Amounts Of Zinc Research Articles

Composite dietary antioxidant intake and osteoporosis likelihood in premenopausal and postmenopausal women: a population-based study in the United States.

Osteoporosis is a skeletal disease characterized by low bone mass, reduced bone strength, and increased fracture risk. We aimed to investigate the association between combined dietary antioxidant intake and the likelihood of osteoporosis in premenopausal and postmenopausal women, based on data from the National Health and Nutrition Examination Survey. Nutrient intake data were obtained using two 24-hour recalls. Composite dietary antioxidant index (CDAI), which refers to the intake amounts of β-carotene, vitamin A, vitamin C, vitamin E, selenium, zinc, copper, and iron, was then constructed. Prevalent osteoporosis was defined according to bone mineral density T scores of ≤ -2.5 and self-reports. Multiple logistic and Poisson regression models were used for association analyses. A total of 3,418 participants (1,157 premenopausal and 2,261 postmenopausal women) 40 years or older were included, 776 (22.70%) of whom had prevalent osteoporosis. In terms of individual nutrients, postmenopausal women in the highest CDAI quartiles for dietary β-carotene, vitamin A, vitamin C, and iron intakes had a low likelihood of osteoporosis. Regarding the CDAI-osteoporosis association, postmenopausal women in the highest quartile were less likely to have osteoporosis (OR Q3 vs Q1 , 0.64; 95% CI, 0.43-0.96; OR Q4 vs Q1 , 0.56; 95% CI, 0.35-0.89; P for trend = 0.013), after controlling for covariates. CDAI was negatively associated with the likelihood of osteoporosis in postmenopausal women. Our findings suggest that the combined intake of antioxidant nutrients can help reduce the likelihood of osteoporosis in women.

Micronutrient Mineral and Nutrient Content of Volcanic Soils and Creeks from the Montserrat Soufriere Hills Volcano. Nature’s Fertilizer: Mineral Nutrient Content of Volcanic Soils

Agricultural soils and potable water supplies provide a major source of minerals known to be essential for plant and animal health. After several hundred years of relative quiescence, the Soufriere Hills Volcano of Montserrat roared back to life in 1995 through 1997, wreaking severe havoc and severe damage to the geography and ecosystems and serious immediate and chronic health risks to the remaining inhabitants of the Island. The pyroclastic ash flow reached temperatures of 1500 °F and progressed down the hillsides at speeds of 80 mph, causing incineration and virtual destruction of everything in its path, while the gaseous and particulate laden plume reached altitudes of 7 miles (10.7 km), impacting air quality and aircraft navigation in the region. A total of 19 individuals became entrapped in the lava flow, and perished quickly as a direct result of the volcanic eruption. Volcanic soils derive from deeper layers of the earths surfaces and are notoriously rich in mineral nutrients representative of those deep mineral deposits. While virtually all combustible objects in the path of the raging ash flow become incinerated within minutes, the aftermath of the eruptions delivers the mineral rich constituents over a wide swath of the surrounding geography often reaching miles from the volcanic origin. Soils and consumable water sources are well known to provide a reliable community source of essential minerals in human nutrition, and in their chronic absence, numerous pathologic sequela may develop. To determine the mineral content of surrounding surface soils, samples of surface ash layers and nearby creeks were obtained from 7 regions and 3 free-flowing creeks and subjected mineral analysis. The surface ash specimens contained abundant amounts of the nutrients Iron, Calcium, Sodium, Magnesium, Sulfur, and non-nutrient Aluminum, intermediate amounts of potassium, Phosphorous, and Manganese, and small amounts of Boron, Copper and Zinc. Creek water runoff originating from higher elevations was consistently acidic with a healthy mean pH of 5.1, and contained smaller proportions of the same minerals, reflective of their relative effective solubility in the acidic water. Thus, the volcanic ash flow while devastating to the environment and public health in the immediate aftermath, provided numerous minerals important to plant and animal nutrition and to human health and health water sources which contributed to the longer-term reinstitution of edible plants and to the recovery of the vibrant lush greenery of the Emerald Isle of the Caribbean.

