Amounts Of Choline Research Articles

EFFECT OF THE INGESTION OF EXCESSIVE QUANTITIES OF CHOLINE ON THE AMOUNT IN TISSUES AND URINE

EFFECT OF THE INGESTION OF EXCESSIVE QUANTITIES OF CHOLINE ON THE AMOUNT IN TISSUES AND URINE

Metabolic Studies in Patients with Cancer of Gastro-intestinal Tract. XV. Lipotropic Properties of Inositol.

Recent studies from this hospital have demonstrated that the livers of patients with gastro-intestinal cancer almost uniformly are infiltrated with fat.1 In contrast to this finding, normal fat contents were found in the livers of 11 patients with carcinoma of the gastro-intestinal tract who each received 8 g of lipocaic† during the night prior to laparotomy. The average hepatic fat concentration of this latter group was only 0.46 that of the control untreated patients.2Lipocaic, however, is a crude mixture which contains significantly large amounts of choline and inositol,† both of which are lipotropic alone.3, 4 In experimental animals, the lipotropic effects of lipocaic apparently are not due to its choline alone,5 and this observation has been confirmed here for human subjects.2 On the other hand, when about 4 times the amount of inositol present in the 8 g of lipocaic was administered to a group of 8 patients with gastro-intestinal cancer, with but one exception the concentrations of fat in their liv...

CHOLINE METABOLISM: I. THE OCCURRENCE AND PREVENTION OF HEMORRHAGIC DEGENERATION IN YOUNG RATS ON A LOW CHOLINE DIET

1. A new effect of a deficiency of choline in young rats in deseribed. 2. The deficiency is characterized by an exterme toxic state in which there is a marked hemorrhagic enlargement and degeneration of the kidneys, a regression of the thymus, and en enlargement of the spleen. 3. The deficiency is prevented by amounts of choline too small to influence the deposition of liver fat. 4. The requirement for choline is greater in young than in older rats. 5. It is suggested that choline is essential for the maintenance of the normal structure of tissues as well as for its lipotropic action.