Midwestern Research Articles

(026) LOWER SEXUAL FUNCTIONING AND, IN PARTICULAR, SEXUAL PAIN IS ASSOCIATED WITH MORE FREQUENT USE OF ALCOHOL AND RECREATIONAL SUBSTANCES WITH SEXUAL ACTIVITY IN YOUNG WOMEN

Abstract Introduction Research on the relationship between alcohol use and women’s sexual functioning has varied, with some studies showing that alcohol use increases self-reported sexual arousal and others showing alcohol-induced decreases in genital arousal (George, 2019). As such, expectancies tend to be self-fulfilling for subjective effects of alcohol, regardless of the physiological effects (Lee et al., 2014). Most research on sexual functioning and alcohol use has failed to look at the intentional use of alcohol to enhance sexual activity, despite the common use of recreation substances with sexual activity (sex-linked substance use, SLSU) in college age populations (Willis et al., 2021; Herbenick et al., 2018). One study found that while drinking was related to fewer problems with sexual function, SLSU was associated with lower sexual functioning for arousal, lubrication, orgasm, and satisfaction but not sexual pain (Witting et al., 2008). It has been proposed that women may engage in SLSU for different reasons such as to overcome inhibitions or to increase pleasure; however, it is unclear how these intentions are related to sexual dysfunction and relationship status. Objective To investigate how patterns of SLSU for different purposes are related to different dimensions of women’s sexual function. Methods We surveyed 701 women (mean age 20.42, SD = 2.55) in the Midwestern US. Participants reported their frequency of SLSU within the last month to “feel less sexually inhibited”, “increase your sexual desire or arousal” and “increase your sexual pleasure, or to make it easier to have an orgasm”. SLSU was measured as a total factor across the three intentions and as individual subfactors. Participants also completed the Female Sexual Function Index (FSFI; Rosen et al., 2000) and demographic measures including relationship status. Using independent multivariate general linear models, we examined how subfactors of the FSFI, particularly pain, were related to frequency of SLSU. Results Our results indicate that among young adult women, higher use of SLSU broadly was associated with FSD as measured by the FSFI. Specifically, lower sexual functioning was associated with more frequent SLSU to feel less sexually inhibited and to increase sexual desire/arousal, but not SLSU to increase sexual pleasure/have an orgasm. Additionally, when considering relationship status, there was an interaction between SLSU and FSD such that women in a relationship without FSD reported the lowest SLSU compared to women in a relationship with FSD and compared to single women without FSD. Single women who did not meet criteria for FSD reported the highest levels of SLSU. When investigating subfactors of the FSFI and SLSU intentions, contrary to prior findings, women with more sexual pain reported more frequent SLSU to feel less sexually inhibited and to increase sexual pleasure/have an orgasm, but not to increase sexual desire/arousal. Conclusions Our results indicate that sexual functioning and in particular, sexual pain functioning, are related to frequency of SLSU. Further, our results suggest that both sexual function and relationship status interact in relation to SLSU. Clinically, these findings reinforce the value of discussing sexual pain and dysfunction alongside substance use intentions, particularly among young college aged women. Disclosure No.

The role of Black men in protecting Black girls' sexual development

AbstractBackgroundBlack girls in the United States are at increased risk for HIV and sexually transmitted infections due to early sexual development, stereotyping, adultification, and lack of protection. The Becoming a Sexual Black Woman framework highlights protection, or lack thereof, as a critical component of Black girls' sexual development.ObjectiveThe purpose of this study was twofold. First, we sought to understand how girls protect their bodies within the societal context of the COVID‐19 pandemic and social injustice. Second, we aimed to explore how Black men can better protect Black girls' sexual development.MethodWe conducted 25 in‐depth interviews with Black girls aged 9 to 18 years, primarily across the Midwestern United States. We performed a directed content analysis by reviewing transcripts, coding data, and developing themes.ResultsFindings revealed four themes: (a) feeling unsafe, (b) adultification of Black girls' bodies and increased vulnerability to harm, (c) desire for more protection by Black male caregivers, and (d) needing Black men to speak up.ConclusionBlack men's engagement in girls' sexual development may significantly influence the health outcomes of Black girls and women throughout their life course.ImplicationsFindings may inform future family‐based interventions that better protect and promote the sexual health and development of Black girls.