Evaluation of Nutritional Profile of Periwinkle (Tympanotonus Fuscatus) from Ekeuku Market, Owerri, Imo State

Shellfish meat are popular due to their high protein content, low carbohydrate values, low fat/cholesterol profile, and the presence of some vital minerals such as copper, calcium, zinc, iron, and manganese. High nutritional values in shellfish has resulted in an increase in demand for the resource which eventually influences the economic growth in both local and international markets. The nutritional profile of periwinkle (Tympanotonus fuscatus) was studied with the aim of providing health related information to consumers. The proximate analysis was evaluated using standard analytical procedures. Results showed that periwinkle samples contained 3.69±0.63% ash, 38.38±0.19% moisture, 20.21±0% protein, 0.25±0.04% fat, 4.33±0% crude fibre and 33.15±0.78% carbohydrate. The results also revealed the mineral content of periwinkle thus: manganese content was 1.30ppm, magnesium content was 9.64ppm, calcium content was 1.55ppm, lead was 0.00ppm, iron was 5.60ppm and zinc was 0.11ppm. The findings from this work showed that periwinkle contained considerable amounts of protein, carbohydrate, ash, fibre, manganese, magnesium, calcium, iron and zinc but low in fat with no lead content. Thus, increase consumption of periwinkle may help address micronutrient and protein deficiency problems.

Meniscus-confined electrochemical additive manufacturing of copper microstructures: Design, fabrication, characterization, and decorative art technology

For the first time, a room-temperature meniscus-confined electrochemical additive manufacturing (MC-ECAM) process is evaluated as a potential decorative art technology for fabricating copper metal. The MC-ECAM has proven to be an excellent method for large-scale printing of decorative copper artworks such as warli art, plant leaves, and paintings. The inherent nature of the MC-ECAM process has the potential to eliminate the traditional time-consuming route to producing such copper microstructures and provide a one-step and efficient solution. The TEM and FE-SEM results revealed that well-oriented microstructures are prepared without surfactant, indicating the ECAM self-assembly mechanism. A small amount of zinc is added to the copper system to prevent corrosion. The XRD analysis also revealed the formation of copper metal, which barely changed even after 10 months of atmospheric ageing with the addition of 2% zinc. The XPS results show that zinc provides excellent stability for the ECAM-printed copper microstructure, further examined by an electrochemical corrosion study. Zinc act as a barrier to corrosion, and the results show that the Cu-Zn 2% exhibits excellent corrosion resistance than the pure copper microstructures.

Acid Resistance and Ion-Exchange Capacity of Natural Mixtures of Heulandite and Chabazite

The recovery and immobilization of metals from wastewater often occurs in an acidic environment that destroys the structure of adsorbents such as zeolites, which are porous crystalline aluminosilicates. The influence of hydrochloric acid solutions on the structure and properties of two natural mixtures of heulandite (HEU) and chabazite (CHA)—tuff from the Georgian Dzegvi-Tedzami deposit (HEU/CHA ≈ 8) and rock from the Kazakhstani deposit Chankanay (HEU/CHA≈1)—was studied by the X-ray energy dispersion spectra and diffraction patterns, as well as by adsorption of water, benzene, and nitrogen methods. It was found that acid-mediated dealumination, decationization, dissolution, and changes in systems of micro- and mesopores depend on the nature and chemical composition of the initial zeolites. It is concluded that, under the influence of acid, (i) zeolite micropores become accessible to relatively large molecules and ions, and the surface area of the adsorbent increases; (ii) the volume of mesopores decreases, and pores with a diameter of less than 4 nm become predominant; (iii) in terms of the degree of dealumination and dissolution rate, Kazakhstani zeolite is more acid-resistant than Georgian heulandite; and (iv) Kazakhstani zeolite retains a high ion-exchange capacity in an acidic environment, while Georgian heulandite, treated with dilute hydrochloric acid solutions, uptakes relatively high amounts of valuable silver, copper, and zinc.

