Amoebic Abscess Research Articles

CONCEPT OF VIDRADHI WSR TO ABSCESS: AN AYURVEDIC REVIEW

Ayurveda, a characteristic arrangement of medication, started in India over 3,000 years prior. The term Ayurveda is taken from the Sanskrit words ayur (life) and veda (science or information). In this manner, Ayurveda means information on life. In the wake of Collecting the information from various samhitas, ayurvedic texts and current books. Acharya sushruta- the father of Indian surgery has logically characterized in a foundational way an abundance of clinical material and the standards of the board for vidradhi, which are legitimate even today. "Sheegra vidhahivat’ meaning of vidradhi itself recommends the destructiveness of the disease. Vidradhi word is advanced from vidra, i.e, a painfull condition like pricking, stabbing or cutting sensation in the skin. The infection Vidradhi (abscess) is a typical infirmity disturbing mankind and debilitating the victim for his standard work. It presents as a limited expanding with torment, red discoloration,local rise of temperature, delicacy and confined capacity of impacted part. it is normal in India with second most noteworthy frequency because of helpless disinfection, stuffing and deficient sustenance. Around the world, roughly 40-50 million individuals are contaminated every year with amoebic abscesses. The current exploration article is intended for relative investigation of Vidradhi and Abscess as far as Samprapti (Pathophysiology), Lakshanas (Clinical elements) and Chikitsa (Treatment) affirms that Vidradhi and Abscess can be comparable disease entities.

Laparoscopic segmental colectomy for a rare case of extraluminal amoeboma masquerading as stromal tumour of the colon

Abstract Entamoeba histolytica is known to cause infectious colitis that presents with diarrhoea or dysentery. Extra intestinal manifestations result in amoebic abscesses to involve organs such as the liver, lungs or brain. Very rarely, it may present like a pseudotumour due to a mass formation if the primary infection was untreated or inadequately treated. We, herein, report a rare case of extraluminal amoebic pseudotumour in a young female with a diagnosis of a gastrointestinal stromal tumour of hepatic flexure of the transverse colon on pre-operative imaging and per operative findings, but final histopathological examination of the resected specimen proved it to be an amoeboma. The rarity of this case was the extraluminal presentation, unlike other reported cases of intraluminal pseudotumour. After an extensive literature search, we believe that this is the first reported case of extraluminal pseudotumour of the transverse colon managed by laparoscopic segmental colectomy.

Clinical insights into liver abscess: a comprehensive analysis of presentation, etiology and management in Northeastern India, Silchar, Assam

Hepatic abscess is a prevalent disease in Northeastern India with a myriad clinical feature. The present study is aimed to understand the clinical profile, microbiological aetiologies, and management outcomes in patients with hepatic abscesses in Northeastern India, Silchar. In the surgery department of Silchar medical college and hospital, 20 cases of hepatic abscess were studied from January 2022 to October 2023. Records were kept for history, examination, and laboratory investigations. Ultrasound-guided aspiration of the abscess was done, and samples were subject to relevant investigation. The mean age of patients was 33 years, 2/3rd of the patients were from lower socioeconomic status. Alcoholic history was elicited from 45% of the patients. The abscesses were predominantly in the right lobe (70%) and solitary (65%). Etiology of the cases, 55% amoebic, 40% pyogenic, and 5% were tubercular in origin. Pigtail catheterization was done in 70% of the patients; percutaneous needle aspiration was done in 25% of the cases. No cases of mortality were noted. Amoebic and tubercular abscess were solitary in nature whereas pyogenic abscesses were multiple. The amoebic and pyogenic abscess had right lobe predominantly affected whereas in tubercular abscesses left lobe involvement was more common. The most common presentation was young male of low socioeconomic status having solitary amoebic abscess usually in the right lobe of liver

Young Man With Multiple Partially Septated Cysts in the Hepatoduodenal Ligament and Retropancreatic

The differential diagnosis of cystic liver changes includes multiple dysontogenetic cysts, liver abscesses and amoebic abscesses. Cystic changes in the abdomen with partly necrotic lymph nodes should also suggest tuberculosis, even in young and immunocompetent patients. In tuberculosis hepatoduodenal lymphadenopathies can be observed, and necrotic lymph nodes might mimic other thin-wall cystic lesions. Unexplained weight loss with clinical signs of severe infection and septicaemia also includes a differential diagnosis of consumption, i.e. miliary tuberculosis and treated immediately.

