with different degrees of iron deficiency anemia (IDA). Hemogram parameters were studied using the “ Mythic 18” (Switzerland) hematological analyzer. For this purpose, the mutual relationships between the main indicators of iron metabolism and the main symptoms of anemia were analyzed using clinical-biochemical methods in the blood of 110 women of reproductive age at various stages of pregnancy. The main contingent of the study consisted of 80 pregnant women with IDA (main group). 30 pregnant women without anemia were included in the comparison group, and 21 healthy women without pregnancy were included in the control group. It has been determined that in multiparous pregnant women, the hemoglobin level in mild anemia is Me = 10.4 (10.0-10.5), in moderate anemia Me = 8.9 (8.3-9.5), in severe anemia Me = 6.9 (6.3-6.9) p&lt;0.001; the level of iron in mild anemia is Me = 9.0 (8.0-9.4), in moderate anemia Me = 6.7 (6.1-7.7), in severe anemia Me = 5.3 (3.5-5.8) p&lt;0.001; the level of ferritin in mild anemia is Me = 19.3 (12.0-28.0), in moderate anemia Me = 9.9 (9.1-12.0), in severe anemia Me = 3.0 (2.0-8.0) p&lt;0.001. During pregnancy, significant changes occur in iron metabolism in iron deficiency anemia. Pregnancy anemia is a significant risk factor for fetal and maternal morbidity. Thus, depending on the severity of anemia, complications such as intrauterine growth retardation, chronic fetal hypoxia, preeclampsia, preterm birth, and primary birth weakness during delivery have been predominant. This allows us to carry out corrective treatment.

A Comparative Study between Efficacy of Ferric Carboxymaltose and Iron Sucrose Complex for Treatment of Iron Deficiency Anemia in Pregnancy

A Comparative Study between Efficacy of Ferric Carboxymaltose and Iron Sucrose Complex for Treatment of Iron Deficiency Anemia in Pregnancy

GAMBARAN TIPE ANEMIA PADA IBU HAMIL BERDASARKAN NILAI INDEKS ERITROSIT DI RSIA RESTU IBU TAHUN 2022

Anemia in pregnant women is a global problem that impacts both mother and fetus. Anemia in pregnancy is associated with maternal morbidity and is an indirect cause of maternal death in the entire population of pregnant women. Classification of anemia based on the erythrocyte index value is divided into normochromic normocytic, normochromic macrocytic, hypochromic microcytic and hypochromic macrocytic anemia. The erythrocyte index values ​​are divided into Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH) and Mean Corpuscular Hemoglobin Concentration (MCHC). The aim of the research is to describe the types of anemia in pregnant women based on the erythrocyte index value at RSIA Restu Ibu Sragen in 2022. This research uses a quantitative descriptive research type with a retrospective approach. The research sample was 51 medical records of pregnant women who experienced anemia at RSIA Restu Ibu Sragen in January-December 2022 using purposive sampling. The materials and tools used were secondary data from laboratory examination results of pregnant women diagnosed with anemia which included hematocrit, hemoglobin, index erythrocytes (MCV, MCH, and MCHC), Microsoft Excel and SPSS Version 21 software. Data analysis used analysis univariate. The results of the study concluded that pregnant women who experienced anemia at RSIA Restu Ibu Sragen were aged 21-34 years with a third trimester pregnancy and were primigravida. Based on the erythrocyte index, normocytic anemia was normochromic in 18 people (35.3%), microcytic hypochromic anemia in 20 people (39.2%), and macrocytic hypochromic anemia in 13 people (25.5%). So it can be said that most pregnant women experience microcytic hypochromic anemia.

Novel TMPRSS6 variants and their impact on iron-refractory iron deficiency anaemia in pregnancy: A North Indian genotype phenotype study.

Iron-refractory iron deficiency anaemia (IRIDA) is a rare autosomal recessive disorder, distinguished by hypochromic microcytic anaemia, low transferrin levels and inappropriately elevated hepcidin (HEPC) levels. It is caused by mutations in TMPRSS6 gene. Systematic screening of 500 pregnant women with iron deficiency anaemia having moderate to severe microcytosis with no other causes of anaemia were enrolled to rule out oral iron refractoriness. It identified a final cohort of 10 (2.15% prevalence) individuals with IRIDA phenotype. Haematological and biochemical analysis revealed significant differences between iron responders and iron non-responders, with iron non-responders showing lower haemoglobin, red blood cell count, serum iron and serum ferritin levels, along with elevated HEPC (9.47 ± 2.75 ng/mL, p = 0.0009) and erythropoietin (4.58 ± 4.07 µ/mL, p = 0.0196) levels. Genetic sequencing of the TMPRSS6 gene in this final cohort identified 10 novel variants, including seven missense and three frame-shift mutations, with four missense variants showing high functional impact defining the IRIDA phenotype. Structural analysis revealed significant damage caused by two variants (p.L83R and p.S235R). This study provides valuable insights into IRIDA among pregnant women in the Indian subcontinent, unveiling its underlying causes of unresponsiveness, genetic mechanisms and prevalence. Furthermore, research collaboration is essential to validate these findings and develop effective treatments.