Student's and Classmates' Prosocial Behavior predict Academic Engagement in Middle School.

Students' academic engagement is greatly informed by a classroom's social climate. However, more research is needed regarding how specific peer behavior, especially prosocial behavior, come to shape academic engagement. The present study investigated whether students' perceptions about their classmates' prosocial behavior were associated with their academic engagement (cognitive, behavioral, affective) across the school year. Indirect effects via increases in students' own prosocial behavior were examined. Participants were 905 middle school students from rural, low-income communities in the Midwestern United States (50% girls, 46% boys; Mage = 12.94 years). Students completed self-report surveys in the fall and spring of the 2022-2023 school year. Results revealed that students' perceptions of their classmates' prosocial behavior were positively associated with students' own prosocial behavior. Students' own prosocial behavior was positively associated with all three dimensions of engagement. The positive indirect effect of classmates' prosocial behavior on engagement through students' own prosocial behavior was significant. The findings highlight the importance of classmates' behavior on individuals' academic engagement and offer insights into classroom-based interventions aimed at improving collective behavior.

Standardization and selection of organic solvent and extraction parameters for charantin in bitter gourd (Momordica charantin L.) fruits

Bitter gourd (Momordica charantia L. Cucurbitaceae) is an important vegetable and medicinal crop that is grown in several tropical countries such as India, China, Malaysia, Bangladesh, part of Africa, Central North America, South North Asia, Singapore, Japan, and Vietnam. It is also used as raw fruit juice for cooking fruits and vegetable dishes. The fruits, leaves, and seeds of this plant contain charantins, which are insulin-like compounds. Therefore, it is essential to develop nutrient-rich extracts that are more effective for diabetes. Ethanol and methanol are edible solvents that enable the preparation of charantin-rich extracts. Experiments were conducted on charantin extraction using ethanol and methanol in a Soxhlet apparatus. The study concluded that methanol is a better solvent for the production of charantin-rich extracts. Methanolic extracts had fewer impurities, less chlorophyll interference in the analysis, and better peak strength. The results of the study showed that there was 380–990 ug/g dry fruit powder dry weight content of charantin-level expression in fruit dried powder in methanolic extract, compared with ethanolic extract, which was 200–700 ug/g dry weight. The data show the significance of the use of methanol for bitter gourd charantin extraction.

Prolonged Opioid Use and Associated Factors After Open Reduction and Internal Fixation of Tibial Shaft Fractures.

The aim of this retrospective cohort study was to determine the rate of prolonged opioid use and identify associated risk factors after perioperative opioid exposure for tibial shaft fracture surgery. We used the MarketScan Commercial Claims and Encounters database (IBM) to identify patients 18 to 64 years old who filled a peri-operative opioid prescription after open reduction and internal fixation of a tibial shaft fracture from January 2016 to June 2020. Multivariable logistic regression identified factors (eg, demographics, comorbidities, medications) associated with prolonged opioid use (ie, filling an opioid prescription 91 to 180 days postoperatively); adjusted odds ratios (ORs) and 95% CIs were reported. The rate of prolonged opioid use was 10.5% (n=259/2475) in the full cohort and 6.1% (n=119/1958) in an opioid-naive subgroup. In the full cohort, factors significantly associated with increased odds of prolonged use included preoperative opioid use (OR, 4.76; 95% CI, 3.60-6.29; P<.001); perioperative oral morphine equivalents in the 4th (vs 1st) quartile (OR, 2.68; 95% CI, 1.75-4.09; P<.001); age (OR, 1.03; 95% CI, 1.02-1.04; P<.001); and alcohol or substance-related disorder (OR, 1.66; 95% CI, 1.15-2.40; P=.01). Patients in the Northeast and North Central (vs South) regions had decreased odds of prolonged use (OR, 0.61-0.69; P=.02-.04). When removing preoperative use, findings were similar in the opioid-naive subgroup. Prolonged opioid use is not uncommon in this orthopedic trauma population, with the strongest risk factor being preoperative opioid use. Nevertheless, shared risk factors exist between the opioid-naive and opioid-tolerant subgroups that can guide clinical decision-making. [Orthopedics. 2024;47(4):e188-e196.].