An unusual case of tubercular liver abscess presenting as pericardial effusion

Tropical nations like India frequently have liver abscess. They are typically amoebic or pyogenic abscesses. It can sporadically be a sign of hepatic tuberculosis (TB). Hepatic tuberculosis should be suspected in cases where the patient doesn’t present with typical complaints of pyogenic/amoebic abscess without response to commonly used antibiotics. Pyogenic/amoebic liver abscesses show the rare complication of rupture into the pericardium, especially if the abscess is left sided. However, a tubercular pericardial effusion presenting with rupture into the pericardium has rarely been reported. We present to you a case of tubercular pericardial effusion in a known diabetic patient secondary to ruptured liver abscess presenting to the emergency department with chief complaints of breathlessness, chest pain and bilateral pedal edema.

Percutaneous drainage of an infected hepatic cyst, responsible for obstructive jaundice by compression on the intrahepatic biliary tract

Hepatic cysts consist of a heterogeneous group of lesions that differ in etiology, prevalence, and clinical manifestations. Liver cystic lesions fall into two main categories: congenital and acquired. Congenital cystic lesions of the liver include polycystic liver disease, simple cysts, ciliated and duct-related liver cysts. Acquired liver cysts are further divided into infected and non-infected. There are two types of infected cysts, parasitic ones (hydatid cysts and amoebic abscesses) and non-parasitic ones, or pyogenic liver abscesses. Infection is a serious complication of cystic liver disease, which can lead to sepsis and death. A diagnosis of cystic infection is usually made by culturing pathogens from the fluid aspirated from the cyst. If an aspirate is not available for testing, the diagnosis of a liver cyst complicated by infection is made by correlating clinical, biochemical, and imaging findings. Infected liver cysts and liver abscesses can be caused by the portal spread of intra-abdominal infections (e.g., appendicitis, diverticulitis, colitis). The placement of a percutaneous drainage catheter allows controlled aspiration of large abscesses for a short-medium period with minimal hemodynamics and physiological stress for the patient. Furthermore, compared to surgical drainage, the results are comparable, while the morbidity is lower.

STUDY OF ETIOLOGY OF LIVER ABSCESS AND IT'S DIFFERENT WAYS OF MANAGEMENT

Background: Liver abscess are cystic, space occupying lesion within liver parenchyma. It has become one of the most common disease with more prevalence in underdeveloped and developing countries. Pyogenic liver abscess more common in western world while amoebic liver abscess are more common in underdeveloped countries and people living with lower socio-economic conditions. Liver abscess, undiagnosed and untreated, has a very high mortality rate. With early diagnosis and prompt institution of specic therapy, the prognosis is good and the mortality is very low. Surgical management was the mainstay for treating liver abscess earlier. However, USG guided percutaneous needle aspiration and percutaneous drainage procedure shown a favorable outcome with less average length of stay in hospital. In this study we aimed to study etiology of liver abscess and its different ways of management. To study the etiology of liver abscess Aim: Materials And Methods: and its different ways of management. This is a prospective, observational study was conducted in GSVM Medical College, LLR & Associated Hospitals, Kanpur (UP).Study was done on 100 patients with different types of liver abscess. Patient with ruptured liver abscess were not included. Outcomes were assessed on the basis of recurrence (with regular follow ups at one month, three months, six months and one year); relieving of symptoms and length of stay in hospital. Results: Out of 100 patients majority of patients were in the age range of 31-45 (56.0%) followed by 46-60 (22.0%) with mean age of 40.74±10.53 years. Most of the cases were males (98%), and females (2.0%). Majority of patients were with lower socioeconomic status (96%). Most of the patient having amoebic liver abscess (66%) with positive ELISA for antibodies, while 34 % of patient having pyogenic liver abscess with 10% having bacterial growth on culture examination having E.coli . 84% of cases having liver abscess in right lobe and were single (66.0%). On the basis of their personal history, comorbidities and clinical features, 14.05 were diabetic, 44.0% were alcoholic, 98% were having fever with 60% cases have chills and rigor and 100% having pain in right upper quadrant. Majority of cases undergone pigt Conclusion: ail treatment were pyogenic (76.4%) and majority of amoebic abscess were treated with aspiration (72.7%) and difference was found statistically signicant with p value of 0.001. Reduction in size of abscess cavity was observed in all the cases but recurrence was higher in conservative treatment (p=0.007) and length of stay was higher in pigtail (p<0.001).

