Knowledge of Nanoscale-structures sustainability is strongly associated with the reliability and the performances of Nano-electro-mechanical systems such as Nanoactuators and Nano-sensors that are widely used in bio-applications. Therefore, the damages in these types of infinitesimal systems must be quickly and accurately detected, located, and repaired. In this study, a novel damage detection framework in Carbon Fiber Reinforced Polymer (CFRP) composite Nanoscale-Pipes (CNP) subjected to the fatigue effect of water internal pressure and thermal effect via Nanoscale-electrical capacitance sensors (NECS). First, a finite element model (FEM) of CNP damage is established, then the electrical potential difference (EPD) between the Nanoscale-electrodes (NEs) pairs before and after damage is measured. The distributed NECS measuring nano-electrodes are installed around the CNP and load the transient external excitations between each other. It is proposed and applied the transfer function (TF) of the CNP as an "open loop control" system to reflect the evolution of damage. The accuracy and reliability of the suggested technology are verified through the experimental results available in the literature. The results show that when the damage under NEs pairs has begun to grow, the signal amplitude value will change suddenly and sensitively, which demonstrates the effectiveness of the proposed method and the good potential for engineering applications.