Organic carbon in Mollisols of the world − A review

Mollisols represent 29 % of agricultural land and they are considered to be one of the most fertile soils in the world. Here, we compare soil organic carbon (SOC) concentrations and pools of Mollisols for the globe, the USA and Poland, and review how differences are caused by climate, land use, and key environmental factors. Globally, the mean thickness of the A horizon in Mollisols is 50 cm. At 0–30 cm the mean SOC concentration is 2.3 %, SOC pool is 84 t ha−1, and clay content calculated at 0–50 cm soil depth is 21 %. Mollisols in the USA have an A horizon thickness of 36 cm and have a mean clay content of 27 % (0–50 cm). SOC concentrations are 2.0 and 1.7 % and SOC pools are 85 and 116 t ha−1 at 0–30 and 0–50 cm soil depth, respectively. Mollisols in Poland have SOC concentrations of 1.8 and 1.5 % at 0–30 and 0–50 cm soil depth, respectively, and lower clay content (17 %) at 0–50 cm depth. The SOC pool at 0–30 cm depth is 74 t ha−1 whereas it is 106 t ha−1 at 0–50 cm. At the global scale, the highest SOC concentrations and pools are in Mollisols from Eastern Europe (including Ukraine and Western Russia) and Asia, while the lowest SOC pools are found in Mollisols from South America. The Mollisols in Western and Central Europe and North America have similar SOC pools, although Mollisols in North America have higher SOC concentrations and lower A horizon thickness. Globally, the mean pH value of Mollisols is 7.1, and the pH is slightly lower in Mollisols of the USA (6.9 ± 0.9). The SOC concentrations and pools are strongly and positively correlated with clay content. Soil moisture and temperature regimes determine SOC concentration and pools in Mollisols, and higher SOC concentrations and pools are in Mollisols with frigid and frigid-cryic soil temperature regimes as well as aquic, xeric, and aridic soil moisture regimes. Mollisols under grassland have the largest SOC pools compared to those cultivated or under forest. The important environmental factors on SOC concentrations and pools in Mollisols worldwide are soil texture, land use, and soil temperature regime.

Racial Disparities in Newborn Drug Testing After Implementation of Question-Based Screening for Prenatal Substance Use.

To examine the association of universal question-based screening for prenatal substance use on racial inequities in prenatal and newborn drug testing. We conducted a retrospective cohort study of 32,802 live births of patients receiving prenatal care at an academic medical center in the midwestern United States from 2014 to 2022, before and after implementation of question-based screening in 2018. Primary outcomes included prenatal and newborn drug test orders. Logistic regression models using a generalized estimating equation framework assessed associations with question-based screening and results, birthing parent age, race, ethnicity, marital status, and insurance type. Charts of patients who indicated difficulties stopping substance use were audited for guideline-directed care. A total of 12,725 of 14,992 pregnant people (85.3%) received question-based screening. Implementation of question-based screening was associated with a decrease in prenatal urine test orders (5.0% [95% CI, 4.6-5.3%] before implementation, 3.1% [95% CI, 2.8-3.4%] after implementation; P <.001), with Black birthing parents having the largest reduction in prenatal urine drug testing (10.3% [95% CI, 9.0-11.7%] before implementation, 4.9% [95% CI, 3.9-5.9%] after implementation). However, rates of newborn drug testing did not change (4.7% [95% CI, 4.4-5.0%] before implementation, 4.5% [95% CI, 4.2-4.8%] after implementation; P =.46), and clinicians continued to order significantly more newborn drug tests for newborns of Black birthing parents compared with other race and ethnicity groups. Implementation of question-based screening for substance use in pregnancy was associated with decreased prenatal urine drug testing but no change in overall newborn drug testing or racial inequities in newborn drug testing for Black birthing people. Further policy efforts are warranted to improve substance use treatment and to eliminate racial inequities in punitive policies such as newborn drug testing and subsequent child protective services reporting.