Serum zinc levels in children aged two months to five years in hospitalized children with pneumonia

Background: Pneumonia is the infection of the lung parenchyma which is one the leading cause of morbidity and mortality among under five age group. The prime aim of this study is to identify the severity and to supplement the children with factors that reduce the mortality caused by pneumonia, zinc being one of the major factors in the immune defense mechanism in reducing the severity and mortality. Our study estimates the amount of zinc in severe pneumonia child thereby to arrive at a rationale to supplement zinc among Pneumonia children to reduce the course of illness. The core objective of this study is to compare serum zinc level in children with severe pneumonia among different age and sex. Methods: A prospective case-control study was carried out with 50 cases and 50 controls in age group of 2 months to 5 years admitted in Government Cuddalore Medical College, Chidambaram. The study period ranges from December 2020 to December 2022. The cases are identified as per history thorough clinical examination and radiological evidence based on IMNCI criteria. All the children in both case and control group were subjected to serum-zinc level analysis after obtaining informed consent from the Parents. Zinc level in both groups were compared and analyzed. Statistical package for the social sciences (SPSS) version-16 was used as a statistical tool. Ethical clearance has been obtained. Results: The mean serum zinc level in children admitted with pneumonia is 55.126 and the mean serum zinc level in controlled growth is 78.803. Zinc level is significantly lower in children with pneumonia. Conclusions: The estimated mean serum zinc levels in pneumonia group children confirms that there is a relative zinc deficiency in children with pneumonia and may play a role in the severity progression. Our study supports the need for zinc supplementation in pneumonia children to boost their immune defense mechanism which in turn reduces the severity and the progression of pneumonia. It tends to curtail the case fatality rate of pneumonia.

Biofertilizers Improve the Leaf Quality of Hydroponically Grown Baby Spinach (Spinacia oleracea L.)

Plant nutrition through mineral fertilizers is commonly used in soilless culture systems. Our study aims to replace intensive mineral fertilizers with bio-fertilizers, at least partially. We supplemented 50% of the mineral fertilizers with Chlorella vulgaris microalgae, a mix of beneficial bacteria and mycorrhiza. In addition, we investigated how to enhance spinach quality by implementing a sustainable and eco-friendly production method. Our research focused on analyzing the parameters of leaf quality and nitrate accumulation of baby spinach grown in a floating culture system utilizing biofertilizers. When mycorrhiza, algae, and bacteria supplemented 50% of mineral fertilizers, 17.5%, 20%, and 21.9% fewer leaf yields than 100% mineral fertilizers (5270 g m−2) were achieved. However, biofertilizers improved the internal leaves’ quality of hydroponically grown baby spinach. The highest amount of total phenolic (356.88 mg gallic acid 100g−1), vitamin C (73.83 mg 100 g−1), total soluble solids (9.4%), phosphorus (0.68%), and iron (120.07 ppm) content were obtained by using mycorrhiza. Bacteria induced the lowest nitrate content (206 mg kg−1) in spinach leaves, while 100% mineral fertilizers showed the highest nitrate (623 mg kg−1) concentration. Moreover, bacteria provided the highest SPAD-chlorophyll (73.72) and titrable acidity (0.31%). The use of microalgae, Chlorella vulgaris, induced the highest amount of potassium (9.62%), calcium (1.64%), magnesium (0.58%), zinc (75.21 ppm), and manganese (64.33 mg kg−1). In conclusion, our findings demonstrate that the utilization of biofertilizers has the potential to significantly reduce the reliance on mineral fertilizers by up to 50%. Furthermore, an improvement in the quality of baby spinach, as evidenced by an increase in health-beneficial compounds, is possible. Thus, implementing biofertilizers in the cultivation of soilless baby spinach presents a promising approach to achieving both environmental sustainability and improved crop quality.

Milk from Halari Donkey Breed: Nutritional Analysis, Vitamins, Minerals, and Amino Acids Profiling

This current research set out to characterize Halari donkey milk by investigating its nutritional constituents, including its proximate analysis, water activity, titratable acidity, energy, and microbiological analysis. A comprehensive profiling of vitamins, minerals, and amino acids was also carried out. It was found that the composition of Halari donkey milk was consistent with previously published donkey milk literature and was comparable to that of human milk. Halari donkey milk has low 0.86 ± 0.04% fat content, 2.03 ± 0.03% protein content, 0.51 ± 0.05% ash content, and high 5.75 ± 0.15% lactose content making it sweet and palatable. The energy content of Halari donkey milk was 40.39 ± 0.31 kcal/100 g, and the water activity ranged from 0.973 to 0.975. Titratable acidity was 0.03 ± 0.01%. Halari donkey milk can be considered acceptable and microbiologically safe, having low total plate count and yeast and mould counts. Mineral testing revealed that Halari donkey milk included significant amounts of magnesium, sodium, calcium, potassium, phosphorus, and zinc. The concentration of different vitamins and amino acids such as isoleucine and valine also contribute to the nutritional value of Halari donkey milk.