Updated Review on the Panorama of Liver Diseases in Benin

Introduction: The aim of this work was to take stock of the epidemiological aspects of liver diseases in Benin. Methods: Two methods were used: documentary research and collection of the position of gastroenterologists on the subject. For the literature search, the sources interviewed were Medline, African Journal On Line (AJOL), Google and Google scholar. Additional searches were made on the websites of European gastroenterology societies (AFEF, EASL). A collection of the opinions of gastroenterologists, most of them members of the Beninese Society of Hepato-gastroenterology was made. Results: From a nosological point of view, the most frequent and serious liver diseases in Benin are mainly infectious: viral hepatitis B and C (9.9% and 4.12% of the general population in 2013). Bacterial liver diseases (ascites fluid infections and tuberculosis of the liver) come in 3rd position after cirrhosis and hepatocellular carcinoma. Amoebic abscesses of the liver tend to regress. The toxic causes are dominated, in addition to alcoholic liver diseases (steatosis, cirrhosis), by drug lesions: two fatal cases of hepatotoxicity by artesunate-amodiaquine combination and asymptomatic and transient cytolysis in 23.8% of 63 children less than 5 years old treated with arthemether-lumefantrine combination have been described. Phytotherapy, alone or in combination with modern drugs, can in some cases be hepatotoxic. Plants with recognized medicinal virtues (may be harmful to the liver (Senna, Moringa oleifera, tamarind). Chronic aflatoxicoses secondary to the consumption of contaminated food (maize, cassava or peanuts) are relatively under-documented. Overload diseases (in particular alcoholic or non-alcoholic fatty liver) are on the increase (3.19% of 662 ultrasounds in 1995 against 14.5% of 411 in 2011 in Cotonou) partly due to the demographic and nutritional transition underway in Benin. These diseases, often blamed on spells cast, lead to hospital deaths from cirrhosis or hepatocellular carcinoma in young economically active subjects. Conclusion: Despite anti-infectious therapeutic advances, the prevention of toxic and metabolic hepatopathies is essential. Clinical research is crucial.

Updates on the worldwide burden of amoebiasis: A case series and literature review

BackgroundAmoebiasis is an intestinal and tissue parasitic infection caused by the protozoan Entamoeba histolytica. Despite significant medical importance and worldwide dispersion, little is known about the epidemiology and distinct geographical distribution of various clinical forms of amoebiasis in the world. In this study, we present an amoebiasis case series referred to Avicenne Hospital (Bobigny, France) from 2010 to 2022 followed by an overview of the released literature to explore diverse clinico-pathology of amoebiasis and to update the actual epidemiological situation of this parasitosis worldwide. MethodsThe referred patients underwent a combination of clinical and parasitological examinations and imaging. The study was followed by an overview of released literature performed based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guideline. ResultsA total of 15 patients with amoebiasis were diagnosed with an average age of 48.5 years old at the occurrence time of infection. Men (78%) were the most affected patients. Most of the cases were reported following a trip to endemic regions, such as Mali, India, Nepal, Algeria, Cameroon or Congo. All of the processed patients exhibited a hepatic amoebiasis. Amoebic abscess was observed in all cases with an average size of 6.3 cm. Of these patients, seven cases (46.7%) benefited from drainage following a risk of rupture or superinfection of the abscess. A compilation of findings extracted from 390 scientific publications via seven major medical databases, allowed us to update the main epidemiological and clinical events that has led to the current worldwide expansion of amoebiasis. We presented a clinical and epidemiological overview of the amoebiasis accompanied with a worldwide illustrative map displaying the current distribution of known amoebiasis foci in each geographical ecozone of Asia, Europe, Africa, Americas, and Australia. ConclusionsAlthough Metropolitan France is not known as an endemic region of amoebiasis, amoebic liver abscess was the most frequent clinical form observed among our 15 patients processed. Most of infected patients had a history of travel to or lived-in endemic areas before arriving in France.

Quantitative Proteomics Reveals Metabolic Reprogramming in Host Cells Induced by Trophozoites and Intermediate Subunit of Gal/GalNAc Lectins from Entamoeba histolytica.