Factors Associated with Erectile Dysfunction Among Older Gay Men

Erectile dysfunction (ED) is a common issue that aging men encounter, but whether internalized gay ageism (i.e., the internalization of ageist messages within the context of aging as a gay man) is related to ED among older gay men is unknown. A cross-sectional web-based survey explored the relationship between internalized gay ageism, health-related and social factors, and ED among older gay men who resided in the Midwest United States (N = 181). Internalized gay ageism was not significantly associated with ED. However, hierarchical regression analysis found that age (β = .224, t = 2.70, p = .008) and overall health (β = −.247, t = −3.05, p = .003) were significantly associated with ED among older gay men, suggesting that older gay men share similar risk factors for ED as the general male population. Future research should continue to explore other factors that are unique to gay men that may be associated with ED.

Factors associated with PrEP use in a community sample of African American men who have sex with men (MSM) and transgender women (TGW) in the United States Midwest

ABSTRACT Black sexual minority men who have sex with men (MSM) in the United States are at disparate risk for contracting HIV infection, but pre-exposure prophylaxis (PrEP) use is suboptimal. Social network methods were used to recruit a community sample of racial minority MSM and transgender women (TGW) in two Midwestern US cities. 250 PrEP-eligible (HIV-negative) participants completed measures assessing current and intended PrEP use; demographic characteristics; PrEP knowledge, attitudes, norms, stigma, and self-efficacy; and structural barriers to PrEP. Multivariate analyses established predictors of current and intended PrEP use. Only 12% of participants reported currently using PrEP, which was associated with greater PrEP knowledge and not having a main partner, with trends for greater PrEP use by younger participants and those with partners living with HIV. Among participants not currently on PrEP, strength of PrEP use intentions was associated with higher PrEP knowledge, PrEP descriptive social norms, and PrEP use self-efficacy. This study is among few to directly compare Black who have adopted PrEP with those who have not. Its findings underscore the potential benefits of employing social network approaches for strengthening PrEP use peer norms, increasing PrEP knowledge and self-efficacy, and optimizing PrEP uptake among racial minority MSM and TGW.

Buffel Grass (Pennisetum ciliare) Ecotypes Suitable for Subtropical Livestock in the North Central Region of Mexico

The objective was to determine the forage production and nutritional quality of six buffel grass ecotypes in vegetative and physiological maturity stages. The experiment was carried out at the Los Cañones Experimental Station in Zacatecas, Mexico. The ecotypes were as follows: E-42, E-45, E-66, E-72, E-S245, and the Titan variety as a control. The experiment design was a completely randomized block with three replications, and the evaluation years were from 2020 to 2022. The variables measured were as follows: plant height (PH), dry matter yield (DMY), leaf (Lf) and stem-inflorescence (St), crude protein (CP), neutral (NDF), and acid detergent fiber (ADF). Pearson’s correlation and a combined analysis of variance were performed for each growth stage. A correlation analysis showed significant relationships (p &lt; 0.05) between variables. In the vegetative stage, ecotypes E-42, E-45, and E-S45 showed accumulations of over 12% of CP, which were higher (p &lt; 0.05) than the ones for Titan. Low values of E-S245 (p &lt; 0.05) for NDF (63.44%) and ADF (44.49%) stood out among all ecotypes. In the maturity stage, Titan was surpassed by E-45 and E-S245 with CP higher than 4%. The neutral and acid fibers in E-42, E-45, and E-S245 were less than in Titan (p &lt; 0.05). Ecotypes E-42 and E-S245 are alternatives to improve feed efficiency in the dry subtropical climate of Zacatecas.