Phytochemical constituents and nutrient evaluation of date palm (Phoenix dactylifera, L.) pollen grains

The pollen of date palm -DPP (Phoenix dactylifera L. variety El- Ghannmi Ahmar.) has been analyzed for the main phytochemical composition , nutrient and mineral composition. The phytochemical screening of chemical constituents of the plant showed that the DPP grains contains phytosterols, flavonoids, alkaloids, protein, carbohydrates, glycosides, phenolic compounds, tannins, terpenoids, saponins, coumarins, lignin, oil and fats, with absent of quinones. The quantitative contents of alkaloids, tannin, phenolic compounds and sterols were (2416±0.034, 2279.6±35.769, 115±5 and 110.1±0.87) mg/100g in DPP grains. While the moisture content of palm pollen grains was 8.041 ± 0.1%, and 91.959 ± 0.1 % for the total solids. Values 0.113±0.003 % and 5.585 ± 0.144 % were estimated for crude fiber and ash contents respectively. Crude fat content of DPP grains was 7.678 ±0.149%, 19.45%, for crude protein and 26.25±0.315 g/100g for carbohydrates ,the energy value was 291.902 Kcal/100g. The predominant minerals were potassium 73.5 mg/g, followed by magnesium 19.6 mg/g , calcium 10.8 mg/g and iron 8.5 mg/g. Comparable amounts of sodium 4.34 mg/g and copper 3.658 mg/g with equal amounts of molybdenum, nitrogen and boron (3.169, 3.11 and 3.024) mg/g respectively were found in DPP grains. Palm pollen also contain useful amount of zinc 2.799 mg/g, manganese 2.702 mg/g, selenium 2.51 mg/g, cobalt 1.986 mg/g, nickel 1.698 mg/g and cadmium 0.12 mg/g. From all the results we can conclude that the date palm pollen was as rich source of antioxidant, energy, and important minerals, so its suitability as a regular component in human diet.

Polyphenol Content, Mineral Compounds Composition, Antimicrobial and Antioxidant Activities of Selected Medicinal Herbs from Slovak Republic

The aim of this study was to determine antioxidant activity (DPPH and phosphomolybdenum method), polyphenols content (total polyphenols, flavonoids, and phenolic acids), mineral compounds composition (Cu, Zn, Mn, Fe, Cr, Ni, Co, Pb and Cd) and antimicrobial activity (with disc diffusion method) of medicinal herbs traditionally used in the Slovak republic. The tested plants belonged to the Primulaceae, Urticaceae, Grossulariaceae, Rosaceae, Lamiaceae, Asteraceae, Equisetaceae, Tropaeolaceae, and Plantaginaceae families. The highest antioxidant activities were found in samples of Rosa canina L. (DPPH—29.43 ± 0.11 mg TE/g; TE—Trolox equivalent) and Fragaria vesca L. (phosphomolybdenum method—679.56 ± 3.06 mg TE/g), both from the Rosaceae family. Total polyphenols (determined using the Folin–Ciocâlteu-reagent) were most abundant in a sample of Fragaria vesca L.—124.51 ± 5.05 mg GAE/g (GAE—gallic acid equivalent), total flavonoids (determined using the aluminum chloride method)—in a sample of Primula veris L.—48.35 ± 3.77 mg QE/g (QE—quercetin equivalent), and total phenolic acids (determined using Arnova reagent)—in a sample of Thymus serpyllum L.—102.31 ± 2.89 mg CAE/g (CAE—caffeic acid equivalent). Regarding mineral compounds composition, samples of Fragaria vesca L. and Thymus serpyllum L. showed the highest levels of iron. In samples of Calendula officinalis L. and Trapaeolum majus L., the highest amounts of zinc were determined, while copper was the most abundant in samples of Urtica dioica L. and Melissa officinalis L. The amounts of heavy metals were within legally acceptable limits. The extract of Equisetum arvense L. showed the strongest inhibitory activity towards Clostridium perfringens CCM 4991 (6 mm), while the one from Mentha piperita L.—towards Candida glabrata CCM 8270 (4.83 mm) and Candida tropicalis CCM 8223 (4.33 mm).

Phytochemical Screening, Antioxidant Potential, and LC-ESI-MS Profiling of Ephedra alata and Ephedra altissima Seeds Naturally Growing in Tunisia.

