American Population Research Articles

A blended genome and exome sequencing method captures genetic variation in an unbiased, high-quality, and cost-effective manner.

We deployed the Blended Genome Exome (BGE), a DNA library blending approach that generates low pass whole genome (1-4× mean depth) and deep whole exome (30-40× mean depth) data in a single sequencing run. This technology is cost-effective, empowers most genomic discoveries possible with deep whole genome sequencing, and provides an unbiased method to capture the diversity of common SNP variation across the globe. To evaluate this new technology at scale, we applied BGE to sequence >53,000 samples from the Populations Underrepresented in Mental Illness Associations Studies (PUMAS) Project, which included participants across African, African American, and Latin American populations. We evaluated the accuracy of BGE imputed genotypes against raw genotype calls from the Illumina Global Screening Array. All PUMAS cohorts had concordance ≥95% among SNPs with MAF≥1%, and never fell below ≥90% for SNPs with MAF<1%. Furthermore, concordance rates among local ancestries within two recently admixed cohorts were consistent among SNPs with MAF≥1%, with only minor deviations in SNPs with MAF<1%. We also benchmarked the discovery capacity of BGE to access protein-coding copy number variants (CNVs) against deep whole genome data, finding that deletions and duplications spanning at least 3 exons had a positive predicted value of ~90%. Our results demonstrate BGE scalability and efficacy in capturing SNPs, indels, and CNVs in the human genome at 28% of the cost of deep whole-genome sequencing. BGE is poised to enhance access to genomic testing and empower genomic discoveries, particularly in underrepresented populations.

High Resolution Class I HLA -A, -B, and -C Diversity in Eastern and Southern African Populations.

Africa remains significantly underrepresented in high-resolution Human Leukocyte Antigen (HLA) data, despite being one of the most genetically diverse regions in the world. This critical gap in genetic information poses a substantial barrier to HLA-based research on the continent. In this study, Class I HLA data from Eastern and Southern African populations were analysed to assess genetic diversity across the region. We examined allele and haplotype frequency distributions, deviations from Hardy-Weinberg Equilibrium (HWE), linkage disequilibrium (LD), and conducted neutrality tests of homozygosity across various populations. Additionally, the African HLA data were compared to those of Caucasian and African American populations using the Jaccard index and multidimensional scaling (MDS) methods. The study revealed that South African populations exhibited 50.4% more genetic diversity within the Class I HLA region compared to other African populations. Zambia showed an estimated 36.5% genetic diversity, with Kenya, Rwanda and Uganda showing 35.7%, 34.2%, and 31.1%, respectively. Furthermore, an analysis of in-country diversity among different tribes indicated an average Class I HLA diversity of 25.7% in Kenya, 17% in Rwanda, 2.8% in South Africa, 13.6% in Uganda, and 6.5% in Zambia. The study also highlighted the genetic distinctness of Caucasian and African American populations compared to African populations. Notably, the differential frequencies of disease-promoting and disease-preventing HLA alleles across these populations emphasize the urgent need to generate high-quality HLA data for all regions of Africa and its major ethnic groups. Such efforts will be crucial in enhancing healthcare outcomes across the continent.

Joint genotype and ancestry analysis identify novel loci associated with atopic dermatitis in African American population