Characterization of Emergency Department Quality Assurance Cases Seen Within a Midwestern United States Health System.

Hospital quality-assurance (QA) processes, including peer-review committees, seek to identify high-risk areas. To characterize emergency department (ED) cases sent for QA review. A retrospective observational study was conducted of ED cases sent to a QA committee from November 2018 through July 2022 at three midwestern US hospitals. The QA records analyzed for these cases included the original incident report, case summary, and the committee determinations. One hundred and forty-seven cases were reviewed by the ED QA Committee. The most frequent referrals came from physicians. Common diagnostic categories included infectious (21%), cardiac (16%), gastrointestinal (11%), and neurologic (10%) concerns. Of the cases, 51% were considered nonpreventable, 33% were potentially preventable, and 9% were preventable. Inpatient boarding in the ED was explicitly implicated as a contributing factor in 6% of case reports. Peer physician reporting represent the largest referral source sent for review with the most frequent diagnostic categories, including infectious, cardiac, gastrointestinal, and neurological conditions. Preventable concerns were rare. This study provides a better understanding of the referral sources, diagnostic categories, and committee determinations in ED quality concerns. These results can target future investigations into case reporting and patient safety.

AgEvidence: a dataset to explore agro-ecological effects of conservation agriculture

Conservation agriculture (CA) is a set of principles thought to be able to enhance crop productivity while minimizing impacts on the environment. The evidence base for CA can be challenging to synthesize because it encompasses many different practices and social and agroecological outcomes. To facilitate synthesis of CA evidence we have created a dataset organizing 218 response variables from five common categories of CA: cover crops, tillage management, pest management, nutrient management, and crop diversification. These data cover the Midwestern United States (U.S.) from 1980–2020. The dataset is also summarized and visualized on the AgEvidence website, which enables users to interactively explore, filter, and download data. We hope this dataset will help a wide variety of stakeholders, including researchers, policy makers, advocacy groups, and growers access the evidence needed to make informed and impactful decisions about how to produce food with less negative environmental impact.

Global Competency Integration in STEAM Fields in Higher Education

The concept of Global Competency (GC) has a growing presence in many collegiate mission statements in the United States. This interconnected, multidisciplinary approach coincides with that of the concept of Science, Technology, Engineering, Arts, and Mathematics (STEAM) education. The focus of this study was to identify what extent GC is present in the classrooms and curriculums, as well as the implementation methods higher education instructors observe and / or utilize in their STEAM field programs. The participants in this study were STEAM-field instructors at higher education institutions in the United States in which GC or an equivalent term is located in their mission or strategic plan. Seventy-six instructors from the midwestern United States completed a survey to generate a GC integration score, and 13 of those also participated in an interview. The quantitative analysis identified a statistically significant difference between the integration scores of Arts and Science instructors and Arts and Engineering instructors. Qualitative analysis identified curriculum and instruction-based strategies of successful integration, common barriers to integration, and the sentiment that integration varies greatly from a regional and sometimes institution-wide setting. The findings of this study can help standardize the concept and integration of GC in higher education as well as provide curriculum developers and administrators with a look at how GC is represented in the current climate of higher education.