ABSTRACTEntamoeba histolytica is an intestinal protozoan parasite with remarkable ability to kill and phagocytose host cells, causing amoebic colitis and extraintestinal abscesses. The intermediate subunit (Igl) of galactose (Gal)- and N-acetyl-d-galactosamine (GalNAc)-specific lectins is considered an important surface antigen involved in the pathogenesis of E. histolytica. Here, we applied mass spectrometry-based quantitative proteomics technology to analyze the protein expression profile changes occurring in host Caco2 cells incubated with E. histolytica trophozoites or stimulated by purified native Igl protein. The expression levels of 1,490 and 489 proteins were significantly altered in the E. histolytica-treated and Igl-treated groups, respectively, among 6,875 proteins totally identified. Intriguingly, central carbon metabolism of host cells was suppressed in both E. histolytica-treated and Igl-treated groups, with evidence of decreased expression levels of several key enzymes, including pyruvate kinase muscle type 2, presenting a Warburg-like effect in host cells. Besides, Igl had potential physical interactions with central carbon metabolism enzymes and the proteolytic degradation family members proteasome subunit alpha and beta, which may be responsible for the degradation of key enzymes in carbon metabolism. These results provided a novel perspective on the pathogenic mechanism of E. histolytica and compelling evidence supporting the important role of Igl in the virulence of E. histolytica.IMPORTANCE Metabolic reprogramming is considered a hallmark of some infectious diseases. However, in amoebiasis, a neglected tropical disease caused by protozoan parasite E. histolytica, metabolic changes in host cells have yet to be proven. In this study, advanced data-independent acquisition mass spectrometry-based quantitative proteomics was applied to investigate the overall host cellular metabolic changes as high-throughput proteomics could measure molecular changes in a cell or tissue with high efficiency. Enrichment analysis of differentially expressed proteins showed biological processes and cellular pathways related to amoeba infection and Igl cytotoxicity. Specifically, central carbon metabolism of host cells was dramatically suppressed in both E. histolytica-treated and Igl-treated groups, indicating the occurrence of a Warburg-like effect induced by trophozoites or Igl from E. histolytica. Distinct differences in ubiquitin-mediated proteolysis, rapamycin (mTOR) signaling pathway, autophagy, endocytosis, and tight junctions provided novel perspectives on the pathogenic mechanism of E. histolytica.

Isolated amoebic brain abscess with excellent therapeutic response.

Isolated amoebic brain abscess with excellent therapeutic response.

Concept of Vidradhi WSR to abscess: an ayurvedic review

Ayurveda, a characteristic arrangement of medication, started in India over 3,000 years prior. The term Ayurveda is taken from the Sanskrit words ayur (life) and veda (science or information). In this manner, Ayurveda means information on life. In the wake of Collecting the information from various samhitas, ayurvedic texts and current books. Acharya sushruta- the father of Indian surgery has logically characterized in a foundational way an abundance of clinical material and the standards of the board for vidradhi, which are legitimate even today. "Sheegra vidhahivat'' meaning of vidradhi itself recommends the destructiveness of the disease. Vidradhi word is advanced from vidra, i.e, a painfull condition like pricking, stabbing or cutting sensation in the skin. The infection Vidradhi (abscess) is a typical infirmity disturbing mankind and debilitate the victim for his standard work. It presents as a limited expanding with torment, red discoloration,local rise of temperature, delicacy and confined capacity of impacted part. it is normal in India with second most noteworthy frequency because of helpless disinfection, stuffing and deficient sustenance. Around the world, roughly 40-50 million individuals are contaminated every year with amoebic abscesses. The current exploration article is intended for relative investigation of Vidradhi and Abscess as far as Samprapti (Pathophysiology), Lakshanas (Clinical elements) and Chikitsa (Treatment) affirms that Vidradhi and Abscess can be comparable disease entities.

Giant Amoebic Liver Abscess: A Rare Diagnosis in a Rural Setting of Sub-Saharan Africa.

Background Extraintestinal amoebiasis is an uncommon complication of Entamoeba histolytica infection, occurring in about 5-10% of patient. Prompt diagnosis and management is essential to prevent complications. However, diagnosis and management in resource-limited settings is very challenging owing to limited diagnostic tools and nonspecific clinical symptoms. Therefore, our case report underscores the role of incisive clinical evaluation, basic investigation, and nonsurgical management of giant amoebic abscess in resource-limited settings. Case Presentation. A 13-year-old female Cameroonian presented with subacute onset of upper abdominal pain, high fever, and chest pain for one week. Before presentation, she had been on treatment at a local traditional practitioner during which her symptoms worsen. After clinical evaluation and basic investigation, she was diagnosed with a giant amoebic liver abscess. She was resuscitated and placed on nonsurgical management. Follow-up after 1 month was significant for complete recovery. Conclusion Amoebic liver abscess is a rare complication of Entamoeba histolytica infection with devastating complications. The diagnosis of this disease requires high index of suspicion in resource-limited settings. Good clinical evaluation and timely nonsurgical therapy can provide recovery to some patients.