Atopic dermatitis (AD) is a chronic itchy inflammatory disease of the skin. Genetic studies have identified multiple risk factors linked to the disease; however, most of studies have been derived from European and East Asian populations. The admixed genome of African American (AA) may provide an opportunity to discovery ancestry-specific loci involved in AD susceptibility. Herein, we present joint analysis of ancestry and genotype effects followed with validation using differential gene expression analysis on AD using 710 AD cases and 1015 non-AD controls from the AA population, genotyped using MEGA followed by imputation using the CAAPA reference panel. The joint analysis identified two novel AD-susceptibility loci, rs2195989 in gene ANGPT1 (8q23.1) and rs62538818 in the intergenic region LURAP1L—MPDZ (9p23). Admixture mapping (AM) results showed potential genomic inflation, and we implemented genomic control and identified five ancestry-of-origin loci with European ancestry effects. The multi-omics functional prioritization of variants in AM signals prioritized the loci SLAIN2, RNF39, and FOXA2. GWAS identified variants significantly associated with AD in the AA population, including SGK1 (rs113357522, OR = 2.81), EFR3A (rs16904552, OR = 1.725), and MMP14 (rs911912, OR = 1.791). GWAS variants were common in the AA but rare in the European population, which suggests an African ancestry-specific risk of AD. Four genes (ANGPT1, LURAP1L, EFR3A, and SGK1) were further validated using qPCR from AD and healthy skin. This study highlighted the importance of genetic studies on admixed populations, as well as local ancestry and genotype-ancestry joint effects to identify risk loci for AD.

Association of triglyceride-glucose-body mass index with all-cause and cardiovascular mortality among individuals with chronic kidney disease

There is still a paucity of research on the relationship between triglyceride-glucose-body mass index (TyG-BMI) and long-term all-cause and cardiovascular disease (CVD) mortality in patients with chronic kidney disease (CKD). The objective of this study was to explore the relationship between the TyG-BMI index and mortality rate and to determine valuable predictive factors for the survival status of this population. Data were obtained from the National Health and Nutrition Examination Survey (NHANES 2001–2018) and the National Death Index (NDI). We used multivariate Cox regression and restricted cubic spline (RCS) to analyze the link between the TyG-BMI index and all-cause and CVD mortality. Subgroup analysis was conducted according to age, gender, race, education and poverty. In addition, receiver operating characteristic (ROC) curves were utilized to assess the differentiation of the TyG-BMI index in predicting mortality. A total of 3089 individuals were enrolled. Over a median follow-up period of 81 months, 1097 individuals passed away. The RCS analysis revealed a U-shaped link between the TyG-BMI index and all-cause and CVD mortality. The ROC curve indicated that the TyG-BMI index has a stronger diagnostic effect than the TyG index. Subgroup analysis results demonstrated that the TyG-BMI index was more significantly correlated with all-cause and CVD mortality rates in elderly patients. In the American population, a U-shaped association was discovered between the baseline TyG-BMI index and all-cause and cardiovascular mortality rates in CKD patients. The thresholds for all-cause and CVD mortality were found to be 299.31 and 294.85, respectively.

Heart Failure Among Asian American Subpopulations

Heart failure (HF) is a leading cause of death in the US. The current evidence on the burdens of HF in Asian American populations, especially Asian American subgroups, is limited and inconsistent. To assess and compare the incidence and prevalence of HF in Asian American subgroups. This retrospective cohort study used electronic health record data from patients 40 years or older with health care encounters from January 1, 2015, to December 31, 2019, recorded in the Oracle Electronic Health Record Real-World Data database, which has more than 100 health care systems across the US contributing to the database as of February 2024. For prevalence analysis, the study samples were those who had at least 1 encounter in the study calendar year. For incidence analysis, participants were additionally limited to those without HF before the study year who also had encounter(s) the year before the study year. Data analysis was performed from August 1, 2023, to July 31, 2024. Race and ethnicity were determined using patient self-reported data, which were categorized as Black, East Asian, South Asian, Southeast Asian, other Asian (without specified ethnicity), and White. Outcomes were incidence and prevalence of HF, identified using recorded International Classification of Diseases, Ninth Revision, Clinical Modification and International Statistical Classification of Diseases, Tenth Revision, Clinical Modification codes. Age- and sex-standardized incidence and prevalence were used to calculate the risk ratio of each racial and ethnic group compared with White patients. Incidence and prevalence analyses were performed for 6 845 791 patients (mean [SD] age, 62.1 [12.5] years; 59.9% female; 2.8% Asian, 6.7% Black, and 90.5% White) and for 13 440 234 patients (mean [SD] age, 61.7 [12.7] years; 57.0% female; 2.9% Asian, 7.1% Black, and 90.0% White), respectively. Using the 2015 population as the standard, age- and sex-standardized HF incidence was 2.26% (95% CI, 2.07%-2.45%) for Southeast Asian patients, 1.56% (95% CI, 1.31%-1.82%) for South Asian patients, and 1.22% (95% CI, 1.06%-1.38%) for East Asian patients compared with 1.58% (95% CI, 1.57%-1.59%) for White patients and 2.39% (95% CI, 2.36%-2.42%) for Black patients. Similarly, heterogeneous rates in Asian American subgroups were also observed in the prevalence analysis. In this study of HF outcomes, the disparities between Southeast and East Asian patients were larger than those between Black and White patients, with the estimates in Southeast Asian patients being similar to those of Black patients. These findings reinforce that individual Asian ethnicities and cardiovascular risk factors should be considered in the assessment of HF risks.