Antimicrobial Resistance Patterns of Outpatient Staphylococcus aureus Isolates

Oral non-β-lactam antibiotics are commonly used for empirical therapy of Staphylococcus aureus infections, especially in outpatient settings. However, little is known about potential geographic heterogeneity and temporal trends in the prevalence of S aureus resistance to non-β-lactams in the US. To characterize the spatiotemporal trends of resistance to non-β-lactam antibiotics among community-onset S aureus infections, including regional variation in resistance rates and geographical heterogeneity in multidrug resistance. This cross-sectional study used data from Veterans Health Administration clinics collected from adult outpatients with S aureus infection in the conterminous 48 states and Washington, DC, from January 1, 2010, to December 31, 2019. Data were analyzed from January to November 2023. Resistance to lincosamides (clindamycin), tetracyclines, sulfonamides (trimethoprim-sulfamethoxazole [TMP-SMX]), and macrolides. Spatiotemporal variation of S aureus resistance to these 4 classes of non-β-lactam antibiotics, stratified by methicillin-resistant S aureus (MRSA) and methicillin-sensitive S aureus (MSSA), and subdivided by regions of the US (Northeast, Midwest, South, and West). Trend tests and bivariate mapping were used to determine significant changes in resistant proportions over time and identify counties where rates of resistance to multiple non-β-lactams were high. A total of 382 149 S aureus isolates from 268 214 unique outpatients (mean [SD] age, 63.4 [14.8] years; 252 910 males [94.29%]) were analyzed. There was a decrease in the proportion of MRSA nationwide, from 53.6% in 2010 to 38.8% in 2019. Among MRSA isolates, we observed a significant increase in tetracycline resistance (from 3.6% in 2010 to 12.8% in 2019; P for trend < .001) and TMP-SMX resistance (from 2.6% in 2010 to 9.2% in 2019; P for trend < .001), modest and not significant increases in clindamycin resistance (from 24.2% in 2010 to 30.6% in 2019; P for trend = .34), and a significant decrease in macrolide resistance (from 73.5% in 2010 to 60.2% in 2019; P for trend < .001). Among MSSA isolates, significant upward trends in clindamycin, tetracyclines, and TMP-SMX resistance were observed. For example, tetracycline resistance increased from 3.7% in 2010 to 9.1% in 2019 (P for trend < .001). Regional stratification over time showed that the Northeast had slightly higher rates of clindamycin resistance but lower rates of tetracycline resistance, while the South had notably higher rates of resistance to tetracyclines and TMP-SMX, particularly among MRSA isolates. Bivariate mapping at the county scale did not indicate clear regional patterns of shared high levels of resistance to the 4 classes of antimicrobials studied. In this study of outpatient S aureus isolates, MRSA became less common over the 10-year period, and MRSA isolates were increasingly resistant to tetracyclines and TMP-SMX. Geographic analysis indicated no spatial overlap in counties with high rates of resistance to both tetracyclines and TMP-SMX. Examining the regional spatial variation of antibiotic resistance can inform empirical therapy recommendations and help to understand the evolution of S aureus antibiotic resistance mechanisms.

Spring black bear harvest and predation pressure on moose calves in a multi‐predator system

AbstractThe moose (Alces alces; mooz in Anishinaabemowin, Ojibwe language will follow scientific names) is a vital subsistence food source to Anishinabe people of the midwestern United States and has recently declined in Minnesota, USA, with poor calf survival as a contributing factor. Predation is the primary cause of moose calf mortality and we explored whether calf predation rates could be reduced through management of a single predator in a multi‐predator system. Thus, we examined predation rates and causes of calf mortality before (2013–2015) and during (2016–2018) implementation of a spring black bear (Ursus americanus; makwa) harvest season, using baits to attract black bears, on the Grand Portage Indian Reservation, Minnesota, where black bears and gray wolves (Canis lupus; ma'iinganag) are the primary predators of moose calves. We validated our early study findings for the 5 years following the initial study with intermittent spring bear hunting seasons, from 2019–2023. The spring bear hunt was canceled because of a pandemic lockdown in 2020, resumed 2021, and was closed in 2022 and 2023. Black bear harvest prior to adding a spring bear hunting season was 0.038 bears harvested/km2 from 2012–2015, whereas after initiating a spring hunting season (2016–2018) it was 17% higher at 0.046 bears/km2. We observed significantly lower bear predation (by 68%) in association with spring bear management and no compensatory change in the level of wolf predation. The validation years strengthened our findings that spring bear hunting seasons reduce moose calf predation rates, with an overall 68% lower proportion of bear predation on moose calves in the years when spring bear hunts were held. Mean proportion of calf predation attributed to bears was 4.9 times higher (30% vs. 6%) in the years when a spring bear hunt was not held. Despite an increasing wolf density during the study period, we did not observe a compensatory increase in wolf predation during spring bear hunt years. The results of this work suggest that the addition of a spring bear hunt, during a time when moose calves are most vulnerable to bear predation, has the potential to increase moose calf survival even in the presence of wolves.