English

BACKGROUND Amoebic liver abscess is a common clinical problem, encountered in clinical practice. There is sparse literature about socio epidemiological and current clinical trends and treatment outcomes. The current article describes the outcomes in a prospectively studied cohort of patients from a tertiary referral centre from Himalayan foothills and Sub Himalayan Gangetic plains of North India. METHODS 101 prospectively enrolled, serial patients, fulfilling the criteria for amoebic liver abscesses were included in the study to evaluate the socio epidemiological, clinical variables and abscess outcomes. The intervention done for abscesses requiring drainage (one-time aspiration vs. indwelling catheter drainage) was mainly dependent upon the content of liquefied pus in the abscess cavity rather than absolute size of the abscess. The colour of the aspirated pus and final outcomes of patients were recorded. RESULTS There were 9.75 cases of lever abscess per 10,000 hospital admissions, similar to the trends reported from other endemic regions. While the socio epidemiological and clinical variables remained unchanged for the last 60 years, the clinical outcome has dramatically improved. The average volume of the abscess noted in the study appeared smaller than the average volume of the abscess noted in earlier studies, possibly suggesting early diagnosis. About 1 / 3 rd abscess were noted to be complicated, either with symptomatic pleural effusion (29) or rupture (5 / 101) and correlated significantly with socio economic status and history of alcoholism. There was no statistical difference in the average volume of the abscess cavity, in patients managed either with one-time aspiration or indwelling catheter drainage. All patients had excellent outcome. None of the patients required surgery and there was no mortality. CONCLUSIONS While there is no change in the epidemiology of amoebic liver abscess, there is a marked change in the outcome, and amoebic abscess is a potentially curable disease. KEYWORDS Amoebic Liver Abscess; Catheter Drainage

Abscesso esplênico amebiano: um relato de caso

Objetivo: Relatar um caso clínico de abscesso esplênico amebiano e discutir suas características clínicas, seu difícil diagnóstico, seu manejo clínico e cirúrgico. Apresentação do caso: Paciente masculino 39 anos foi admitido com queixa de dor abdominal em região de flanco esquerdo, náuseas e inapetência, negando febre, vômitos e alterações do hábito intestinal. Ao exame físico abdominal evidenciou um abdome tenso, reativo, com dor à palpação de flanco esquerdo, com sinal de descompressão brusca positiva e Giordano positivo à esquerda. Na admissão foi realizada tomografia computadorizada de abdome que evidenciou coleções hipodensas no baço e presença de líquido livre na cavidade abdominal, com hipótese de abscesso esplênico. Foram realizadas esplenectomia e pancreatectomia caudal e iniciado ceftriaxona e metronidazol. Após a cirurgia foi solicitada cultura da secreção com resultado positivo no dia 05/07/2019 para pesquisa direta de Entamoeba histolytica, definindo o diagnóstico de abscesso esplênico por ameba. Paciente recebeu alta no dia 06/07/2019 com receita de metronidazol para término do tratamento. Considerações finais: O abscesso esplênico amebiano é uma patologia raríssima com poucos dados na literatura, havendo uma dificuldade e demora no diagnóstico e no tratamento dessa patologia o que implica diretamente no prognostico do paciente. Portanto, é necessário que mais casos sobre a patologia sejam relatados para melhor entendimento sobre o diagnóstico e manejo do abscesso esplênico amebiano.

Case report: multiple and atypical amoebic cerebral abscesses resistant to treatment