Biochemical profile of renal amyloidosis in a Latin American cohort.

Two-thirds of patients with immunoglobulin light chain (AL) amyloidosis have renal involvement. The biochemical profile of kidney damage is poorly described. A cross-sectional study was conducted involving patients diagnosed with AL amyloidosis and renal involvement between January 1, 2010, and April 30, 2022 at the Hospital Italiano de Buenos Aires. Participants were retrospectively identified from the Institutional Amyloidosis Registry. Patients diagnosed with AL amyloidosis and evidence of renal involvement were included. Individuals with other types of amyloidosis were excluded. The selection process involved a thorough review of medical records and registry data to ensure accurate identification and inclusion of eligible participants. Seventy-seven patients were included. At diagnosis, 90% of the subjects had proteinuria, with a median of 4.3g/24h, 61% had renal failure, and 47% presented nephrotic syndrome. Semi-automated urinary electrophoresis revealed 55% with non-selective and 21% with moderately selective glomerular proteinuria. Urine immunofixation indicated 64% with lambda monoclonal free light chains and 12% with kappa. Serum immunofixation demonstrated 48% with lambda monoclonal type and 25% with lambda IgG.At the time of diagnosis of AL amyloidosis, the median age was 66years (IQR 53-72) and 49% were men. In addition to kidney involvement, other organs were also affected: heart in 53%, gastrointestinal system in 19%, peripheral nervous system in 16%, and liver in 16% of patients. Our study provides a biochemical profile in renal amyloidosis due to immunoglobulin light chains in a Latin American population. Proteinuria emerged as the most commonfinding in this cohort with frequent multiorgan involvement.

764. PREDICTING AGE-SPECIFIC PREVALENCE OF BARRETT'S OESOPHAGUS IN AUSTRALIAN AND UNITED STATES

Abstract Background Barrett’s esophagus is the precursor to esophageal adenocarcinoma (EAC). EAC detected from endoscopic surveillance programs accounts for &amp;lt;10% of all EAC, suggesting a large number of patients with Barrett’s esophagus are likely unaccounted for. Several studies have estimated the observed prevalence of Barrett’s esophagus to be approximately 1%, but this may be an underestimate. The aim of this study is to use population incidence of EAC and rate of progression from Barrett’s esophagus from large cohort studies to estimate a realistic prevalence of Barrett’s esophagus. Methods A simple tree cohort model was created for progression to EAC from birth to death (100 years) for American and Australian population. Lifetime risk of esophageal cancer and adenocarcinoma were endpoints. This was then used to back-calculate age-specific and overall prevalence of Barrett’s esophagus using an optimisation algorithm. Results Lifetime risk of esophageal cancer and adenocarcinoma in US Whites is 0.56% and 0.36% respectively, while in Australian population is slightly higher at 0.81% and 0.61% (range 0.57% - 0.65%). Estimated overall prevalence of Barrett’s esophagus is ~3% (±0.3%) and ~5.4% (±0.6%) in US White and Australian populations, while in males is 5.3% (±0.6%) and 7.4% (±0.3%), respectively. Female cohorts were seen to have lower chance of developing esophageal cancer, adenocarcinoma, and Barrett’s esophagus. Conclusion Cohort studies of Barrett’s esophagus are likely to underestimate its prevalence of this silent disease. Computational models based on progression from Barrett’s esophagus to EAC accounting for undetected disease reveal higher estimates, which can help in future screening options.