Multi-criteria analysis for sustainable and cost-effective development of desalination plants in Chile

In Chile, there is an increasing demand for freshwater supply for human consumption, agriculture, and industrial activities. In this sense, the country is highly threatened by climate change, which is drastically affecting the availability of water resources in the north-central region due to desertification processes. Therefore, seawater reverse osmosis (SWRO) desalination is becoming one of the most feasible alternatives to address current and future challenges regarding water scarcity in the country. This investigation aims to evaluate potential locations for a sustainable and cost-effective installation of desalination projects; the latter, under a multi-criteria and geographic information system (GIS)-model. The model was tested in the highly water scarcity-threatened Valparaiso Region, Chile, as a case study. The model was developed integrating economic and socio-environmental criteria involved in the development and/or construction of desalination projects. The results of the multi-criteria analysis show that the Valparaıso Region presents optimal areas for developing SWRO projects. Both the northern and central areas of the Region show appropriate locations for installing SWRO plants and their freshwater distribution lines, ensuring short- and long-term water supply, especially for agriculture and population consumption. The results obtained in this study could be extrapolated as a tool to assess the desalination projects development in other world regions to make future desalination projects more viable and sustainable for addressing global water demands.

The transition from physical sibling abuse to bullying perpetration through trait anger: A longitudinal study.

Experiencing physical sibling abuse is a form of family violence that is common but understudied. While it is often perceived as a normative aspect of sibling relationships, there are apparent behavioral consequences. The current study aims to advance the literature by utilizing the displaced aggression model and I3 theory to longitudinally examine trait anger as a pathway linking physical sibling abuse to bullying perpetration. Using data from the Bullying, Sexual, and Dating Violence Trajectories from Early to Late Adolescence in the Midwestern United States, 2008-2013, adolescents (n = 851, M = 14.8 years) completed questionnaires at baseline and were reassessed 6 months later. Results suggested that when adolescents experience physical sibling abuse, they are more likely to engage in bullying perpetration. Mediation analyses indicated that as adolescents were physically abused by a sibling at home, they were more likely to report higher levels of trait anger, which subsequently increased their risk of engaging in bullying perpetration. These results suggest that experiencing physical sibling abuse has long-term detrimental consequences, including elicitation of trait anger, subsequently predicting bullying perpetration.

The Lofar Global Citizenship Radio Array - “Gloray” (Ska-Low-North)

Abstract This talk describes a proposed transformation of LOFAR, the world’s largest, most sensitive high-resolution radio telescope that operates at low frequencies (&lt;300 MHz), into a multidisciplinary intercontinental facility that will be a unique engine for capacity building and development throughout Europe, North Africa, the Middle East and West Asia. As an astronomical array, GLORAY would be the “Hubble Space Telescope” of low-frequency radio astronomy, having a resolution more than 50 times better than any other presently planned low-frequency facility, including SKA-LOW. The mutually interdependent network of LOFAR antenna stations that presently stretch from Ireland to Latvia would be extended to cover North Africa, the Middle East and West Asia and converted into “innovation hubs”. These would form an intercontinental network for pure research, applied research, capacity building, education and science diplomacy within and between the participating countries.

Mosquito Species Diversity and Abundance Patterns in Plots with Contrasting Land Use and Land Cover in Bloomington, Indiana.