BackgroundThe parasite Entamoeba histolytica is the causal agent of amoebiasis, a worldwide emerging disease. Amebic brain abscess is a form of invasive amebiasis that is both rare and frequently lethal. This condition always begins with the infection of the colon by E. histolytica trophozoites, which subsequently travel through the bloodstream to extraintestinal tissues.Case presentationWe report a case of a 71-year-old female who reported an altered state of consciousness, disorientation, sleepiness and memory loss. She had no history of hepatic or intestinal amoebiasis. A preliminary diagnosis of colloidal vesicular phase neurocysticercosis was made based on nuclear magnetic resonance imaging (NMRI). A postsurgery immunofluorescence study was positive for the 140 kDa fibronectin receptor of E. histolytica, although a serum analysis by ELISA was negative for IgG antibodies against this parasite. A specific E. histolytica 128 bp rRNA gene was identified by PCR in biopsy tissue. The final diagnosis was cerebral amoebiasis. The patient underwent neurosurgery to eliminate amoebic abscesses and was then given a regimen of metronidazole, ceftriaxone and dexamethasone for 4 weeks after the neurosurgery. However, a rapid decline in her condition led to death.ConclusionsThe present case of an individual with a rare form of cerebral amoebiasis highlights the importance of performing immunofluorescence, NMRI and PCR if a patient has brain abscess and a poorly defined diagnosis. Moreover, the administration of corticosteroids to such patients can often lead to a rapid decline in their condition.

Les protozooses à tropisme hépatique

The liver is an organ assuming an important role in blood filtering, and because of that it can be in contact with numerous parasites. Protozoa i.e. unicellular eukaryotes, but also helminths that are much more voluminous can be responsible for hepatic localization. Some of them induce a disease mostly with hepatic symptoms, while others are involved in multi-organ manifestations. Diagnosis is sometimes difficult because of few functionnal consequences, or the parasite can even stop its development. Clinical manifestations can also be severe, as for the amoebic abscess of the liver. For these reasons, diagnosis combines direct exam with serology and imagery. Interestingly, the liver tissues are able to respond variously to these infections, with an immune reaction that can be necrotic, granulomatous or fibrotic. The different protozoan infecting liver are detailed in this article regarding their impact on liver functions.

Amoebic liver abscess: About an observation

Amebiasis is a parasitic pathology responsible for a dysenteric syndrome and extra-intestinal complications. It’s caused by infection with an amoeba, Entamoeba histolytica, whose geographical distribution is cosmopolitan, but which is particularly prevalent in the tropics. Only a minority of infections are symptomatic and some of them can lead to extra-intestinal complications, the main one being hepatic amoebiasis. We report the case of a 38-year-old patient from central Senegal who developed an amoebic liver abscess treated by percutaneous drainage. The epidemiological, diagnostic and therapeutic aspects of amoebic abscesses are discussed.

Amoebic Cerebral Abscess: Still A Diagnostic Dilemma with Fatal Outcome

Amoebiasis is defined as infection with Entamoeba histolytica, which enters the body through feco – oral route after consumption of food or water contaminated by cysts. We present a rare case of amoebic brain abscess in a 45 years old patient who came with headache, fever and right sided weakness for 15 days. He was emperically being treated for tuberculosis. As Entamoeba was not suspected, no serological or microbiological investigations for the same were done. Histopathological examination of abscess sent after frontal lobectomy revealed trophozoites of Entamoeba histolytica. Demonstration of trophozoites of Entamoeba on histopathology sections was a surprising finding which clinched the diagnosis in this case. Amoebic brain abscess should be considered as differential diagnosis in all patients who present with signs & symptoms of central nervous system involvement in endemic areas. Early diagnosis and aggressive management with metronidazole is imperative to limit the morbidity and prevent the mortality.

A comparative study of liver abscess: therapeutic aspiration verses continuous catheter drainage

Background: Previously liver abscesses were treated primarily by surgery but with advances in imaging techniques the trend is changing towards use of potent antimicrobials and minimally invasive ultrasound guided interventional procedures and surgery is being done only in selected cases. We conducted this study to find out the feasibility, limitations, effectiveness, outcome and complications of therapeutic needle aspiration and continuous catheter drainage of liver abscess.Methods: This was a hospital based randomized control prospective study in which patients with liver abscess were included. 100 patients of liver abscess selected by simple randomization to 2 groups namely Group A (needle aspiration) or Group B (continuous catheter drainage) undergo the above two interventional procedures. For statistical purposes P value less that 0.05 was taken as statistically significant.Results: This study consisted of 100 patients out of whom there were 78 (78%) males and 22 (22%) females with a M:F ratio of 1:0.28. Single hepatic abscess (75%) was more common than multiple abscesses (25%) and pyogenic abscess (67%) was more common than amoebic abscess (33%). Right lobe of liver was most commonly involved (61%) followed by left lobe (22%). All patients in both the groups were treated successfully and there was no treatment failure in any of the groups.Conclusions: Therapeutic needle aspiration as well as continuous catheter drainage both are equally effective in management of liver abscess but needle aspiration had the advantage of being less expensive, easily available and requiring less hospital stay.