49158 Examination of Medicaid Insurance as a barrier to patient choice in scalp psoriasis treatment modalities in the African American population

49158 Examination of Medicaid Insurance as a barrier to patient choice in scalp psoriasis treatment modalities in the African American population

Genomic Landscape in Prostate Cancer in a Latin American Population.

This study aims to describe genomic characteristics of patients with metastatic prostate cancer (mPC). This study is a retrospective, multicenter cohort study of patients with mPC and reports on genomic testing. Patients were included from 12 academic centers in five countries. A total of 349 patients with PC were included in this study. Most patients (209, 59.9%) were de novo metastatic. Genomic analysis was performed in 233 (66.6%) patients in the metastatic castration-resistant prostate cancer (mCRPC) setting, and only 115 (32.8%) patients had a tumor evaluation in the metastatic hormone sensitive prostate cancer scenario. The evaluation of somatic and/or germline mutations was performed through multigene panel analyses in 290 (83.09%) patients, and next-generation sequencing of BRCA1 and BRCA2 genes was performed in 59 (16.91%) patients. Analyzing the mCRPC subgroup, with a median follow-up of 15.6 months (IQR, 14-19.06), the median progression-free survival (PFS) was not reached (NR) and the PFS at 16 months was 58.7% (95% CI, 50.8 to 67.8). When comparing patients with BRCA mutations with those who are not BRCA-mutated in the mCRPC scenario, the median PFS was NR (95% CI, 14 to NR) and 26.3 months (95% CI, 16.7 to 36.5; P = .2), respectively. Two of six patients with BRCA mutations were treated with targeted therapies (poly-ADP-ribose polymerase inhibitors). Our study, to the best of our knowledge, represents one of the larger data sets for somatic testing in patients with PC in Latin America (LATAM). It adds valuable information to the growing body of knowledge about the genomic landscape of advanced PC in real-world daily practice scenarios in LATAM countries, which are not always well-represented in large-scale randomized clinical trials.

Comparing the Diagnostic Yield of Germline Exome Versus Panel Sequencing in the Diverse Population of the Texas KidsCanSeq Pediatric Cancer Study.

To evaluate the relative diagnostic yield of clinical germline genomic tests in a diverse pediatric cancer population. The KidsCanSeq study enrolled pediatric cancer patients across six sites in Texas. Germline analysis included both exome sequencing and a therapy-focused pediatric cancer gene panel. The results were categorized by participants demographics, the presence of pathogenic or likely pathogenic (P/LP) variants, and variants of uncertain significance (VUS) in cancer predisposition genes (CPGs). Pediatric actionable CPGs were defined as those with cancer surveillance recommendations during childhood. Cancer P/LP variants were reported by at least one platform in 103 of 578 (17.8%) participants of which 76 were dominant cancer genes (13.1%) with no significant differences by self-described race or Hispanic ethnicity. However, the proportion of participants with VUS was greater in Asian and African American participants (P = .0029). Diagnostic yield was 16.6% for exome versus 8.5% for panel (P < .0001) with 42 participants with concordant germline results. Exome-only results included P/LP variants in 30 different CPGs in 54 participants, whereas panel-only results included seven participants with a copy number or structural P/LP variants in CPGs. There was no significant difference in diagnostic yield limited to pediatric actionable CPGs (P = .6171). Approximately 18% of a diverse pediatric cancer population had germline diagnostic findings with 50% of P/LP variants reported by only one platform because of CPGs not on the targeted panel and copy number variants (CNVs)/rearrangements not reported by exome. Although diagnostic yields were similar in this diverse population, increases in VUS results were observed in Asian and African American populations. Given the clinical significance of CNVs/rearrangements in this cohort, detection is critical to optimize germline analysis of pediatric cancer populations.