Retrospective audit compares screening and treatment of pregnancy-related anaemia in regional New South Wales with Australian guidelines

BackgroundAnaemia during pregnancy is common worldwide. In Australia, approximately 17% of non-pregnant women of reproductive age have anaemia, increasing to a rate of 25% in pregnant women. This study sought to determine the rate of screening for anaemia in pregnancy in regional New South Wales, and to determine whether screening and treatment protocols followed the recommended guidelines.MethodsThis retrospective study reviewed antenatal and postnatal (48 h) data of women (n = 150) who had a live birth at Bathurst Hospital between 01/01/2020 and 30/04/2020. Demographic data, risk factors for anaemia in pregnancy, antenatal bloods, treatments provided in trimesters one (T1), two (T2) and three (T3), and postpartum complications were recorded. These were compared to the Australian Red Cross Guidelines (ARCG) using descriptive statistics.ResultsOf the women with screening data available (n = 103), they were mostly aged 20-35yrs (79.6%), 23.3% were obese, 97.1% were iron deficient, 17% were anaemic and only a few (5.3%) completed the full pregnancy screening as recommended by the ARCG while a majority completed only partial screenings specifically Hb levels in T1 (56.7%), T2 (44.7%) and T3 (36.6%). Compliance to oral iron was largely undocumented, but constipation was a common side effect among the women. IV iron was administered in 14.0% of women, approximately 1.75x higher than the recommended rate.ConclusionsThis study provided useful information about compliance to screening and treatment guidelines for anaemia in pregnancy. We identified the need for improved documentation and communication between various health providers to ensure adequate antenatal care to prevent maternal complications during pregnancy. This will improve patient care and encourage further developments in maternal care, bridging the rural health gap.

Data integrity of 14 randomised controlled trials

BackgroundA review of the literature on iron treatments for iron-deficient anaemia in pregnancy indicated duplication of baseline and outcome tables in two separate randomised controlled trials (RCTs) that share only a single author. AimTo assess the integrity of randomised clinical trials from Dr A.M. Darwish, Assiut University, Egypt. DesignAssessment of Research Integrity. MethodsWe tabulated the characteristics of studies, compared baseline and outcome tables between articles and looked for implausible findings. We used the distribution of baseline p-values to assess whether the summary statistics of baseline characteristics were consistent with properly conducted randomisation. ResultsWe identified 14 RCTs (1,405 participants) published between October 2004 and September 2019. Two pairs of studies showed considerable similarities in baseline characteristics, while another pair of studies was plagiarized. The analysis of baseline p-values indicated a low probability that all the studies featured randomised treatment allocation. ConclusionOur analysis of the RCTs of Dr Darwish suggests possible integrity problems. We recommend a critical investigation of the studies that have not been retracted. Until that has been completed, these studies should not be used to inform clinical practice.

Pregnancy Anaemia: Improving Treatment Success with Oral Iron

Pregnancy Anaemia: Improving Treatment Success with Oral Iron

Associations Between Clinical, Diet, and Social Determinants of Health and Hemoglobin and Anemia in Early Pregnancy

Associations Between Clinical, Diet, and Social Determinants of Health and Hemoglobin and Anemia in Early Pregnancy

Neighborhood Structural and Social Determinants of Health (SSDoH) Predict Pregnancy Anemia in Chicago

Neighborhood Structural and Social Determinants of Health (SSDoH) Predict Pregnancy Anemia in Chicago

Pemeriksaan Haemoglobin pada Ibu Hamil Desa Bangun Rejo Kecamatan Tanjung Morawa Kabupaten Deli Serdang Provinsi Sumatera Utara Tahun 2024

Anemia is the most common nutritional problem in Indonesia and in the world. Anemia is a condition where red cells are insufficient to meet the body's physiological needs. Basically, anemia is a condition where there is a decrease in hemoglobin, hematocrit and erythrocyte count below normal values. The process of this activity starts from the preparation, implementation and evaluation stages. The result was that the participants were 23 pregnant mothers who lived in Bangun Rejo Village. During the implementation, the mothers' hemoglobin levels were checked after which they were given education about anemia in pregnancy. The conclusion of this service is that 19 pregnant women (82.6%) did not experience anemia and 4 people (17.4%) experienced mild anemia and after the examination, pregnant women were given education about anemia in pregnant women. It is hoped that pregnant women will pay more attention to the condition of their pregnancy and eat food that contains good nutrition for pregnant women and have their condition checked regularly.

Hubungan Pengetahuan Ibu Hamil Tentang Anemia dengan Kepatuhan Konsumsi Tablet Fe di BPM Boloni Tanaka Kec. Medan Johor Tahun 2023

Insufficient knowledge about anemia has an influence on health behavior, especially when a woman is pregnant, which will result in less than optimal health behavior for pregnant women to prevent pregnancy anemia. Pregnant women who have less knowledge about anemia can result in less consumption of foods containing iron during pregnancy due to their ignorance. Objective: To determine the relationship between pregnant women's knowledge about anemia and compliance with taking Fe tablets. Research population: the population used is the population of all patients at BPM Boloni Tanaka Kec. Medan Johor in 2023 as many as 32 pregnant women. Research Type: The type of research used is an analytical survey with a cross sectional research design. Data collection uses a questionnaire. Data were processed using univariate analysis using descriptive statistics and bivariate analysis using the Chi-square test. The results of the Chi-square test analysis show that the p value = 0.000, which means less than α = 0.05, so it can be concluded that there is a significant relationship between pregnant women's knowledge about anemia and compliance with consuming Fe tablets at BPM Boloni Tanaka District. Medan Johor in 2023.