Most Ephedra species are adapted to arid and desert conditions and are widely used in folk medicine to treat several disorders. The design of the current study was to determine the functional properties of seeds of two Ephedra species (E. alata and E. altissima) naturally growing in Tunisian arid zones by evaluating their mineral contents and bioactive compounds. The flame atomic absorption spectrometry revealed that seeds contained remarkable amounts of sodium (Na), potassium (K), calcium (Ca), magnesium (Mg), copper (Cu), zinc (Zn), and iron (Fe). The colorimetric investigation revealed high total polyphenol, flavonoid, and condensed tannin contents. Furthermore, by utilizing high-performance liquid chromatography-electrospray ionization-mass spectrometry method (HPLC-ESI/MS), a total of 11 phenolics were identified and quantified including 7 flavonoid compounds and 4 phenolic acids that were mostly predominated by gallic acid and quercetrin. Results so far have been very encouraging and proved that Ephedra seeds are a valuable source of natural bioactive compounds and minerals which could potentially be used for industrial and pharmaceutical purposes.

Impact of zinc structural on the photovoltaic Properties of iron Pyrite

FeS2 pyrite is one of the most interesting photovoltaic materials with low-cost and natural abundance but with small band gap of 0.95 eV. In the present work, we show the feasibility of increases band gap was determined by Zinc alloying of Iron pyrite. We showed that we can increase the band gap of FeS2 pyrite to 1.15eV by theoretical calculation and to 1.16eV using experimental method, by just adding a very small amount of Zinc (1%). We prepared our samples by chemical vapor transport technic and we utilized the technic of linear muffin-tin orbital method in the atomic-sphere approximation (LMTO-ASA). The effect of Zinc alloyed Iron pyrite were examined by transmission electron micrograph TEM, XRD, Raman spectroscopy and optical characterization.

Serum zinc levels in cancer patients are low and difficult to elevate when complicated by liver cirrhosis: A retrospective study.

In this study, we analyzed blood zinc concentration in patients with various cancer types and the degree of improvement in relation to the underlying disease following treatment with zinc preparations. Serum zinc levels of 530 cancer patients whose blood zinc levels were measured at our hospital from 2016 to 2021 were retrospectively examined in accordance with the primary disease. Changes in zinc levels were analyzed in 155 patients whose zinc levels had been measured on 2 or more occasions in accordance with whether they had received zinc preparations. In addition, the concentration course of zinc before and after zinc formulation administration in 73 patients was examined in accordance with the presence or absence of liver cirrhosis complications. Mean serum zinc levels were below normal in all carcinomas measured, and zinc levels were significantly lower in cirrhosis-hepatocarcinoma cases than in other primary disease cases. Furthermore, serum zinc levels in patients who did not receive zinc preparations decreased significantly over time. In patients who received zinc preparations, the elevated levels of zinc after treatment were significantly lower in patients with cirrhosis than in those without cirrhosis. There was a weak inverse correlation between pre-dose zinc concentration and increased zinc concentration in patients with cirrhosis. In the analysis of covariance, the presence of liver cirrhosis was predominantly correlated with elevated zinc per dose. In summary, serum zinc levels in cancer patients are low and especially low in cancer patients with liver cirrhosis compared with those without cirrhosis after the administration of zinc preparations.

Геохимические особенности и зональность залежи Филизчайского колчеданно-полиметаллического месторождения (южный склон Большого Кавказа)

The article discusses the geochemical features and zoning of the ore deposit of the Filizchay deposit on the southern slope of the Greater Caucasus. The spatial distribution of valuable (Cu, Zn, Pb) components, their sum, as well as the distribution of Ag, which have a high content for the Filizchay deposit, are considered. A field model was built on the basis of the Leapfrog GEO program. In order to quantify zoning, the index of geochemical zoning was calculated based on the ratios of the concentrations of elements accumulated in the upper part of the ore deposit (Zn, Pb, Ag) and elements accumulated in the lower part of the deposit (Cu, Co, Mn). It has been established that in the Azerbaijan part of the southern slope of the Greater Caucasus, as we move from the northwest to the southeast, there is a regional ore zonality, expressed in the change of chalcopyrite-pyrrhotite ores by sulfide-polymetallic ones, as a result of which there is a decrease in the concentration of copper and, accordingly, an increase in the amount of zinc and especially lead. According to the degree of intensity of manifestation of zinc, lead and silver mineralization in the deposit, two parts can be distinguished: the western one is richer, where almost all the maxima are concentrated, and the eastern one is poorer, which accounts for most of the minima. Additional exploration work is recommended in the eastern part. The distribution of elements in individual wells established a clear zoning in terms of the thick ness of the ore deposit, manifested in a regular change in the mineral and chemical composition of ores from a lying to a hanging side. This leads to the accumulation of copper, cobalt, tin and manganese in the foot, and the concentration of zinc, lead, cadmium, thallium, mercury, antimony, etc. in the hanging side of the ore deposit.

