Aminoglutethimide Treatment Research Articles

The effect of aminoglutethimide on the metabolism of testosterone in rat liver in vitro

Testosterone was incubated with liver slices of rats treated with aminoglutethimide (Elipten Ciba) for 7 or 14 days. Testosterone was metabolized more rapidly in the slices of both male and female liver after aminoglutethimide administration. Quantitative analysis of the testosterone metabolites indicated stimulation of ring A reduction and decrease of oxidation of the 17 β-hydroxy group after aminoglutethimide treatment.