Centering Asian Americans in Social Work Education, Research, and Policy

ABSTRACT The Asian American population is incredibly diverse in terms of ethnicity, culture, language, religion, class, and histories of war shaped by U.S. imperialism. Understanding this immense diversity is crucial for engaging with communities while recognizing the diversity–convergence paradox - the idea that Asian Americans share common experiences of discrimination and racialization despite their varied backgrounds and social locations. This paradox offers a critical lens to address health and social challenges for Asian Americans and other minoritized populations. Drawing on insights that account for this paradox, this article reflects on the authors’ experiences as Asian American social work scholars and alumni of the Council on Social Work Education’s Minority Fellowship Program. We discuss contemporary and historical issues facing Asian American communities as well as offer recommendations for advancing antiracism, diversity, equity, and inclusion within social work and beyond.

Treatment of secondary uterine malignancy following radiotherapy for cervical cancer: a study based on the SEER database

BackgroundRadiotherapy is one of the main treatments for cervical cancer. Long-term complications of radiation exposure include the emergence of secondary tumors. This is a retrospective study based on an American population. We discuss the optimal treatment modality for patients with radiation-induced secondary uterine malignancy based on the Surveillance, Epidemiology, and End Results database.MethodsThe study included patients with a definitive pathological diagnosis of cervical cancer who were diagnosed with a uterine malignant tumor ≥ 1 year later. Patients in whom cervical cancer was not the first tumor or patients with missing data were excluded. Univariate and multivariate analyses were performed using the COX regression model to screen independent prognostic factors affecting overall survival. Kaplan-Meier survival curves were analyzed using the R software package.ResultsWe screened 142 patients with a secondary uterine malignancy after cervical cancer treatment, 115 patients with a secondary uterine malignancy after radiotherapy, and 27 patients with a secondary uterine malignancy who did not receive radiotherapy. The average latency period for developing a secondary tumor was 8 years, and 57.04% of the patients had a second tumor at ≥ 60 years of age. In patients with a secondary uterine malignancy after radiotherapy, surgery improved the prognosis [hazard ratio (HR), 0.374; 95% confidence interval (CI), 0.229–0.612], whereas radiotherapy and chemotherapy did not reduce the risk of death. In the subgroup analysis, the surgery plus chemotherapy group had a significantly better survival prognosis than the other groups (HR, 0.251; 95% CI, 0.122–0.515).ConclusionsThe results suggest that the treatment modality in patients with secondary uterine malignancy after radiotherapy for cervical cancer has a significant impact on survival. The survival outcomes of patients receiving surgery combined with chemotherapy are superior to those of patients receiving other treatments.

Characteristics, Treatment, and Prognosis of Heart Failure Patients with Chronic Obstructive Pulmonary Disease in the Colombian Heart Failure Registry (RECOLFACA).

The impact of chronic obstructive pulmonary disease (COPD) on heart failure (HF) has yet to be well assessed in the Latin American population. This study aimed to analyze the impact of COPD on HF patients from the Colombian Heart Failure Registry (RECOLFACA). The primary outcome was all-cause mortality. A Cox proportional-hazards regression model was used to assess the impact of COPD on mortality. From the total of 2528 patients in the registry, 2514 patients had information regarding COPD diagnosis. COPD diagnosis was associated with a worse functional class and higher use of diuretics than non-COPD patients (p < 0.001). Patients with this comorbidity had a significantly better ejection fraction (median ejection fraction 35% vs. 32% in non-COPD patients; p = 0.004), with a higher occurrence of HF with preserved ejection fraction (HFpEF) in the COPD group (p = 0.000). Finally, patients with COPD had a significantly higher risk of mortality in the multivariate regression model (HR 1.47; 95% CI 1.02, 2.11). COPD is a prevalent comorbidity among patients with HF in Colombia, showing a different clinical profile and a worse functional class than patients without this condition. Patients with COPD and HFpEF have a high mortality risk according to our results.