Trace Elements in Dental Enamel Can Be a Potential Factor of Advanced Tooth Wear

Enamel is the outermost layer of the tooth and has no ability to regenerate after tooth eruption. Its mineral composition is likely to be responsible for the enamel resistance to any agents that appear in oral cavity. The objective of this study was to compare the content of Ca, Mg, Zn and Cu in specific layers of healthy and worn tooth enamel. Three groups of dental enamel samples were analyzed. The amounts of Ca, Mg and Zn in the enamel bioptates were established using atomic absorption spectroscopy after an acid biopsy technique had been applied. The concentration of Cu was established using an electrothermic method with an AA spectrometer. The analysis was carried out using parametric tests (the Pearson’s linear correlation coefficient and the t-test for the correlation coefficient). Results: A statistically significant difference was confirmed between the mean amount of zinc in severely worn dentition and all the layers in vitro and in vivo. Strong positive relationships between magnesium and zinc contents were shown at some depths. A significant difference was registered between the amount of copper in the severely worn dentitions compared to the superficial layer of the healthy teeth in vitro and in vivo. Conclusion: It appears that zinc metabolism may play an important role in enamel formation and may influence enamel’s resistance to wear after tooth eruption.

Utilization of urban waste as liquid organic fertilizer for vegetable crops in urban farming system

Converting vegetable, fruit, food, fish offal and slaughterhouse waste that become a problem for the community in the urban areas into useful plant fertilizer is the solution. This study aims to determine (1) the potential of urban organic waste into liquid organic fertilizer and (2) the effectiveness of liquid organic fertilizer (LOF) in increasing the growth and yield of vegetable crops in urban farming systems. The study used Randomized Block Design (RBD) with some treatments P0 (control) and P1 (LOF with 6 types of waste) consisting of P2 (vegetable waste), P3 (fruit waste), P4 (sprouts waste), P5 (food waste), P6 (catfish waste) and P7 (blood waste). The treatment was repeated 3 times for a total of 28 experimental units. The three vegetable plants; eggplant, Bok Choy and mustard, were used in the experiment. The study found that liquid organic fertilizers from vegetables, fruit, sprout, food, fish, blood waste and mixed waste all contain organic matter, varying amounts of nitrogen (N), phosphorus (P), potassium (K), carbon (C), magnesium (Mg), calcium (Ca), copper (Cu), zinc (Zn), iron (Fe) and humic acid. All liquid organic fertilizer treatments increased eggplant and Bok Choy vegetable growth and yield; however, the type of organic waste used as a raw material for LOF did not affect growth but eggplant and Bok Choy yield. LOF from blood waste (P7) and fish waste (P6) has higher measured nutrients and yield from eggplant, Bok Choy and mustard vegetables than other treatments.

Dietary Zinc Differentially Regulates the Effects of the GPR39 Receptor Agonist, TC-G 1008, in the Maximal Electroshock Seizure Test and Pentylenetetrazole-Kindling Model of Epilepsy.

