Timely personalized preparation for pregnancy has an important preventive, prognostic, clinical value for the further course of gestational processes. Pregnancy planning by expectant parents, in principle a man and a woman, becomes especially important in the conditions of the COVID-19 pandemic, taking into account the tropism of the SARS-Cov-2 (COVID-19) virus to the vascular endothelium.
 The purpose of the study was to determine the features of pre-gravid preparation of future parents after suffering from the COVID-19 disease through the use of personalized preventive measures.
 Research materials and methods. 42 women and 42 of their men of reproductive age who were sick with COVID-19 were examined. The main group is represented by 21 couples who planned pregnancy after personalized training. Pregnancy occurred spontaneously in a short time after the disease in the comparison group (21 married couples). The developed and proposed preconception preparation algorithm included a timely assessment of their somatic condition in the postcovid period, including hemostasiological blood parameters, markers of inflammation (ferritin, CRP, D-dimer), detection of accompanying infectious flora, and determination of the safest term through which to rationally recommend pregnancy planning, personalized pre-gravid preparation 3-4 months before expected natural fertilization.
 Research results and their discussion. The presence of infectious processes in the body of women is a concomitant factor of the course of COVID-19 and the features of the clinical manifestations of the post-covid syndrome. Increased levels of markers of inflammation (ferritin, CRP, D-dimer) and decreased levels of vitamin D, magnesium are the basis for the pathogenetic justification of the stage of complex personalized preconception preparation.
 Conclusions. Features of the pre-gravid preparation of future parents (male/female) after having experienced the disease of COVID-19 are: 1) timely assessment of their somatic condition in the post-covid period, including hemostasiological indicators of blood, markers of inflammation (ferritin, CRP, D-dimer), detection of accompanying infectious flora and determination of the safest period through which to rationally recommend pregnancy planning; 2) use according to the indications of preventive comprehensive personalized prevention and personalized pregravid preparation 3-4 months before the expected natural fertilization, including by taking vitamin macro-microelement amino acid complexes containing Methylfolate and continuing their intake throughout the gestation period. Indicators of the blood coagulation system were monitored by trimester of pregnancy.