The effect of laparoscopic and abdominal surgery on the treatment of ectopic pregnancy: a systematic review and meta-analysis.

This study aimed to compare the efficacy of laparoscopic surgery (LS) and abdominal surgery (AS) in ectopic pregnancy surgery. A computer-based search was conducted in several databases such as CNKI, Wanfang data, VIP data, Chinese Biomedical Literature Database (CBM disc), PubMed, Cochrane Library, Embase, and others to gather domestic and foreign literature on treating ectopic pregnancy. This search was carried out from the inception of each database to July 2022. The literature review was performed using Endnote X9 software, and the data were analyzed using STATA 15.1 software for the meta-analysis. Eight articles that met the inclusion criteria were included in the study. The meta-analysis showed that the laparoscopic group had shorter operation time than AS group [SMD = -1.28, 95%CI (-2.02, 0.54), p = 0.001], had less intraoperative bleeding [SMD = -3.06, 95%CI (-3.82, -2.31), p < 0.01], shorter postoperative anus exhaust time [SMD = -2.60, 95%CI (-3.26, -1.93), p < 0.01], and shorter hospital stay [SMD = -1.74, 95%CI (-2.09, -1.39), p < 0.01] with few complications [RR = 0.22, 95%CI (0.08, 0.55), p = 0.001]. LS has more evident advantages in the treatment of patients with ectopic pregnancy. However, due to the lack of English literature that meets the inclusion criteria, further studies are needed to determine if LS has the same efficacy for European and American populations.

Racial and ethnic disparities in health risk from industrial surface water pollution in the United States, 2011–2021

Industrial chemical pollution is released into surface water at a large scale annually in the United States. However, geographic variation and racial disparities in potential exposure are poorly understood at a national scale. Using county-level Risk-Screening Environmental Indicators data for 2011–2021 and American Community Survey data, this study analyzes the spatial and temporal distribution of health risk from modeled water releases using a Gamma hurdle model. Several racial disparities in presence of risk and amount of risk were identified, particular for Black or African American and Asian populations. At least 200 million U.S. residents live in a county where health risk from this pollution is present. Exposure reduction in high-risk areas may improve health for the broader population while also reducing inequities.

Rotating-Hinge Total Knee Arthroplasty: Clinical and Radiographic Results from a Medium-Term, Multi-Center Study in a Latin American Population

Background: Hinged prostheses are a good choice in the setting of complex knee arthroplasty. Nevertheless, the results could be different in the Latin-American people. Methods: A retrospective follow-up was performed. Seventy-six patients underwent pTKA using hinged prosthesis from 2012 to 2017. Survival analysis was performed with the Kaplan-Meier method. Functional results were assessed using Oxford Knee Score (OKS), OKS-APQ (Activity and Participation Questionnaire) and KOOS-12. Radiologic assessment was performed at each follow-up. In all the surgeries the rotating-hinge prosthesis solved the cases of complex knee surgery. Results: Seventy-six patients underwent pTKA using hinged prosthesis from 2012 to 2017. Survival analysis was performed with the Kaplan-Meier method. Functional results were assessed using Oxford Knee Score (OKS), OKS-APQ (Activity and Participation Questionnaire) and KOOS-12. Radiologic assessment was performed at each follow-up. In all the surgeries the rotating-hinge prosthesis solved the cases of complex knee surgery. Hinge prostheses for complex knee arthroplasty in Latin-American people have a 10-year survivorship of 90.8% which is within the range of 51% to 92.5%, shown in a recent literature review of non-Latin American world population. Conclusions: Rotating Hinge prostheses are a good option for patients with major deformities, grade 3 ligament instability, neurological sequalae that compromises the knee joint and severe bone loss. The Latin-American population shows a similar behavior in terms of survivorship in comparison with the literature from the rest of the world. However, comparative studies with greater statistical power are needed to show more accurate conclusions. Level of Evidence: Level III