The G-protein coupled receptor 39 (GPR39) is gaining increasing attention as a target for future drugs, yet there are gaps in the understanding of its pharmacology. Zinc is an endogenous agonist or an allosteric modulator, while TC-G 1008 is a synthetic, small molecule agonist. Zinc is also a positive allosteric modulator for the activity of TC-G 1008 at GPR39. Activation of GPR39 by TC-G 1008 facilitated the development of epileptogenesis in the pentylenetetrazole (PTZ)-induced kindling model of epilepsy. Congruently, TC-G 1008 decreased the seizure threshold in the maximal electroshock seizure threshold (MEST) test. Here, we investigated the effects of TC-G 1008 under the condition of zinc deficiency. Mice were fed a zinc-adequate diet (ZnA, 50 mg Zn/kg) or a zinc-deficient diet (ZnD, 3 mg Zn/kg) for 4 weeks. Following 4 weeks of dietary zinc restriction, TC-G 1008 was administered as a single dose and the MEST test was performed. Additional groups of mice began the PTZ-kindling model during which TC-G 1008 was administered repeatedly and the diet was continued. TC-G 1008 administered acutely decreased the seizure threshold in the MEST test in mice fed the ZnD diet but not in mice fed the ZnA diet. TC-G 1008 administered chronically increased the maximal seizure severity and the percentage of fully kindled mice in those fed the ZnA diet, but not in mice fed the ZnD diet. Our data showed that the amount of zinc in a diet is a factor contributing to the effects of TC-G 1008 in vivo.

Evaluation of the quality indicators of collector-drainage water for reusing purposes: a study from Sirdarya province, Uzbekistan

Currently, in the countries of the Aral Sea basin, due to the negative effects of climate change and the unreasonable use of water resources, the reduction and pollution of existing water resources, the increase in demand for water and its protection are required. Due to the increase in the amount of mineralization due to the discharge of the mineralized collector-drainage waters formed in the irrigated areas to the rivers, their use is limited due to the pollution of the upper and lower streams of the river basins. Researches revealed that the mineralization of Central Mirzachol drainage water has increased by 3.5 times, the total hardness has increased by 4 times, the amount of cation and anion and heavy metals is also high. It was found that the quality of the water of the Central Mirzachol drainage is the worst, and the water of the Boyovut well has a relatively good quality indicator. As a result of the discharge of collector-drainage waters to the Syr Darya River, the main water source of the province, the total hardness of the river reaches 2.0 times, the mineralization is 1.2 times, the amount of cations potassium, sodium, calcium and magnesium, the amount of sulfates and chlorides from anions, heavy metals: manganese, caused the amount of zinc, tin, copper to exceed the permitted standards.

КОНЦЕНТРАЦИЯ ЦИНКА, МАРГАНЦА, МЕДИ В ПОКРОВНОМ ВОЛОСЕ КРУПНОГО РОГАТОГО СКОТА В ЗАВИСИМОСТИ ОТ УСЛОВИЙ СОДЕРЖАНИЯ, СЕЗОННОСТИ И ТОПОГРАФИЧЕСКОГО УЧАСТКА ТЕЛА

The article presents studies on the concentration of trace elements in the coat hair of cattle. They reflect the amount of copper, manganese and zinc in the hair coat of cattle under the influence of seasonality, type of maintenance, topographical area of the animal's body. Based on the results, it can be concluded that, in contrast to the factor of the topographic site, the seasonality and type of maintenance possess a pronounced impact on the concentrations of the studied trace elements in the hair coat. And the variability within the studied groups emphasizes the individuality of the accumulation of trace elements by every individual animal. This reflects the multifunctionality of the hair coat, which consists not only in performing the thermoregulatory function, but also in reflecting the mineral status of the animal's body.

Dual role of trace elements in magnesium dissolved age hardened A356 alloy on microstructure and peak micro hardness

The present work reflects the effects of trace addition of copper (up to 1 wt.%) and zinc (0.5 wt.%) on the microstructure and hardness property of heat treated A356 (Al-7Si) alloy. Small amount of zinc and copper was introduced into A356 in both atomic form (alloy) and powder form (composite) and its age hardening behaviour were investigated. To enhance the wettability during composite fabrication and solid solution strengthening in alloys, a small quantity of magnesium (1 wt.%) was added. The main objective of this study is to introduce lower melting point zinc reinforcement into A356 matrix alloy by copper coating of zinc particles and then reinforcing it into A356 matrix. All stir cast specimens were subjected to T6 treatment by solutionizing at 520 °C for 2 h followed by 60 °C water quench and then aging at 100 and 200 °C to determine peak hardness value. Microstructure analysis showed that a minimum 1 wt.% copper was required to form Al2Cu intermetallic phase during solidification resulting in finer grain structure with hardness improvement. Under as-cast conditions, a maximum hardness of 85 VHN was obtained in 1 wt.% copper reinforced composite. Under peak aged conditions, aging at 100 °C showed 116% hardness improvement in 1 wt.% Cu reinforced composite.