Land use and land cover (LULC) gradients are associated with differences in mosquito species composition and the entomological risk of mosquito-borne disease. Here, we present results from a season-long study of mosquito species richness and abundance with samples collected at 9 locations from 2 plots with contrasting LULC, an urban farm and a forest preserve, in Bloomington, IN, a city in the midwestern USA. With a total sampling effort of 234 trap-nights, we collected 703 mosquitoes from 9 genera and 21 species. On the farm, we collected 15 species (285 mosquitoes). In the preserve, we collected 19 species (418 mosquitoes). Thirteen species were common in both study plots, 2 were exclusive to the farm, and 6 were exclusive to the forest preserve. In both plots, we collected Aedes albopictus and Ae. japonicus. In the farm, the most common mosquito species were Culex restuans/Cx. pipiens and Coquillettidia perturbans. In the preserve, Ae. japonicus and Ae. triseriatus were the 2 most common mosquito species. Time series analysis suggests that weather factors differentially affected mosquito species richness and mosquito abundance in the plots. Temperature, relative humidity (RH), and precipitation were positively associated with richness and abundance at the farm, while increases in the SD of RH decreased both richness and abundance at the preserve. Our results highlight the importance that LULC has for mosquito species diversity and abundance and confirm the presence of Ae. albopictus and Ae. japonicus in southwestern Indiana.

Geographic and racial disparities in bi-specific antibodies trials access for diffuse large B-cell lymphoma.

1525 Background: The trials of bispecific antibodies to treat diffuse large B-cell lymphoma (DLBCL) have increased exponentially. However, there is a geographic limitation to offering these trials and universal access appears to be limited. Here, we investigate the geographical and racial disparities in accessing bispecific antibodies trials for DLBCL. Methods: We searched ClinicalTrials.gov using the terms for DLBCL and bispecific antibodies. A total of 13 out of 51 clinical trials with one or more open sites in the United States (US) were included in this systematic review. 2020 US Census Bureau data was used to obtain data on race and ethnicity. Analysis for this study was performed using SPSS version 26. Results: The majority of the included trials were Phase I (62%) followed by Phase II (23%), and Phase I/II (15%). A total of 885 participants were either enrolled or expected to enroll in these clinical trials. Nine (69%) clinical trials were only open in the US while 4 (31%) clinical trials were open in the US and other countries. The majority of the trials were funded by the pharmaceutical industry 62%. There were 50 unique study sites distributed over 24 states with a 2.4 (1-10) mean number of trials per state and 9.9 (1-39) mean number of sites per trial. Study sites were distributed in 24 different states. Midwestern states had the highest number of trials 28%, followed by Southern 26%, Northeastern 24%, and Western 22%. The highest number of study locations (10) and the highest number of open studies (10) were in California. Twenty-seven states had no open bispecific antibodies trials including three in the Northeast (Maine, Rhode Island, and Vermont), five in the Midwest (Illinois, Indiana, Nebraska, North and South Dakota), eight in the South (Delaware, Virginia, District of Columbia, West Virginia, Mississippi, Arkansas, Louisiana, and Oklahoma), and eleven in the West (Arizona, Colorado, Idaho, New Mexico, Montana, Nevada, Wyoming, Alaska, Hawaii, Oregon, and Washington). Using US Census Bureau data, only 20% of African Americans (AA) (8 349 699 of 41 104 200) lived in a county with a bispecific antibodies trial. There were only five states (21%) with 50% or more of the AA population living in a county with an open bispecific antibodies trial and seven states (29%) with 30-49.9% of their AA county residents. Five states (21%) had less than 10% of the AA population living in a county with an open bispecific antibodies trial. Nine (90%) out of ten states with the highest proportion of AA residents (18.6%-41.4%) have no (five states) or only one clinical trial site (four states). Conclusions: There is significant geographic and racial disparity in accessing bispecific antibodies trials for DLBCL. Strategies should be framed to address the causes of the observed disparities and to improve access to these trials.