Phylogenetic position of Zeldia punctata (Nematoda: Cephalobidae) using 28S rDNA from Limpopo Province, South Africa

The Cephalobidae (Free-living nematodes) family are bacterivores that inhabit soil. Bacterial-feeding nematodes are one of the main consumers of soil bacteria. Therefore, study on this group of nematodes is essential. This molecular study was conducted in 2024 at Limpopo University to identify the free-living bacterivores nematodes from South Africa's soils, using a 28S rDNA marker. The recovered nematode was extracted using the tray method, and then its DNA was extracted using the Chelex method. The nematode was identified as Zeldia punctata. Afterwards, 28S rDNA was amplified using specific primers to identify the nematode. The Nblast analysis based on the 28S rDNA showed South African Z. punctata has 98% similarity (DQ145662) with the American population. Phylogenetic analysis using maximum likelihood placed this species with those molecularly identified as Z. punctata in the same clade with highly supported (94%) bootstrap values. In conclusion, this species was properly identified using 28S rDNA. However, other rDNA markers are recommended to better understand Zeldia phylogeny.

Collum Femoris-Preserving Hip Stem: Clinical and Radiographical Results from a Medium-Term, Multi-Centric Study in a Latin American Population

Background: There is a lack of information related to the medium-term results of short stem prosthesis in the Latin-American population. This study represents the longest follow-up results of the CFP prosthesis in the Latin-American population. Methods: Two-hundred fifty-five patients treated with anatomic neck preserving from June 2013 to June 2020 were enrolled in the current study. The mean follow-up was 81 (60-96) months. All the subjects were available for the follow-up examination at a minimum of 5 years after surgery. Clinical results were assessed using Oxford Hip Score (OHS). Radiologic assessment was performed at each follow-up. Results: Follow-up was 81 (60-96) months. Two-hundred fifty-five patients were contacted. The patients with hip dysplasia were operated with the CFP stem in 10.2% of all cases; with regards to the Dorr classification of the proximal femur, type 1: 9.8%; type 2: 88.6% and type 3: 1.6%. The overall prosthesis survival was 96.1%. The functional results were OHS pre: 9.1 (3-35), post: 44.4 (27-48). Conclusion: The surgeries with CFP stem have excellent clinical results. The main indication of this short stem is primary hip osteoarthritis; nevertheless, we have some experience in dysplastic hips with good clinical results and survivorship. The results are comparable in terms of survivorship when this stem is implanted in Dorr 1, 2 and 3; however, we had a limitation, the sample was not comparable in the three groups. The overall survivorship, the functional scales and the radiographical results in the Latin-American population are comparable with literature reported around the world. Level of Evidence: Level III

Is the mantid Brunneria borealis (Mantodea: Coptopterygidae) really a native North American, or actually a South American colonist?

Abstract The common grass mantid, Brunneria borealis Scudder, is well known as perhaps the only completely parthenogenetic species among the more than 2,400 named mantid species. An abundant mantid within its broad geographic range, it has long been considered a native North American endemic; however, all other known species in the genus Brunneria (and in its family, Coptopterygidae) are South American. We were able, for the first time, to perform a genetic comparison between B. borealis and a congeneric South American species, B. subaptera. We sequenced a standard segment of the mitochondrial cytochrome oxidase I (COI) gene for which there is no variation among different populations among localities throughout the range of B. borealis, and compared this sequence with haplotypes from different South American populations of B. subaptera. The single B. borealis haplotype falls within the genetic variation of populations of B. subaptera, suggesting that the North American mantid is really a colonist from this South American species.

Incidence of Cytogenetic Abnormalities in Myelodysplastic Syndrome in the African American Population: A Decade-Long Single-Center Real-World Experience

Incidence of Cytogenetic Abnormalities in Myelodysplastic Syndrome in the African American Population: A Decade-Long Single-Center Real-World Experience